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Journal of the Science of Food and Agriculture



GPCRs in Medicinal Chemistry

8 - 10 September 2008

GPCRs in Medicinal Chemistry



JSFA presents mouth-watering papers

SCI peer-review journals are accessible online, or browse through the popular papers in the Members’ lounge at HQ

peas in podPea and whey to help lower blood pressure
Extracts from pea and whey can help in the fight against hypertension. These extracts have been shown to have angiotensin converting enzyme (ACE) inhibitory properties. ACE inhibitors are already a class of drug commonly handed out to sufferers of elevated blood pressure. Researchers at the University of Ghent in Belgium were interested in purifying the extracts that have this ACE inhibiting activity for their clinical potential. They subjected the protein extracts that have this activity to several techniques including centrifugation and ultrafiltration and increased the inhibitory activity of the extracts by 800 times in pea and over 5,000 times in whey.
Fractionation of angiotensin I converting enzyme inhibitory activity from pea and whey protein in vitro gastrointestinal digests.
Vanessa Vermeirssen, John Van Camp, Willy Verstraete, Journal of the Science of Food and Agriculture, DOI: 10.1002/jsfa.1926 (Available on EarlyView)

Identifying impurities in honey with an electronic nose
Researchers working in the US and Belgium have discovered a quick and accurate way to detect whether honey has been adulterated. The zNose uses a surface acoustic wave to check the aroma of the honey. The wave travels between two electrodes and any molecules between these two electrodes slow the wave, allowing accurate sampling of the aroma. The scientists used the zNose to detect invert sugars from beet and sugar cane sources. These cheaper sugars can be added as a filler for honey, compromising its purity. The zNose could detect adulteration with the cheaper invert sugar sources at as little as 1%, proving itself as a cheap and efficient method for quality control.
Fast aroma profiling to detect invert sugar adulteration with zNose.
Els A Veraverbeke, Joseph Irudayaraj, Jeroen Lammertyn, Journal of the Science of Food and Agriculture, DOI: 10.1002/jsfa.1961 (Available on EarlyView)

Novel fat creates heat-resistant chocolate
Chocolate is eaten all over the world, but in tropical temperatures requires constant refrigeration. In India researchers are looking at methods to make chocolate more resistant to higher temperatures. They replaced up to 20% of the cocoa butter with kokum fat, a fat found in the seeds of trees native to southern India. This fat has a high melting point of 39–43°C, making it ideal as a cocoa butter replacement for hotter climates. Hardness of chocolate with this fat increased by up to a third and percentage of solid chocolate at 30°C by 40%, with very little change in the overall quality of the chocolate.
Application of kokum (Garcinia indica) fat as cocoa butter improver in chocolate.
B Maheshwari, S Yella Reddy, Journal of the Science of Food and Agriculture. DOI: 10.1002/jsfa.1967 (Available on EarlyView)

Traditional Indian medicine helps treat diabetes
Scientists at Annamalai University in India have found that the Bael fruit, a native of the Indian sub-continent long employed in traditional medicine, can be used to treat type II diabetes mellitus. Diabetics are unable to control their blood sugar levels and the therapies currently available are dietary modification — drugs that lower blood sugar and insulin injections.

The researchers compared the effects of the fruit extract with a blood sugar-lowering drug in rats with diabetes. They found that the fruit extract had effects comparable to the drug, lowering both blood sugar and blood lipid levels to near normal levels and that the extract performed even better than the drug in lowering kidney and liver lipid levels.
Antihyperlipidaemic effect of Aegle marmelos fruit extract in streptozotocin-induced diabetes in rats.
N Kamalakkannan, P Stanely Mainzen Prince, Journal of the Science of Food and Agriculture, DOI: 10.1002/jsfa.1978 (Available on EarlyView).