Antifungal Agents: Discovery and Mode of Action

Readership: researchers in the agrochemical and pharamceutical industries, teachers wishing to keep course material abreast of developments.

• Improved screening test involving expression of target genes in model systems - S Axiotis et al
• High-throughput biochemical screening: advantages and disadvantages - JS Major
• Cellular reporters for antifungal drug discovery - WE Timberlake
• Gene disruption, repeat-induced point mutation and antisense RNA: their application and value in biochemical screening research - CE Caten and DW Hollomon
• The function of sterols in antifungal control - LW Parks et al
• Inhibition of sterol biosynthesis: application to the agrochemical industry - BC Baldwin and AJ Corran
• Progress in the use and delivery of polyenes in antifungal therapy - MH White
• Inhibition of phospholipid and phosphoinositide biosynthesis - GD Robson and AJP Trinci
• Inhibition of fungal acetyl-CoA carboxylase: a novel target discovered with the myxobacterial compound soraphen - L Pridzunet al
• Nucleic acid metabolism as a target for antifungals: the mechanism of action of LY214352 - G Gustafson
• Defining a new molecular target in fungal protein synthesis: eukaryotic elongation factor 3 - MF Tuite et al
• Tubulins: lessons from existing products that can be applied to target new antifungals - JA Butters et al
• Glucan biosynthesis as a target for antifungals: the echinocandin class of antifungal agents - WL Current et al
• Chitin biosynthesis as a target for antifungals - CA Munro and NAR Gow
• Mitochondrial respiration as a target for antifungals: lessons from research on strobilurins - H Sauter et al
• Plant antifungal proteins: novel crop protection agents - SB Rees et al
• The mode of action of the anilinopyrimidines: a new fungicide target - RJ Milling et al
• Discovery and mode of action of the phenylpyrrole fungicide fenpiclonil - ABK Jespers and MA de Waard
• Th1 and Th2 cytokines in murine candidiasis - L Romani et al
• Plant-pathogen interactions: a target for fungicide development - JA Bailey
• Where do we stand? Where do we go? - D Berg and R Tiemann
• Screening for novel antifungal agents directed against the basal mRNA transcription apparatus - CR Wobbe et al
• Molecular analysis of benzimidazole resistance in Rhynchosporium secalis - IE Wheeler et al
• The effects of synthetic putrescine analogues and polyamine biosynthesis inhibitors on germline development in Uromyces viciae-fabae - DR Walters and M Reitz
• Aliphatic and cyclic diamines as novel antifungal agents - ND Havis et al
• Structural and molecular properties of Candida albicans cytochrome P450 sterol 14 alpha-demethylase - DC Lamb et al
• Inhibition of squalene synthase in plant pathogenic fungi - AJ Corran et al
• Calcium signalling and pH homeostasis as novel targets for antifungal compounds - ND Read at al

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