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8th International Symposium on Agglomeration

2003 Richardson Travel Award Report by Ian Gabbott, University of Sheffield.

Bangkok, Thailand

Buoyed by the hot and sunny Bangkok weather, participants attending the 8th International Symposium on Agglomeration arrived to find a complete program of oral and poster presentations featuring the latest developments in agglomeration technology. The most recent in the successful International Symposium series of meetings, held in the heart of Bangkok, included over 40 technical presentations, 10 invited lectures and many more contributed papers and posters. The symposium encompassed all types of size enlargement processes, including wet and dry granulation, compaction, spray drying, prilling, encapsulation, coating, instantising, and pelletisation over a similarly broad range of industries, from chemical, pharmaceutical, cosmetics, detergents and food to iron and steel, coal and coke and mineral processing.

Starting the daily sessions were captivating keynote lectures by - Hans Leuenberger (University of Basel, Switzerland - The challenge of FDA's PAT initiative), Jim Jones (Massey University, New Zealand - Where did the liquid go?), Michael Hounslow (University of Sheffield, UK - Kinematics in high shear granulation) and T. Charinpanitkul (Chulalongkorn University, Thailand - Recent agglomeration technology in Thailand). Other invited speakers were Y. Fukumori (Kobe Gakuin University, Japan), W. Fromm (Glatt GmbH, Germany), A.D. Salman (University of Sheffield, UK), W. Tanthapanichakoon (National Nanotechnology Center, Thailand Science Park).

The 8th International Symposium on Agglomeration was organised by The Industrial Pharmacists Group, PhAT, the Thai Powder Technology Center, Thailand, and the National Metal and Materials Technology Center. It was sponsored on this occasion by the International Association for Pharmaceutical Technology, the Swiss Society of Pharmaceutical Scientists, and Technology Training Center, TTC. Attendance has continued to grow with scientific participation representing over 12 different countries.

Overall, agglomeration modelling, population balance modelling, and granule structure continue to be popular topics, in addition to tabletting and compaction, particularly favoured by the pharmaceutical industry. Work presented at this meeting focussed primarily on high shear granulation, with fewer papers based upon fluid bed, spray drying, roller compaction and extrusion/spheronisation methods. The main technological developments presented at the meeting were focussed on granule characterisation and measurement techniques, such as the use of x-ray tomography to look inside granules and determine their structure, both qualitatively and quantitatively. This emphasises a shift in thinking from treating the granulation process as a so-called 'black box' in days gone by to the more modern detailed approach, where everything from droplet characterisation to powder morphology and granule microstructure are important considerations. Another area which is progressing is the use of DEM computer simulations to predict and model granulation processes and granule behaviour.

On a more personal note, the International Symposium provided me with my first attendance of a major conference in the field of agglomeration. It was a very rewarding experience which included braving the overly keen air conditioning to listen to other researchers talk about their current research interests, followed by discussions about respective issues over the vast banquet lunches on offer throughout. The International Symposium was also an opportunity for me to present some of my own work, aimed at overcoming the trade-off between the strength and dissolution rate of granules made by conventional granulation methods. This was well received and provided me with an opportunity to discuss my research with others and generate ideas about how to progress further.

The International Symposium program helps to focus the attention of researchers and industrial partners on current developments, research activities and unresolved questions. The symposium attempts to identify research needs and problems in current agglomeration processes, and brings together researchers to discuss novel approaches, results and future opportunities. The International Symposium on Agglomeration returns in 2009 when the University of Sheffield in the UK will play host. Mark your calendars now!

By Richardson Bursar Steven Craythorne
School of Chemistry, Queens University Belfast