18 March - 19 March 2013

4th RSC/SCI Symposium on Ion Channels as Therapeutic Targets

Organised by:

 SCI’s Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector


Registration Closed

This event is no longer available for registration.


Ion Channels are important targets for therapeutic intervention due to their extensive roles in human physiology and the pathophysiology of disease. A large number of successful drugs targeting ion channels have been discovered for diseases such as hypertension, epilepsy and chronic neuropathic pain. Recent advances in the science of ion channels have reinvigorated the search for new medicines in this field. Examples include the continued refinement of high throughput and automated electrophysiology platforms allowing efficient identification of lead compounds and their mechanisms of action; the genetic association of ion channel targets with human disease (e.g. the role of NaV1.7 in pain); the break-throughs in structural biology that have led to the successful determination of the 3-dimensional structures of several ion channels.

The objectives of the symposium are to showcase the most recent advances in ion channel science and to promote scientific interaction between researchers with a shared interest in ion channel drug discovery. The speakers will include international leaders in ion channels science and drug discovery both from academia and from industry. In addition there will be a poster session, an exhibition and opportunities for informal networking. A number of therapeutic areas will be included with a special focus on ion channel therapeutics for pain indications.


18th March

Event Schedule
Registration and refreshments
Opening remarks
Drugging the ion channel family: where we are and where we are heading David Pryde, Neusentis, UK
Structure, function and pharmacology of sodium channels at atomic resolution Bill Catterall, University of Washington, USA
The discovery of and early clinical development of CNV1014802: a novel, Nav1.7 selective, state-dependant sodium channel blocker for the treatment of neurotic pain Ged Giblin, Convergence, UK
Block of NaV1.7 modulators for the treatment of pain Charles Cohen, Xenon Pharmaceuticals, Canada
NaV1.8 modulators for the treatment of pain Sharan Bagal, Pfizer Neusentis, UK
6 x 5 minute teaser talks for posters
Poster session / reception

19th march

Event Schedule
Opening remarks - Potassium channel section
Structural mechanisms of K2P channel gating Stephen Tucker, University of Oxford, UK
Potassium channel modulators for the treatment of autoimmune disorders David, Madge, Xention, UK
Ion channels and pain Peter McNaughton, University of Cambridge, UK
The discovery and optimisation of a highly selective series of TRPV4 antagonists Sarah Skeratt, Pfizer Neusentis, UK
Opening remarks - Novel approaches - beyond ion channel modulators
To be confirmed
Analgesic peptides from animal venoms that target acid-sensing ion channels Eric Lingueglia, Institute of Molecular and Cellular Pharmacology, France
Perspectives on early clinical development of voltage-gated ion channel blockers Simon Tate, Convergence, UK
Closing remarks
Accessibility Grants

SCI accessibility grants are available to support SCI members with disabilities, long term health conditions, those who require a carer, and members who are nursing parents to attend SCI events. Download an application form to apply for a grant.

Venue and Contact

Abington Hall

Abington Hall, Granta Park, Great Abington, Cambridge, CB21 6GP. 
Stansted airport is a 30-minute drive away, and is easily accessible from the M11. 
Cambridge rail station is 10 miles away.
Directions and a map can be downloaded from the Maggi Churchouse Events website.

Maggi Churchouse

Tel: +44 (0)1359 221004

Email: maggi@maggichurchouseevents.co.uk

RSC/SCI Member £280
Non-Member £340
RSC/SCI Student Member £140
Non-Member Student £170

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Accredited cpd Centre - The CPD Standards Office - CPD Provider 41057 - www.cpdstandards.com

Additional Info

A late booking fee of £40 will be added to payments received after 7th February.

Payment may be made by card (online), or by cheque or bank transfer (please complete and return a registration form to receive an invoice). Please refer to the website for the cancellation policy.

Data protection: The information you supply will be used for the administration of the meeting. A list of participants' names and addresses will be distributed at the conference. If you do NOT wish your address to be included, please indicate when registering.

Conference Dinner

The conference dinner will be held at Abington Hall on Monday 18th March and is included in the registration fee.

Students and Bursaries

Discounted rates are available to RSC and SCI student members, and some student bursaries will be available.

Call for Posters

Posters are seen as an important part of the meeting. They will be displayed throughout the meeting and during a dedicated poster session on the evening of 18th March. Offers of posters relevant to the themes of the meeting are invited. Please submit a one-page abstract in Word format, to reach the secretariat by 18th January 2013.


We are pleased to be able to offer exhibitor spaces at this event at a fixed rate of £500 (excluding delegate). Those companies wishing to have a trade stand should apply early to avoid disappointment as space is limited.

Organising Committee

Karl Gibson (Chair), Sandexis
Ged Giblin, Convergence
Richard Hamlyn, Xention
Nigel Swain, Pfizer Neusentis


Stansted airport is a 30-minute drive away, and is easily accessible from the M11. 
Cambridge rail station is 10 miles away.