The family of protein tyrosine phosphatases (PTPs) play critical roles in celluar signalling pathways and are recognised as potential drug targets in diabetes, cancer and cardiovascular disease. However, development of therapeutics targeting the family of protein tyrosine phosphatases has lagged far behind that of kinases. We have been investigating the structure, function and regulation of this family of enzymes and are exploring strategies for inhibiting PTPs. In addition, receptor-type PTPs are poorly understood and recent development in theis area will be discussed.
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University of Westminster
University of Westminster, School of Life Sciences, 115 New Cavendish Street London W1W 6UW
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Dr Alistair Barr, Department of Human and Health Sciences, Faculty of Science and Technology, University of Westminster.