17 October 2023

Exploring Chemical Space 2023

Organised by:

 SCI's Fine Chemicals Group

SCI, London, UK

Registration Closed

This event is no longer available for registration.


Chemical space is vast and affords nearly unlimited opportunities to develop novel functional molecules. This meeting seeks to explore how computational chemistry and synthetic methodology can be used to rapidly explore chemical space and create new opportunities to solve problems in organic chemistry, drug discovery and agrochemicals.

In 2011, we first brought researchers together to share their insights and discoveries in how to tackle chemical space exploration. In the years since, there has been significant progress in the field with developments in computational chemistry, identification and optimisation of novel bioactive molecules, beyond rule-of-5 compliant chemical space and much more.  12 years later we are again engaging leading industrial and academic speakers to explore and discuss their state-of-the-art science.


This event will be of interest to academic and industrial chemists with an interest in identifying novel functional molecules.  The topics covered will be relevant to both early career and established scientists looking to apply new techniques and approaches in their research.

Call for Posters

Contributions are invited for posters. An abstract of maximum 250 words (does not include author names, affiliations, references or figure captions) indicating title, authors, institution included with the poster, should be sent to conferences@soci.org by Monday 17 July 2023 with the subject line “Exploring Chemical Space - poster abstract”. You can download an abstract template here.


Tuesday 17 October 2023

Registration and refreshments
Application of emerging synthetic technologies to fragment based drug discovery
Wojciech Zawodny, Astex
Real world comparison of dynamic ultra large library screening with commercial library screening against different target classes
Jonathan Heal, RxCelerate
Chemical libraries space – a new library design paradigm
Alexandre Varnek, University of Strasbourg
Chemical space inspired design using the generated databases (GDBs)
Jean-Louis Reymond, University of Bern
Lunch and poster session
Saturated benzene bioisosteres for medicinal chemistry
Pavel Mykhailiuk, Enamine (remote presentation)
The bRo5 chemical space as a source of new oral drugs: we can see the light at the end of the tunnel
Giulia Caron, University of Turin
New strategies for identification of weak acids at Syngenta
Alex Smith, Syngenta
Refreshment break
On-demand continuous flow synthesis
Tim Jamison, MIT (remote presentation)
Discovery and development of MK-1454, a therapeutic cyclic dinucleotide sting agonist
Matthew Maddess, Merck
Close of conference

SCI’s Fine Chemicals Group are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with full inclusivity where attendees from all backgrounds are welcome. We are open to offering flexible presentation options. 

Sponsorship Information

For further information and prices, please email conferences@soci.org.

Venue and Contact


14/15 Belgrave Square

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org

Early bird - ends 11 Sept 2023
SCI Member - £90
Non-member - £120
Student Member - £45
After early bird
SCI Member - £140
Non-member - £170
Student Member - £70
All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org.

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Accredited cpd Centre - The CPD Standards Office - CPD Provider 41057 - www.cpdstandards.com



Organising Committee

Helen Horsley, SCI / UCB
Martin Lowe, SCI / Exscientia
Antonio Misale, SCI / Janssen Pharmaceutical Companies of Johnson & Johnson
Nat Monck, SCI / Evotec
Jason Tierney, SCI / Medchemica / Top Tier Consultancy