14 April - 15 April 2021

37th Process Development Symposium 2021

Organised by:

SCI's Fine Chemicals Group

Online Webinar

Registration Closed

This event is no longer available for registration.

Process Development is the application of chemistry to the scale up of new synthetic processes from the laboratory, through pilot plant to full-scale commercial manufacture and into life cycle management. It is an extremely broad discipline, crossing the boundaries between synthetic organic chemistry, process technology and chemical engineering. The area of Process Development continues to be a challenging and important area for the research into and application of modern synthetic organic chemistry, as well as enabling technologies.
The symposium aims to bring together a wide range of speakers from across the Pharmaceutical, Agrochemical and Fine Chemical industries, as well as from an academic background. This meeting brings together experts from across the entire spectrum of the discipline to present state-of-the-art process development.

Day 1 - Wednesday 14 April           

09:00   Welcome and introduction to day 1   
09:05  Site-specific and enantioselective sp3 C-H functionalization
Prof Guosheng Liu, SIOC, China

09:50   Analytical techniques for process understanding: established and novel approaches to reaction monitoring         
Dr Maria Ciaccia, Syngenta, UK

10:30  Break           

10:50  Experimental design and its place in process development
   Dr Laura Forfar, Catalysis Consulting Ltd, UK

11:35  Regioselective preparation and functionalization of azoles for the synthesis of active
pharmaceutical ingredients
            Dr Simon Wagschal, Janssen Pharmaceutical Companies of Johnson & Johnson, Switzerland

12:15  Lunch

Site-specific and enantioselective sp3 C-H functionalization
Prof Guosheng Liu, SIOC, China

13:15  Development of late-stage difluoromethylation methods for the synthesis of a CDK2/4/6 inhibitor
Dr Shengquan Duan, Pfizer, USA     

14:00  Process development of a robust manufacturing route for sugammadex
            Dr Sue Zultanski, Merck, USA

14:40  Break           

15:00  Process development in the synthesis of CF corrector VX-661
Dr Cristian Harrison, Vertex pharmaceuticals, USA

15:45  Process chemistry award winner 2020: Design, development and applications of
           catalytic synthesis methods based on phosphorus and silicon 

  Prof Ross Denton, University of Nottingham, Academic award winner, UK

16:25  Closing remarks          

16:30  Close of the day

Day 2 - Thursday 15 April            

09:00  Welcome and introduction to day 2          

09:05  Particle design and modelling technologies for API manufacturing
            Dr Claire Wombwell, Johnson Matthey, UK

09:50  New perspectives: approaches for the application of metal scavengers to impurity
           control in pharma
Dr Sunil Rana, Biotage GB Ltd, UK

10:30  Break           

10:50  Probing reagent / catalyst (dis)function
Prof Guy Lloyd Jones, University of Edinburgh, UK

11:35  The application of C-H functionalisation in the development of a concise and convergent route to nemiralisib
Dr Katherine Wheelhouse, GlaxoSmithKline, UK

12:15  Lunch

13:15  Right particle journey: crystallisation process development from labs to scale to 
support drug product processing
 Dr Rachel Sullivan, AstraZeneca, UK

14:00  An enantioselective total synthesis of (+)-duocarmycin SA
Dr Michael Schmidt, Bristol Myers Squibb, USA

14:40  Break            

15:00  Automation and autonomy to enable process chemistry
Prof Jason Hein, University of British Columbia, Canada

15:45  Application of transition-metal catalysis, biocatalysis and flow chemistry as
           state-of-the-art technologies in the synthesis of LCZ696
Dr Florian Kleinbeck, Novartis, Switzerland

16:25  Closing remarks           

16:30  Close of the day


Before early bird (ends Monday 15 March)
£150 SCI member
£200 Non-member
£75 student member
After early bird
£250 SCI member
£310 Non-member
£75 student member

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Organising Committee
  • Louis Diorazio, SCI/AstraZeneca

  • Max Espensen, Pharmaron

  • Stella James, SCI/Bionow

  • Dave Lathbury, SCI/Astute Chemical Development Ltd

  • David Pascoe, SCI/GlaxoSmithKline

  • Hazmi Tajuddin, SCI/Syngenta

  • Robert Walton, SCI/Pfizer

  • Hilmar Weinman, Janssen Pharmaceutical Companies of Johnson & Johnson

  • Andy Wells, Charnwood Technical Consulting Ltd 

Exhibition and Sponsorship

For further information and prices please email jacqui.maguire@soci.org

Conference team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org