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Electronic Laboratory Notebooks

Following the highly-successful SCI Electronic Laboratory Notebooks conference held on 9 February 2005, speakers, SCI Members and delegates can now continue their discussions online. This forum is moderated by Dr David Witty.

To join the debate, use any of the 'Click here to add your comments' links below, and your comments will be posted shortly. The topics are grouped under three headings: Legal, Technical, and Practical . For information on how to post a message, or start a new topic, click here.

Update: Many of the presentations from the conference are now available. Click here for our download page.

Practical
Legal
Technical
 

  • Organisational implications
    What are the financial and organisational implications of starting down the ELNB road?
An organisation just starting up (or a 'forced' rearrangement of an old one) has to decide how to record its data/information/knowledge and I suspect will go down the ELNB road. The disruption and cost are already there for a new organisation, whatever path it chooses.

But what about the vast majority of existing companies of all shapes and sizes? Costs and disruption can be huge. Do we have any examples from those who have introduced an ELNB system into their organisation AND can subsequently see a tangible benefit AND are prepared to say so? No system will be perfect, most certainly not first time round but can we see examples of where a business benefit has been achieved, or is this still too early?

In the same vein, can anyone highlight an example of where ELNB information has been trawled to provide previously unsuspected outcomes?

In practical terms does negative result information really lead to positive outcomes, elsewhere? Come on champions, you've made the pitch, let's see the play! (PS. I'm all for ELNBs)

Posted by KV
 
 

  • Standards
    Is there a need for a standard for the exchange of electronically encoded Laboratory Notebook information? How will companies / universities exchange information in the future?
While E-notebooks come in in a variety of formats and layouts, the metadata and fields associated with at least the chemistry portion of a reaction could quite easily be standardised. This would allow the relatively easy construction of translator programs which would allow experiments from one vendor application to be used to populate another's reaction database. This would clearly be very valuable for academic and industrial collaborations. In the era of mergers, such a capability may be essential.

Anyone want to have a go at specifying the essential fields? How about these for starters:

- Title
- Date
- Identifier
- Author
- Scheme (may need to specify an exchangeable drawing format) Reagents (wt, mol, vol) Solvents (vol)
- Products (ID, wt, mol, yield) could also specify intermediates where necessary
- Atmosphere (type, pressure)
- Temperature
- Technology (e.g. microwave, array)
- Description (text)
- Hazard (which standards - could be overall for the reaction or associated with particular reagents/ products / solvents) Spectra recorded (or attached)
Posted by DW
 
 

  • Universities
    What should universities be doing now on both the teaching and research sides to prepare for ELNs? Are they relevant?
As far as teaching is concerned it probably is irrelevant, as when most graduates go into industry need to learn a lot of new software, a fair bit is in-house. As for research, this would benefit the universities in the same way as it would benefit industry, searchable, IP etc.
Posted by JM
 
 

  • Witnesses
    What is the role of a witness - who can be one and what are they signing up to?
My interpretation (of US patent law) is that the witness corroborates the entry made by the author both in terms of the timeframe, and the substance of the entry, which is why the witness should be knowledgeable in the relevant scientific discipline. I believe a witness could be called as a witness in court if a patent is subjected to an interference, so by witnessing a notebook entry you are identifying yourself as a potential witness in court.
Posted by JA

In my experience as a medicinal chemist within the pharmaceutical industry, a witness should be 'one skilled in the art' so that they could reliably stand up in a patent court. This is usually interpreted as a scientist from the same discipline. Thus, a chemist would witness a chemist's notebook and biologists would witness each other's books. Furthermore, the witness is signing to say they have 'read and understood' what is set down in the lab notebook. Generally a witness will not be someone very familiar with your work, i.e. your supervisor or another member of your project team, but rather someone with the knowledge to take your book and repeat your experiment.

I believe the electronic lab notebook would actually make life a lot easier for the witness. The mandatory fields will ensure some degree of consistency between scientists, the pre-loaded phrases will make the report easier to read than the shorthand currently employed by many scientists and there will finally be no problems from illegible handwriting!
Posted by TM

 
 

  • Wireless
    Aren't (wireless?) Laptops / Tablets essential for successful long term ELN deployments?
I do not think so - there are numerous examples where tablet / wireless technology has not been used and still ROI (return on investment) has been seen from an ELN - it is not just about being able to wite up as you go - there are lots of other benefits, most of which are more valuable than "wireless" benefits. Nevertheless, some situations do benefit from this type of technology but it is not a prerequisite for an ELN deployment and success.
Posted by PDG
 
 

  • Implications
    What implications have ELNs for the design of laboratories / write-up areas?
The past 10-15 years have seen lab designs change to move desks out of labs into a separate 'write-up' area. Surely this is silly in the era of the ELN when data can be entered into the notebook in real time when the experiment is happening. This practice should lead to fewer transcription errors, but perhaps it will also lead to the reversal of the lab design trend as desks move back into labs. Certainly more computers will be needed in the labs. Write-up areas with storage for spectra should be unnecessary, but perhaps will give way to more communal areas.
Posted by DW
 
 

  • Accretion of data
    Once introduced, will the rapid accretion of data cause a similarly rapid reduction in performance in ELN features, such as reaction searching?
It will do if the database has not been designed to take large volumes of data into consideration. There are various techniques that can be used to limit this impact.
Posted by PDG
 
 

  • Small companies
    Are ELNs relevant for a small company?

Guess this depends on cost at the end of the day...I'm sure they're relevant for any organisation from the knowledge management point of view - perhaps more so in a small organisation if there is high turnover of some contract staff for example...if however the cost per person becomes too high in smaller organisations there is a problem.
Posted by LM

 
 

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