12 November 2019

ADMET 2019

Organised by:

SCI's Young Chemists' Panel

London, UK

Register for this event

Prices start from £115.00

Synopsis

This is the 8th one day event organised by SCI's Young Chemists’ Panel to highlight the challenges associated with ADMET (Adsorption, Distribution, Metabolism, Elimination and Toxicity) in Medicinal Chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems.

This event runs back-to-back with What a Chemist Needs to Know About Biology 1: In Vitro Biology.


Attendees
The event is aimed at organic chemists (graduate or PhD) working in a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
Programme
09.15
Registration and refreshments
09.55
Welcome and introduction
10.00
Absorption
  • Practical understanding of concepts & parameters
  • How do you know you have a problem?
  • Sources of problem – Solubility, Permeability, PGP Efflux
  • Chemical strategies to improve absorption
  • Worked examples
11.15
Refreshment break
11.45
Metabolism and clearance I
  • Practical understanding of concepts & parameters
  • How do you know you have a problem?
  • Sources of problem – Phase I / Phase II Metabolism
  • Chemical strategies to address metabolism
  • Worked examples
13.00
Lunch
14.15
Metabolism and clearance II
  • Cytochrome P450s and Drug¬≠-Drug interactions
  • Volume of distribution – how to understand and influence
  • Plasma protein binding – impact & influence
  • Worked examples
15.45
Refreshment break
16.15
Drug toxicity and toxicology
  • Context & common issues
  • Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity
17.15
Summary and closing remarks
17.30
Networking reception

Confirmed speakers
  • Dr Ted Parton, Mekinopsis Ltd
  • Dr Peter Astles, Eli Lilly
  • Dr Kurt Pike, AstraZeneca

Venue and Contact

SCI

14/15 Belgrave Square
London
SW1X 8PS

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Early bird fees before Friday 27 September 2019

One day fee   Two day fee*
SCI Member   £115   SCI Member   £200
SCI Student Member   £40   SCI Student Member   £70
Non-Member   £170   Non-Member   £300

Standard fees after Friday 27 September 2019

One day fee   Two day fee*
SCI Member   £165   SCI Member   £250
SCI Student Member   £70   SCI Student Member   £100
Non-Member   £220   Non-Member   £350

*The two day fee includes registration to What a Chemist Needs to Know About Biology 1: In Vitro Biology on Monday 11 November 2019.

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Booking Process
For booking terms and conditions click here.
CPD Info

SCI Members attending this meeting are able to claim CPD points.

Accredited cpd event - The CPD Standards Office
Exhibition and sponsorship

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.


Organising Committee
  • Ed Cochrane, SCI / Sygnature Discovery
  • Peter Blencowe, SCI / Cancer Technology
  • Ben Whitehurst, SCI / Heptares
  • Tom Pesnot, SCI / Concept Life Sciences
  • Nicole Trainor, SCI / University of Dundee
  • Paula Jackson, SCI / Redxpharma