Glycans, in the form of polysaccharides or glycoconjugates, are the most abundant class of biomolecules. Every cell has multiple types of glycan on its surface where they play vital roles in cell-cell and cell matrix interactions. Structural determination is essential for understanding the roles that glycans play in biological systems. Mass spectrometry (MS), with its ultra-high sensitivity and ability to analyse complex mixtures of glycans, is the most powerful tool currently available for glycan structure analysis. Our laboratory is engaged in numerous world-wide collaborations in which we exploit high sensitivity mass spectrometric methodologies for the structural characterisation of glycans found in a diverse range of biological material. This presentation will review MS strategies incorporating MALDI-TOF-TOF MS/MS and nanoLC-ES-MS/MS for defining the glycomes of cells, tissues and purified glycoconjugates as well as establishing glycoprotein site-specific glycosylation. The broad range of Dr Haslam's research activities will be illustrated by data from ongoing collaborative projects embracing host pathogen interactions and human disease.
Venue and Contact
This is a FREE event. No need to book.
Become an SCI Member and save on this and future events
See Membership Options
Sign up as an Event Member to join this event. SCI Full or Student Members receive discounts on event registrations
Booking terms and conditions
SCI Members attending this meeting are able to claim CPD points.
The lecture will be preceded by tea/coffee in the Nyholm room and followed by a Mixer in the Nyholm Room.