18 March 2015

Phenotypic Approaches in Drug Discovery

Organised by:

SCI's Fine Chemicals Group

SCI, London, UK

Registration Closed

This event is no longer available for registration.

Recent reports have suggested that target-based approaches are useful but not informative enough and limit understanding the full pharmacology of drug actions. Some have suggested that phenotypic screening is a more successful approach to discovering novel drugs. Therefore, it is no surprise that phenotypic screening is making a comeback in drug discovery. This meeting will introduce the uses of phenotypic screening and systems pharmacology and will provide practical insights into some of the recent changes in its use and cover the benefits and issues in this area from a range of talks including case studies.

This meeting is targeted at all those who are involved in target selection and hit identification in drug discovery and those interested in furthering their knowledge of current and emerging approaches to these areas.


Day 1

Registration and refreshments
Welcome and introduction
The cellular uptake of pharmaceutical drugs is carrier-mediated and thus a problem not of biophysics but of systems biology
Professor Douglas Kell, University of Manchester
Novel macrolide inspired macrocycles, the rule breakers for “Hard Targets”, identified by phenotypic screening
Dr Mihailo Banjanac, Fidelta
Phenotypic screening using human primary cell based assays
Dr Jeroen DeGroot, BioFocus
Lunch and exhibition
Zebrafish phenotypic screens for anti-inflammatory (or pro-resolution) drug discovery
Professor Steve Renshaw, University of Sheffield
Phenotype in Agrochemical Discovery
Dr Anthony Flemming, Syngenta
A chemogenomic approach to elucidating a mechanism for directing stem cell differentiation
Dr Robert Owen, Pfizer
Refreshment break
In silico approaches to support mode-of-action analysis using chemical and biological data
Dr Andreas Bender, University of Cambridge
Chemical Proteomics: a multifaceted tool in drug discovery
Dr Andreas Bender, University of Cambridge
Integrating phenotypic screens with in vivo imaging and reverse phase protein array technologies to advance translation
Dr Neil Carragher, Edinburgh Cancer Research Centre
Closing remarks
Wine reception
Accessibility Grants

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Venue and Contact


14/15 Belgrave Square
London SW1X 8PS

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Early Bird Fees - before 6 February 2015

SCI Member GB£100
SCI Student Member GB£35
SCI Subsidised Member GB£65
Non-Member GB£135

Standard Fees - after 6 February 2015

SCI Member GB£120
SCI Student Member GB£45
SCI Subsidised Member GB£80
Non-Member GB£165

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