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GPCRs in Medicinal Chemistry

8 - 10 September 2008

GPCRs in Medicinal Chemistry



SCI Member puts Franklin in the frame

Michael Abraham’s painting to mark the 50th anniversary of the discovery of DNA is donated to SCI

artist Professor Michael AbrahamJames Watson, Francis Crick and Maurice Wilkins were awarded the Nobel Prize for their roles in the discovery. But many still feel it an outrage that the contributions of another scientist – crystallographer Rosalind Franklin – were not recognised.

It was Franklin’s X-ray photographs of DNA – which have been described as ‘among the most beautiful X-ray photographs of any substance ever taken’ – that helped Watson and Crick to unravel DNA’s complex, elusive structure.

Particularly, one extraordinarily clear image confirmed Watson and Crick’s suspicions that DNA took the form of a double helix. The discovery greatly accelerated scientific advancement, including the Human Genome Project, in which Watson has been heavily involved.

To mark the anniversary of the discovery of the DNA double helix, SCI Member Michael Abraham (picured), a professor of medicinal/physical chemistry at University College London, was asked to paint a memorial picture. His painting was part of the Foreign Office DNA50/Brain research exhibition at the British Embassy, the Hague in 2003–4.

In Prof Abraham’s painting he has made a long-lasting tribute not only to the discovery, but to those involved, particularly Franklin, who died of cancer in 1957, aged just 37.

The main feature of the oil painting is a golden symbol of the helical structure of DNA. On the two strands are the names of the key workers involved in the discovery of the structure. Watson and Crick are on one strand, and Franklin and Wilkins are on the other. The helical structure extends from the lowest to the highest form of life, from a primeval soup to humans, the arm signifying not only humans in general, but the work needed to 'pull out' and identify DNA and its structure.

At the centre of the painting is a representation of the famous X-ray photograph of Franklin, and around the painting are the base pairs fitted together as worked out by Watson and Crick.

Professor Abraham studied painting with the portrait painter Francis Gower for several years, and later with the figurative painter David Carr and then the abstract painter Nigel Caple. He has had several solo exhibitions in London and elsewhere in the UK, as well as exhibiting in numerous mixed shows. He has permanent installations at the Frythe Laboratory (now GSK), the University of Liverpool, and the Royal Free Hospital, Hampstead.

SCI was delighted when Professor Abraham kindly offered to donate the picture to the Society, and the AGM was the perfect opportunity for Michael to formally hand over the painting; with guests treated to a personal account of the painting’s origins and history. The painting can be viewed in hallway 14 of SCI’s Belgrave Square headquarters in London.