Synopsis
Fibrosis disease is the result of a dysregulated wound healing process and is responsible for considerable patient mortality affecting multiple organs in diseases such as idiopathic pulmonary fibrosis (IPF), diabetic nephropathy, steatohepatitis and systemic sclerosis. Fibrosis disease pathology is often complex and this inaugural symposium on fibrosis will provide mechanistic insight and progress in medicinal chemistry and drug discovery from experts across the world.
Programme
Event Day
Event Section
- 09:00
- Registration and refreshments Session chair: Luis Castro, UCB
- 09:30
- Welcome and opening remarks Luis Castro, UCB
- 09:35
- The common denominator of chronic disease - Fibrosis Prof Robert M Strieter, Novartis
- 10:20
- Out of the frying-pan PI3K and into....? Generation of a robust pathway toolbox to investigate the anti-fibrotic behaviour of GSK2126458A Simon Peace, GlaxoSmithKline
- 10:50
- Refreshments Session chair: Richard Hatley, GlaxoSmithKline
- 11:20
- Design of mechanism-based amine oxidase inhibitors for the treatment of fibrosis Dr Jonathan Foot, Pharmaxis
- 11:50
- Tissue transglutaminase - a credible therapeutic target in the treatment of fibrotic disease due to its multifunctional roles? Martin Griffin, Aston University
- 12:20
- Structure-based design, synthesis, and biological evaluation of novel autotaxin inhibitors Lisa Miller, University of Strathclyde
- 12:23
- Toward novel treatment units in fibrosis Frances Potjewyd, University of Strathclyde
- 12:26
- Structure activity relationship of PF-8380 and development of a novel chemotype towards autotaxin inhibition Emma Duffy, University of Strathclyde
- 12:30
- Lunch Session chair: Tim Johnson, UCB
- 13:30
- Structure activity relationships of av integrin antagonists - industrial medicinal chemistry with 4th year MSci undergraduates Simon Macdonald, GlaxoSmithKline, and Thomas McInally, University of Nottingham
- 14:00
- Harnessing our understanding of scleroderma to develop and validate innovative anti-fibrotic therapies David Abraham, University College London
- 14:30
- Discovery and quantitation of novel liver fibrosis biomarkers: towards the first antibody-free biomarker assay for liver fibrosis Bevin Gangadharan, University of Oxford
- 14:40
- Refreshments
- 15:10
- Role of NOX enzymes in fibrotic diseases: development of a 1st in class NOX1/4 inhibitor GKT137831 Ursula Ney, Genkyotex
- 15:40
- Does CB2 agonism protect from inflammation related organ damage and fibrosis? Uwe Grether, F Hoffmann-La Roche
- 16:10
- IPF active macrocycles identified from phenotypic screening Gordon Saxty, Fidelta
- 16:50
- Closing remarks Luis Castro, UCB
- 17:00
- Meeting close
Accessibility Grants
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Venue and Contact
UCB
UCB
208/216 Bath Road
Slough
SL1 3WE
United Kingdom
UCB is a 5 minute taxi journey from Slough railway station, 30 minutes by car from Heathrow Airport and easily accessible by car from the M25, M4 and M40.
Maggi Churchouse
Tel: +44 (0)1359 221004
Email: maggi@maggichurchouseevents.co.uk
Fees
Early Bird Rate - before 7 August 2015
GB£100 . . . . . . . . . . . . . . . . RSC/ SCI Member
GB£130 . . . . . . . . . . . . . . . . Non-Member
GB£50. . . . . . . .. . . . . . . . . . RSC/ SCI Student Member
GB£65. . . . . . . . . . . . . . . . . .Student* Non-Member
Standard Rate - from 7 August 2015 to 7 October 2015
GB£120 . . . . . . . . . . . . . . . . RSC/ SCI Member
GB£150 . . . . . . . . . . . . . . . . Non-Member
GB£60. . . . . . . . . . . . . . . . . .RSC/ SCI Student Member
GB£75. . . . . . . . . . . . . . . . . .Student* Non-Member
GB£30 . . . . . . . . . . . . . . . . . Late payment fee for any payments received after Wednesday 7 October 2015
* Student is undergraduate or post-graduate, not post-doc
GB£119. . . . . . . . . . . . . . . . . One night's B&B accomodation at the Copthorne Slough Windsor Hotel
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Booking Process/Deadlines
Booking terms and conditions
CPD Info
SCI Members attending this meeting are able to claim CPD points.
Additional Info
Call for Posters
Posters are invited for display throughout the meeting. Please download a template and send a one-page abstract to the secretariat by Friday 9 October 2015.
Exhibition
Very limited space is available. For further information and prices please visit the Secretariat website or email maggi@maggichurchouseevents.co.uk.
Accommodation
A number of rooms have been held at the nearby 4* Copthorne Slough Windsor Hotel for the night of Monday 9 November. The charge is £119 for single occupancy of a standard double room with breakfast. Compimentary Wi-Fi is also included. You may book your room as part of the registration process.
For further information and prices please visit the Secretariat website.
Organising Committee
Dr Richard Hatley, GlaxoSmithKline
Dr Simon Peace, SCI/GlaxoSmithKline
Dr Mark Healy, SCI/Novartis
Dr Fabien Lecomte, UCB Pharma
Dr Mihiro Sunose, Sygnature Discovery