12 November 2019
ADMET 2019
Organised by:
SCI's Young Chemists' Panel
London, UK
Registration Closed
This event is no longer available for registration.
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Synopsis
This is the 8th one day event organised by SCI's Young Chemists’ Panel to highlight the challenges associated with ADMET (Adsorption, Distribution, Metabolism, Elimination and Toxicity) in Medicinal Chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems.
This event runs back-to-back with What a Chemist Needs to Know About Biology 1: In Vitro Biology.
Attendees
The event is aimed at organic chemists (graduate or PhD) working in a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.Programme
- 09.15
- Registration and refreshments
- 09.55
- Welcome and introduction
- 10.00
- Absorption
- Practical understanding of concepts & parameters
- How do you know you have a problem?
- Sources of problem – solubility, permeability, PGP efflux
- Chemical strategies to improve absorption
- Worked examples
- 11.15
- Refreshment break
- 11.45
- Metabolism and clearance I
- Practical understanding of concepts & parameters
- How do you know you have a problem?
- Sources of problem – phase I / phase II metabolism
- Chemical strategies to address metabolism
- Worked examples
- 13.00
- Lunch
- 14.15
- Metabolism and clearance II
- Cytochrome P450s and drugdrug interactions
- Volume of distribution – how to understand and influence
- Plasma protein binding – impact & influence
- Worked examples
- 15.45
- Refreshment break
- 16.15
- Drug toxicity and toxicology
- Context & common issues
- Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity
- 17.15
- Summary and closing remarks
- 17.30
- Networking reception
Venue and Contact
SCI
14/15 Belgrave Square
London
SW1X 8PS
Conference Team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
Fees
Early bird fees before Friday 27 September 2019
| One day fee | Two day fee* | |||||
| SCI Member | £115 | SCI Member | £200 | |||
| SCI Student Member | £40 | SCI Student Member | £70 | |||
| Non-Member | £170 | Non-Member | £300 | |||
Standard fees after Friday 27 September 2019
| One day fee | Two day fee* | |||||
| SCI Member | £165 | SCI Member | £250 | |||
| SCI Student Member | £70 | SCI Student Member | £100 | |||
| Non-Member | £220 | Non-Member | £350 | |||
*The two day fee includes registration to What a Chemist Needs to Know About Biology 1: In Vitro Biology on Monday 11 November 2019.
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Booking Process/Deadlines
For booking terms and conditions click here.CPD Info
SCI Members attending this meeting are able to claim CPD points.
Exhibition and sponsorship
An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.
Organising Committee
- Ed Cochrane, SCI / Sygnature Discovery
- Peter Blencowe, SCI / Cancer Technology
- Ben Whitehurst, SCI /AstraZeneca
- Tom Pesnot, SCI / Concept Life Sciences
- Nicole Trainor, SCI / University of Dundee
- Paula Jackson, SCI / Redxpharma