Challenges and Issues in High Throughput Screening

Discusses a technique of key importance in many pharmaceutical companies

Reveals all the latest developments to allow screening professionals and managers in the pharmaceutical and agrochemical industries to evaluate emerging techniques for lead identification

Advances in technology over the past 10 years have enabled a remarkable increase in the rate at which compounds can be screened against a wide range of therapeutic targets. In the mid 1980s, 10,000 compounds tested per year against each target was considered acceptable. It is now possible to test this number of compounds in a day. With this increased efficiency, the focus of interest has shifted from the mechanics of screening to the identification and selection of new targets, securing access to increased chemical diversity and maintaining high throughput technologies that ensure cost effectiveness and efficiency.

Contents

• Aligning science and business for more effective screening and drug discovery
• Leading targets - how to separate the wheat from the chaff
• Genome, cell and tissue closure: creating a molecular framework for target discovery, drug screening and pharmacogenomics
• From sequence to high throughput screening
• Screening strategies - pros and cons of testing mixtures
• Exclusivity and legal issues in sharing screening libraries
• Diversity analysis and its role in compound selection
• Assay technology issues in high throughput screening
• Issues in screen design: whole organism or biochemical approaches
• Cost benefit analysis in relation to automation
• Fluorescence as an enabling technology for high sensitivity assays
• The impact of high throughput screening: removing the bottlenecks
• High throughput data analysis
• Metabolic microscopy: novel approaches to high throughput screening in strain development and fermentation analysis using diffuse reflectance FT-IR and dispersive Raman spectroscopy with chemometrics
• Comparison of time resolved fluorescence and colourimetric readout systems for a protein-protein interaction high throughput screen.

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