15 April - 16 April 2013

Proteinase 2013

Organised by:

SCI’s Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector and hosted by Novartis

Switzerland

Registration Closed

This event is no longer available for registration.

Synopsis

This symposium will cover progress in the design and synthesis of protease inhibitors for a diverse range of disease indications, while also covering a range of novel drug discovery activities: from 'Molecules to Medicines’.

Attendees

This meeting is aimed at medicinal chemists and other scientists interested in furthering their knowledge of proteases in the context of drug discovery.

Programme

15th April 2013

Event Schedule

09:00: Plenary 1 Novartis
10:00: To be confirmed
10:45: Refreshments
11:15: β-secretase inhibitors for treatment of Alzheimer's disease Brian O'Neill, Pfizer, USA
12:00: Optimisation of g-secretase modulators through variation of scaffolds Thomas Lübbers, Roche, Switzerland
12:45: Lunch
13:45: Discovery of novel notch inhibitor Warren J Porter, Lilly, USA
14:30: Application of chemical biology in the discovery of fatty acid amide hydrolase (FAAH) inhibitors and γ-secretase modulators (GSMs) Douglas S Johnson, Pfizer, USA
15:15: Flash poster presentations
15:45: Refreshments and poster session
16:30: Discovery of peptide deformylase inhibitor GSK1322322, a novel mechanism of action antibiotic Kelly Aubart, GlaxoSmithKline, USA
17:15: Close
19:30: Conference Dinner

16th April 2013

Event Schedule

08:45: Discovery and development of Odanacatib: a selective cathepsin K Inhibitor for the treatment of osteoporosis Shawn Statchel, Merck, USA
09:45: Discovery of potent, orally bioavailable, nonpeptide, noncovalent inhibitors of Cathepsin S Prabhakar K Jadhav, Lilly, USA
10:30: Refreshments
11:15: Discovery and optimisation of N-arylpyridones, a novel class of non-electrophilic neutrophil elastase inhibitors Peter Sjö, AstraZeneca, Sweden
11:45: Silencing HCV with a potent and selective irreversible protease inhibitor Deqiang Niu, Celgene Avilomics Research, USA
12:30: Lunch
13:30: Novel allosteric inhibitors of the HCV full length NS3/4a protein David Norton, Astex, UK
14:15: From transition state analogues to fragment-based drug discovery using SPR biosensor technology Helena Danielson, Beactica/Uppsala University, Sweden
15:00: Molecular recognition in protein-ligand binding: what drives the binding? Gerhard Klebe, Philipps University, Germany
16:00: Close

Venue and Contact

Novartis

The Auditorium, Fabriekstrasse 6, Novartis Campus, Basel, Switzerland. Novartis is easily accessible from the airport and railway station - just 15 minutes from both locations by taxi, tram or bus. The site is also easily accessible from nearby motorways, and there is plenty of on-site parking. Further travel information is available on the website.

Maggi Churchouse - Secretariat

Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
W: www.maggichurchouseevents.co.uk/bmcs

Maggi Churchouse

Tel: +44 (0)1359 221004

conferences@soci.org

Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Additional Info

Call for Posters

Posters are seen as an important part of the meeting and will be displayed throughout. Poster sessions will take place at lunchtime on both days and during a dedicated session on Monday afternoon. Offers of posters relevant to the themes of the meeting are invited. Please submit a one-page abstract in Word format, to reach the Secretariat by 24th February. Please download a template here and send a one-page abstract to the secretariat by 24 February 2013.

Exhibition

We are pleased to be able to offer exhibitor spaces at this event, and the exhibitor fee of £500 includes one delegate’s attendance. Exhibitors may display roller banners only, and only a few stands are available.

Conference Dinner

The conference dinner will be held on 11 April in the Gilgenstube at the Safran Zunft Restaurant in Basel, an historical building used by guild of spice traders, now an up-market restaurant offering Swiss and regional specialities. The cost of the conference dinner is £80.

Hotels

A number of hotel accommodation options have been identified, and further information may be found here. Please note that bedrooms which have not been booked will be released between 15th February and 9th March.

Organisers

Helena Danielson, Uppsala University
Stephen East, Evotec
Adrian Hall, Eisai
Fionna Martin, Lilly
Richard Sedrani, Novartis
Steve Swallow, AstraZeneca