14 May - 15 May 2018

Kinase 2018: towards new frontiers - 8th SCI / RSC symposium on kinase inhibitor design

Organised by:

SCI's Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector

Cambridge

Registration Closed

This event is no longer available for registration.

Synopsis
With more than 25 FDA-approved small molecules, the field of kinase inhibition continues to attract significant investment from the drug discovery and development community. The 8th SCI / RSC symposium on kinases will encompass case studies of ongoing programmes as well as successful past programmes. A range of topics including CNS kinase inhibitors, allosteric inhibitors and non-oral delivery methods will be covered, along with views and perspectives on the future of kinase inhibitor research.
Attendees
This event is aimed at all scientists interested in furthering their knowledge of kinases. It will also have wider appeal to members of the drug discovery community eager to understand how enzyme inhibitor programmes are approached and executed across the pharmaceutical industry.
Programme

Day 1 - 14th May 2018

Event Schedule
09:30
Registration and refreshments
10:00
Opening remarks
10:05
Keynote presentation: Targeting PI3Ks in immunity, infection and cancer Klaus Okkenhaug, University of Cambridge and Babraham Institute, UK
10:45
Discovery and development of a novel, immunosuppressive class of lipid kinase inhibitors able to prolong allogeneic organ engraftment James Reuberson, UCB, UK
11:15
Refreshments, exhibition and posters
11:45
Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Ka that promotes selective degradation of mutant-p110a Emily Hanan, Genentech, USA
12:20
Roger Griffin Memorial Lecture: Inhibitors of the mitotic kinase MPS1: discovery of an orally bioavailable preclinical development candidate Julian Blagg, Institute of Cancer Research, UK
13:00
Lunch, exhibition and posters
14:00
A potent and orally bioavailable ERK1/2 series identified through fragment screening which modulates the phosphorylation and catalytic activity of ERK1/2 Valerio Berdini, Astex Pharmaceuticals, UK
14:30
NVP-LXS196, a novel PKC inhibitor for the treatment of uveal melanoma Julien Papillon, Novartis Institutes for Biomedical Research, USA
15:00
Reserved for late breaker
15:30
Refreshments, exhibition and posters
16:00
flash poster presentations (session 1)
16:20
Identification of low clearance indole acid AMPK activators for the treatment of diabetic nephropathy David Ebner, Pfizer, USA
16:35
New leads from old drugs: repurposing kinase inhibitor chemotypes for tropical diseases Michael Pollastri, Northeastern University, USA
17:30
Flash poster presentations (session 2)
17:50
Network reception, exhibition and posters
19:00
Conference dinner

Day 2 - 15th May 2018

Event Schedule
09:00
Strategy and tactics for the discovery of Kinase inhibitors for CNS targets. A Lundbeck perspective Klaus Bæk Simonsen, Lundbeck
09:40
Building on the success of Osimertinib - achieving CNS exposure in oncology drug discovery Nicola Colclough, AstraZeneca, UK
10:20
Refreshments, exhibition and posters
10:50
Chemical strategies for activating PINK1, a protein kinase mutated in Parkinson’s disease Youcef Mehellou, Cardiff School of Pharmacy and Pharmaceutical Sciences, UK
11:30
BBB penetrating tetracyclic TRK-selective inhibitor CH7057288: additional efficacy against brain metastasis in vivo model Toshiya Ito, Chugai, Japan
12:10
Interactive session
12:45
Lunch, exhibition and posters
13:45
Discovery of the clinical candidate AZD1390: a high quality, potent and selective inhibitor of ATM kinase with the ability to cross the blood brain barrier Thomas Hunt, AstraZeneca, UK
14:25
Structural mechanisms of regulation of the PI3Ks and related kinases Roger Williams, MRC Laboratory of Molecular Biology, UK
15:05
Closing remarks
15:10
Close of event

Venue and Contact

Babraham Research Campus

Cambridge Building
Babraham Hall
Babraham
Cambridge
CB22 3AT

Please click here for directions and a location map.

Maggi Churchouse

Tel: +44 (0)1359 221004


Fees

Early bird fees before Wednesday 7 February 2018

GB£269 . . . . . . . . . . . . . . . . . SCI / RSC Member
GB£140 . . . . . . . . . . . . . . . . . SCI / RSC Student Member
GB£325 . . . . . . . . . . . . . . . . . Non-Member
GB£159 . . . . . . . . . . . . . . . . . Student Non-Member

Standard fees after Wednesday 7 February 2018

GB£324 . . . . . . . . . . . . . . . . . SCI / RSC Member
GB£168 . . . . . . . . . . . . . . . . . SCI / RSC Student Member
GB£392 . . . . . . . . . . . . . . . . . Non-Member
GB£196 . . . . . . . . . . . . . . . . . Student Non-Member

Late rates for payments received from 12th April onwards. £40 Late payment fee to be added to the above standard rates.

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Booking Process
For booking terms and conditions click here.
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Additional Info

Accommodation

Accommodation options can be found here.

Coach Transport

A coach has been booked to provide transport. This is provided gratis, and you are advised to book your requirements at the time of registration, as the limited number of spaces will be allocated on a "first come, first served" basis. For more information click here.

Exhibition and sponsorship

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please contact us by email. Spaces are limited and will be allocated on a first come, first served basis.

Students and Bursaries

Discounted rates are offered to SCI and RSC student members, and some student bursaries are available. Please download a bursary application form here. The deadline for bursary applications is 2 April 2018.