26 November 2014

CNS Drug Discovery

Organised by:

SCI's Young Chemists' Panel

Takeda, Cambridge, UK

Registration Closed

This event is no longer available for registration.

Synopsis

This one day event will be held at the heart of the prestigious Cambridge Science Park and will bring together eight speakers from pharmaceutical and biotechnology companies, as well as academia, to focus on the challenges and breakthroughs in drug discovery for disorders of the central nervous system. The event has been tailored to deliver an overview of the medicinal chemistry requirements of centrally-acting drugs and an introduction to hot CNS drug targets.

Several in-depth medicinal chemistry case studies will be presented on the discovery of drug hits, leads and clinical candidates for the treatment of CNS disorders which will include Parkinson’s disease, glioblastoma, Alzheimer’s disease and schizophrenia. Special consideration will be given to designing molecules with brain penetration and applying contemporary approaches to hit generation and lead optimisation, such as fragment screening and structure-based drug design.


Attendees

The meeting is aimed at scientists in the industrial and academic fields with a background in medicinal chemistry or drug discovery. It is ideally suited to those studying for a postgraduate degree or working in the pharmaceutical or biotechnology industry. This symposium will engage both those who are familiar with medicinal chemistry and drug discovery, and those who are new to the area but interested in learning more.


Programme

Day 1

Section 1
09:15
Registration and refreshments
09:45
Welcome
09:50
CNS drug discovery: a bluffer's guide
Dr Craig Jamieson, University of Strathclyde
10:25
An introduction to CNS disorders and targets
Dr Peter Joyce, Vertex
11:00
Refreshment break
11:30
The discovery of brain penetrant compounds with efficacy in schizophrenia related models
Dr Will Buffham, Takeda
12:05
Is L-dopa the best we can do? New approaches to the treatment of Parkinson's disease
Dr Sarah Salvage, King's College London
12:40
Lunch
13:40
Phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of glioblastoma: opportunities and challenges
Dr Rob Heald, Argenta
14:15
Structure based drug discovery using stabilised GPCRs: application to glutamate receptors
Dr John Christopher, Heptares Therapeutics Ltd
14:50
Refreshment break
15:20
The challenge of drug discovery in Alzheimer's disease
Dr Mike Hutton, Eli Lilly
15:55
The discovery of novel, selective phosphodiesterase 10A (PDE10A) inhibitors from a low molecular weight hit with an unexpected binding mode
Dr Mauro Marigo, Lundbeck
16:30
Concluding remarks

Venue and Contact

Takeda Cambridge Ltd

418 Science Park
Milton Road
Cambridge
CB4 0PZ
UK

 

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Earlybird fees - before 17 October 2014
GB£80 . . . . ... . . . .SCI Member
GB£25 . . . . . . . . . .SCI Student
GB£55. . . . . . . . . . SCI Subsidised Member
GB£110 . . . . . . . . .Non Member

Standard fees - after 17 October 2014
GB£100 . ... . . . . . .SCI Member
GB£35 . . . . . . . . . .SCI Student
GB£65. . . . . . . . . . SCI Subsidised Member
GB£130 . . . . . . . . .Non Member

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