13 June - 15 June 2016

6th SCI/RSC Symposium on GPCRs in Medicinal Chemistry

Organised by:

SCI's Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector

Aptuit, Verona, Italy

Registration Closed

This event is no longer available for registration.

Synopsis

The key role of G-protein coupled receptors (GPCRs) in human disease underpins their importance to modern medicine. We are pleased to announce that Aptuit, Italy will support the sixth meeting in this series on GPCR drug discovery, which will combine cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.

Programme

Day 1 - 13 June 2016

08:30: Registration and refreshments
09:20: Opening remarks Jonathan Goldman, Aptuit, and an Organising Committee member
09:30: Plenary: The seventh millennium of GPCR drug discovery Fiona Marshall, Heptares Therapeutics, UK
10:20: Insights into chemistry and biology of GPCRs from molecular modelling Irina Tikhonova, Queen's University Belfast, UK
10:55: Refreshments and exhibition
11:25: Biased agonism @ FPR2 Olivier Corminboeuf, Actelion, Switzerland
1200: TAAR1 agonists – a new approach for the treatment of psychiatric disorders Roger Norcross, Roche Pharma Research & Early Development, Switzerland
12:30: Binding of anticholinergics to the M3 receptor: explaining kinetics by mutagenesis and molecular dynamics simulations Christofer Tautermann, Boehringer Ingelheim, Switzerland
13:00: Lunch and exhibition
14:00: Design, synthesis and pharmacological profile of the GPR40 receptor agonist MK-8666 Ravi Nargund, Merck, USA
14:40: High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 Gyorgy Snell, Takeda California, USA
15:10: Refreshments and exhibition
15:40: Universal mechanism of activation of G proteins by GPCRs Madan Babu, Medical Research Council LMB, UK
16:25: Close
16:30: Coaches depart for visit to Vineyard (Cantina Sociale di Soave - Soave and Valpolicella) and evening meal
20:00: Coaches leave Vineyard for Verona city centre

Day 2 - 14 June 2016

09:30: Recent computational trends in exploring G protein-coupled receptor (GPCR) ligand recognition pathways Stefano Moro, University of Padova, Italy
10:00: Discovery of small molecule modulators of PAR–2 Roland Bürli, AstraZeneca and MedImmune, UK
10:30: Refreshments, exhibition and posters
11:00: Nutrient sensing GPCR FFAR1 (GPR40): allosteric agonist binding mode and physical properties influence agonist pharmacology Bruce Ellsworth, Bristol-Myers Squibb, USA
11:30: Roles of waters to predict binding affinity, selectivity and kinetics: a key component of high end GPCR SBDD Jonathan Mason, Heptares Therapeutics, UK
12:15: Lunch, exhibition and posters
13:15: Design and synthesis of highly selective 5-HT2C receptor agonists as potential novel treatment for neuropsychiatric diseases Andreas Haupt, AbbVie, Germany
13:50: Dopamine D3/D2 antagonist PF-04363467 attenuates drug-seeking behaviour without concomitant D2 side effects Travis Wager, Pfizer, USA
14:25: Discovery of mGluR2 negative allosteric modulators for the treatment of neuropsychiatric disorders Speaker to be confirmed, Janssen, Belgium
15:00: Refreshments, exhibition and posters
15:30: Acquired resistance to smoothened inhibitors in cancer patients Hayley Sharpe, Genentech, USA
16:05: Plenary: How many GPCR structures do we need? Vsevolod (Seva) Katritch, University of South California, USA
16:55: Flash poster presentations
17:30: Poster session
19:00: Conference dinner at Aptuit

Day 3 - 15 June 2016

09:00: What happens when you thermostabilise a GPCR? Bernadette Byrne, Imperial College London, UK
09:40: Rationalising activity cliffs at the adenosine A2a receptor via crystallography Zara Sands, UCB, Belgium
10:15: Refreshments
10:45: Mas-1 receptor inverse agonists for cardiovascular disease Graeme Semple, Arena Pharmaceuticals, UK
11:20: To be confirmed
12:00: Closing remarks David Miller, Takeda Cambridge, U
12:05: Close

Venue and Contact

Aptuit Verona SRL

Via Alessandro Fleming 4
37135 Verona
Italy

Maggi Churchouse

Tel: +44 (0)1359 221004

Email: maggi@maggichurchouseevents.co.uk

Fees

Earlybird fees - by 9 March 2016
GB£360 . . . . . . . . . .SCI/RSC Member
GB£440. . . . . . . . . . Non-member
GB£150 . . . . . . . . . .SCI/RSC Student Member
GB£190 . . . . . . . . . .Non-member Student

Standard fees - between 10 March and 11 May 2016
GB£420 . . . . . . . . . .SCI/RSC Member
GB£500 . . . . . . . . . Non-member
GB£170 . . . . . . . . . .SCI/RSC Student Member
GB£215 . . . . . . . . . .Non-member Student

* Student is undergraduate or post-graduate, not post-doc

Exhibition stands are available, priced at:

GB£1,100 . . . . . . . . . . Exhibition stand including one full delegate
GB£1,450 . . . . . . . . . . Exhibition stand including two full delegates

Late fees - for payments received from 12th May onwards
GB£30 Late payment fee will be added to the above standard rates

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Additional Info

Accommodation and Conference Dinner

Some bedrooms have been held at a number of hotels in the city centre. Please download this list.

For all other accommodation requests (including last-minute bookings), we suggest you use the 24-hour service provided by Verona Booking.

The conference registration fee includes two dinners, and you are asked to opt in at time of registration:
- Monday - a vineyard visit to the Cantina Sociale di Soave (Soave and Valpolicella) followed by dinner.
- Tuesday - conference dinner at Aptuit.