29 April 2021

3rd SCI-RSC Symposium on Transporters in Drug Discovery and Development

Organised by:

SCI's Fine Chemicals Group, RSC’s Biological and Medicinal Chemistry Sector and the Drug Metabolism Discussion Group (DMDG)

Online webinar: 10:30 BST

Register for this event

Prices start from £85.00

Early bird offer ends 8 March 2021

Synopsis

Cell surface transporters play a key role in human health and disease, both through their impact on drug disposition and as therapeutic targets in their own right. This third meeting in the series will feature talks on transporter structural biology, the impact of transporters on ADME and biodistribution, transporters as therapeutic targets and other aspects of transporters relevant to drug discovery and development


Attendees
Bringing together leading exponents in the field from industry and academia, the meeting will appeal to medicinal chemists, DMPK scientists and other workers interested in the impact of transporters on human health. 

Programme

Morning session

10.30
Opening remarks
10.40

Calculation of an In Vitro Apical Efflux Ratio from P-glycoprotein (P-gp) - Impact on Screening and Compound Optimization  
Carina Cantrill, Roche

11.10
PBPK of transporter-mediated hepatic disposition using the imaging biomarker gadoxetate
Daniel Scotcher, University of Manchester
11.40
Break
11.50
Transporter PBPK modelling and DDI
Venkatesh Reddy, AstraZeneca, UK
12.20
Heteromeric amino acid transporters: disease and structure
Manuel Palacin, Institute for Research in Biomedicine, Spain
12:50
Lunch break

 

Afternoon session

14:00
Structural insight into substrate and inhibitor interactions with human multi-drug transporters ABCB1 and ABCG2
Kaspar Locher, ETH Zurich, Switzerland
14.30
Malarial Transporters
Jeremy Burrows, Medicines for Malaria Venture, Switzerland
15:00
Break
15.10
Discovery of macrocyclic peptide inhibitors of bacterial LPS transport
Evan Green, Genentech USA
15.40
Plenary Address: Genomics of Transporters: Informing drug development
Kathy Giacomini, UCSF
16.30
Closing remarks
16:40
Meeting close
 

Before early bird (ends Monday 8 March)
£85 SCI/RSC/DMDG* member
£115 Non-member
£45 SCI/RSC/DMDG* student member
After early bird
£135 SCI/RSC/DMDG* SCI member
£175 Non-member
£45 SCI/RSC/DMDG* student member

 *RSC and DMDG members should email their name, organising body and membership number to conferences@soci.org in order to receive the relevant code to book for this event.

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Organising Committee
  • Emmanuel Callens, Selcia
  • John Cumming, Roche
  • Jamie Henshall, UCB
  • Fabien Lecomte, UCB
  • Martin Lowe, UCB
  • Mohammed Ullah, UCB

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org