Interview with Mark Burton
16 Feb 2011
Mark Burton has been a member of SCI since 2009. He is a member of the BioResources Group's Early Career Network and a PhD student at the University of Nottingham. Here he shares an insight into his research into the function of chemical insecticides, as well as his career aspirations.
What is the focus of your research?
My research focuses on physiological resistance to pyrethroid and DDT insecticides. I'm interested in mutations of the target site: the voltage-gated sodium channel (VGSC) identified in a number of field pest insect species, which confers potentially high levels of resistance to these compounds. Understanding how single-point mutations can confer high levels of resistance is key to improving insecticide biochemistry already used in the field. Additionally, my interests also encompass the effects and interaction of natural toxins upon the physiology of the VGSC and neuronal transmission. While there are many potential commercial applications, I would say that my work does not focus on immediately bringing a commercially viable product to the table. Rather, the science enables us to try and find out why insecticide compounds are becoming redundant in controlling different species. This information is important for regulatory bodies, which can save time and money by implementing alternative compounds and strategies for insect pest control.
What (if any) are the barriers to finding commercial applications for your research?
The commercial application of this type of research has long-term and short-term opportunities. The science aims to gain an understanding of the function of chemical insecticides and improve the efficacy of such compounds through analysis of the molecular and genetic detail of individual species. Unfortunately, this approach doesn't offer immediate 'wow' solutions, such as development of new compounds with potential commercial success. Instead it builds an in-depth knowledge surrounding these compounds and approached funding and supporting agri-innovation.
What experience will speakers bring to the event?
Contributors all have a wealth of experience from various aspects of new venturing: biotechnology, agronomy, business development and investment. They include Prof Ian Crute, AHDB chief scientist and former head of Rothamsted Research. Private and corporate investors will explain what they are looking for, and several innovation support organisations, including the Technology Strategy Board will be represented.
One case study will be from Oxitec, a university spin-out exploiting novel insect control technology to combat malaria and crop pests, while the experiences of a much larger global company will be provided by Arysta LifeScience. resistance observed in the field, which can eventually be applicable to the development of new compounds. It is a long-winded but necessary approach if we want to maintain the use of current compounds acting upon a limited number of 'target sites' for insect specificity.
What are your career goals?
I would like to follow up my work with a post-doc in a similar field. Doing a PhD with Rothamsted Research and the University of Nottingham has enabled me to have the freedom and opportunity to explore different career avenues, including industry, research and academia. A real driver for this type of work has to be working, within a team, to be the first to find a solution to a problem that has befuddled others. I also hope to take the opportunity to contribute to the development of the Bioresources Early Career Network. I am also keen to work with the Early Career Network committee to develop young researchers' interests in all aspects of bioresources, and to help showcase new work and business innovation.
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