15 May 2013

Choosing the Right Target in Drug Discovery

Organised by:

SCI’s Fine Chemicals Group

SCI HQ, London, UK

Registration Closed

This event is no longer available for registration.

Synopsis
This symposium will cover the current approaches to novel target selection in drug discovery. The differentiation of drug candidates through on- and off-target mechanisms and pathways will be discussed. Methods for target validation, mechanism clarification, measuring or predicting tractability, efficacy and safety will be covered to show how a better understanding of these interacting effects can allow the development of better quality Lead and Clinical Candidates.
Attendees
This event is aimed at all scientists interested in furthering their knowledge of drug discovery. It will also have wide appeal to members of the drug discovery community eager to understand how to select and validate novel targets. Analysis of pathway effects with on- and off-target activity of drug candidates can help in compound prioritisation and optimisation. 
Programme

Event Day

Event Schedule
09:30
Registration and refreshments
09:55
Welcome and intro
10:00
Targeting multi-protein regulatory systems: Allostery and protein-protein interactions.
10:50
Phenotypic vs target screening approaches – black or white or shades of grey Graeme Walker, AstraZeneca
11:30
Selection and validation of cancer drug targets: Objective computational assessment and chemical tools Paul Workman,The Institute of Cancer Research, London
12:15
Lunch and exhibition
13:30
The genomics of drug sensitivity in cancer: preclinical biomarker discovery in cancer cells Mathew Garnett, Sanger Institute
14:10
RNAi screening: pitfalls and bear-traps Michael Howell, London Research Institute, CRUK
14:50
Mode of action analysis and biomarker discovery by phospho-proteomics Christian Eckert, Evotec, Germany
15:30
Refreshment break
16:00
Drug Discovery Toxicology: approaches to improving candidate drug safety Peter Newham, AstraZeneca
16:40
The expanding role of the medicinal chemist: application of chemical tools to enhance biological target selection Ian Storer, Pfizer Neusentis
17:30
Closing remarks and Wine reception (Evotec)

Venue and Contact

SCI

SCI HQ, London, UK
Please click here for a location map.

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Earlybird fees - before 3 April 2013
GB£100 . . . . . . . . .SCI Member 
GB£30. . . . . . . . . . SCI Student
GB£60. . . . . . . . . . SCI Subsidised Member
GB£130 . . . . . . . . .Non Member

Standard fees - after 3 April 2013
GB£120 . . . . . . . . .SCI Member 
GB£36 .. . . . . . . . . SCI Student
GB£72 . . . . . . . . . .SCI Subsidised Member
GB£156 . . . . . . . . .Non Member

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