27 March - 29 March 2019

36th SCI Process Development Symposium

Organised by:

SCI's Fine Chemicals Group

Cambridge, UK

Join this event

Prices start from £375.00

Early bird offer ends 1 February 2019

Synopsis

Process Development is the application of chemistry to the scale up of new synthetic processes from the laboratory, through pilot plant to full scale commercial manufacture and into life cycle management. It is an extremely broad discipline, crossing the boundaries between synthetic organic chemistry, process technology and chemical engineering.

The area of Process Development continues to be a challenging and important area for the research into and application of modern synthetic organic chemistry, as well as enabling technologies.
Attendees
The symposium aims to bring together a wide range of speakers from across the Pharmaceutical, Agrochemical and Fine Chemical industries, as well as from an academic background. This meeting brings together experts from across the entire spectrum of the discipline to present state of the art process development. As an established and well attended meeting, the process development symposium offers an excellent opportunity for networking between like-minded process scientists of all levels of experience and from all areas of the chemical industry.

Wednesday 27 March 2019

11.00 Registration and refreshments
   
12.15 Lunch
   
  CHAIR: David Pascoe, GlaxoSmithKline, UK
   
13.25 Opening remarks
   
13.30

Identification and Development of a Highly Efficient Commercial Route to Wee-1 Kinase Inhibitor AZD1775
Dr Thomas Langer, AstraZeneca, UK

   
14.10

Novel industrial applications for electrochemistry - expecting the unexpected
Dr Patrik Stenner, Evonik, Germany

   
14.50

Homogeneous catalysis research @ BASF: A new Pd-catalyzed low pressure carbonylation
Dr Mathias Schelwies, BASF, Germany

15.30 Refreshment break and exhibition
   
  CHAIR: Stella James, Bionow, UK
   
16.10

New catalytic strategies for complex alkyl amine synthesis
Prof Matt Gaunt, University of Cambridge

   
16.50

MK-8591 — development of an enzymatic cascade for commercial manufacture
Dr Becky Ruck, MSD, USA

   
17.30 Closing remarks
   
17.45 Wine reception sponsored by Chiralquest
   
19.00 Dinner for residents
   

 

Thursday 28 March 2019

  CHAIR: David Lathbury, Astute Chemical Development Consulting Ltd, UK
   
09.00

Total synthesis of polycyclic natural products
Prof Ang Li, SIOC, China

   
09.40

Some process development aspects of industrial fluorine chemistry
Dr Christoph Taeschler, Lonza AG, Switzerland

   
10.20 Refreshment break and exhibition
   
  CHAIR: Rob Walton, Pfizer, UK
   
10.50

Authorisation: Aprotic solvents and the pharmaceutical industry
Dr Jo Lloyd and Dr Tom Griffiths, ERM, UK

   
11.30 Title to be confirmed
Dr Kaid Harper, Abbvie, USA
   
12.10 Lunch and exhibition
   
  CHAIR: Steven Oliver, Merck Sharp & Dohme, UK
   
13.10

Leveraging integrated technology platform and intimate partnership in innovative API development and manufacturing
Dr Gangli Gong, STA Pharmaceutical Co Ltd

   
13.50

Flow chemistry, an enabling technology in Pharma
Dr Francesco Venturoni, Novartis Switzerland

   
14.30

Impurity evaluation — current areas of interest and future challenges
Dr Andy Teasdale, AstraZeneca, UK

15.10 Refreshment break and exhibition
   
  CHAIR: To be confirmed
   
15.40

Making a difference to malaria sufferers throughout the world – Process development of Tafenoquine Succinate
Mr Andrew Kennedy, GlaxoSmithKline, UK

   
16.20 Process Chemistry Award winner 2018
Prof Ian Fairlamb, University of York, UK
   
17.20 Closing remarks
   
17.30 Wine reception sponsored by Johnson Matthey
   
19.00 Conference dinner

 

Friday 29 March 2019

  CHAIR: Andy Wells, Charnwood Technical Consulting Ltd, UK
   
09.00

ERK Inhibitor LY3214996 Development and Route Selection (ERK = extracellular signal-regulated kinases)
Dr Nick Magnus, Lilly, USA

   
09.40

Developing fundamental understanding of processes using ReactIR and FBRM in manufacturing process development
Dr Hazmi Tajuddin, Syngenta, UK

10.20 Refreshment break and exhibition
   
  CHAIR: To be confirmed
   
10.50

Development and scale-up of continuous flow processes for the manufacture of active pharmaceutical ingredients
Dr Peter Poechlauer, Patheon, Austria

   
11.30

Commercial route design of a NASH drug candidate
Dr Steve Twiddle, Pfizer, UK

   
12.10 Conference close

Venue and Contact

Churchill College

Storey’s Way
Cambridge
CB3 0DS

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Early bird fees before Friday 1 February  2019

£375 SCI Member
£260 SCI Subsidised Member
£420 Non-Member

 

Standard fees after Friday 1 February 2019

£495 SCI Member
£290 SCI Subsidised Member
£550 Non-Member

 

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CPD Info

SCI Members attending this meeting are able to claim CPD points.

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Sponsors

Additional Info

Accommodation

Accommodation can be booked for delegates at the college in single study ensuite or standard bedrooms. Bedrooms will be allocated on a first come, first served basis.
The accommodation package is for 2 nights - Wednesday 27 and Thursday 28 March and includes full English or Continental breakfast. Rooms must be vacated by 10.00am on the day of departure. To make a reservation, please click here.

Please note: Bedrooms at the college will be available from 14.00 on the day of arrival. Those not wishing to stay in college accommodation can book accommodation directly through www.visitcambridge.org.

Workshop

An optional workshop will be held on the morning of the first day, prior to the conference, which will introduce the basic challenges faced by the initial chemical development of a candidate drug. The topics covered will be initial route selection, through process development, including physical form selection and analytical development. Discussion of the pros and cons of the various options for supplying early development material, including outsourcing will be outlined and how they might impact the later development stages. The workshop will be of interest to late stage PhD students and also early career industrial chemists who want to know more about chemical development. Limited places available.

The workshop will run from 10.00 - 13.00.

£20   Member tate
£30   Non-member rate

 

Exhibition and Sponsorship

An exhibition will run alongside the conference during refreshment breaks, for companies and related organisations who may wish to exhibit. For further information and prices please email jacqui.maguire@soci.org

Organising Committee

  • Dave Lathbury, SCI/Astute Chemical Development Ltd
  • David Pascoe, SCI/GlaxoSmithKline
  • Robert Walton, SCI/Pfizer
  • Louis Diorazio, SCI/AstraZeneca
  • Stella James, SCI/Bionow
  • Alan Robinson, SCI/Syngenta
  • Steven Oliver, Merck Sharp & Dohme
  • Andy Wells, Charnwood Technical Consulting Ltd

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