A year after the world was put on alert about the rapidly spreading covid-19 virus, mass vaccination programmes are providing a welcome light at the end of the tunnel.
However, for many people vaccination remains a concern. A World Economic Forum – Ipsos survey: Global Attitudes on a Covid-19 Vaccine, indicates that while an increasing number of people in the US and UK plan to get vaccinated, the intent has dropped in South Africa, France, Japan and South Korea. The survey was conducted in December 2020, following the first vaccinations in the US and the UK.
This study shows that overall vaccination intent is below 50% in France and Russia. ‘Strong intent’ is below 15% in Japan, France and Russia.
Many cities are still in lockdown
Between 57% and 80% of those surveyed cited concerns over side effects as a reason for not getting a covid-19 vaccination. Doubts over the effectiveness of a vaccine was the second most common reason cited in many countries, while opposition to vaccines in general was mentioned by around 25% those who will refuse a vaccination.
The survey was conducted among 13,542 adults aged 18–74 in Canada, South Africa, and the US, while those surveyed in Australia, Brazil, China, France, Germany, Italy, Japan, Mexico, Russia, South Korea, Spain and the UK were aged 16–74.
A previous survey, Global Attitudes on a Covid-19 Vaccine carried out in July and August 2020, indicated that 74% of those surveyed intended to get vaccinated. At that time the World Economic Forum said that this majority could still fall short of the number required to ‘beat covid-19.’
Commenting on the newest data Arnaud Bernaert, Head of Health and Healthcare at the World Economic Forum said; ‘As vaccinations roll out, it is encouraging to see confidence improve most in countries where vaccines are already made available. It is critical that governments and the private sector come together to build confidence and ensure that manufacturing capacity meets the global demand.’
World Economic Forum-Ipsos Survey indicates a rise in number of people in US and UK intending to get vaccinated.
With the imperative now to move towards some sort of ‘normality’, as well as getting economies moving, fears over vaccination need to be allayed. However, what also needs to be considered is what underlies those fears. Misinformation, no doubt, has a part to play. This highlights a lack of trust in governments and a sector that has worked tirelessly to develop vaccines in record time.
As different companies bring their vaccines to the market, care now needs to be taken to reassure people around the world that whichever manufacturer’s vaccine they are given, they are in safe hands. As any adverse reactions occur – an inevitability with any vaccine rollout – these ought to be made known to the wider public by companies and governments as soon as it is feasible, preventing space for the spread of rumour and misinformation, which could undo the hard work of the scientists, businesses and governments bringing vaccines to the public.
Researchers have worked tirelessly to bring vaccines to the market
Here is a roundup on some of the most recent research and scientific efforts against the coronavirus.
Novartis has reached an agreement with the US Food and Drug Administration to proceed with a phase III clinical trial of hydroxychloroquine in hospitalized Covid-19 patients. The large trial will be conducted at more than a dozen sites in the US and tested on approximately 440 patients to evaluate the use for this treatment.
Additionally, Norvatis plans to make its hydroxychloroquine intellectual property available to support broad access to hydroxychloroquine. Read more here.
Causaly, an innovative technology company that harnesses AI to interpret vast databases of biomedical knowledge, is collaborating with UCL academics to increase research on potential therapeutic agents and the identification of biomarkers.
Several researchers and research groups within UCL have been granted access to Causaly technology, allowing them the access to rapidly analyse and derive insights from biomedical literature.
Read more here.
As part of the UK’s wider efforts to support the development of a vaccine, a new government-led Vaccine Taskforce will soon be launched to drive forward the manufacturing and research efforts to fight the virus.
The government will review regulations to facilitate fast and safe vaccine trials, as well as operational plans, to ensure a vaccine can be produced at a large scale when it becomes available. Industry and academic institutions will be given the resources and support needed.
Business Secretary Alok Sharma said, ‘UK scientists are working as fast as they can to find a vaccine that fights coronavirus, saving and protecting people’s lives. We stand firmly behind them in their efforts. The Vaccine Taskforce is key to coordinating efforts to rapidly accelerate the development and manufacture of a potential new vaccine.’ Read more here.
A new biosensor for the COVID-19 virus
Research teams at Empa and ETH Zurich have developed an alternative test method in the form of an optical biosensor. The sensor made up of gold nanostructure, known as gold nonoislands on a glass substrate, combines two different effects to detect covid-19: an optical and a thermal one.
According to the release, ‘Artificially produced DNA receptors that match specific RNA sequences of the SARS-CoV-2 [virus] are grafted onto the nanoislands,’ and researchers will then use the optical phenomena, - localised surface plasmon resonance - to monitor the presence of the virus.
The biosensor is not yet ready to be used to monitor and detect COVID-19, however tests showed the sensor can distinguish between very similar RNA sequences of SARS-CoV-2 virus and its relative, SARS-Cov. Read more here.
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Coeliac disease is caused by an autoimmune response to gluten and affects approximately 1 in 100 people worldwide. Those affected must eat a gluten-free diet, or they may experience uncomfortable digestive symptoms, mouth ulcers, fatigue and anaemia.
What’s the big deal with gluten? Video: TED-Ed
Problems occur for coeliac disease patients when they are exposed to gluten – a protein found in wheat and other grains – and the immune system is triggered to attack the body. This results in inflammation, mainly in the intestines, and causes the subsequent acute symptoms related to the condition.
Over 90% of coeliac disease patients carry immune recognition genes known as HLA-DQ2.5. These genes are human leukocyte antigen (HLA) genes, which usually relate to specific diseases.
ImmusanT, a leader in the development of therapies for autoimmune disorders, has developed a vaccine that targets patients carrying the HLA-DQ2.5 genes. This novel therapeutic vaccine, known as Nexvax2, works by reprogramming specific T cells that are responsible for triggering an inflammatory response when gluten is consumed.
The IHNV virus has spread worldwide and is fatal to salmon and rainbow trout – costing millions in sales of lost farmed fish. The current vaccination approach requires needle injection of fish, one by one. Now, however, Seattle-based Lumen Bioscience has come up with a new technology to make recombinant vaccines in a type of blue-green algae called Spirulina that costs pennies to produce and can be fed to fish in their feed.
To be effective, oral vaccines have not only to survive the gut environment intact but must also target the appropriate gut-associated immune cells. The approach developed by Lumen overcomes many of the problems with complex and expensive encapsulation strategies attempted in the past, according to CEO Brian Finrow.
‘[It] focuses on a new oral-vaccine platform [using] engineered Spirulina to express high amounts of target antigen in a form that is both provocative to the immune system – ie generates a desirable immune response that protects against future infection – and can be ingested orally without purification, in an organism that has been used as a safe food source for both humans and fish for decades.’
To produce the new oral vaccine, the Lumen researchers first developed a strain of Spirulina that manufactures recombinant proteins in its cell walls that the salmon immune system recognises as IHNV viruses. They then rapidly grew the strain in a large-scale indoor production system – requiring only light, water, salt and trace nutrients – and harvested and dried all the raw Spirulina biomass. This dried powder can then be fed to the fish.
Vaccines are much debated these days, but before starting a discussion about them, let’s see how a vaccine is defined.
The World Health Organisation defines a vaccine as:
‘a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body’s immune system to recognize the agent as foreign, destroy it, and “remember” it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.’
We put in our bodies something that looks like or has a tiny part of the ‘microbe’ that produces the disease so that our body can produce the right agents to fight it in case we actually contract the real illness.
A vaccine is comprised of an active ingredient and other added ingredients. Like any other drug, the active ingredient is the key component that triggers the immune response. Beside this, the added ingredients have different roles, such as improving the immune response, or acting as a preservative, stabiliser, or suspending fluid.
These added ingredients are the ones that are sometimes contested due to their toxicity. But when speaking about toxicity, there is a very important point to make. Everything is toxic.
It all comes down to the dose you eat, drink, or otherwise insert into your body. An important indicator of toxicity is LD50 (lethal dose 50), which is the dose at which 50% of individuals die. Sodium chloride, also known as table salt, has a LD50 of 12,400mg/kg (868g of salt for a 70kg individual) for humans. The lower the LD50 indicator is, the more toxic a compound is.
Table salt can also be toxic.
Aluminium salts are used in many vaccines as adjuvants. This means that they help by stimulating the immune response and by a slow release of the active ingredient.
The most used salts are aluminium hydroxide, aluminium phosphate and potassium aluminium sulphate. Data about these compounds are freely accessible by searching for their material safety data sheets (MSDS) on the big chemical suppliers’ websites. The 11th section of an MSDS file is the toxicological information section, which contains the LD50 value, carcinogenicity information, and others.
Section 11 of the aluminium phosphate MSDS Sigma-Aldrich
None of the salts above are reported as carcinogenic, and the LD50 of aluminium phosphate is more than 5,000mg/kg for mice. The total quantity of the aluminium in a vaccine is less 1mg (0.001g), which is a very low quantity. In the normal European diet the amount of aluminium we intake from food varies between 3–10mg a day.
Vaccine composition lists also include compounds and products used in the manufacturing process – even though at the end of manufacture they are present only in trace amounts, if at all.
One of the chemicals on this list that scares people is formaldehyde, which is indeed carcinogenic with and LD50 of 42mg/kg for mice. Nevertheless, the quantity present in a vaccine dose is less 0.1 mg. One 200g pear contains 12mg of formaldehyde. We should always remember ‘the dose makes the poison’, as compound interest illustrates below.
The does makes the poison – ‘toxic’ chemicals in food. Compound Interest
Vaccination is a personal decision. Nevertheless, it should be based on information from multiple verified sources. Easily accessible and clear information can be found on the Vaccine Knowledge Project website designed by the Vaccine Research Group from the University of Oxford.