10 September - 13 September 2023
SCI / RSC 22nd Medicinal Chemistry Symposium
Organised by:
SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector
Churchill College, Cambridge, UK
Registration Closed
This event is no longer available for registration.
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Synopsis
The organisers invite you to the 22nd SCI-RSC Medicinal Chemistry symposium, Europe’s premier biennial Medicinal Chemistry event, focusing on first disclosures and new strategies in Medicinal Chemistry.Attendees
SCI and RSC members will be able to register at discounted rates which are detailed on the fees section further down the page.
- SCI members should login with their account details
- RSC members should enter the Event discount code EJRFChem221 and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration.
- RSC student members should enter the Event discount code EJRFChem221S and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration.
- Students who are not a member of SCI/RSC should email conferences@soci.org from their institution email address to request the relevant voucher code to book for this event
Sponsorship
Please note that the exhibition for this event is now full.
For further details regarding sponsorship opportunities, please contact conferences@soci.org
Sunday 10 September 2023
- 13:00
- MedChem training workshop (please see below for more details)
Sixties Room - 15:00
- Registration and refreshments
Main concourse of the college, a few minutes’ walk from the Porter’s Lodge - 18:30
- Welcome BBQ and exhibition
Jock Colville Lawn
Monday 11 September 2023
All talks will be held in the Wolfson Hall
- 08:30
- Welcome and opening remarks
Gordon Saxty, Chair of the Organising Committee - 08:40
- From parasites to viruses and cancers: exploiting NMT inhibition for selective cancer therapy
Andrew Bell, Myricx Pharma - CHAIRPERSON: Gordon Saxty, NS-MC Consulting
- 09:10
- Substrate reduction therapy for the treatment of metachromatic leukodystrophy
Suga Thurairatnam, Sanofi US - 09:40
- Discovery of reversible highly potent and selective MAGL inhibitors
Uwe Grether, Roche - 10:10
- Refreshment break and exhibition
Marquee/Jock Colville Lawn - CHAIRPERSON: Andrew Williams, Chairman of the RSC BMCS
- 10:40
- Discovery of EDI048, a GI-targeted soft-drug for the treatment of chronic pediatric cryptosporidiosis
Joe Young, Novartis - 11:10
- Discovery of VX-147 as a targeted therapy for APOL1-mediated kidney disease
Timothy Senter, Vertex - 11:40
- Malcolm Campbell memorial prize presentation
Charles Coombes and Matt Fuchter - 11:50
- CDK7 inhibition: a new target for cancer therapy
Charles Coombes and Matt Fuchter - 12:20
- Lunch and exhibition
- CHAIRPERSON: John Cumming, Roche
- 13:30
- In silico enabled discovery of potent, selective and brain-penetrant DLK inhibitors for the treatment of neurodegenerative diseases
Rachel Lagiakos, Schrodinger - 14:00
- Pre-clinical and clinical evaluation of TAK-279/NDI-034858, a highly potent and selective Tyk2-JH2 inhibitor for the treatment of autoimmune diseases through structure-based drug design
Silvana Leit, Nimbus - 14:30
- Malaria therapy based on plasmodium Phosphatidylinositol-4-kinase and host hemoglobin degradation pathway
Godwin Dziwornu, H3D - 15:00
- Refreshment break and exhibition
Marquee/Jock Colville Lawn - CHAIRPERSON: Dr Vicki Steadman, Sai Life Sciences
- 15:30
- Flash poster presentations
- 16:00
- Fragment-based drug design of allosteric SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) inhibitors
James Day, Astex - 16:30
- From hammer to scalpel – honing a blunt instrument into a precision therapeutic
Andy Novak, Sygnature - 17:00
- Lenacapavir, a first-in-class long-acting HIV capsid inhibitor
Eda Canales, Gilead Sciences - 17:30
- Poster session 1 and networking reception
- 19:30
- College dinner
Churchill College (for residents and delegates who have included as optional extra)
Tuesday 12 September 2023
All talks will be held in the Wolfson Hall
- CHAIRPERSON: Hayley Binch, Roche
- 08:30
- Discovery of CVN293, a blocker of KCNK13, a novel microglial target for neurodegenerative diseases
Roland Bürli, Cerevance - 09:00
- Positive allosteric modulators of the α7 nAChR for the treatment of cognitive disorders: invention of MK-4334
Ian Bell, Merck US - 09:30
- SAGE-718: a first-in-class NMDAR PAM for the potential treatment of cognitive impairment
Matthew Hill, Sage Therapeutics - 10:00
- Refreshment break and exhibition
Marquee/Jock Colville Lawn - CHAIRPERSON: Chris Swain, Cambridge MedChem Consulting
- 10:30
- Discovery and first-time disclosure of NT-0796, a clinical phase NLRP3 inflammasome inhibitor for inflammation
David Harrison, NodThera - 11:00
- Discovery of LAS202051, a potent Acetyl-CoA carboxylase (ACC) inhibitor for the topical treatment of acne
Jordi Bach, Almirall - 11:30
- Lessons learnt building the GSK pan-BET bromodomain portfolio
Phil Humphreys, GSK - 12:00
- Lunch and exhibition
- CHAIRPERSON: Nadia Ahmad, Charles River
- 13:10
- Discovery of AZD0011, an orally bioavailable arginase inhibitor that reactivates T-cell Anti-Tumor response
Scott Mlynarski, Astrazeneca - 13:40
- Fragment-based drug discovery approaches to the development of protein-protein interaction inhibitors
John Skidmore, The ALBORADA Drug Discovery Institute, University of Cambridge - 14:10
- LMW inhibitors of IL-1b, from fragment hits to cellular PoC
Konstanze Hurth, Novartis - 14:40
- Refreshment break and exhibition
Marquee/Jock Colville Lawn - CHAIRPERSON: Joanne Pinder, Vertex
- 15:10
- Flash poster presentations
- 15:40
- Discovery of a novel class of brain penetrant inhibitors of KRAS G12C
Jason Kettle, Astrazeneca - 16:10
- Design and discovery of MRTX0902: an inhibitor of the SOS1: KRAS protein-protein interaction
Chris Smith, Mirati Therapeutics - 16:40
- RSC hall of fame winner: Karin Briner, head of drug discovery at Genentech
- 17:10
- Poster Session 2
Marquee, Jock Colville Lawn - 19:00
- Networking reception and Gala Dinner at St Johns College, Cambridge
(please note, this is a ticketed event)
Wednesday 13 September 2023
All talks will be held in the Wolfson Hall
- CHAIRPERSON: Jamie Scott, AstraZeneca
- 08:30
- AI-driven drug discovery delivers phase 1/2 clinical A2AR antagonist
Thorsten Nowak, Exscientia - 09:00
- Fadaltran, a selective antagonist for the peripheral AR alpha 2c receptors: a new option for the treatment of diabetic foot ulcers
Carsten Schmeck, Bayer - 09:30
- Discovery and Characterization of a Novel mGlu7 Negative Allosteric Modulator: ADX94827
Jean-Laurent Paparin, Addex - 10:00
- Refreshment break and exhibition
Marquee/Jock Colville Lawn - CHAIRPERSON: Mark Healy, Novartis
- 10:30
- Data-driven optimisation of azabenzimidazoles as mGluR2 modulators for CNS disorders
Jonathan Bentley, Evotec - 11:00
- Discovery and characterization of potent, efficacious and orally available antimalarial plasmepsin X inhibitors
Teresa de Haro Garcia, UCB (remote speaker) - 11:30
- Structure-based discovery of GS-9770: the road to a novel, unboosted, HIV protease inhibitor
Ana Z. Gonzalez, Gliead Sciences - 12:00
- Lunch and exhibition
- CHAIRPERSON: Gordon Saxty, NS-MC Consulting
- 13:10
- The discovery of sebetralstat, an oral, small molecule oral plasma kallikrein inhibitor to treat attacks of hereditary angioedema
Rebecca Davie, KalVista - 13:40
- Successful optimization to obtain advanced g-secretase modulators for the treatment of Alzheimer’s disease
Rosa Maria Rodriguez Sarmiento, Hoffman La Roche - 14:10
- Discovery of PF-07817883: a next generation oral protease inhibitor for the treatment of COVID-19
Matthew Sammons, Pfizer - 14:40
- Closing remarks
Gordon Saxty, NS-MC Consulting
Gala dinner dress code
Lounge suits or cocktail dresses.
Medchem Workshop
Sunday 13:30 - 16:30
The workshop is now fully booked, please email conferences@soci.org to be added to the waiting list.
As part of the conference, we are pleased to offer the opportunity to participate in a Medicinal Chemistry Workshop which will take place on the Sunday afternoon.
The workshop is based on an interactive, team-based game that allows you to explore various aspects of the drug discovery process. Delegates will work together in teams with peers from other organisations and the learning experience will be facilitated by a dedicated and diverse team of experienced professional medicinal chemists from across the pharmaceutical industry. This is a great way to accelerate your learning curve in medicinal chemistry, learning from your peers and our experts and it’s a lot of fun to play!
This event will be of interest to early career scientists, typically with five years or fewer post-graduate experience in medicinal chemistry.
To register your interest, please click here. There is no additional charge associated with participation in the workshop but places are limited
Accommodation and Conference Dinners
Space is now extremely limited, please contact conferences@soci.org to be added to the waiting list.
Package 1 - Conference only, NO accommodation and NO dinners included
Package 2 - Conf + 3 nights standard en-suite accom with dinners
If you are booking Package 1 (no accommodation or dinners included), you can choose to book onto one or more of the evening dinners as optional extras.
Alternative accommodation
St Johns College - https://bit.ly/StJohnsCollegeAccommodation
Fitzwilliam College - https://bit.ly/FitzWilliamAccommodation
University of Cambridge - https://www.accommodation.cam.ac.uk/VisitingCambridge/
Venue and Contact
Churchill College
Storey's Way
Cambridge
CB3 0DS
Conference Team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
Fees
| SCI/RSC* Member - £485 Non-member - £600 SCI/RSC** Student Member - £200 Undergrad/Postgrad Student*** (not a member of SCI/RSC) - £300 |
Optional on-site accommodation
* RSC members should enter the Event discount code EJRFChem221 and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration.
** RSC student members should enter the Event discount code EJRFChem221S and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration.
*** Students who are not a member of SCI/RSC should email conferences@soci.org from their institution email address to request the relevant code to book for this event
All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org.
Become an SCI Member and save on this and future events
See Membership OptionsSign up as an Event Member to join this event. SCI Full or Student Members receive discounts on event registrations
Booking Process/Deadlines
Bursaries
A limited number of student bursaries are available as a contribution to the cost of registration fees, travel and accommodation. For more information and to receive an application form, please contact conferences@soci.org.
SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with inclusivity of gender and ethnicity. Attendees from all backgrounds and ages are welcome.
Partners
Exhibitors
Sponsors
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Organising Committee
Nadia Ahmad, Charles RiverMark Healy, Novartis
Joanne Pinder , Vertex
Jamie Scott, AstraZeneca
John Cumming, Roche
Gordon Saxty, NS-MC Consulting
Chris Swain, Cambridge MedChem Consulting
Andrew Williams, Chairman of the RSC BMCS