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Tissue scaffolds and heavy metal removal

SCI peer-review journals are accessible online, or browse through the popular papers in the Members’ lounge at IHQ
 

water Cheap, effective heavy metal removal
Heavy metals are a serious problem in both domestic and industrial wastewater. Researchers working jointly in Greece and Russia believe they may have found a more cost-effective method for heavy metal removal.

Currently treatment involves a myriad of processes ranging from precipitation, sedimentation, coagulation to filtration and biosorption. The current processes have a number of disadvantages, including the high cost of electro-coagulation and additional purification processes needed to remove purification agents. The team used a galvanochemical removal process using an anode and cathode of suitable, different electrochemical potentials. They successfully removed 90% of zinc over five hours using an anode-cathode pair of iron and coke. This process, unlike electro-coagulation, does not use any electricity and the anode-cathode has the potential to be recycled, making this a cheap and effective way to remove heavy metals.
Removal of zinc from dilute aqueous solutions by galvanochemical treatment, AI Zouboulis, CA Prochaska and PM Solozhenkin, Journal of Chemical Technology and Biotechnology, DOI: 10.1002/jctb.1233 (Available on EarlyView)

Improved bone tissue scaffolds
Scientists at Tsinghua University in China have been working on scaffolds for bone tissue engineering. Bone tissue scaffolds are often required to help repair or replace damaged or diseased tissues in cases of trauma, congenital and degenerative diseases, cancer and cosmetics. These scaffolds are made from materials from a natural source such as collagen. They provide a framework in which bone tissue cells can reproduce and can then be transplanted into the patient. As the scaffold is biodegradable it will be broken down, leaving just the active bone tissue cells creating new bone.

The researchers reinforced their collagen-based scaffold with biocompatible chitosan fibres. The fibres improved the mechanical properties of the structure, increasing the porosity and providing ideal pore size for cell growth without altering its degradation rate. A comparison with and without the fibres demonstrated a 20% increase in cell growth with the fibres.
Collagen-based scaffolds reinforced by chitosan fibres for bone tissue engineering, Xiaoming Li, Qingling Feng, Yunfeng Jiao and Fuzhai Cui, Polymer International, DOI: 10.1002/pi.1804 (Available on EarlyView).

Filtering blood for toxins
Chinese researchers have been examining methods to remove bilirubin from blood. Bilirubin is a metabolite produced by aging red blood cells. It is normally joined to albumin to decrease its toxicity and is then processed in the liver. If, due to disease or damage, the liver is unable to remove bilirubin it can lead to jaundice. This condition, particularly common in newborn babies, can lead to accumulation of bilirubin in the brain causing neurological damage.

Attempts have been made to remove bilirubin directly from patients’ blood before, but have only been successful in mild cases of hyperbilirubinemia. The researchers prepared activated nylon membranes with affinity for bilirubin. The membranes were tested using solutions that mimicked jaundiced blood. They found that the membranes were able to remove bilirubin successfully, but only at low feed-through rates, making them unsuitable for medical use at present.
Adsorption of bilirubin on poly-L-lysine-containing nylon membranes: applications in affinity chromatography, Wei Shi, Fengbao Zhang, Guoliang Zhang, Dongtao Ge, Qiqing Zhang, Polymer International, DOI: 10.1002/pi.1766 (Available on EarlyView)

Novel production of biomaterial
Researchers in Indicinal plant purificationia have produced a hydrogel that they hope will have medical and health applications. These hydrogels have a very high capacity for absorbing aqueous media into their structures giving them good potential in the medical field. The researchers used polyvinyl alcohol and combined it with casein to make a biocompatible, non-toxic, non-carcinogenic material with good elasticity and film forming properties. The hydrogel could have applications in contact lens production, wound dressing, artificial implants and drug delivery.

Current hydrogel production tends to lead to contamination from toxic precursors and reduced biocompatibility. The Indian group used freeze-thawing cycles to create a highly elastic hydrogel with good biocompatibility. This material had none of the toxic contaminants from more traditional production methods.
Preparation and characterization of spongy cryogels of poly(vinyl alcohol)-casein system: water sorption and blood compatibility study, Anil Bajpai, Rajesh Saini, Polymer International, DOI: 10.1002/pi.1773(Available on EarlyView)