Mosquitoes are a vector of the malarial parasite. Image: Pixabay
There were 219m cases of malaria in 2017, up 2m on the previous year. Increasingly, the disease is drug-resistant and prevention methods are difficult both in non-immune travelers and in areas where the disease is endemic. Moreover, most malaria drugs are designed to reduce symptoms after infection rather than prevent infection or transmission.
New compounds have been discovered with the potential to be novel antimalarial drugs. Image: Pixabay
A team of scientists are working to change that, aiming to treat the malaria parasite at an earlier stage – when it affects the human liver – rather than waiting until the parasite is in the blood. If successful, their work could have a significant impact on global health.
With a rapidly increasing population, the world is struggling to meet the demand for food, water, energy, and medicine. In 2011, the global population reached 7bn – approximately the amount of grains of sand you can fit it a post box, says Sir Martyn Poliakoff – and this number has since increased.
On Wednesday 25 April 2018 at his Public Evening Lecture, Sir Martyn discussed the role of photochemistry – the study of light’s effects on chemical reactions – in creating a greener and more sustainable society as essential resources deplete.
‘Chemists have to help address the sustainability challenges facing our society,’ he said. His research group at the University of Nottingham is proving that photochemistry can make an impact.
Fighting Malaria with Green Chemistry. Video: Periodic Videos
There are 1.3bn individuals in the world who are considered ‘profoundly’ poor. To define this Sir Martyn illustrated the profoundly poor ‘can, in their head, list everything they own’.
Today, there are more people worldwide that use mobile phones than toothbrushes. As no one wants to consume less, he asked: ‘Can we provide more for the poor without robbing the rich?’
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The world’s largest agriculture companies have joined forces to invest in new and innovative technologies that will hopefully eradicate malaria by 2040. The ‘Zero by 40’ campaign was launched at the annual Commonwealth Heads of Government meeting held in London last week.
The programme has the support of the Bill & Melinda Gates Foundation and the Innovative Vector Control Consortium, based in Liverpool, UK, as well as companies BASF, Bayer, and Syngenta – among others.
Mosquitos are known vectors of the malaria virus. Image: James Gathany/Centre for Disease Control
Malaria affects over 200 million people each year – most cases are found in Africa but the disease is still prevalent in South East Asia and in the Mediterranean. Although the number of cases has been slowly falling year-on-year, this progress is threatened by insecticide resistance.
It is estimated that four out of five malaria cases have been prevented through long-lasting insecticide-treated bed nets (LLINs) and indoor residual spraying (IRS) techniques. The campaign is a continued sign of commitment from the agriculture industry, with companies already having produced innovative solutions to tackle the global issue.
Both Syngenta and Bayer have introduced new IRS products – either in the final stages of development or already employed across Africa. BASF has developed a new generation mosquito net with an insecticide derived from crop use to deter resistant mosquitos.
Insecticides used in agriculture are used as control mechanisms for the mosquito population.
‘Our industry collaboration, supported by our funders including the Bill & Melinda Gates Foundation and the UK’s Department of International Development, is starting to bear fruit and is saving lives today,’ said Nick Hamon, CEO of IVCC.
‘But we still have a long way to go to achieve our ambition of ending the disease burden of malaria by 2040,’ Hamon said. ‘This new initiative will not only secure the current supply of solutions, but will pave the way for desperately needed new forms of chemistry and new vector control tools to reduce the disease burden of malaria which still affects millions of people.’