1 November 2013
Life is Sweet-Glycomics and Glycoproteomics - Providing New Biological Insights
Organised by:
SCI's Biotechnology Group in conjunction with the University of Westminster
University of Westminster
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Synopsis
Glycans, in the form of polysaccharides or glycoconjugates, are the most abundant class of biomolecules. Every cell has multiple types of glycan on its surface where they play vital roles in cell-cell and cell matrix interactions. Structural determination is essential for understanding the roles that glycans play in biological systems. Mass spectrometry (MS), with its ultra-high sensitivity and ability to analyse complex mixtures of glycans, is the most powerful tool currently available for glycan structure analysis. Our laboratory is engaged in numerous world-wide collaborations in which we exploit high sensitivity mass spectrometric methodologies for the structural characterisation of glycans found in a diverse range of biological material. This presentation will review MS strategies incorporating MALDI-TOF-TOF MS/MS and nanoLC-ES-MS/MS for defining the glycomes of cells, tissues and purified glycoconjugates as well as establishing glycoprotein site-specific glycosylation. The broad range of Dr Haslam's research activities will be illustrated by data from ongoing collaborative projects embracing host pathogen interactions and human disease.Venue and Contact
University of Westminster
University of Westminster, School of Life Sciences, 115 New Cavendish Street London W1W 6UW
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Comms Team SCI
Tel: 0207 598 1594
Email: Communications@soci.org
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