25 May 2017

ADMET 2017

Organised by:

SCI’s Young Chemists' Panel

SCI London

Registration Closed

This event is no longer available for registration.

Synopsis
This is the seventh one day event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) in medicinal chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems. Topics will include how to identify problems with solubility, permeability, clearance, duration and chemical-related toxicology; how to interpret data from commonly used non-efficacy tests; and real life examples of solutions to ADMET problems.
Attendees
The event is aimed at organic chemists (graduate or PhD) working within a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
Programme

Event - 25 May 2017

Day Schedule
09:15
Registration and refreshments
09:55
Introduction and welcome
10:00
Absorption: • Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Solubility, Permeability, PGP Efflux • Chemical strategies to improve absorption • Worked examples
11:15
Refreshments
11:45
Metabolism and clearance I • Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem - Phase I / Phase II Metabolism • Chemical strategies to address metabolism • Worked examples
13:00
Lunch
14:15
Metabolism and clearance II • Cytochrome P450s and Drug-Drug interactions • Volume of distribution – how to understand and influence • Plasma protein binding – impact & influence • Worked examples
15:45
Refreshment break
16:15
Drug toxicity and toxicology • Context & common issues • Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity
17:15
Summary and closing remarks
17:30
Wine reception & close.

Venue and Contact

SCI

14/15 Belgrave Square 
London
SW1X 8PS

Please click here for a location map.

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Early bird fees before Monday 24 April 2017

One day fee

GB£115 . . . . . . . . . . . . . . . . SCI Member 
GB£40 . . . . . . . . . . . . . . . . . SCI Student Member
GB£170 . . . . . . . . . . . . . . . ..Non-Member

Two days fee

GB£200 . . . . . . . . . . . . . . . . SCI Member 
GB£70 . . . . . . . . . . . . . . . . . SCI Student Member
GB£300 . . . . . . . . . . . . . . . ..Non-Member

SCI Platinum Corporate Members receive 25% off the above rates

Standard fees after Monday 24 April 2017

One day fee

GB£140 . . . . . . . . . . . . . . . . . SCI Member 
GB£50 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£205 . . . . . . . . . . . . . . . . . Non-Member

Two days fee

GB£240 . . . . . . . . . . . . . . . . . SCI Member 
GB£85 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£360 . . . . . . . . . . . . . . . . . Non-Member

SCI Platinum Corporate Members receive 25% off the above rates

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Booking Process
For booking terms and conditions click here
CPD Info

SCI Members attending this meeting are able to claim CPD points.

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Sponsors

Additional Info

Exhibition

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first serve

Speakers

Dr Darren McKerrecher, AstraZeneca
Dr Ted Parton, Mekinopsis Ltd
Dr Peter Astles, Eli Lilly

Related Links

Please click here to view the event flyer.