1 October 2024
Highlights in Medicinal Chemistry V
Organised by:
SCI’s Fine Chemicals Group
SCI, London, UK
Synopsis
This meeting aims to showcase vignettes of modern medicinal chemistry to bring new thinking to the subject, challenge perceptions and encourage scientific interaction between researchers. The short presentation format of the meeting also aims to provide a focussed forum to promote examples of medicinal chemistry excellence.
Attendees
This meeting is targeted at academic and industrial scientists engaged in all aspects of the drug discovery process and those interested in broadening their knowledge at the forefront of medicinal chemistry.
Confirmed speakers
Ed Tate, Imperial College London
Modulating protein-protein interactions in immunology: from chemical biology to covalent ligand discovery
Ingo Hartung, Merck Healthcare
Quo vadis small molecule drug discovery
Suzanne O'Connor, Centre for Targeted Protein Degradation Dundee
Developing PROTACs targeting the MAPK Pathway
Thomas Pesnot, Concept Life Sciences
Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)
Efthymios S. Gavriil, Imperial College London
Discovery of Hedgehog Acyltransferase (HHAT) Inhibitors as a Novel Strategy to Stop Hedgehog Signalling in Cancer
Fionn O’Hara, F. Hoffmann-La Roche Ltd
Deep learning guided identification of peripherally restricted MAGL inhibitors
Rebecca Stevens, GSK / University of Strathclyde
A Multistep High-Throughput Chemistry Direct-to-Biology Platform to take PROTAC Synthesis and Testing to a New Level
Jonathan Shannon, Sygnature Discovery
Novel Macrocyclic NLRP3 inhibitors
Stephen Atkinson, AstraZeneca
Development of a Series of Pyrrolopyridone MAT2a Inhibitors
Pol Hernández-Lladó, University of Oxford
Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres
Ludovica Sirocchi, Boehringer Ingelheim
Discovery of a novel selective warhead to covalently target Asp12 in K-Ras G12D
Development of a Series of Pyrrolopyridone MAT2a Inhibitors
Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres
Discovery of a novel selective warhead to covalently target Asp12 in K-Ras G12D
Plenary Speakers
Prof Ed Tate
Imperial College London
Ed holds the GSK Chair in Chemical Biology at Imperial College London, he is also Group Leader at the Francis Crick Institute, and academic founder of Myricx Bio, a biotech company developing his lab’s research toward clinical applications. Following his PhD (2000) with Steve Ley in Cambridge and postdoctoral research in Paris, he was awarded a BBSRC David Phillips Fellowship in 2006 to start his group at Imperial College. He sits on the advisory boards of several international research institutes and biotechs, and develops new drug discovery technologies with companies including Pfizer, GSK and AstraZeneca. His research has been recognised by multiple awards and Fellowships including the 2020 Corday-Morgan Prize of the Royal Society of Chemistry and a 2022 Cancer Research UK Programme Award. In 2023 he was appointed to the GSK Endowed Chair in Chemical Biology at Imperial College.
Dr Suzanne O Connor
Centre for Targeted Protein Degradation Dundee
Suzanne is a Senior Drug Discovery Scientist at the University of Dundee where she leads PROTAC drug discovery projects for the treatment of cancer, in collaboration with Alessio Ciulli and Boehringer Ingelheim. She has a Medicinal Chemistry degree from Trinity College Dublin, a Research Masters in Drug Discovery and Development from Imperial College London and a PhD in Fragment Based Drug Discovery from the Institute of Cancer Research, under the supervision of Prof. Ian Collins. Prior to joining the Centre for Targeted Protein Degradation in Dundee, Suzanne has worked at Evotec in lead optimisation drug discovery for the treatment of chronic pain, and at AstraZeneca working on a variety of oncology drug discovery projects.
Dr Ingo Hartung
Merck Healthcare
Ingo Hartung is a synthetic organic chemist by training (PhD University of Hannover/Germany, Postdoc Stanford University/US) with more than 15 years of Pharma industry experience (Schering AG, Bayer AG, Merck KGaA). He has been project leader in oncology and cardiology NCE drug discovery and has had portfolio responsibility for preclinical research in the areas of epigenetics and immuno-oncology. In his current role he is head of Merck’s Medicinal Chemistry & Drug Design department and is leading Merck’s global cross-functional targeted protein degradation platform. His research interests comprise all aspects of innovation in small molecule drug discovery with a special focus on new synthetic modalities like protein degraders. He is the author of >50 scientific publications and patents.
Programme
The programme will be confirmed in due course.
SCI’s Fine Chemicals Group are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with full inclusivity where attendees from all backgrounds are welcome. We are open to offering flexible presentation options.
Sponsorship and exhibition information
For further information and prices, please email conferences@soci.org.
Call for oral abstracts
Abstracts for focussed 20-minute talks with contributions from the whole field of medicinal chemistry are now invited: please submit a one-page abstract to conferences@soci.org by Thursday 28 March 2024, with “Highlights V – short talk abstract” in the subject line. An abstract template can be downloaded here.
Venue and Contact
SCI
14/15 Belgrave Square
London
SW1X 8PS
Conference Team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
Fees
Early bird - ends Tuesday 3 September 2024
SCI Member - £95
Non-member - £125
Student Member - £50
SCI Member - £95
Non-member - £125
Student Member - £50
After early bird
SCI Member - £145
Non-member - £175
Student Member - £80
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Booking Process/Deadlines
CPD Info
SCI Members attending this meeting are able to claim CPD points.
Exhibitors
Sponsors
Organising committee
Dr Nicola Chessum, SCI / Boehringer Ingelheim RCV GmbH & Co KGDr Helen Horsley, SCI / UCB
Dr Sarah Major, SCI / Dark Blue Therapeutics
Dr Joanne Pinder, SCI / Vertex Pharmaceuticals (Europe) Ltd
Dr Hugh Tawell, SCI / Domainex