High Thoughput Screening - The Next Generation

High Throughput Screening is playing an ever-increasing role in the identification of lead compounds in the pharmaceutical and agrochemical industries. This book provides an authoritative and up-to-date account of the area and will be of particular interest for researchers and managers from the pharmaceutical and agrochemical industries.

Readership

Researchers and managers in the pharmaceutical and agrochemical industries. Lecturers/students with an interest in this field.

Contents

• Does technology deliver the goods?
• Advances in technology to improve HTS - developing multiplexed assays
• Homogenous non-radioactive proximity assays for cell-free and cell-based screening in 1536
• Microfluidic devices - a route to the integration of biology and chemistry in drug discovery
• Re-engineering of the drug discovery process, utilising a unique combination of library design and parallel synthesis
• Combining high information content and high capacity in a platform for drug discovery
• The potential of molecular biophotonics in drug discovery
• Rapid physiochemical profiling as a aid to drug candidate selection
• High throughput screening of nature's diversity: success, issues and future directions
• Successful applications of cominatorial chemistry to lead identification
• Structure-based filtering and design of chemical libraries.

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