23 February - 24 February 2023

ADMET 2023

Organised by:

 SCI's Young Chemists’ Panel

SCI, London, UK

Register for this event

Prices start from £200.00

Early bird offer ends 12 January 2023

Synopsis

This is the 8th event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Adsorption, Distribution, Metabolism, Elimination and Toxicity) in Medicinal Chemistry. The aim is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems.


Attendees

The event is aimed at organic chemists (graduate or PhD) working in a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.


Confirmed Speakers

James Smith, Astrazeneca
Kurt Pike, Johnson & Johnson
Ted Parton, MeKinOpsis
Simon Peace, GSK


Sponsorship

For further information and prices, please email conferences@soci.org


Programme

Thursday 23 February 2023

09:15
Registration and refreshments
09:55
Introduction and welcome to Day 1
10:00
Adsorption
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Solubility, Permeability, PGP Efflux • Chemical strategies to improve absorption • Worked examples
11:15
Refreshment break
11:45
Metabolism and clearance I
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Phase I / Phase II Metabolism • Chemical strategies to address metabolism • Worked examples
13:00
Lunch
14:15
Metabolism and clearance II
Cytochrome P450s and Drug-Drug interactions • Volume of distribution – how to understand and influence • Plasma protein binding – impact & influence • Worked examples
15:45
Refreshment break
16:15
Drug toxicity and toxicology
Context & common issues • Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity
17:15
Summary and closing remarks
17:30
Networking reception and close

Friday 24 February 2023

09:15
Introduction and welcome to Day 2
09:30
Interactive workshop in breakout rooms
11:30
Worked examples (small groups)
12:30
De-brief from the morning session
12:45
Lunch
14:00
Final comments and close

Venue and Contact

SCI

14/15 Belgrave Square
London
SW1X 8PS

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Fees
Before early bird - ends 11 Jan 2023
SCI Member - £200
Non-member - £300
Student Member - £85
After early bird
SCI Member - £250
Non-member - £350
Student Member - £105

All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org.

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Booking Process/Deadlines

Booking terms and conditions


CPD Info

SCI Members attending this meeting are able to claim CPD points.

CPD logo 2021-2023


Sponsors

Organising Committee

Ross Mclennan, University of Dundee
Kim Roper, University of Birmingham
Russell Wood, Malvern Panalytical