15 October - 16 October 2024

Targeting protein degradation 4

Organised by:

SCI’s Fine Chemicals group and RSC’s Biological and Medicinal Chemistry Sector

Cranfield University, UK

Register Now

Prices start from £215.00

Early bird offer ends 10 September 2024


One of the most exciting new therapeutic modalities to emerge in the 21st century has been Targeted Protein Degradation (TPD). In 2021, the Targeted Protein Degradation Market size was valued at USD 400.5 million and is poised to grow from USD 507.0 million in 2022 to USD 3,300.0 million by 2030 and so has attracted interest from academia, non-profit organisations through to CROs and small and large pharma. 

This multidisciplinary meeting aims to present the latest developments in the design, biology, chemistry and ADME in TPD within the general themes of PROTACS (including non-oncology targets), Molecular Glues and non-PROTAC degraders. We aim to highlight the newest in enabling technologies such as computational techniques, Direct to Biology, HT synthesis (click, photochemistry etc) and structural biology methods.

The meeting aims is targeted at academic and industrial scientists engaged in all aspects of research into the ubiquitin proteasome pathway and those interested in broadening their knowledge in this rapidly expanding field.
Call for oral and poster presentations

Submissions for oral and/or poster presentations are welcomed around the conference general themes. Abstracts should be maximum 300 words indicating title, authors, institution and prefer­ence for presentation option (Oral presentation and/or Poster) and sent to conferences@soci.org with the subject line “Targeting Protein Degradation 2024 - abstract submission”. Presentation slots are inevitably limited and will be allocated to achieve a balanced programme. Prizes will be awarded for the best presentation and poster. An abstract template can be downloaded here.

Deadline for oral presentations - Friday 31 May 2024 (decisions by end of June)
Deadline for poster presentations - Friday 30 August 2024

Exhibition and sponsorship
For further information and prices, please email conferences@soci.org.
Confirmed speakers

Identification, optimization and characterization of Cyclin K molecular glue degraders
Douglas Thomson, Proxygen

Targeting chromatin regulatory proteins with therapeutic degraders
Danette Daniels, Foghorn

Molecular mechanisms and rational design of protein degraders
Alessio Ciulli, Centre for Targeted Protein Degradation, Dundee

Making it stick – how can we convert inhibitors into molecular glue degraders?
Ben Belanie, ICR Centre for Protein Degradation

CRBN-midi: expanding the toolbox for structural and biophysical characterization of protein degraders
Alena Kroupova, Centre for Targeted Protein Degradation, Dundee

Targeting cancer with panKRAS degraders
Vesna Vetma¸ Centre for Targeted Protein Degradation, Dundee

Discovery of Novel Small Molecules Binders of Soluble Mutant HTT and Derivatization into PROTACs
Geoffrey Schwertz, UCB

Photocatalysis enabled One-Pot PROTAC Library Synthesis
Jacqueline Bitai, Boehringer Ingelheim, RCV GmbH & Co KG

Exploring the Pharmacokinetics of PROTACs: A Focus on Solubility and Metabolic Stability
Gabriele Cruciani, Department of Chemistry, Biology and Biotechnology, University of Perugia

Gazing into the crystal ball - what have we learnt and where does TPD research need to go next?
Ian Churcher - Janus Drug Discovery Consulting Ltd

CRBN-midi: expanding the toolbox for structural and biophysical characterization of protein degraders
Alena Kroupova, Centre for Targeted Protein Degradation, Dundee

Discovery of BclxL protein degraders for overcoming cancer resistance
Jim Sheppeck, AstraZeneca

Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of “undruggable” targets
David Selwood, Wolfson Institute for Biomedical Research, University College London

Activin Receptor-like Kinase 2 Degradation as a Novel Therapeutic Strategy Towards the Treatment of Diffuse Intrinsic Pontine Glioma
Daniel Webb, Charles River Laboratories

Leveraging XChem Crystallographic Fragment Screening and Chemist-Assisted Robotics for Silent Hotspot Mapping and Rapid Fragment Expansion
Thomas Webb, Centre for Targeted Protein Degradation

PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease
Alessia De Santis, University of Florence

Structural Insights into PROTAC Handle Development for the Cullin-2 Substrate Adaptor KLHDC2
Melissa Sweeney, University of Oxford


Tuesday 15 October 2024

Session 1
Session 2
Session 3
Posters/Wine reception
Conference dinner

Wednesday 16 October 2024

Session 4
Session 5
Session 6
Event close
The full programme will be confirmed in due course.

SCI’s Fine Chemicals Group are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with full inclusivity where attendees from all backgrounds are welcome. We are open to offering flexible presentation options.

Accessibility Grants

SCI accessibility grants are available to support SCI members with disabilities, long term health conditions, those who require a carer, and members who are nursing parents to attend SCI events. Download an application form to apply for a grant.

SCI’s Delegates require accommodation will need to email venuecranfield@cranfield.ac.uk or call 01234 754341 and quote Society of Chemical Industry, reference 395664  in order to receive the rates offered to you. Upon reservation guests will be asked to provide payment.
If the guest wants to hold a specific room (twin, accessible etc.) it will need to be asked at time of booking otherwise the reservation will be made on a run of house basis and we cannot guarantee availability at time of check in.

Mitchell Hall


  • Single room with breakfast: 108.00 per night, per room
  • Double room with breakfast: £135.00 per night, per room


  • Single room with breakfast: 108.00 per night, per room
  • Double room with breakfast: £135.00 per night, per room

Venue and Contact

Cranfield University

Located in: Cranfield University
College Road
MK43 0AL



Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org

Early bird - ends Tuesday 10 September 2024
SCI/RSC Member - £215
Non-member - £295
SCI/RSC Student Member - £135
After early bird
SCI/RSC Member - £260
Non-member - £345
SCI/RSC Student Member - £185

Conference dinner
There will be a dinner available for delegates on the first night. This provides a valuable networking experience.
Places are available as 'optional extras' at £60 pp based on 3 x course meal and drinks included.

*RSC members should enter the Event discount code EJRFCHEM235 and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration. 

*RSC student members should enter the Event discount code EJRFCHEM235S and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration.

All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org

Become an SCI Member and save on this and future events

See Membership Options

Sign up as an Event Member to join this event. SCI Full or Student Members receive discounts on event registrations

Booking Process/Deadlines

Booking terms and conditions

Travel information

Cranfield University is well situated for access by road and rail (via Bedford and Milton Keynes). Taxis and buses are available from Bedford and Milton Keynes stations to the University. For air travellers, Bed­ford mainline railway station directly connects to Luton and Gatwick air­ports, Milton Keynes serves Birmingham International. Those travelling via Heathrow will need to travel into central London and from there onto Bed­ford or Milton Keynes.

For more details please see the link here.
A limited number of bursaries are available for students as a contribution to the cost of registration fees, travel and accommodation. For more information and to receive an application form, please contact conferences@soci.org with “Targeting protein degradation 4’ in the title.




Organising committee
Sean Bew, UEA
Stuart Cameron, Concept life sciences
Nicola Chessum, Boehringer-Ingelheim
Katherine Jones, Charles River
Suzanne O’Connor, University of Dundee
Hannah Woodward, MSD