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GPCRs in Medicinal Chemistry

8 - 10 September 2008

GPCRs in Medicinal Chemistry



Curbing environmental impact of oil spills


SCI peer-reviewed jounals are accessible online and Members visiting London can browse through them at IHQ

Impact of oil spillsClean spill of health?
Researchers working in Egypt have created a novel method for cleaning up crude oil spills. They make use of crosslinked cinnamoyloxyethylmethacrylate (CEMA) combined with a co-polymer isoctyl acrylate (IOA). This co-polymer helps to promote a less crystalline structure, increasing its oil holding capacity. They were then combined with a crosslinking promoter to create a three-dimensional network structure with oil absorbent properties.

This material has advantages over present oil absorbents such as polypropylene fibre or fabrics and foam sheets due to their relatively poor oil absorbent capacity and bulkiness. The material had good oil absorbent capacity and was able to be reused with little loss of oil holding capacity.

Crosslinked cinnamoyloxyethyl methacrylate and isooctyl acrylate copolymers as oil sorbers, Ayman M Atta, Rasha AM El-Ghazawy, Reem K Farag, Ahmed F El-Kafrawy, Abdel-Azim A Abdel-Azim, Polymer International, DOI: 10.1002/pi.1820 (Available on EarlyView)

The honey trap for beetles
Longhorned beetles are significant pests which can cause serious economic damage boring into wood structures, even causing collapse in seriously infested buildings. Researchers in Germany and the US have looked at methods to control the old-house borer beetles (Hylotrupes bajulus) without using toxic insecticides.

They baited traps with a mixture of male sex pheromones and monoterpenes — volatile organic compounds extracted from Scots pine (Pinus sylvestris L). The beetles responded best to high concentration of monoterpenes, although shunned those with very high concentrations. The addition of the male pheromone caught significantly more females than males and the best combination involved a mixture of both attractants.

Enhancement of attraction and trap catches of the old-house borer, Hylotrupes bajulus (Coleoptera: Cerambycidae), by combination of male sex pheromone and monoterpenes, Gadi VP Reddy, Regina Fettköther, Uwe Noldt, Konrad Dettner, Pest Management Science, DOI: 10.1002/ps.1044 (Available on EarlyView)

Soaking up a stink
Hydrogen sulphide is a gaseous by-product of many industries including wastewater treatment, paper manufacturing and petroleum refining. This gas is responsible for the unpleasant ‘rotten egg’ smell and can be detected by people at concentrations as low as one part per billion.

Ensuring complete cleansing of this gas is extremely important as the smell can lower quality of life as well as being damaging to vegetation and highly corrosive. Researchers at the University of La Coruña, Spain, have developed a method to remove hydrogen sulphide using a biotrickling filter. This combines both inorganic longevity with excellent biological removal of the gas. A filter of plastic rings with a very high surface area has hydrogen sulphide degrading bacteria trickled onto it from above, and as the gas rises it is degraded by the bacteria. Degradation rates of up to 100% were achieved, making this an excellent technology for treatment of waste gases.

Autotrophic deodorisation of hydrogen sulfide in a biotrickling filter, Yaomin Jin, María C Veiga, Christian Kennes, Journal of Chemical Technology and Biotechnology, DOI: 10.1002/jctb.1275 (Available on EarlyView)

Beating egg fraud
It is illegal to misrepresent goods sold and this applies to selling battery eggs as barn or free-range. Scientists working in the UK and Australia have now found a quick, cheap and effective way to screen eggs to check their origins.

When an egg is laid it picks up fluorescent dust from whatever surface it is laid onto. Under UV light this dust can be visualised and the pattern of the surface it was laid onto is visible. Eggs laid in battery cages could be distinguished from those laid in barn or free range conditions due to the lines on the eggs. Eggs laid in battery cages tended to have fine white parallel lines, whereas barn or free range did not.

The test’s effectiveness is, however, reduced when eggs are washed. As eggs in Europe remain unwashed it could be used at both the packaging stage and in retail outlets (see page 6).

Method for checking label accuracy in barn and free range eggs, Neville G Gregory, Mark J Gepp, Peter J Babidge, Journal of the Science of Food and Agriculture, DOI: 10.1002/jsfa.2152 (Available on EarlyView)