15 April - 16 April 2013
Proteinase 2013
Organised by:
SCI’s Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector and hosted by Novartis
Switzerland
Registration Closed
This event is no longer available for registration.
Synopsis
This symposium will cover progress in the design and synthesis of protease inhibitors for a diverse range of disease indications, while also covering a range of novel drug discovery activities: from 'Molecules to Medicines’.Attendees
This meeting is aimed at medicinal chemists and other scientists interested in furthering their knowledge of proteases in the context of drug discovery.Programme
15th April 2013
Event Schedule
- 09:00
- Plenary 1 Novartis
- 10:00
- To be confirmed
- 10:45
- Refreshments
- 11:15
- β-secretase inhibitors for treatment of Alzheimer's disease Brian O'Neill, Pfizer, USA
- 12:00
- Optimisation of g-secretase modulators through variation of scaffolds Thomas Lübbers, Roche, Switzerland
- 12:45
- Lunch
- 13:45
- Discovery of novel notch inhibitor Warren J Porter, Lilly, USA
- 14:30
- Application of chemical biology in the discovery of fatty acid amide hydrolase (FAAH) inhibitors and γ-secretase modulators (GSMs) Douglas S Johnson, Pfizer, USA
- 15:15
- Flash poster presentations
- 15:45
- Refreshments and poster session
- 16:30
- Discovery of peptide deformylase inhibitor GSK1322322, a novel mechanism of action antibiotic Kelly Aubart, GlaxoSmithKline, USA
- 17:15
- Close
- 19:30
- Conference Dinner
16th April 2013
Event Schedule
- 08:45
- Discovery and development of Odanacatib: a selective cathepsin K Inhibitor for the treatment of osteoporosis Shawn Statchel, Merck, USA
- 09:45
- Discovery of potent, orally bioavailable, nonpeptide, noncovalent inhibitors of Cathepsin S Prabhakar K Jadhav, Lilly, USA
- 10:30
- Refreshments
- 11:15
- Discovery and optimisation of N-arylpyridones, a novel class of non-electrophilic neutrophil elastase inhibitors Peter Sjö, AstraZeneca, Sweden
- 11:45
- Silencing HCV with a potent and selective irreversible protease inhibitor Deqiang Niu, Celgene Avilomics Research, USA
- 12:30
- Lunch
- 13:30
- Novel allosteric inhibitors of the HCV full length NS3/4a protein David Norton, Astex, UK
- 14:15
- From transition state analogues to fragment-based drug discovery using SPR biosensor technology Helena Danielson, Beactica/Uppsala University, Sweden
- 15:00
- Molecular recognition in protein-ligand binding: what drives the binding? Gerhard Klebe, Philipps University, Germany
- 16:00
- Close
Venue and Contact
Novartis
The Auditorium, Fabriekstrasse 6, Novartis Campus, Basel, Switzerland. Novartis is easily accessible from the airport and railway station - just 15 minutes from both locations by taxi, tram or bus. The site is also easily accessible from nearby motorways, and there is plenty of on-site parking. Further travel information is available on the website.
Maggi Churchouse - Secretariat
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
W: www.maggichurchouseevents.co.uk/bmcs
Maggi Churchouse
Tel: +44 (0)1359 221004
Booking Process/Deadlines
CPD Info
SCI Members attending this meeting are able to claim CPD points.
Additional Info
Call for Posters
Posters are seen as an important part of the meeting and will be displayed throughout. Poster sessions will take place at lunchtime on both days and during a dedicated session on Monday afternoon. Offers of posters relevant to the themes of the meeting are invited. Please submit a one-page abstract in Word format, to reach the Secretariat by 24th February. Please download a template here and send a one-page abstract to the secretariat by 24 February 2013.
Exhibition
We are pleased to be able to offer exhibitor spaces at this event, and the exhibitor fee of £500 includes one delegate’s attendance. Exhibitors may display roller banners only, and only a few stands are available.
Conference Dinner
The conference dinner will be held on 11 April in the Gilgenstube at the Safran Zunft Restaurant in Basel, an historical building used by guild of spice traders, now an up-market restaurant offering Swiss and regional specialities. The cost of the conference dinner is £80.
Hotels
A number of hotel accommodation options have been identified, and further information may be found here. Please note that bedrooms which have not been booked will be released between 15th February and 9th March.
Organisers
Helena Danielson, Uppsala University
Stephen East, Evotec
Adrian Hall, Eisai
Fionna Martin, Lilly
Richard Sedrani, Novartis
Steve Swallow, AstraZeneca