24 February - 25 February 2021

7½th SCI -RSC symposium on GPCRs in medicinal chemistry

Organised by:

SCI’s Fine Chemicals Group and RSC’s Biological and Medicinal Chemistry Sector

Online webinar

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Synopsis

The key role of G protein-coupled receptors (GPCRs) in human disease underpins their importance to modern medicine. We are pleased to be holding this 7½th interim meeting in the series on GPCR drug discovery, which will combine cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.

 

The meeting will consist of:

Clinical candidates
Case studies in GPCR drug discovery and development
New structural biology and drug design
Allosteric modulation

Exhibitor sponsor opportunities

Two afternoon sessions


Programme

 For the current programme and list of confirmed speakers, please click here.

 

Programme

Wednesday 24 February

 

Session chair:Adrian Hall, UCB, BE

13.00

Opening remarks

13.05

The resolution revolution: GPCR structure-based drug design in 2020 vision

James Errey, Evotec, UK

13.40

Exhibitor talk 1

13.45

Structurally enabled discovery of orally bioavailable macrocyclic antagonists of the Calcitonin Gene-Related Peptide (CGRP) receptor

Andrew Cansfield, Sosei Heptares, UK

14.20

Refreshment break

 

 

Session chair:to be confirmed, Evotec, IT

14.35

Fragment- and structure-guided drug design using ConfoBodies delivers novel, superior chemotypes on difficult to drug GPCRs

Christel Menet, Confo Therapeutics, BE

15.10

Exhibitor talk 2

15.15

Discovery of brain penetrant vasopressin 1a receptor antagonists
Hasani Ratni, F Hoffmann-La Roche, CH

15.50

Open discussion

16.15

Close

 

 

Thursday 25 February

 

Session chair:Daniele Andreotti, Evotec, IT

13.00

Opening remarks

13.05

Structural changes in GPCRs upon G protein and arrestin coupling

Chris Tate, Laboratory of Molecular Biology, Medical Research Council, UK

13.40

Exhibitor talk 3

13.45

Receptor mutations meets ligand SAR: a powerful tool to aid computational modelling
Anneli Nordqvist, AstraZeneca, SE

14.20

Refreshment break

 

 

Session chair:Caroline Low, Consultant, UK

14.35

The challenging task of modulating the GABAB receptor: an academic perspective

Claudia Mugnaini, University of Siena, IT

15.10

Exhibitor talk 4

15.15

BAY 2395840 – a potent and selective hBradykinin B1 receptor antagonist, generated within the Bayer-Evotec Strategic Alliance

Adam Davenport, Evotec, UK

15.50

Closing remarks

Caroline Low, Consultant

followed by Open discussion

16.15

Close

 


Fees

Discounted rates will be offered to SCI and RSC student members, and some student bursaries will be available on application. For further details, please click here.

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Booking Process/Deadlines

Booking terms and conditions


Partners

Call for abstract
For more information, please click here.

Organising committee
  • Daniele Andreotti, Evotec, Italy
  • Adrian Hall, UCB, Belgium
  • Duncan Hay, Vertex, UK
  • Caroline Low, Consultant, UK
  • Nigel Swain, Sosei Heptares, UK
Exhibition and Sponsorship
For further details, please click here.

Contact

Maggi Churchouse

Tel: +44 (0)1359 221004

Email:  maggi@maggichurchouseevents.co.uk