Synopsis
One of the most exciting new therapeutic modalities to emerge in the 21st century has been Targeted Protein Degradation (TPD). In 2021, the Targeted Protein Degradation Market size was valued at USD 400.5 million and is poised to grow from USD 507.0 million in 2022 to USD 3,300.0 million by 2030 and so has attracted interest from academia, non-profit organisations through to CROs and small and large pharma.
This multidisciplinary meeting aims to present the latest developments in the design, biology, chemistry and ADME in TPD within the general themes of PROTACS (including non-oncology targets), Molecular Glues and non-PROTAC degraders. We aim to highlight the newest in enabling technologies such as computational techniques, Direct to Biology, HT synthesis (click, photochemistry etc) and structural biology methods.
Attendees
The meeting aims is targeted at academic and industrial scientists engaged in all aspects of research into the ubiquitin proteasome pathway and those interested in broadening their knowledge in this rapidly expanding field.
Call for oral and poster presentations
Submissions for oral and/or poster presentations are welcomed around the conference general themes. Abstracts should be maximum 300 words indicating title, authors, institution and preference for presentation option (Oral presentation and/or Poster) and sent to conferences@soci.org with the subject line “Targeting Protein Degradation 2024 - abstract submission”. Presentation slots are inevitably limited and will be allocated to achieve a balanced programme. Prizes will be awarded for the best presentation and poster. An abstract template can be downloaded here.
Deadline for oral presentations - Friday 31 May 2024 (decisions by end of June)
Deadline for poster presentations - Friday 30 August 2024
Exhibition and sponsorship
For further information and prices, please email
conferences@soci.org.
Programme
Tuesday 15 October 2024
- 09.45
- Registration
- 10.25
- Opening Remarks
- 10.30
- Plenary lecture: Gazing into the crystal ball - what have we learnt and where does TPD research need to go next?
Ian Churcher, Janus
- 11.10
- Discovery of Novel Small Molecules Binders of Soluble Mutant HTT and Derivatization into PROTACs
Geoffrey Schwertz, UCB
- 11.35
- Discovery of BclxL protein degraders for overcoming cancer resistance
Jim Sheppeck, AZ
- 12.00
- Targeting cancer with panKRAS degraders
Vesna Vetma, Centre for Targeted Protein Degradation, Dundee
- 12.25
- Lunch
- 13.30
- Photocatalysis enabled One-Pot PROTAC Library Synthesis
Jacqueline Bitai, Boehringer Ingelheim
- 13.55
- Exploring the Pharmacokinetics of PROTACs: A Focus on Solubility and Metabolic Stability
Gabriele Cruciani, Department of Chemistry, Biology andBiotechnology, University of Perugia
- 14.20
- CRBN-midi: expanding the toolbox for structural and biophysical characterization of protein degraders
Alena Kroupova, Centre for Targeted Protein Degradation, Dundee
- 14.45
- Leveraging XChem Crystallographic Fragment Screening and Chemist-Assisted Robotics for Silent Hotspot Mapping and Rapid Fragment Expansion
Thomas Webb, Centre for Targeted Protein Degradation, Dundee
- 15.10
- Refreshments
- 15.30
- Making it stick – how can we convert inhibitors into molecular glue degraders?
Ben Belanie, ICR Centre for Protein Degradation
- 16.10
- Identification, optimization and characterization of Cyclin K molecular glue degraders
Douglas Thomson, Proxygen
- 16.25
- TBC
Andrea Testa, Amphista
- 16.45
- TBC
- 17.00
- Poster Flash Presentations
- 17.15
- Posters, Wine Reception
- 19.00
- Conference Dinner
Wednesday 16 October 2024
- 09.00
- Refreshements
- 09.30
- Plenary lecture: Molecular mechanisms and rational design of protein degraders
Alessio Ciulli, Centre for Targeted Protein Degradation, Dundee
- 10.10
- D2B
Rob Law, GSK
- 10.35
- A career doing STUFF
Mike Hann, GSK
- 11.15
- Refreshments
- 11.30
- Enabling targeted protein degradation in bacteria
Ester Morreale, Crick Institute
- 11.55
- Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of “undruggable” targets
David Selwood, Wolfson Institute for Biomedical Research, University College London
- 12.20
- Structural Insights into PROTAC Handle Development for the Cullin-2 Substrate Adaptor KLHDC2
Melissa Sweeney, University of Oxford
- 12.45
- Lunch
- 13.50
- Plenary lecture: Targeting chromatin regulatory proteins with therapeutic degraders
Danette Daniels, Foghorn
- 14.30
- TBC
- 14.55
- PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease
Alessia De Santis, University of Florence
- 15.20
- Activin Receptor-like Kinase 2 Degradation as a Novel Therapeutic Strategy Towards the Treatment of Diffuse Intrinsic Pontine Glioma
Daniel Webb, Charles River Laboratories
- 15.45
- Closing Remarks
SCI’s Fine Chemicals Group are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with full inclusivity where attendees from all backgrounds are welcome. We are open to offering flexible presentation options.
Accessibility Grants
SCI accessibility grants are available to support SCI members with disabilities, long term health conditions, those who require a carer, and members who are nursing parents to attend SCI events. Download an application form to apply for a grant.
Accommodation
SCI’s Delegates require accommodation will need to
email
venuecranfield@cranfield.ac.uk or call 01234 754341 and quote Society of Chemical Industry, reference 395664 in order to receive the rates offered to you. Upon reservation guests will be asked to provide payment.
If the guest wants to hold a specific room (twin, accessible etc.) it will need to be asked at time of booking otherwise the reservation will be made on a run of house basis and we cannot guarantee availability at time of check in.
Mitchell Hall
https://venuecranfield.co.uk/mitchellhall/
- Single room with breakfast: 108.00 per night, per room
- Double room with breakfast: £135.00 per night, per room
CMDC
https://venuecranfield.co.uk/cmdc/
- Single room with breakfast: 108.00 per night, per room
- Double room with breakfast: £135.00 per night, per room
Venue and Contact
Fees
Early bird - ends Tuesday 10 September 2024
SCI/RSC Member - £215
Non-member - £295
SCI/RSC Student Member - £135 |
After early bird
SCI/RSC Member - £260
Non-member - £345
SCI/RSC Student Member - £185 |
Conference dinner
There will be a dinner available for delegates on the first night. This provides a valuable networking experience.
Places are available as 'optional extras' at £60 pp based on 3 x course meal and drinks included.
*RSC members should enter the Event discount code EJRFCHEM235 and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration.
*RSC student members should enter the Event discount code EJRFCHEM235S and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration.
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Booking Process/Deadlines
Booking terms and conditions
Travel information
Cranfield University is well situated for access by road and rail (via Bedford and Milton Keynes). Taxis and buses are available from Bedford and Milton Keynes stations to the University. For air travellers, Bedford mainline railway station directly connects to Luton and Gatwick airports, Milton Keynes serves Birmingham International. Those travelling via Heathrow will need to travel into central London and from there onto Bedford or Milton Keynes.
For more details please see the link here.
Bursaries
A limited number of bursaries are available for students as a contribution to the cost of registration fees, travel and accommodation. For more information and to receive an application form, please contact
conferences@soci.org with “Targeting protein degradation 4’ in the title.
Organising committee
Sean Bew, UEA
Stuart Cameron, Concept life sciences
Nicola Chessum, Boehringer-Ingelheim
Katherine Jones, Charles River
Suzanne O’Connor, University of Dundee
Hannah Woodward, MSD