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Synopsis
This is the 8th event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Adsorption, Distribution, Metabolism, Elimination and Toxicity) in Medicinal Chemistry. The aim is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems.
Attendees
The event is aimed at organic chemists (graduate or PhD) working in a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
Confirmed Speakers
James Smith, Astrazeneca
Kurt Pike, Johnson & Johnson
Ted Parton, MeKinOpsis
Simon Peace, GSK
Sponsorship
For further information and prices, please email conferences@soci.org
Programme
Thursday 23 February 2023
- 09:15
- Registration and refreshments
- 09:55
- Introduction and welcome to Day 1
- 10:00
- Adsorption
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Solubility, Permeability, PGP Efflux • Chemical strategies to improve absorption • Worked examples - 11:15
- Refreshment break
- 11:45
- Metabolism and clearance I
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Phase I / Phase II Metabolism • Chemical strategies to address metabolism • Worked examples - 13:00
- Lunch
- 14:15
- Metabolism and clearance II
Cytochrome P450s and Drug-Drug interactions • Volume of distribution – how to understand and influence • Plasma protein binding – impact & influence • Worked examples - 15:45
- Refreshment break
- 16:15
- Drug toxicity and toxicology
Context & common issues • Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity - 17:15
- Summary and closing remarks
- 17:30
- Networking reception and close
Friday 24 February 2023
Day 2 of the ADMET event is an interactive industry-standard DMPK workshop developed and facilitated by professional drug-discovery scientists to provide a step-change in knowledge and understanding. The objective is to embed key principles from day 1 in the context of free (unbound) drug and increase fluency in handling & interpreting DMPK data. The workshop comprises training in small groups, with expert scientists from ADMET and medicinal chemistry on hand to ensure a rich training experience.- 10:15
- Introduction & Welcome to Day 2
- 10:30
- Interactive workshop in breakout groups
- 12:30
- Lunch
- 13:30
- Worked examples in breakout groups
- 14:45
- De-brief & wrap-up
- 15:00
- Close
SCI’s Young Chemists’ Panel are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with inclusivity of gender and ethnicity. Attendees from all backgrounds and ages are welcome.
Venue and Contact
SCI
14/15 Belgrave Square
London
SW1X 8PS
Conference Team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
Fees
| Before early bird - ends 12 Jan 2023 SCI Member - £200 Non-member - £300 Student Member - £85 |
| After early bird SCI Member - £250 Non-member - £350 Student Member - £105 |
All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org.
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Booking Process/Deadlines
CPD Info
SCI Members attending this meeting are able to claim CPD points.
Sponsors
Organising Committee
Ross Mclennan, University of Dundee
Kim Roper, University of Birmingham
Russell Wood, Malvern Panalytical