The study of highly pathogenic viruses is limited by the need for biosafety level 3 or 4 laboratories to handle wild type viruses. Using pseudotyping technology overcomes this and also has several other advantages over using wild type virus. We successfully pseudotyped isolates from each lyssavirus species allowing us to study the antigenic properties of the viral glycoproteins, develop novel therapeutics against the protoype species, rabies virus, and undertake serosurveillence studies to further our understanding of the public health threat these viruses pose. We are currently expanding this technology to include other emerging, zoonotic viruses.
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University of Westminster
School of Life Sciences,115 New Cavendish Street London W1W 6UW
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Prof Kieran Clarke, Department of Physiology, Anatomy & Genetics, University of Oxford