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Mixed Mode Chromatography - conference papers

Mixed Mode Chromatography

This item first appeared in 2007

Separation Science and Technology conference June 2007

Adsorption chromatography is an established downstream technique in biopolymer purification. Base matrices are functionalised with ligands to affect selectivity of the sorbent. Downstream processes have relied on a series of orthogonal steps to affect a high degree of purification. With recent developments in ligand design and development the more established techniques in chromatography have been supplemented with new families of ligands referred to as 'Mixed Mode'.

The purpose of this meeting was to provide an update into these new ligands and demonstrate the utility of this technique in a process environment. We reviewed new areas of application for mixed mode chromatography in the bioseparations industries and the complementarity of this approach to established chromatographic processes. The international group of speakers includeed experts in mixed mode chromatography from academia and the bioseparations industries as well as chromatography sorbent suppliers. The conference was designed to benefit both expert and novice Chromatographers alike who are keen to consider all options available in downstream processing.

Conference programme

10.00 Welcome and Brief Overview:
Mixed Mode Chromatography - A Multimodal Technique Based on Established Chromatographic Approaches
(pdf 70Kb)
Dr Peter Levison, Pall Life Sciences, UK
10.15 Recent Advances in Mixed Mode Chromatography
Dr Sylvio Bengio, Pall Life Sciences, France
10.45 Libraries of Multimodal Chromatographic Media as a Tool for Downstream Process Development
Dr Jean-Luc Maloisel, GE Healthcare Bio-Sciences AB, Sweden
11.15 Mixed Mode Adsorbents for Isolation of Therapeutic Antibodies (pdf 1.9Mb)
Mr Allan Lihme, UpFront Chromatography A/S, Denmark (delivered by Rob Noel)
11.45 Development of Selective Chemical Ligand Adsorbents for Downstream Processing of Biotherapeutics (pdf 1.4Mb)
Dr Dev Baines, ProMetic BioSciences, UK
13.45 Quantitative Structure Property Relationship Models for Evaluating Mixed Mode Chromatographic Systems (pdf 4.8Mb)
Prof Steve Cramer, Rensselaer Polytechnic Institute, USA
14.15 Purification of Recombinant Proteins Using Mixed Mode Chromatography (pdf 600Kb)
Dr Andrew Lees, Fina BioSolutions LLC, USA
14.45 Development of a MEP HyperCel IgG Purification Process for a Commercial Polyclonal Antibody Product (pdf 1.5Mb)
Dr Richard Francis, Protherics PLC, UK
15.35 Ultra Scale-Down of Mixed Mode Chromatography with Realistic Feedstocks (pdf 200Kb)
Mr Paul Beckett, University College London, UK
16.05 Developments in Mixed Mode Chromatography in Biopharmaceutical Purification (pdf 450Kb)
Dr John Liddell, Avecia Biologicals, UK

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