11 June 2014

Efficient Methods for Hit ID

Organised by:

Caroline Low - Independent Consultant , Nigel Swain - Pfizer Neusensis , David Witty - Convergence Pharmaceuticals

RSC, Burlington House, London, U.K.

Registration Closed

This event is no longer available for registration.

Synopsis

Much research into new medicines is now taking place in smaller companies or in departments with limited budgets for expensive and slow High Throughput Screens. Furthermore, screening capacity for certain target classes can be limited by automated screening technology capabilities. Hit discovery therefore has to use smarter, cheaper and more effective strategies; even large companies need to contain costs and make use of faster hit discovery processes.

This meeting will examine opportunities for conducting hit discovery more efficiently, from the creation of lead-like collections, knowledge based design of specific protein ligands, to exploiting informatics in directing compound synthesis choices. It will demonstrate future strategies being adopted by both small and large organisations, new initiatives such as the European Lead Factory, as well as considering novel approaches.

Attendees

This symposium is appropriate for chemists and screening scientists engaged in hit discovery and lead optimisation, whether bench chemists or project leaders, those engaged in hit deconvolution or library design. The meeting will conclude with a panel discussion on the issues raised.

Programme

Day 1

10:00: Registration and refreshments
10:30: Finding quality leads from screens: what to screen, how to screen it?
Darren Green, GlaxoSmithKline, U.K.
11:10: Collaborative Hit ID in academia-industry alliances
Martin Swarbick, Cancer Research UK, U.K.
11:50: IMI European lead factory: New opportunities for drug discovery
Phil Jones, Innovative Medicine’s Initiative, U.K.
12:30: Lunch break and Poster Session
13:50: Using Bioactivity Databases and Computational Algorithms: From Ligand Design to Mode-of-Action Analysis
Krishna Bulusu, University of Cambridge, U.K.
14:30: Off-Rate Screening. An efficient method to kinetically sample hit to lead chemical space in unpurified reactions
James Murray, Vernalis, U.K.
15:10: Refreshment break
15:30: Rational design of multiple-acting ligands
Ola Engkvist, AstraZeneca, Sweden
16:10: EKO and EKOS: A new perspective on discovery of small molecules to perturb protein-protein interactions
Kevin Burgess, Texas A & M University, USA
16:50: Panel discussion
17:30: Wine Mixer

Accessibility Grants

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Venue and Contact

RSC

Royal Society of Chemistry
Burlington House, Picadilly
London ‎W1J 0BA

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org

Fees

Earlybird fees - before 1 May 2014
GB£100 . . . . . . . . .SCI / RSC Member
GB£30. . . . . . . . . . SCI / RSC Student
GB£60. . . . . . . . . . Subsidised Member
GB£135 . . . . . . . . .Non Member

Standard fees - after 1 May 2014
GB£120 . . . . . . . . .SCI / RSC Member
GB£40 .. . . . . . . . . SCI / RSC Student
GB£75. . . . . . . . . ..Subsidised Member
GB£165 . . . . . . . . .Non Member

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Booking Process/Deadlines

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CPD Info

SCI Members attending this meeting are able to claim CPD points.

Exhibitors

Additional Info

Exhibition and Sponsorship

An exhibition will take place alongside the conference for companies and related organisations who may wish to exhibit. Please email conferences@soci.org for further information and prices. Spaces are limited and will be allocated on a first-come, first-served basis.