10 September - 12 September 2018

7th SCI/RSC Symposium on GPCRs in Medicinal Chemistry

Organised by:

SCI's Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector

Verona, Italy

Registration Closed

This event is no longer available for registration.

Synopsis

The key role of G protein-coupled receptors (GPCRs) in human disease underpins their importance to modern medicine. We are pleased to announce that Aptuit, Italy will once again support the seventh meeting in this series on GPCR drug discovery, combining cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.

The meeting will consist of:

First disclosures of clinical candidates
Case studies in GPCR drug discovery and development
New structural biology and drug design
Allosteric modulation

Also: poster session - trade exhibition opportunities - two evening dinners and vineyard visit - accommodation agency booking service

Attendees

This meeting will be of interest to medicinal chemists, pharmacologists, computational chemists, structural biologists and all those involved in drug discovery.

Confirmed speakers

Allosteric modulators of GPCRs: theoretical and practical considerations
Arthur Christopoulos, Monash University, Australia

GPCR Consortium: four years of progress in structural biology
Michael Hanson, GPCR Consortium, USA

Structure and mechanism of human CNS GPCRs
Daniel Rosenbaum, University of Texas Southwestern Medical Center, USA

Shedding light on G protein bias: structures of GPCRs coupled to G proteins determined by cryo-EM and X-ray crystallography
Chris Tate, MRC Laboratory of Molecular Biology, UK

Trisubstituted cyclohexanes as dual antagonists of CCR2 and CCR5
Robert Cherney, BMS, USA

Application of structure-based drug design to peptidergic GPCRs
Miles Congreve, Heptares Therapeutics, UK

Mining structural GPCR-ligand interaction maps to navigate medicinal chemistry space
Chris de Graaf, Vrije Universiteit Amsterdam, The Netherlands

Novel and potent spirocyclic compounds as ghrelin receptor agonists
Cristina Gardelli, AstraZeneca, Sweden

Identification of highly selective orexin 1 receptor antagonists: structure-based scaffold modifications to improve subtype selectivity and synthesis of a novel bicyclic scaffold
Uta Lessel, Boehringer Ingelheim, Germany

GPCR drug discovery with structural insights
Xiayang Qiu, Pfizer, USA

Chemical optimization of centrally acting anti-obesity agents
Lothar Schwink, Sanofi-Aventis, Germany

Presentation title to be confirmed
Brock Shireman, Janssen, USA

Venue and Contact

Aptuit Verona SRL

Aptuit
Via Alessandro Fleming 4
Verona
IT-37135
Italy

Mrs Maggi Churchouse

Tel: +44 (0)1359 221004

Fees

Early bird fees before Tuesday 5 June 2018

GB£430 . . . . . . . . . . . . . . . . . SCI/RSC Member
GB£180 . . . . . . . . . . . . . . . . . SCI/RSC Student Member*
GB£530 . . . . . . . . . . . . . . . . . Non-Member
GB£228 . . . . . . . . . . . . . . . . . Student Non-Member*

Standard fees after Wednesday 6 June 2018

GB£505 . . . . . . . . . . . . . . . . . SCI/RSC Member
GB£205 . . . . . . . . . . . . . . . . . SCI/RSC Student Member*
GB£600 . . . . . . . . . . . . . . . . . Non-Member
GB£260 . . . . . . . . . . . . . . . . . Student Non-Member*

*Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment. Member is paid-up member of the RSC or SCI.

Discounted rates are offered to RSC and SCI student members, and some student bursaries are available. Please download a bursary application form from our website here.

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Booking Process/Deadlines

For booking terms and conditions click here.

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Partners

Organising Committee

Adrian Hall, UCB, Belgium
Caroline Low, Consultant, UK
Jon Mason, Heptares Therapeutics, UK
Fabrizio Micheli, Aptuit, Italy
David Miller, Inflazome, Ireland
Sarah Skerratt, Vertex, UK