31 October 2014
SCI's Biotechnology Group in conjunction with the University of Westminster
University of Westminste
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Platelets are highly reactive fragments of megakaryocytes that play a central role in thrombosis and haemostasis. They have also been implicated in wound repair, inflammation and immunity, and blood/lymphatic vessel separation. However, it remains unclear how the number and reactivity of platelets in the circulation is regulated. Recent findings from the Senis lab have identified the receptor-like protein-tyrosine phosphatase CD148 and the immunoreceptor tyrosine-based inhibition motif-containing receptor G6b-B as critical regulators of the threshold of platelet activation and platelet homeostasis. Professor Senis will discuss what lead his group to investigate these receptor-like proteins in platelets, how they modulate platelet reactivity and thrombosis, and their potential as novel anti-thrombotic drug targets.
Professor Yotis Senis, Cardiovascular and Respiratory Sciences, University of Birmingham
University of Westminster
University of Westminster, School of Life Sciences, 115 New Cavendish Street London W1W 6UW
Tel: 0207 598 1594
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