10 November 2015

1st SCI/RSC Symposium on Fibrosis Disease: Medicinal Chemistry Progress from Biological Target to the Clinic

Organised by:

 SCI's Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector

Slough, UCB

Registration Closed

This event is no longer available for registration.

Synopsis
Fibrosis disease is the result of a dysregulated wound healing process and is responsible for considerable patient mortality affecting multiple organs in diseases such as idiopathic pulmonary fibrosis (IPF), diabetic nephropathy, steatohepatitis and systemic sclerosis. Fibrosis disease pathology is often complex and this inaugural symposium on fibrosis will provide mechanistic insight and progress in medicinal chemistry and drug discovery from experts across the world.
Programme

Event Day

Event Section
09:00
Registration and refreshments Session chair: Luis Castro, UCB
09:30
Welcome and opening remarks Luis Castro, UCB
09:35
The common denominator of chronic disease - Fibrosis Prof Robert M Strieter, Novartis
10:20
Out of the frying-pan PI3K and into....? Generation of a robust pathway toolbox to investigate the anti-fibrotic behaviour of GSK2126458A Simon Peace, GlaxoSmithKline
10:50
Refreshments Session chair: Richard Hatley, GlaxoSmithKline
11:20
Design of mechanism-based amine oxidase inhibitors for the treatment of fibrosis Dr Jonathan Foot, Pharmaxis
11:50
Tissue transglutaminase - a credible therapeutic target in the treatment of fibrotic disease due to its multifunctional roles? Martin Griffin, Aston University
12:20
Structure-based design, synthesis, and biological evaluation of novel autotaxin inhibitors Lisa Miller, University of Strathclyde
12:23
Toward novel treatment units in fibrosis Frances Potjewyd, University of Strathclyde
12:26
Structure activity relationship of PF-8380 and development of a novel chemotype towards autotaxin inhibition Emma Duffy, University of Strathclyde
12:30
Lunch Session chair: Tim Johnson, UCB
13:30
Structure activity relationships of av integrin antagonists - industrial medicinal chemistry with 4th year MSci undergraduates Simon Macdonald, GlaxoSmithKline, and Thomas McInally, University of Nottingham
14:00
Harnessing our understanding of scleroderma to develop and validate innovative anti-fibrotic therapies David Abraham, University College London
14:30
Discovery and quantitation of novel liver fibrosis biomarkers: towards the first antibody-free biomarker assay for liver fibrosis Bevin Gangadharan, University of Oxford
14:40
Refreshments
15:10
Role of NOX enzymes in fibrotic diseases: development of a 1st in class NOX1/4 inhibitor GKT137831 Ursula Ney, Genkyotex
15:40
Does CB2 agonism protect from inflammation related organ damage and fibrosis? Uwe Grether, F Hoffmann-La Roche
16:10
IPF active macrocycles identified from phenotypic screening Gordon Saxty, Fidelta
16:50
Closing remarks Luis Castro, UCB
17:00
Meeting close

Venue and Contact

UCB

UCB
208/216 Bath Road 
Slough 
SL1 3WE 
United Kingdom

UCB is a 5 minute taxi journey from Slough railway station, 30 minutes by car from Heathrow Airport and easily accessible by car from the M25, M4 and M40.

Maggi Churchouse

Tel: +44 (0)1359 221004

Email: maggi@maggichurchouseevents.co.uk


Fees

Early Bird Rate - before 7 August 2015

GB£100 . . . . . . . . . . . . . . . . RSC/ SCI Member 
GB£130 . . . . . . . . . . . . . . . . Non-Member 
GB£50. . . . . . . .. . . . . . . . . . RSC/ SCI Student Member
GB£65. . . . . . . . . . . . . . . . . .Student* Non-Member

Standard Rate - from 7 August 2015 to 7 October 2015

GB£120 . . . . . . . . . . . . . . . . RSC/ SCI Member
GB£150 . . . . . . . . . . . . . . . . Non-Member
GB£60. . . . . . . . . . . . . . . . . .RSC/ SCI Student Member
GB£75. . . . . . . . . . . . . . . . . .Student* Non-Member
GB£30 . . . . . . . . . . . . . . . . . Late payment fee for any payments received after Wednesday 7 October 2015
* Student is undergraduate or post-graduate, not post-doc

GB£119. . . . . . . . . . . . . . . . . One night's B&B accomodation at the Copthorne Slough Windsor Hotel

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Booking Process

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Additional Info

Call for Posters

Posters are invited for display throughout the meeting. Please download a template and send a one-page abstract to the secretariat by Friday 9 October 2015.

Exhibition

Very limited space is available. For further information and prices please visit the Secretariat website or email maggi@maggichurchouseevents.co.uk.

Accommodation

A number of rooms have been held at the nearby 4* Copthorne Slough Windsor Hotel for the night of Monday 9 November. The charge is £119 for single occupancy of a standard double room with breakfast. Compimentary Wi-Fi is also included. You may book your room as part of the registration process. 
For further information and prices please visit the Secretariat website.

Organising Committee

Dr Richard Hatley, GlaxoSmithKline
Dr Simon Peace, SCI/GlaxoSmithKline
Dr Mark Healy, SCI/Novartis
Dr Fabien Lecomte, UCB Pharma
Dr Mihiro Sunose, Sygnature Discovery