Much research into new medicines is now taking place in smaller companies or in departments with limited budgets for expensive and slow High Throughput Screens. Furthermore, screening capacity for certain target classes can be limited by automated screening technology capabilities. Hit discovery therefore has to use smarter, cheaper and more effective strategies; even large companies need to contain costs and make use of faster hit discovery processes.
This meeting will examine opportunities for conducting hit discovery more efficiently, from the creation of lead-like collections, knowledge based design of specific protein ligands, to exploiting informatics in directing compound synthesis choices. It will demonstrate future strategies being adopted by both small and large organisations, new initiatives such as the European Lead Factory, as well as considering novel approaches.
This symposium is appropriate for chemists and screening scientists engaged in hit discovery and lead optimisation, whether bench chemists or project leaders, those engaged in hit deconvolution or library design. The meeting will conclude with a panel discussion on the issues raised.
- Registration and refreshments
- Finding quality leads from screens: what to screen, how to screen it?
Darren Green, GlaxoSmithKline, U.K.
- Collaborative Hit ID in academia-industry alliances
Martin Swarbick, Cancer Research UK, U.K.
- IMI European lead factory: New opportunities for drug discovery
Phil Jones, Innovative Medicine’s Initiative, U.K.
- Lunch break and Poster Session
- Using Bioactivity Databases and Computational Algorithms: From Ligand Design to Mode-of-Action Analysis
Krishna Bulusu, University of Cambridge, U.K.
- Off-Rate Screening. An efficient method to kinetically sample hit to lead chemical space in unpurified reactions
James Murray, Vernalis, U.K.
- Refreshment break
- Rational design of multiple-acting ligands
Ola Engkvist, AstraZeneca, Sweden
- EKO and EKOS: A new perspective on discovery of small molecules to perturb protein-protein interactions
Kevin Burgess, Texas A & M University, USA
- Panel discussion
- Wine Mixer
Venue and Contact
Earlybird fees - before 1 May 2014
GB£100 . . . . . . . . .SCI / RSC Member
GB£30. . . . . . . . . . SCI / RSC Student
GB£60. . . . . . . . . . Subsidised Member
GB£135 . . . . . . . . .Non Member
Standard fees - after 1 May 2014
GB£120 . . . . . . . . .SCI / RSC Member
GB£40 .. . . . . . . . . SCI / RSC Student
GB£75. . . . . . . . . ..Subsidised Member
GB£165 . . . . . . . . .Non Member
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