4 April - 5 April 2019

Protein-Protein Interactions 2019

#PPIs19

Organised by:

SCI's Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector in association with PPI-Net

Leeds, UK

Registration Closed

This event is no longer available for registration.

Synopsis

Virtually all vital cellular processes are controlled by protein-protein interactions (PPIs), including gene expression, proliferation, intracellular communication and apoptosis. The understanding and manipulation of PPIs therefore plays an important role in fathoming the biology of healthy and diseased states. Achieving this goal will lead to new probes of cell signalling pathways or systems biology, and molecular therapeutics for addressing unmet medical need.

To date, only a few PPIs have been the subject of drug discovery initiatives by the pharmaceuticals industry. Given the potential opportunities around modulating more of the estimated >650,000 PPIs, this field continues to generate considerable scientific interest, which has stimulated significant academic and industrial innovation. This meeting will address recent advances in the area. Topics will include: inducing protein degradation using small molecules, protein engineering and synthetic biology, integration of computational and experimental methods to study PPIs, characterisation and identification of new PPI inhibitors and lead optimization challenges for molecules targeting PPIs from case studies in drug discovery.

Speakers from both industry and academia will describe strategies for addressing these challenges whilst showcasing the opportunity for creativity and innovation.
Attendees
The event is aimed at all scientists (including PhD students and those in early career), from industry and academia, with an interest in the understanding or manipulation of protein-protein interactions. This encompasses medicinal and computational chemists, structural biologists, biochemists, chemical biologists, and molecular and cell biologists.
Programme

Thursday 4 April
10.00 Registration
10.20 Introductory remarks
10.30 Plenary Talk: Structure based design of high affinity inhibitors of B-cell lymphoma 6 (BCL6) protein-protein interaction
Graeme Robb, AstraZeneca
11.15 Preclinical validation of a therapeutic peptide targeting a protein/protein interaction
Angelita Rebollo, Centre d’Immunologie et des Maladies Infectieuses
11.45 Designing and disrupting protein-protein interactions in test tubes and cells
Dek Woolfson, University of Bristol
12.15 Lunch, exhibition and posters
13.30 Mimicking Protein-Protein Interactions in Persistent Bacteria
Anna Barnard, Imperial College
13.45 Platforms for the generation and high-throughput screening of cyclic peptide libraries
Ali Tavassoli, University of Southampton
14.15 Stabilising Protein-Protein Interactions: A Challenge for Ligand Discovery
Richard Doveston, University of Leicester
14.45 A novel crosslinking method allows rapid and unbiased analysis of dynamic and tight protein-protein interaction interfaces in vitro
Jim Horne, University of Leeds
15.00 Ligand directed fragment ligation targeting protein-protein interactions
Zsófia Hegedüs, University of Leeds
15.15 Peptide grafting into a repeat-protein scaffold can impart low nanomolar affinity for Keap1
Sarah Madden, University of Cambridge
15.30 Stabilization of Protein-Protein Interactions
Pim J. de Vink, Eindhoven University of Technology
15.45 Refreshments
16.00 A new method to probe protein interactions in solution
Maya Wright, Fluidic
16.15 Plenary talk: Fragment Based Drug Discovery for PPIs
David Rees, Astex Pharmaceuticals
17.00 Poster session and wine mixer

Friday 5 April
09.00 Plenary talk: Navigating the landscape of Bcl-2-binding peptides
Amy Keating, Massachusetts Institute of Technology
09.45 A new class of RAS-effector protein-protein interaction inhibitors derived using an intracellular antibody fragment
Philip Fallon, Domainex
10.15 Nanobodies directed against Tau protein to modulate its protein interactions in Alzheimer’s disease
Isabelle Landrieu, Universite de Lille
10.45 Refreshments
11.15 Discovery of Mcl-1-specific inhibitor AZD5991 and structure based design learnings from Mcl-1 PPI inhibition
Elisabetta Chiarparin, AstraZeneca
11.45 Getting in to deep water: the discovery and optimisation of BCL6 inhibitors 
Ben Bellenie, ICR
12.15 Lunch, exhibition and posters
13.30 Development of a potent class of small molecule inhibitors of the MDM2-p53 protein-protein interactions
Ian Hardcastle, University of Newcastle
14.00 Interaction of viral envelope proteins with host prohibitins
Anja Winter, Keele University
14.30 The design and synthesis of selective CREBBP bromodomain ligands
Stuart Conway, University of Oxford
15.00 Refreshments and poster prize presentation
15.15 Plenary talk: PROTAC-mediated Protein Degradation: A New Therapeutic Modality
Craig Crews, Yale University
16.00 Closing remarks
16.15 Close

Venue and Contact

University of Leeds

School of Chemistry
University of Leeds
Woodhouse Lane
Leeds
LS2 9JT

Conference Team

Tel: :+44 (0)20 7598 1561

Email: conferences@soci.org


Fees

Early bird fees before Friday 22 February 2019

£165 SCI/RSC Member
£60 SCI/RSC Student Member
£95 SCI Subsidised Member
£220 Non-Member

 

Standard fees after Friday 22 February 2019

£220 SCI/RSC Member
£85 SCI/RSC Student Member
£135 SCI Subsidised Member
£290 Non-Member

 

 

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Exhibitors

Sponsors

Additional Information

Organising committee

  • Dr Tilly Bingham, SCI/ Concept Life Sciences (Chair)
  • Dr Nicola Chessum, SCI/ The Institute of Cancer Research
  • Dr Jason Tierney, SCI/ Anima Biotech
  • Dr Douglas Williamson, Vernalis
  • Prof Andy Wilson, University of Leeds

Student Bursaries

A limited number of student bursaries of up to £350 each are available to registered participants, as a contribution to the cost of registration fees, travel and accommodation. The closing date for applications is 22 February 2019, to receive an application form please email conferences@soci.org

Exhibition and Sponsorship

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.


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