27 January 2016

New Approaches in Medicinal Chemistry

Organised by:

GlaxoSmithKline, Stevenage, UK

Registration Closed

This event is no longer available for registration.

Synopsis

This one day symposium is to be held at one of GSK’s major research and development centres in Stevenage. The event is aimed at introducing and reviewing a wide range of hot topics and approaches that may be used in discovering the drugs of tomorrow.

By bringing together speakers from the key global centres of excellence in drug discovery, the day has been designed to deliver what is current and of high interest to those pushing forward the frontiers of drug discovery. There will be discussion around the physicochemical property space that should guide successful drug design as well as when the traditional rules are not appropriate for meeting the requirements of a specific drug target or project.

Furthermore attention will be given to how a drug binds to its target and the importance of understanding the thermodynamic and kinetic profile of this binding event to guide further design iterations.

The day will also look to cover approaches and technologies such as DNA encoded libraries, chemoproteomics and novel ways of hit finding via activity directed synthesis.

Attendees

The meeting is aimed at scientists in the industrial and academic fields with a background in medicinal chemistry or drug discovery. It is ideally suited to those studying for a postgraduate degree or working in the pharmaceutical or biotechnology industry. This symposium will engage both those who are familiar with medicinal chemistry and drug discovery, and those who are new to the area but interested in learning more.

Programme

Day 1 - 27 January 2016

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09.30: Registration and refreshments
09:45: Welcome and introduction
09:50: Designing better molecules: using the past to predict the future Dr Tim Ritchie, TJR-Chem, Italy
10:25: Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates Dr Björn Over, AstraZeneca R&D, Sweden
11:00: Refreshment break and posters
11:30: Thermal proteome profiling for unbiased identification of drug targets and detection of downstream effectors Dr Marcel Muelbaier, GlaxoSmithKline, Germany
12:05: The design and optimisation of covalent kinase inhibitors Dr Richard Ward, AstraZeneca, UK
12:40: Lunch and posters
13:40: Bigfoot, the Loch Ness Monster, and halogen bonds: separating rumors from reality in molecular design Dr David Lawson, Takeda, USA
14:15: High-end GPCR ligand design: from waters to kinetics Dr Andrea Bortolato, Heptares Therapeutics, UK
14:50: Refreshment break and posters
15:20: The realisation of activity-directed synthesis Prof Adam Nelson, University of Leeds, UK
15:55: DNA-encoded chemical libraries as a new paradigm in target chemical tractability assessment Dr Ghotas Evindar, GlaxoSmithKline, USA
16:30: Concluding remarks
16:40: Wine reception

Venue and Contact

GlaxoSmithKline

Gunnels Wood Road
Stevenage
Herts
SG1 2NY
UK

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org

Fees

Early bird fees before Friday 11 December 2015

GB£80 . . . . . . . . . . . . . . . . . SCI Member
GB£25 . . . . . . . . . . . . . . . . . SCI Student Member*
GB£55 . . . . . . .. . . . . . . . . . .SCI Subsidised Member
GB£110 . . . . . . . . . . . . . . . . Non-Member

Standard fees after Friday 11 December 2015

GB£100 . . . . . . . . . . . . . . . . SCI Member
GB£35 . . . . . . . . . . . . . . . . . SCI Student Member*
GB£65 . . . . . . . . . . . . . . . . . SCI Subsidised Member
GB£130 . . . . . . . . . . . . . . . . Non-Member

* A limited amount of student member places are available.

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Booking Process/Deadlines

For booking terms and conditions click here.

CPD Info

Attendees to this meeting are able to claim CPD points.

Exhibitors

Additional Info

Organising Committee

Dr Steve Andrews, Alzheimer's Research UK Cambridge Drug Discovery Institute
Mr Will Farnaby, SCI/Takeda
Dr Michael Lainchbury, Charles River Laboratories
Dr Ben Whittaker, SCI/Charles River Laboratories
Dr Mark Rackham, SCI/GlaxoSmithKline

Call for Poster Abstracts

Posters are invited. Interested applicants should send a maximum one page abstract to conferences@soci.org with the subject line "New Approaches in Medicinal Chemistry – poster submission" by Friday 4 December 2015. Early submission is recommended due to limited spaces. Please note, if you are an SCI Member your poster will be eligible to be displayed in the C&I area of our website. Click here to see some examples.

Please click here to download the poster abstract template.

Academic Bursaries

Limited bursary places will be available to academic attendees with preference given to those presenting posters and SCI Student Members. This bursary will cover delegate registration fees not travel expenses. To register please email an application to conferences@soci.org by Friday 15 January 2016. You will be notified by Monday 18 January 2016 if your application has been successful.

Please click here to download an application form.

Exhibition

An exhibition will run alongside the conference during refreshment breaks, for companies and related organisations who may wish to exhibit. For further information and prices please email conferences@soci.org.