In honour of World Health Day, held on 7 April 2019 annually, we have collated the five most innovative healthcare projects we have featured on SCI’s website over the past year.
Using 2D imaging techniques to diagnose problems with the heart can be challenging due to the constant movement of the cardiac system. Currently, when a patient undergoes a cardiac MRI scan they have to hold their breath while the scan takes snapshots in time with their heartbeat.
Still images are difficult to obtain with this traditional technique as a beating heart and blood flow can blur the picture. This method becomes trickier if the individual has existing breathing problems or an irregular heartbeat.
An innovative new screening method using cell aggregates shaped like spheres may lead to the discovery of smarter cancer drugs, a team from the Scripps Research Institute, California, US, has reported.
The 3D aggregates, called spheroids, can be used to obtain data from potentially thousands of compounds using high throughput screening (HTS). HTS can quickly identify active compounds and genes in a specific biomolecular pathway using robotics and data processing.
Several thousand antibiotic combinations have been found to be more effective in treating bacterial infections than first thought.
Antibiotic combination therapies are usually avoided when treating bacterial infections, with scientists believing combinations are likely to reduce the efficacy of the drugs used. Now, a group at UCLA, USA, have identified over 8,000 antibiotic combinations that work more effectively than predicted.
Researchers at the University of Copenhagen, Denmark, have identified a mechanism that prevents natural DNA errors in our cells. These errors can lead to permanent damage to our genetic code and potentially diseases such as cancer.
Mutations occurring in human DNA can lead to fatal diseases like cancer. It is well documented that DNA-damaging processes, such as smoking tobacco or being exposed to high levels of ultraviolet (UV) light through sunburn, can lead to increased risk of developing certain forms of cancer.
Treatments for Alzheimer’s disease can be expensive to produce, but by using novel cultivation of daffodils one small Welsh company has managed to find a cost-effective production method of one pharmaceutical drug, galanthamine.
Alzheimer’s disease is a neurodegenerative disease with a range of symptoms, including language problems, memory loss, disorientation and mood swings. Despite this, the cause of Alzheimer’s is very understood. The Alzheimer’s disease drug market is currently worth an estimated US$8bn.
The Svalbard Islands are in Northern Norway.
The finding is all the more unexpected as the team was seeking a virgin environment to try and establish what a background level of antimicrobial resistance in soil bacteria looks like.
Scientists found genes important to antimicrobial resistance in soil bacteria.
‘We took 40 samples to give us an idea of what the baseline of resistance might look like in nature, but we were surprised by how different the sites were from each other,’ says lead scientist David Graham at Newcastle University. Areas with high wildlife or human impact had greatest diversity of resistance DNA in the soil.
The results show that antibiotic resistance genes are accumulating even in the most remote locations. Included in a number of samples was a multidrug resistant gene called New Dehli strain, first isolated in India.
Newcastle University find antibiotic resistant genes in Arctic. Video: Newcastle University
Some sites had levels of antimicrobial resistance 10 times greater than others, particularly those with elevated levels of phosphorus, a nutrient usually scarce in Arctic soils.
‘There was much greater resistance diversity in sites with strong signatures of faecal matter,’ says Graham, indicating that migratory birds most likely brought the antimicrobial resistance genes, depositing them via their guano.