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Telephone: +44 (0)1638 781709

Compact high pressure benchtop reactor

ASYNT - Compact high pressure benchtop reactorThe Quadracell 4-position high pressure reactor from Asynt is a new synthetic tool for scientists seeking the convenience of routine parallel pressure chemistry in a compact footprint.

The reactor is simple to set up and to operate, with heating and agitation provided by a standard magnetic hotplate stirrer and magnetic flea.

Constructed in Stainless Steel 316, it has four cells – each with a reaction volume of 10 mL – that can routinely operate at temperatures up to 250°C. For labs using aggressive or caustic media, it is optionally available constructed from Hastelloy C276 for enhanced chemical resistance.

Different versions are available to safely operate up to your chosen maximum working pressure of 50, 100 or 200 Bar. Each reactor is supplied as standard with a pressure release valve, pressure gauge, gas inlet and gas outlet via two stainless steel needle valves.


Telephone: +44 (0)845 864 7747

Automating production of compound libraries

Uniqsis - Automating production of compound librariesThe FlowSyn from Uniqsis is a compact integrated continuous flow reactor system designed for easy, safe and efficient operation.

Application Note 29 describes an efficient continuous flow synthesis protocol to create a new library of pyrazoles developed by chemists at GalChimia (Coruna, Spain). The aim was to develop a continuous flow protocol to replace the traditional two-step synthesis and to examine its scope.

The authors demonstrate how a range of conditions could be quickly evaluated thereby facilitating rapid reaction optimisation. In addition, useful quantities of a wide range of pyrazoles could be prepared in less than one hour each.

The range of chemistries that can be explored with flow systems grows ever wider, as exemplified by the growing number of applications published both in the academic press and in Uniqsis’ application notes. Typical examples include hydrogenation, nitration, bromination, metalation, molecular rearrangements and synthesis of compounds such as dihyropyridine, indole, pyrazole, quinolinone and benzimidazole.