Get your product noticed. Let C&I give it the profile it deserves.
Contact Genevieve Kanowski on +49-6201-606 638 or by email gkanowski@wiley.com to get into the next edition of Supply Line.
This month's product is:
Telephone: +44 (0)1638 781709
Email: enquiries@asynt.com
Web: asynt.com/product/reactomate-reaction-systems
Efficient scale-up of agrochemicalsAsynt reports Globachem Discovery, Alderley Park UK, has benefited ReactoMate reactor systems for the scale-up of novel agrochemicals. Globachem Discovery, the UK R&D arm of Globachem, a Belgian agrochemical business, operates in the early phases of the R&D pipeline. After initial biological efficacy and early toxicology validation, these molecules move to the Belgian R&D division for further development.
Vicky Jackson of Globachem Discovery commented: ‘We assessed several suppliers to offer flexibility and the ability to transition new compounds from the bench to commercial manufacturing. Today, our chemists look to the ReactoMate systems to support synthesis from milligram to kilogram scale. This allows us to perform a wide range of chemistries such as reductions, oxidations, organometallic and classic peptide coupling reactions.
‘The reactors allow us to work from -20°C to 180°C and perform distillations under vacuum. The software allows us to data log key information, store reaction profiles, control the temperature and the stirring speed.’
Telephone: +44 (0)1638 781709
Email: enquiries@asynt.com
Web: asynt.com/product/drysynvortex
Development of high performance polymersAsynt has supplied Polymer Mimetics (Liverpool, UK) with a range of equipment to exploit novel chemistries for a new generation of high-performance polymers. Polymer Mimetics is a joint venture between the University of Liverpool and Scott Bader, building upon a new polymerisation process developed by Steve Rannard from the University’s Department of Chemistry. The technology takes widely available chemical building blocks and, in a highly scalable process, transforms them into superior performance polymeric products with the potential to engineer in degradability.
Paul Findlay, Chief Technology Officer at Polymer Mimetics said: ‘In setting up a laboratory, a key factor influencing our choice of supplier was being able to effectively and safely conduct multiple reactions, on one stirrer hotplate, at the same time enhancing the number of candidate polymers that can be synthesised. As some reactions involve viscous solutions, Asynt’s DrySyn Vortex overhead stirrer platform enabled us to agitate and heat multiple viscous reactions in parallel, under inert atmospheres.’
Telephone: +81-466 238382
Email: europe@bicr.co.jp; northamerica@bicr.co.jp; enquiries@bicr.co.jp
Web: biochromato.com/plate- and-seals/eps
Contamination-free microplate sealing BioChromato reports pharmaceutical companies undertaking Absorption, Distribution, Metabolism and Excretion (ADME) studies are integrating RAPID Easy Piercing Seals (EPS) into their screening protocols.
Commonly scientists use 96 or 384 well microplates for storing their large number of samples to be screened. To maintain integrity, it is important that the microplates are effectively sealed and the seal does not contaminate the samples even after repeated sampling with an HPLC autosampler.
Traditional seals often rely on silicone-based adhesives to create a seal. As a result, contamination issues can arise as common HPLC solvents such as acetonitrile, water and DMSO can extract siloxane out of the adhesive. By comparison, RAPID EPS seals use a synthetic rubber adhesive to create an air tight seal and do not introduce contamination. The seal also leaves no particulate material when pierced by an HPLC Autosampler, but offers sealing over a working temperature range of -80°C to 80°C.
Telephone: +44 (0)845 864 7747
Email: info@uniqsis.com
Web: uniqsis.com/paProducts Detail.aspx?ID=ACC_CHIP
Controlled turbulent mixingThe Uniqsis range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream that is not diffusion dependent for flow chemistry reactions.
Available in sizes from 270µl to 20ml, the expanded range can be used from -80°C to over 150°C. Chips up to 2ml can be operated up to 40bar and are available in 2-channel or 3-channel inlet configurations. Larger 10ml and 20ml chips have a premixing channel followed by a residence domain and can operate up to 10bar.
They can be used as mixing modules prior to a coil reactor residence time unit, or as reactor blocks for rapid exothermic reactions such nitrations, an important synthetic procedure that, following reduction of the nitro group, provides a useful route for the introduction of amino groups onto aromatic rings.
Machined from borosilicate glass, they can be attached to a FlowSyn column heater module, Cold Coil or Polar Bear Plus cryogenic reactor modules.