Glycans, in the form of polysaccharides or glycoconjugates, are the most abundant class of biomolecules. Every cell has multiple types of glycan on its surface where they play vital roles in cell-cell and cell matrix interactions. Structural determination is essential for understanding the roles that glycans play in biological systems. Mass spectrometry (MS), with its ultra-high sensitivity and ability to analyse complex mixtures of glycans, is the most powerful tool currently available for glycan structure analysis. Our laboratory is engaged in numerous world-wide collaborations in which we exploit high sensitivity mass spectrometric methodologies for the structural characterisation of glycans found in a diverse range of biological material. This presentation will review MS strategies incorporating MALDI-TOF-TOF MS/MS and nanoLC-ES-MS/MS for defining the glycomes of cells, tissues and purified glycoconjugates as well as establishing glycoprotein site-specific glycosylation. The broad range of Dr Haslam's research activities will be illustrated by data from ongoing collaborative projects embracing host pathogen interactions and human disease.
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The lecture will be preceded by tea/coffee in the Nyholm room and followed by a Mixer in the Nyholm Room.