Mixed Mode Chromatography download page
Separation Science and Technology conference June 2007
 Adsorption chromatography is an established downstream technique in biopolymer purification.
Base matrices are functionalised with ligands to affect selectivity of the sorbent. Downstream
processes have relied on a series of orthogonal steps to affect a high degree of purification.
With recent developments in ligand design and development the more established techniques
in chromatography have been supplemented with new families of ligands referred to as 'Mixed
Mode'.
The purpose of this meeting was to provide an update into these new ligands and demonstrate
the utility of this technique in a process environment. We reviewed new areas of application for
mixed mode chromatography in the bioseparations industries and the complementarity of this
approach to established chromatographic processes. The international group of speakers includeed
experts in mixed mode chromatography from academia and the bioseparations industries as well
as chromatography sorbent suppliers. The conference was designed to benefit both expert and novice
Chromatographers alike who are keen to consider all options available in downstream processing.
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Conference programme |
| 10.00 |
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Welcome and Brief Overview:
Mixed Mode Chromatography - A Multimodal Technique Based on
Established Chromatographic Approaches (pdf 70Kb)
Dr Peter Levison, Pall Life Sciences, UK |
| 10.15 |
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Recent Advances in Mixed Mode Chromatography
Dr Sylvio Bengio, Pall Life Sciences, France |
| 10.45 |
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Libraries of Multimodal Chromatographic Media as a Tool for Downstream
Process Development
Dr Jean-Luc Maloisel, GE Healthcare Bio-Sciences AB, Sweden |
| 11.15 |
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Mixed Mode Adsorbents for Isolation of Therapeutic Antibodies (pdf 1.9Mb)
Mr Allan Lihme, UpFront Chromatography A/S, Denmark (delivered by Rob Noel) |
| 11.45 |
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Development of Selective Chemical Ligand Adsorbents for Downstream
Processing of Biotherapeutics (pdf 1.4Mb)
Dr Dev Baines, ProMetic BioSciences, UK |
| 13.45 |
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Quantitative Structure Property Relationship Models for Evaluating Mixed
Mode Chromatographic Systems (pdf 4.8Mb)
Prof Steve Cramer, Rensselaer Polytechnic Institute, USA |
| 14.15 |
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Purification of Recombinant Proteins Using Mixed Mode Chromatography (pdf 600Kb)
Dr Andrew Lees, Fina BioSolutions LLC, USA |
| 14.45 |
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Development of a MEP HyperCel IgG Purification Process for a Commercial
Polyclonal Antibody Product
(pdf 1.5Mb)
Dr Richard Francis, Protherics PLC, UK |
| 15.35 |
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Ultra Scale-Down of Mixed Mode Chromatography with Realistic
Feedstocks (pdf 200Kb)
Mr Paul Beckett, University College London, UK |
| 16.05 |
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Developments in Mixed Mode Chromatography in Biopharmaceutical
Purification (pdf 450Kb)
Dr John Liddell, Avecia Biologicals, UK |
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