18 February - 19 February 2020

Applied late-stage functionalisation: where chemistry meets biology

Organised by:

SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector

Manchester, UK

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Prices start from £230.00

Synopsis
The last decade has seen the rapid development of Late-stage functionalisation as a powerful method for enabling rapid SAR generation from a lead structure and allowing access to complex structures, biological probes and new chemical space where de-novo synthesis is not trivial. Both the inorganic catalyst and biocatalysis fields have seen new advancements over the last few years with the search for more efficient, selective, functional group tolerant, predictable methodology and new late stage transformations still a key focus. Not only are LSF methods of use in rapid SAR generation but are also finding great utility throughout the pharmaceutical industry, from metabolic identification to scale-up processes. The purpose of this meeting is to highlight some of the hot and emerging developments in the inorganic catalysis and biocatalysis arenas and both the academic and application of Late-stage functionalisation methodologies.
Attendees
This meeting is aimed at industrial and academic members of the scientific community working in pharmaceuticals, medicinal chemistry, biochemistry, biotechnology, chemical biology or broadly interested in synthesis, catalysis and enzymatic reactions. The programme will be of interest to academics, postgraduates, undergraduates and early to late career industrialists across CRO’s, SME’s and large organisations.
Draft Programme
Tuesday 18 February
10.00
Registration and refreshments
10.45
Welcome and introduction
10.50
Biocatalysis Plenary: How enzyme engineering enables design of biocatalysts suitable for industrial applications
Prof. Uwe Bornscheuer, Greifwald, Germany
11:10
Refreshment break, exhibition and posters
14.10
GenoChemetics: Tools and Opportunities, C-H Activation Enabled in Living Cells
Prof. Rebecca Goss, St Andrews, UK
13.00
Lunch and exhibition and posters
14.00
Technologies and Automation in LSF: Exploring Chemical Space in Medicinal Chemistry
Dr Cara Brocklehurst, Novartis, Switzerland
14.50
Biocatalysis in Hit Discovery
Dr Martin Hayes, Astra Zeneca, Sweden
15:40
Refreshment break exhibition and posters
16.00
C-H activation for late-stage peptide diversification
Prof. Lutz Ackermann, Georg-August-Universitat Göttingen, Germany
16:50
Closing remarks
16.55
Networking reception
Wednesday 19 February
09.15
Registration and refreshments
09.45
Opening Remarks
09.50
Chemistry Plenary : Catalytic Regioselective Functionalization of C-H Bonds
Prof. John Hartwig, Berkley, USA
10.50
Refreshment break exhibition and posters
11.10
S,O-Ligand promoted Pd-catalyzed C-H olefination of aromatic compounds
Prof. Tati Fernández-Ibáñez, University of Amsterdam, Holland
12.00
Integration of biocatalysis into medicinal chemistry programs for late-stage oxidation using PolyCYPs enzymes     
Dr Julia Shanu-Wilson, Hypha Discovery, UK
12.50
Lunch exhibition and posters
13.50
Selective Halogenation using Mined and Engineered Halogenases
Prof. Jared Lewis. University of Indiana, USA
14.40
Late-stage Functionalization
Prof. Tobias Ritter, Harvard, USA/Max-Plank institute, Germany
15.40
Closing remarks
16.00
Close

Venue and Contact

University of Manchester

Barnes Wallis Building
Sackville Street Campus
Manchester
M1 7JA

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Early bird fees before Friday 13 December 2019

£230 SCI Member
£80 SCI Student Member
£300 Non-Member

Standard fees after Friday 13 December 2019

£360 SCI Member
£100 SCI Student Member
£430 Non-Member

SCI Platinum Corporate Members receive 25% off the above rates


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Booking Process

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Accommodation
SCI have obtained special hotel rates for this conference. If you require hotel accommodation for the conference and would like to use SCI's special hotel rates please book your hotel room by clicking here.
Partners

Exhibitors

Exhibition and Sponsorship

An exhibition will take place alongside the conference for companies and related organisations who may wish to exhibit. Please email conferences@soci.org for further information and prices. Spaces are limited and will be allocated on a first-come, first-served basis.


Call for papers

Contributions are invited from those working in all areas of late stage functionalisation and biotransformations in academia and industry.

There are two options:

  • Oral paper
  • Poster

An abstract of maximum one A4 page or 300 words indicating title, authors and preference for presentation option (Oral or Poster) should be sent to conferences@soci.org by Friday 13 December 2019 with the subject line "LSF 2020 – abstract submission". Oral presentation slots are inevitably limited and will be allocated to achieve a balanced programme. Topics may be results, reviews or plans and may have already been presented elsewhere. An abstract template can be downloaded here. Prizes will be awarded for the best poster.


Student Bursaries

A limited number of student bursaries are available to registered participants, as a contribution to the cost of registration fees, travel and accommodation. The closing date for applications is 13 December 2019, to receive an application form please email conferences@soci.org.


Organising Committee
  • Brian Cox, University of Sussex
  • Chris Davis, SCI / Vertex
  • Liz Jones, SCI / Syngenta
  • Igor Larrosa, SCI / University of Manchester
  • Martin Lowe, SCI / UCB
  • Tom Pesnot, SCI / Concept life sciences
  • Nick Turner, University of Manchester
  • Francis Wilson, Summit Therapeutics