9 February 2021

FCG/YCP New Year Special

Organised by:

SCI’s Fine Chemicals Group and Young Chemists’ Panel

Online Webinar 15:00 - 16:30 GMT

Registration Closed

This event is no longer available for registration.

Synopsis

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New methods for C(sp3)–H functionalization: from C–C bond formation to fluorination

In recent years, the development of light-driven reactions has contributed numerous advances in synthetic organic chemistry.

This seminar will describe Abigail Doyle’s group’s efforts to develop new methods for C(sp3)–H functionalization via Ni-photoredox and photoredox catalysis. Using the combination of Ni-photoredox catalysis, they have developed a suite of cross-coupling reactions between chloride-containing electrophiles and abundant C(sp3)–H partners. In these reactions, photoinduced activation of the nickel catalyst contributes to the generation of chlorine radical as a potent hydrogen atom transfer agent.

The group has also recently developed a suite of reactions for C(sp3)–H oxidation to aliphatic fluorides, chlorides, alcohols, ethers, and thioethers via photoredox catalysis. In these reactions, sequential hydrogen atom transfer and oxidative radical-polar crossover enable access to a carbocation from a C(sp3)–H partner that can be trapped by a variety of nucleophiles, including halides, water, alcohols, and thiols under exceptionally mild conditions.

The development, scope, and mechanistic analysis of these methods will be presented.

Attendees

This event is relevant to industry and academic scientists working in process chemistry, as well as those keen to find out more about this area. Feedback from the previous series highlighted the valuable training and learning opportunities offered by these lectures making them applicable to students

Speaker

Abigail Doyle photo - cropped black & white

Prof Abigail Doyle

Princeton University

Abigail Doyle is the A. Barton Hepburn Professor of Chemistry in the Chemistry Department at Princeton University. She obtained her Ph.D. in catalysis and physical organic chemistry at Harvard University in 2008 under the direction of Prof. Eric Jacobsen after receiving her A.B. and A.M. in chemistry and chemical biology from Harvard in 2002. She joined the faculty at Princeton University in 2008 and is currently a co-PI for the NSF CCI Center for Computer Assisted Synthesis (C-CAS) and the DOE EFRC Bioinspired Light-Escalated Chemistry (BioLEC). The Doyle laboratory is interested in developing new approaches to chemical synthesis and catalysis, with a focus on Ni-catalyzed cross-coupling and nucleophilic fluorination methodology.

Programme

15.00: Presentation: Prof Abigail Doyle
15.45: Q&A
16.00: Panel discussion

Panel discussion

We will also be hosting an open panel discussion with Industry leaders including Rebecca Ruck and Louis Diorazio discussing topics including (bio)catalysis, sustainability, green chemistry, diversity in the workplace.

Dr Rebecca T. Ruck joined MSD Research Laboratories, Process Research & Development in 2005 and is currently Executive Director of Enabling Technologies, Small Molecule PR&D in Rahway, NJ. Her team, which is composed of biologists, chemists and engineers, is tasked with leveraging its expertise in areas such as Catalysis, Biotechnology, Reaction Modeling and Flow Chemistry to enable processes for Active Pharmaceutical Ingredients in the MSD pipeline and developing new capabilities that will allow us to continue to do so into the future.

Louis Diorazio joined Zeneca in 1998, prior to the Astra merger, and has worked in chemical development from pre-clinical through to commercialisation activities. Since 2008, he has been on the organising committee of the SCI Process Development Symposium. He is currently Principal Scientist for Route Design where his focus has been on accelerating the introduction of the optimal commercial route to drug projects.

Organising committee

• Tim Gorman – YCP/Evotec
• Daniel Hamza – FCG/Sygnature
• Fred Hancock – FCG
• Joe Howard – YCP/BioTechne
• Caroline Low – FCG/Caroline Low Consultancy
• Antonio Misale – FCG/Johnson and Johnson
• Oliver Ring – YCP/AstraZeneca
• Jason Tierney – FCG/Anima Biotech