13 April - 14 April 2015

Proteinase 2015

Organised by:

SCI's Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector

Novartis, Basel, Switzerland

Registration Closed

This event is no longer available for registration.

Synopsis

This symposium will cover progress in the design and synthesis of protease inhibitors for a diverse range of disease indications, while also covering a range of novel drug discovery activities: from 'Molecules to Medicines'.

Attendees

This meeting is aimed at medicinal chemists and other scientists interested in furthering their knowledge of proteases in the context of drug discovery.

Programme

Day 1 - Monday 13 April

09:00: Plenary: From weak fragments to highly potent and selective plasma kallikrein inhibit
Stefanie Flohr, Novartis
10:00: Inhibitors of cathepsin C - not your typical oral small molecules
Michael Palovich, GlaxoSmithKline
10:45: Refreshments, exhibition and posters
11:15: The bioactive conformation - discovery of BAY 85-8501, a highly potent binder of human neutrophil elastase
Franz von Nussbaum, Bayer
12:00: Gamma-secretase
Alexander Flohr, Roche
12:45: Lunch, exhibition and posters
13:45: Discovery of potent brain penetrant BACE inhibitors
Fionna Martin, Lilly
14:30: Discovery of MK-8931: a BACE inhibitor in phase 3 clinical development for Alzheimer's disease
Jared Cumming, Merck
15:15: Flash poster presentations
15:45: Refreshments, poster session and exhibition
16:30: Factor XIa inhibitors as new anticoagulants
Mimi Quan, BMS

Day 2 - Tuesday 14 April

08:45: Plenary: Understanding the role of proteolysis in disease
Charles Craik, University of California, San Francisco
09:45: Allosteric inhibitors of MALT1 paracaspase in targeted therapies
Daniel Krappmann, German Research Centre for Environmental Health
10:30: Refreshments, exhibition and posters
11:15: Moving in the cathepsin target space - discovery of RG7236 as a potent and highly selective cathepsin S inhibitor
Wolfgang Haap, Roche
12:00: Drugging DUBs with an NMR pyramid
Gregg Siegal, ZoBio
12:45: Lunch, exhibition and posters
13:45: Discovery and structure-based optimization of adenain inhibitors
Eva Altmann, Novartis
14:30: Discovery of the macrocyclic HCV NS3/4A protease inhibitor MK-5172
Mike Rowley, Merck
15:15: Speaker to be confirmed
16:00: Closing remarks

Venue and Contact

Novartis

The Auditorium
Fabrikstrasse 6
Novartis Campus
4056 Basel
Switzerland

Maggi Churchouse

Tel: +44 (0)1359 221004

Email: maggi@maggichurchouseevents.co.uk

Fees

Earlybird rates before 22 January 2015
GB£335 . . . . . . . . . . . . . . . .RSC/SCI Member
GB£395 . . . . . . . . . . . . . . . .Non-Member
GB£95. . . . . . . . . . . . . . . . . RSC/SCI Student Member
GB£130 . . . . . . . . . . . . . . . .Student Non-Member

Standard rates after 22 January 2015
GB£395 . . . . . . . . . . . . . . . . RSC/SCI Member
GB£465 . . . . . . . . . . . . . . . . Non-Member
GB£110 . . . . . . . . . . . . . . . . RSC/SCI Student Member
GB£155 . . . . . . . . . . . . . . . . Student Non-Member

* Student is undergraduate or post-graduate student, not post-doc

GB£80. . . . . . . . . . . . . . . . . .Conference dinner (optional)
GB£40. . . . . . . . . . . . . . . . . .Late fee for payments received from Friday 13 March

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Additional Info

Organising Committee

Helena Danielson, Uppsala University
Stephen East, Evotec
Karl Gibson, Sandexis
Fionna Martin, Lilly
Richard Sedrani, Novartis
Steve Swallow, AstraZeneca

Call for Posters

The abstract submission deadline is Friday 27 March. Selected student speakers will be invited to deliver single-slide, two-minute flash presentations prior to the poster session.

Exhibition

Those companies wishing to have a trade stand should apply early to avoid disappointment as these are limited. For further information and prices please email maggi@maggichurchouseevents.co.uk.

Accommodation and Conference Dinner

Rooms will be held at discounted rates at a series of hotels close to the conference
venue; and an optional conference dinner will be available on registration.