Marking Black History Month and following on from the #BlackInChem initiative, SCI is continuing its look back at some of the unsung Black scientists who pioneered, and made important contributions, to the advancement of science.
Today we profile Lewis Howard Latimer, much admired by his contemporaries; Alexander Graham Bell and Thomas Edison, but sadly a name, and story, that is not as well known.
Lewis Howard Latimer | Image Credit: By Unknown author - http://www.lrc.rpi.edu/resources/news/pressReleases/img/Lewis.jpg, Public Domain, https://commons.wikimedia.org/w/index.php?curid=2032528
Lewis Howard Latimer, the youngest of four children, was born in Chelsea, Massachusetts, on 4 September 1848. His father, George Latimer, a slave who had escaped, became something of a cause celebre when his owner recaptured him. However, abolitionists took his case to the Supreme Court and his freedom was secured.
Lewis proved to be an excellent student, with a particular flair for drawing, as well as writing poetry and stories, but lack of finance and restricted access to education meant that by 15 years of age, Lewis had joined the US Navy. The history books indicate that he was honourably discharged in 1865; when the Civil War ended.
Soon after, Latimer found work as an office boy with the patent firm Crosby, Halstead and Gould. It is here that combining his talent for drawing, and developing the skills of a draughtsman he was eventually promoted to the position of head draftsman. The history books record that Latimer’s first patent, in 1874 with colleague Charles Brown, was an improved toilet system for railroad cars.
Lewis Latimer was instrumental in helping Alexander Graham Bell file his patent for the telephone ahead of his competitors.
Latimer had many inventions, but it could be argued that his drawings for Alexander Graham Bell’s telephone, helped seal his place in science history. The story goes that Bell was in a race against time, as rivals were also looking to gain patent rights for a similar device. Bell hired Latimer who used his expertise in drawing and submitting patent applications to help Bell file his patent just hours, it said, before his rival in 1876.
By 1880 Latimer had taken up the post of mechanical draughtsman for the inventor Hiram Maxim, who was also the founder of the US Electric Lighting Company. Now focused on incandescent lighting, Latimer along with Joseph Nichols, invented a light bulb which used a carbon filament, an improvement on Thomas Edison’s paper filament. The invention, patented in 1881, was sold to the US Electric Lighting Company in the same year.
Latimer invented a process for making carbon filaments for light bulbs | Editorial credit: Claudio Zaccherini / Shutterstock.com
1A booklet by the Thomas Alva Edison Foundation noted; ‘Latimer invented and patented a process for making carbon filaments for light bulbs. He taught the process to company workers, and soon it was being used in factory production. Latimer also assisted in installing Maxim lighting systems in New York City, Philadelphia, Montreal and London. During the installation of lighting in Montreal, where a lot of people spoke only French, Latimer learned the language in order to competently instruct the workers. In London he set up the first factory for the Maxim-Weston Electric Light Company. That required him to teach the workmen all the processes for making Maxim lamps, including glass blowing. In just nine months Latimer had the factory in full production.’
In 1882 Latimer left Hiram Maxim and in 1884 joined the Edison Electric Light Company, where he was given the title draughtsman-engineer. In 1890 he joined the Edison Legal Department, and in 1893 testified in a case where the company said that its incandescent lamp patents had been infringed. In 1896 the Board of Patent Control of GE and Westinghouse was formed and Latimer became its Chief Draughtsman. He continued in that role until 1911 when he joined the consulting firm Edwin W Hammer.
On 24 January 1918, Latimer was named one of the 28 charter members – and the only African-American member – of the Edison Pioneers, ‘a distinguished group of people who worked to keep the ideals of Thomas Edison alive.’ The Edison Pioneers helped create the US’ electric power industry.
Latimer received patents for several inventions, including the safety elevator. He also had a passion for social justice. In a letter written in 1895 in support of the National Conference of Coloured Men, Latimer wrote: ‘I have faith to believe that the nation will respond to our plea for equality before the law, security under the law, and an opportunity, by and through maintenance of the law, to enjoy with our fellow citizens of all races and complexions the blessings guaranteed us under the constitution.’
Latimer died on 11 December 1928. Edison Pioneers historian and long time private secretary of Thomas Edison, William H. Meadowcroft wrote1 ‘Lewis Howard Latimer was of the coloured race, the only one in our organisation, and was one of those to respond to the initial call that led to the formation of the Edison Pioneers, January 24 1918. Broadmindedness, versatility in the accomplishment of things intellectual and cultural, a linguist, a devoted husband and father, all were characteristics of him, and his genial presence will be missed from our gatherings…We hardly mourn his inevitable going so much as we rejoice in pleasant memory at having being associated with him in a great work for all peoples under a great man.’
1For more information on Latimer’s life, work and legacy, see the Edison Electric Institute resource: Thomas Alva Edison Associate: Lewis Howard Latimer: A Black Inventor.
A little talked about element, with the atomic mass 140, plays a surprisingly important role in everyday life. It has not only lit many a path, but can be credited with improving and saving the lives of billions of people by enabling cleaner air.
In his talk '140Ce: White light & Clean Air' Andy Walker, Johnson Matthey’s Technical Marketing Director explained why the soft, ductile silvery-white metal Cerium, deserves more recognition.
Walker began by outlining the history of SCI, celebrating its 140th anniversary this year. As an employee of Johnson Matthey, Walker highlighted that George Matthey was among the pioneers of SCI. In addition Walker explained that his PhD research had involved looking at catalysts that included Cerium.
Cerium is a lanthanide and the 26th most abundant element on earth. Indeed it was the first lanthanide to be discovered, found as its ore cerium silicate, in 1803. Cerium makes up 66ppm of the earth’s crust, which is about 5 times as much as lead. It is the only one of the lanthanides able to take on the +4 oxidation state, making it very useful in some of its applications. It is mined in the US, Brazil, India, Sri Lanka, Australian and China, with annual global production of 24 000 tonnes.
However, this straightforward look at the history of Cerium conceals a much more interesting narrative about how this element shaped the life of a number of prominent chemists of the day. Indeed Cerium was found as early as 1751 at a mine in Vestmanland, Sweden by Axel Cronstedt, who also discovered Nickel. Believing it to be an ore of Tungsten, he sent it to Carl Wilhelm Scheele for analysis. However, Scheele was not able to identify it as a new element.
This turn of events for Scheele, perhaps unfairly, helped to seal his moniker as the ‘unlucky chemist’. Scheele, a prominent chemist and pharmacist, had a number of discoveries to his name. He isolated lactic acid, and discovered hydrogen fluoride and hydrogen sulphide.
But as Walker explained, his most notable discovery was oxygen, some three years before Joseph Priestley. Sadly for Scheele; it took him six years to publish his findings, by which time Priestley had already presented his data. Putting a contemporary slant on Scheele’s misfortune, Walker added that the cautionary tale here was that getting things out into the public domain as soon as possible can be important to ensure credit goes to the right people.
Further work by Scheele led to the discovery of a number of elements including barium and chlorine, but sadly he did not receive any recognition because he didn’t manage to isolate them and identify them correctly. The chemist Sir Humphrey Davy did so, some years later, getting the credit for their discovery and isolation.
So it was in 1803 that chemists Wilhelm Hisinger and Jons Jacob Bezelius proved that Cerium was indeed a new element, naming it Cerium after an asteroid/dwarf planet which had been called Ceres. The successful isolation of Cerium took place in 1875, carried out by American chemists William Hillebrand and Thomas Norton, by passing an electric current through molten cerium chloride.
99.95% fine cerium isolated on white background
Once isolated, the earliest application of Cerium was in incandescent gas mantles. Developed by Carl Auer von Welsbach, in 1891, he perfected a mixture of 99% thorium oxide and 1% ceria, which gave a soft white light. Introducing his new mantle commercially in 1892, von Welsbach was able to monetise his development selling his product throughout Europe.
Gas mantles have been replaced, but Cerium’s importance in producing white light remains. As Walker explained, most white LEDs use a blue gallium nitride LED covered by a yellowish phosphor coating made of cerium-doped Yttrium Aluminium Garnet crystals.
In the medical arena, Cerium was used by Sir James Young Simpson, Professor of Medicine and Midwifery at Edinburgh who did a lot of work in the area of anaesthetics. Simpson found that cerium nitrate suppressed vomiting, particularly that associated with morning sickness, and well into the last century, medication containing Cerium could be bought over the counter. In addition Cerium has been the basis of treatments for burns.
Other applications for this versatile element are self cleaning ovens and mischmetal alloy, used in flints for cigarette lighters. Walker shared that the chemist and author Primo Levi, while imprisoned in Auschwitz, was able to steal cerium-iron rods from the laboratory he was forced to work in. Making them into cigarette lighter flints, he was able to barter for bread. Cerium is used to harden surfaces; it is a good polishing agent. Cerium sulphide has been used to replace the pigment cadmium red as a non-toxic alternative and Cerium is widely used across the chemical industry as a catalyst to produce a host of chemicals.
Catalysis is probably where Cerium has impacted most people as the element is the basis for the catalytic converters that have provided cleaner air for billions of people. Walker explained that the driver for the development came during the 1950s when photochemical smog was a problem in the Los Angeles Basin. Measurements at the time indicated that vehicles were responsible for the majority of the hydrocarbon and NOx emissions that led to the polluted air.
This turn of events led researchers to develop systems that could mitigate the emissions. Johnson Matthey was among those doing the early work on catalytic converters. Meanwhile, the automotive industry was pushing back on their introduction, concerned about the costs, durability and effectiveness. Working with Ricardo Engineering, Johnson Matthey carried out durability tests over 25 000 miles which also showed that the catalysts could pass US emissions tests.
The catalysts had to operate in three ways, at the same time, oxidising carbon monoxide (CO) and hydrocarbons (HC) while reducing NOx. Early catalysts, circa 1975, were based on Palladium and Platinum and focused on oxidising the CO and HC. Around 1978 a second catalyst was introduced to reduce NOx.
However, the introduction of Cerium then made it possible to develop a single catalyst that was able to carry out the functions that the researchers had wanted to achieve. Hence, 1981 saw the introduction of the three way catalytic converter with all three reactions enabled over a single catalyst. More recently ceria-zirconia oxide based catalysts have been developed with much higher oxygen storage capacity than ceria.
The impact of these developments has allowed the implementation of much more stringent air quality and emissions standards. Indeed Johnson Matthey estimates that its Cerium-based catalysts are responsible for removing around 40 tonnes of pollutants every minute of every day.
A single element has indeed impacted many lives.
Antimicrobial resistance (AMR), now referred to as the silent pandemic, is causing governments, regulatory and health bodies to make a lot of noise.
Issuing a statement in late August 2021, the Global Leaders Group on Antimicrobial Resistance called on countries to ‘significantly reduce the levels of antimicrobial drugs used in global food systems’. The Global Leaders Group on Antimicrobial Resistance includes heads of state, government ministers and leaders from the private sector and civil society. It was established during 2020 to accelerate global political momentum, leadership and action AMR.
Co-chaired by Mia Amor Mottley, Prime Minister of Barbados and Sheikh Hasina, Prime Minister of Bangladesh, the Group is calling for all countries to take action to tackle the issue. Steps include: Ending the use of antimicrobial drugs that are of critical importance to human medicine to promote growth in animals, eliminating or significantly reducing over-the-counter-sales of antimicrobial drugs that are important for medical of veterinary purposes, and reducing the overall need for antimicrobial drugs by improving infection prevention and control, hygiene, bio security and vaccination programmes in agriculture and aquaculture.
Leaders are calling for the reduction in the use of antimicrobial drugs.
Speaking at the second meeting of the Global Leaders Group on Antimicrobial Resistance, Inger Andersen, Under-Secretary-General of the United Nations and Executive Director the United Nations Environment Programme said: ‘Already 700 000 people die each year of resistant infections. There are also serious financial consequences: in the EU alone, AMR costs an estimated €1.5 billion per year in health care and productivity costs…’ But Andersen added that now was an opportune moment to make change. ‘With concern over zoonotic diseases at an all-time high, governments can take advantage of the synergies available from tackling emerging disease threats concurrently. The Global Leaders Group has strategic access to forums to promote AMR integration in post-covid-19 plans and financing…It’s time to for us to act on the science and respond rapidly to AMR,’ Andersen said.
The Communiqué from the G7 Health Ministers’ Meeting held in Oxford, UK during June also gave significant space the AMR issue and the link with the pandemic. ‘We reiterate the need for ongoing education and reinforced stewardship of the use of antimicrobials, including avoiding their use where there is no science-based evidence of effectiveness. The pandemic has also highlighted the importance of infection prevention and control measures to tackle AMR, targeting both health-care associated and community-associated infections.’ Adding a sense of urgency the Communiqué continued: ‘We must act strongly and across disciplines if we are to curb the silent pandemic of antimicrobial resistance.’
A letter from the BactiVac Bacterial Vaccinology Network reminded the G7 Health Ministers that the 2016 O’Neill Report estimated that by 2050, 10 million lives each year and a cumulative US$100 trillion of economic output will be at risk due to increasing AMR unless proactive solution are developed now. In its letter to the G7, the Network issued this warning. ‘The headlines on AMR may have less immediate impact, but the news is no less stark. Over the long-term, AMR bacteria will cause more prolonged suffering than covid-19, with a more insidious impact on all our lives.’ Signatories to the letter included Professor Calman MacLennan, Senior Clinical Fellow and Group Leader, Jenner Institute, University of Oxford, Professor of Vaccine Immunology, University of Birmingham.
Researchers are collaborating to understand how AMR is impacted by a range of factors
The G7 also stressed the need for collaborative efforts for a better understanding of how AMR is impacted by a range of factors. Taking up this challenge; several initiatives has been put in place to study this. Most recently the United Nations Environment Programme and the Indian Council of Medical Research have launched a project looking at ‘Priorities for the Environmental Dimension of Antimicrobial Resistance in India.’ The project aims to strengthen the environmental aspects of national and state-level AMR strategies and action plans. In a similar development the European Food Safety Agency published an assessment of the role played by food production and its environment in the emergence and spread of antimicrobial resistance. Publishing the findings in the EFSA journal, the report indicated that fertilisers of faecal origin, irrigation and water are the most significant sources of AMR in plant-based food production and aquaculture.
Meanwhile, the first quarter of 2021 saw Ineos donate £100 million to the University of Oxford to establish a new antimicrobials research facility. The Ineos Oxford Institute for Antimicrobial Resistance aims to create collaborative and cross disciplinary links involving the university’s department of chemistry and department of zoology. The Institute also intends to partner with other global leaders in the field of AMR.
Partnering with India, the UK has committed £4 million to the AMR fight. With a total investment of £8 million, the partners have established five joint research projects which aim to develop a better understanding of how waste from antimicrobial manufacturing could be inadvertently fuelling AMR.
SCI was pleased to support #BlackInChem, working alongside our Corporate Partners and members to amplify the voices of our Black chemists.
We have heard stories from several Black chemists who highlighted the steps being taken by many companies to increase diversity. But we can also see that there are many more steps that can be taken to encourage the next generation of budding Black chemists and scientists.
#BlackInChem has had support from Scott Bader, an SCI Corporate Partner, with both Damilola Adebayo and Luyanda Mbongwa sharing their perspectives as employees of Scott Bader. Elsewhere, Cláudio Laurenço gave a compelling account of his journey to become a post-doctoral research associate at a leading consumer goods company.
Cláudio Laurenço worked for free and was overlooked before eventually securing his PhD and starting his career in chemistry.
These chemists are following in the footsteps of some pioneering Black scientists such as Percy Lavone Julian, who has been profiled on the SCI Blog.
Many organisations have expressed their support and shared thoughts on what steps they are taking to encourage and ensure diversity. Indeed, #BlackInChem is a global effort and companies such as GSK have shown their support as well as numerous Black chemists talking about their experiences and achievements over the last week.
Percy Lavon Julian’s pioneering work enabled a step-change in the treatment of glaucoma | Editorial credit: spatuletail / Shutterstock.com
Over the coming months, we will be profiling other Black chemists, past and present, and continuing the dialogue around diversity.
This week SCI is joining with business and academia to mark #BlackInChem, an initiative to advance and promote a new generation of Black chemists.
Over the coming weeks, we shall be profiling past and present Black chemists, many of whom are unsung heroes, and whose work established the foundations on which some of our modern science is built. We start with the outstanding contribution made by Percy Lavon Julian (1899-1975).
Born on 11 April 1899 in Montgomery, Alabama, US, Percy L Julian was the son of a clerk at the United State Post Office and a teacher. He did well at school, and even though there were no public high schools for African Americans in Montgomery, he was accepted at DePauw University, Indiana, in 1916.
Due to segregation Julian had to live off campus, even struggling initially to find somewhere that would serve him food. As well as completing his studies, he worked to pay his college expenses. Excelling in his studies, he graduated with a BA in 1920.
Julian wanted to study chemistry, but with little encouragement to continue his education, based on the fact there were few job opportunities, he found a position as a chemistry instructor at Fisk University, Nashville, Tennessee.
In 1922 Julian won an Austin Fellowship to Harvard University and received his MA in 1923. With no job offers forthcoming, he served on the staff of predominantly Black colleges, first at West Virginia State College and in 1928 as head of the department of chemistry at Howard University.
In 1929 Julian received a Rockefeller Foundation grant and the chance to earn his doctorate in chemistry. He studied natural products chemistry with Ernst Späth, an Austrian chemist, at the University of Vienna and received his PhD in 1931. He returned to Howard University, but it is said that internal politics forced him to leave.
Physostigmine was synthesised by Julian
Julian returned to DePauw University as a research fellow during 1933. Collaborating with fellow chemist and friend Josef Pikl, he completed research, in 1935, that resulted in the synthesis of physostigmine. His work was published in the Journal of the American Chemical Society.
Physostigmine, an alkaloid, was only available from its natural source, the Calabar bean, the seed of a leguminous plant native to tropical Africa. Julian’s research and synthesis process made the chemical readily available for the treatment of glaucoma. It is said that this development was the most significant chemical research publication to come from DePauw.
Once the grant funding had expired, and despite efforts of those who championed his work, the Board of Trustees at DePauw would not allow Julian to be promoted to teaching staff. He left to pursue a distinguished career in industry. It is said that he was denied one particular position as a town law forbid ‘housing of a Negro overnight.’ Other companies are also said to have rejected him because of his race.
However, in 1936 he was offered a position as director of research for soya products at Glidden in Chicago. Over the next 18 years, the results of his soybean protein research produced numerous patents and successful products for Glidden. These included a paper coating and a fire-retardant foam used widely in World War II to extinguish gasoline fires. Julian’s biomedical research made it possible to produce large quantities of synthetic progesterone and hydrocortisone at low cost.
Percy Lavon Julian | Editorial credit: spatuletail / Shutterstock.com
By 1953 Julian Laboratories had been established, an enterprise that he went on to sell for more than $2 million in 1961. He then established the Julian Research Institute, a non-profit research organisation. In 1967 he was appointed to the DePauw University Board of Trustees, and in 1973 he was elected to the National Academy of Sciences, the second African American to receive the honour.
He was also widely recognised as a steadfast advocate of human rights. Julian continued his private research studies and served as a consultant to major pharmaceutical companies until his death on 19 April 1975. Percy Lavon Julian is commemorated at DePauw University with the Percy L Julian Science and Mathematics Center named in his honour. During 1993 the United States Postal Service commemorated Julian on a stamp in recognition of his extraordinary contribution to science and society.
The Organisation for Economic Cooperation and Development (OECD) defines the Blue Economy as ‘all economic sectors that have a direct or indirect link to the oceans, such as marine energy, coastal tourism and marine biotechnology.’ Other organisations have their own definitions, but they all stress the economic and environmental importance of seas and oceans.
Header image: Our oceans are of economic and environmental importance
To this end there are a growing number of initiatives focused on not only protecting the world’s seas but promoting economic growth. At the start of 2021 the Asian Development Bank (ADB) and the European Investment Bank (EIB) joined forces to support clean and sustainable ocean initiatives in the Asia-Pacific region, and ultimately contribute to achieving Sustainable Development Goals and the climate goals of the Paris Agreement.
Both institutions will finance activities aimed at promoting cleaner oceans ‘through the reduction of land-based plastics and other pollutants discharged into the ocean,’ as well as projects which improve the sustainability of all socioeconomic activities that take place in oceans, or that use ocean-based resources.
ADB Vice-President for Knowledge Management and Sustainable Development, Bambang Susantono, said ‘Healthy oceans are critical to life across Asia and the Pacific, providing food security and climate resilience for hundreds of millions of people. This Memorandum of Understanding between the ADB and EIB will launch a framework for cooperation on clean and sustainable oceans, helping us expand our pipeline of ocean projects in the region and widen their impacts’.
The blue economy is linked to green recovery
In the European Union the blue economy is strongly linked to the bloc’s green recovery initiatives. The EU Blue Economy Report, released during June 2020, indicated that the ‘EU blue economy is in good health.’ With five million people working in the blue economy sector during 2018, an increase of 11.6% on the previous year, ‘the blue economy as a whole presents a huge potential in terms of its contribution to a green recovery,’ the EU noted. As the report was launched, Mariya Gabriel, Commissioner for Innovation, Research, Culture, Education and Youth, responsible for the Joint Research Committee said; ‘We will make sure that research, innovation and education contribute to the transition towards a European Blue Economy.’
The impact of plastics in oceans is well known and many global initiatives are actively tackling the problem. At the end of 2020 the World Economic Forum and Vietnam announced a partnership to tackle plastic pollution and marine plastic debris. The initiative aims to help Vietnam ‘dramatically reduce its flow of plastic waste into the ocean and eliminate single-use plastics from coastal tourist destinations and protected areas.’ Meanwhile young people from across Africa were congratulated for taking leadership roles in their communities as part of the Tide Turners Plastic Challenge. Participants in the challenge have raised awareness of the impact of plastic pollution in general.
But it isn’t just the health of our oceans that governments and scientists are looking at. There is growing interest in the minerals and ore that could potentially be extracted via sea-bed mining. The European Commission says that the quantity of minerals occupying the ocean floor is potentially large, and while the sector is small, the activity has been identified as having the potential to generate sustainable growth and jobs for future generations. But adding a note of caution, the Commission says, ‘Our lack of knowledge of the deep-sea environment necessitates a careful approach.’ Work aimed at shedding light on the benefits, drawbacks and knowledge gaps associated with this type of mining is being undertaken.
With the push for cleaner energy and the use of batteries, demand for cobalt will rise, and the sea-bed looks to have a ready supply of the element. But, the World Economic Forum points out that the ethical dimensions of deep-sea cobalt have the potential to become contentious and pose legal and reputational risks for mining companies and those using cobalt sourced from the sea-bed.
Energy will continue to be harnessed from the sea.
But apart from its minerals, the ocean’s ability to supply energy will continue to be harnessed through avenues such as tidal and wind energy. During the final quarter of 2020, the UK Hydrographic Office launched an Admiralty Marine Innovation Programme. Led by the UK Hydrographic Office, the programme gives innovators and start-ups a chance to develop new solutions that solve some of the world’s most pressing challenges as related to our oceans.
The UK’s Blue Economy is estimated to be worth £3.2 trillion by the year 2030. Marine geospatial data will be important in supporting this growth by enabling the identification of new areas for tidal and wind energy generation, supporting safe navigation for larger autonomous ships, which will play a vital role in mitigating climate change, and more.
The Organisation for Economic Cooperation and Development (OECD) has published its Science Technology and Innovation Outlook 2021: Time of Crises and Opportunity report.
Published at the beginning of 2021, the report focuses on the ‘unparalleled mobilisation of the scientific and innovation community’ in response to the covid-19 pandemic. The report indicates that newly funded research initiatives have been established by public research agencies and organisations, private foundations and charities, while the health sector has similarly invested in an array of research programmes worth billions of dollars in record time.
The pandemic has led an unprecedented mobilisation of the scientific and innovation community
However, the report also exposes gaps in overall system resilience to future crises. ‘It’s a wake-up call that highlights the need to recalibrate science, technology and innovation (STI) policies, so that they better orient research and innovation efforts towards sustainability, inclusivity and resiliency goals,’ the report asserts.
Highlighting the rapid response by governments around the world, the report indicates that in the first few months of the pandemic, national research funding bodies spent around $5 billion on emergency financial support. This includes $300 million in Asia-Pacific, excluding China, over $850 million in Europe and more than $3.5 billion in North America. At the same time, research efforts led to around 75,000 scientific publications on covid-19 being released between January and November 2020, the report says. The largest share came from the US, followed by China and the UK. Research databases and scientific publishers removed paywalls so that covid-19 related information could be quickly shared.
Research efforts led to around 75,000 scientific publications on covid-19 being released between January and November 2020
‘These developments mark important changes that could accelerate the transition to a more open science in the longer run,’ the report says. It is also noted that not only have researchers continued their work with more than three quarters of scientists indicating that they had shifted to working from home at some point in 2020, but almost two thirds experienced, or expected to see, an increase in the use of digital tools for research as a consequence of the crisis. The report also mentions the contribution of the general public, with so called ‘frugal innovations’ in response to shortages of medical equipment and emergency supplies.
Looking to the future of the research community, the report says that postgraduate training regimes require reform to support a diversity of career paths. ‘The crisis has shown that the need for STI expertise is not limited to the public laboratory; it is also important for business, government and NGOs […] Reforming PhD and post-doctoral training to support a diversity of career paths is essential for improving societies’ ability to react to crises like covid-19 and to deal with long-term challenges like climate change that demand science-based responses […] There has been a 25% increase in the number of people with PhDs in OECD countries over the past decade with no corresponding increase in academic posts. The pandemic is expected to make matters worse, more than half of the scientists participating in the OECD Science Flash Survey expect the crisis to negatively affect their job security and career opportunities,’ the report says.
Post-graduate training regimes require reform to support a diversity of career paths
While still in the midst of the pandemic, the report stresses that STI policies now need to be reoriented to tackle the challenges of sustainability, inclusivity and resiliency. ‘In the short-term governments should continue their support for science and innovation activities that aim to develop solutions to the pandemic and mitigate its negative impacts, while paying attention to its uneven distributional effects. Science for policy will remain in the spotlight as governments seek to strike the right balance in their response to covid-19. This will effect public perceptions of science that could have long term implications for science-society relations.’
The report concludes that governments now have the task of developing public sector capabilities to deliver more ambitious STI policy. This will require engagement from stakeholders and citizens in order to capture a diversity of knowledge and values.
More people are looking at their nutritional intake, not only to improve wellbeing but also reduce their environmental impact. With this, comes a move to include foods that are not traditionally cultivated or consumed in Europe.
Assessing whether this growing volume of so called ‘novel foods’ are safe for human consumption is the task of the European Food Safety Authority. The EFSA points out, ‘The notion of novel food is not new. Throughout history new types of food and food ingredients have found their way to Europe from all corners of the globe. Bananas, tomatoes, tropical fruit, maize, rice, a wide range of spices – all originally came to Europe as novel foods. Among the most recent arrivals are chia seeds, algae-based foods, baobab fruit and physalis.’
Under EU regulations any food not consumed ‘significantly’ prior to May 1997 is considered to be a ‘novel food’. The category covers new foods, food from new sources, new substances used in food as well as new ways and technologies for producing food. Examples include oils rich in omega-3 fatty acids from krill as a new source of food, phytosterols as a new substance, or nanotechnology as a new way of producing food.
Providing a final assessment on safety and efficacy of a novel food is a time consuming process. At the start of 2021 the EFSA gave its first completed assessment of a proposed insect-derived food product. The panel on Nutrition, Novel Foods and Food Allergens concluded that the novel food dried yellow meal worm (Tenebrio molitor larva) is safe for human consumption.
Dried yellow meal worm (Tenebrio molitor larva) is safe for human consumption, according to the EFSA.
Commenting in a press statement, as the opinion on insect novel food was released, Ermolaos Ververis, a chemist and food scientist at EFSA who coordinated the assessment said that evaluating the safety of insects for human consumption has its challenges. ‘Insects are complex organisms which makes characterising the composition of insect-derived products a challenge. Understanding their microbiology is paramount, considering also that the entire insect is consumed,’
Ververis added, ‘Formulations from insects may be high in protein, although the true protein levels can be overestimated when the substance chitin, a major component of insects’ exoskeleton, is present. Critically, many food allergies are linked to proteins so we assess whether the consumption of insects could trigger any allergic reactions. These can be caused by an individual’s sensitivity to insect proteins, cross-reactivity with other allergens or residual allergens from insect feed, e.g. gluten.’
EFSA research could lead to increased choice for consumers | Editorial credit: Raf Quintero / Shutterstock.com
The EFSA has an extensive list of novel foods to assess. These include dried crickets (Gryllodes sigillatus), olive leaf extract, and vitamin D2 mushroom powder. With the increasing desire to find alternatives to the many foods that we consume on a regular basis, particularly meat, it is likely that the EFSA will be busy for some time to come.
A year after the world was put on alert about the rapidly spreading covid-19 virus, mass vaccination programmes are providing a welcome light at the end of the tunnel.
However, for many people vaccination remains a concern. A World Economic Forum – Ipsos survey: Global Attitudes on a Covid-19 Vaccine, indicates that while an increasing number of people in the US and UK plan to get vaccinated, the intent has dropped in South Africa, France, Japan and South Korea. The survey was conducted in December 2020, following the first vaccinations in the US and the UK.
This study shows that overall vaccination intent is below 50% in France and Russia. ‘Strong intent’ is below 15% in Japan, France and Russia.
Many cities are still in lockdown
Between 57% and 80% of those surveyed cited concerns over side effects as a reason for not getting a covid-19 vaccination. Doubts over the effectiveness of a vaccine was the second most common reason cited in many countries, while opposition to vaccines in general was mentioned by around 25% those who will refuse a vaccination.
The survey was conducted among 13,542 adults aged 18–74 in Canada, South Africa, and the US, while those surveyed in Australia, Brazil, China, France, Germany, Italy, Japan, Mexico, Russia, South Korea, Spain and the UK were aged 16–74.
A previous survey, Global Attitudes on a Covid-19 Vaccine carried out in July and August 2020, indicated that 74% of those surveyed intended to get vaccinated. At that time the World Economic Forum said that this majority could still fall short of the number required to ‘beat covid-19.’
Commenting on the newest data Arnaud Bernaert, Head of Health and Healthcare at the World Economic Forum said; ‘As vaccinations roll out, it is encouraging to see confidence improve most in countries where vaccines are already made available. It is critical that governments and the private sector come together to build confidence and ensure that manufacturing capacity meets the global demand.’
World Economic Forum-Ipsos Survey indicates a rise in number of people in US and UK intending to get vaccinated.
With the imperative now to move towards some sort of ‘normality’, as well as getting economies moving, fears over vaccination need to be allayed. However, what also needs to be considered is what underlies those fears. Misinformation, no doubt, has a part to play. This highlights a lack of trust in governments and a sector that has worked tirelessly to develop vaccines in record time.
As different companies bring their vaccines to the market, care now needs to be taken to reassure people around the world that whichever manufacturer’s vaccine they are given, they are in safe hands. As any adverse reactions occur – an inevitability with any vaccine rollout – these ought to be made known to the wider public by companies and governments as soon as it is feasible, preventing space for the spread of rumour and misinformation, which could undo the hard work of the scientists, businesses and governments bringing vaccines to the public.
Researchers have worked tirelessly to bring vaccines to the market
Waking up after a night of overindulgence on food and wine and realising you don’t have a headache is very satisfying. But realising, soon afterwards, you have heartburn can bring your mood down rapidly.
After years of discussion and argument around Brexit, the UK woke up to find that a Trade and Cooperation Agreement between the UK and the EU been reached. A major headache had been avoided.
UK Businesses have a new trading landscape
However, the UK chemicals sector soon realised that after pulling back the curtains and taking a look at the new trading landscape, a feeling of heartburn was rising. The chemical sector’s regulatory obligation now requires that it establishes a UK-REACH system. The deal negotiated means that the UK has no access to the data it submitted to the EU’s REACH database.
In effect, the UK chemical sector has to populate the UK-REACH system from scratch. This will require an array of steps possibly including testing and renegotiating data sharing with other companies. According to the Chief Executive of the Chemical Industries Association (CIA), Steve Elliot, this is set to burn a £1 billion hole in the UK chemical sector’s pocket.
‘Failure to secure access to what has been a decade’s worth of investment by UK chemical businesses in data for EU REACH will leave the industry facing a bill of more than £1 billion in unnecessarily duplicating that work for a new UK regime,’ said Elliot in a statement on 24 December 2020, the day that the UK government excitedly announced the new trade deal.
UK-REACH could cost more than £1 billion
As a slightly belated Christmas gift, and perhaps just taking the edge off the heartburn, the UK government’s Environment Minister, Rebecca Pow announced, on 31 December, that the UK-REACH IT system was up and running. Pow said that the government had worked closely with partners, industry and stakeholders developing the IT system to manage the UK’s chemicals industry.
‘Having our own independent chemicals regulatory framework will ensure that we make decisions that best reflect the UK’s needs while maintaining some of the highest chemical standards in the world,’ she said.
But will these high standards do what REACH was set up for in the first place, and protect human health and the environment? According to CHEM Trust, a UK-German charity focused on preventing man-made chemicals from causing long term damage to wildlife or humans, the deal does not go far enough.
Critiquing the outcome, Michael Warhurst, Executive Director of CHEM Trust said, ‘CHEM Trust’s initial assessment is that this agreement does not adequately protect human health and the environment in the UK from hazardous chemicals. This is because it doesn’t retain UK access to the EU’s chemicals regulation system REACH. The agreement includes an annex on chemicals, but does not facilitate the type of close cooperation with the EU post-Brexit that civil society groups such as CHEM Trust, and also the chemicals and other industries are seeking.’
But on a positive note, Warhurst added; ‘The deal […] commits the UK to not regress from current levels of protection, includes a rebalancing procedure which could increase protection on both sides and offers a platform on which a closer partnership could be negotiated in the future.’
No one doubts that there is still much to be digested, along with those left over Christmas chocolates that nobody really likes, regarding the UK-EU Free Trade Agreement. ‘Although this Free Trade Agreement represents a mixed bag for our industry,’ said the CIA’s Elliot, ‘we shouldn’t underestimate the huge value that a deal brings in terms of certainty.’
2021: A year to look forward to
As people return to their desks after the Christmas break, one might dare to hope that the heartburn can be quelled with a dose of optimism after the challenging year that has just passed. With this as a basis, along with eventually emerging from the global pandemic, Elliot believes 2021 should be ‘a year to look forward to’.
It’s quite likely that most people who end up in the vicinity of a scorpion will more than likely beat a hasty retreat, not least because they can impart a potentially life threatening dose of venom should one get stung.
But scientists are now finding that the venom from these creatures, along with snakes and spiders, could be beneficial in treating heart attacks. Scorpion venom in particular contains a peptide that has been found to have a positive impact on the cardiovascular system of rats with high blood pressure. Reporting their findings in Journal of Proteome Research, scientists from Brazil, Canada and Denmark say that they now have a better understanding of the processes involved.
Scorpion venom is a complex mixture of molecules including neurotoxins, vasodilators and antimicrobial compounds, among many others. Individual venom compounds, if isolated and administered at the proper dose, could have surprising health benefits, the researchers say.
One promising compound is the tripeptide KPP (Lys-Pro-Pro), which the researchers say is part of a larger scorpion toxin. KPP was shown to cause blood vessels to dilate and blood pressure to decline in hypertensive rats.
A blood vessel on organic tissue
To understand how KPP worked, the researchers treated cardiac muscle cells from mice, in a Petri dish, with KPP and measured the levels of proteins expressed by the cells at different times using mass spectrometry. They found that KPP regulated proteins associated with cell death, energy production, muscle contraction and protein turnover. In addition the scorpion peptide triggered the phosphorylation of a mouse protein called AKT, which activated another protein involved in production of nitric oxide, a vasodilator.
Treatment with KPP led to dephosphorylation of a protein called phospholamban, which led to reduced contraction of cardiac muscle cells. Both AKT and phospholamban are already known to protect cardiac tissue from injuries caused by lack of oxygen. The researchers said that these results indicate that KPP should be further studied as a drug lead for heart attacks and other cardiovascular problems.
Conceptual image for cardiovascular problems .
The week provides the opportunity for participants to promote overall awareness for the wide ranging aspects of wellbeing, including social, physical, emotional, financial, career and environmental.
This week, 22-26 June, 2020 is World Wellbeing Week. The observance began in Jersey, the Channel Islands in 2019 and has since been taken up across the world.
Wellbeing and healthy lifestyle concept
Since the beginning of the global lockdown, people have been encouraged to maintain some sort of physical activity or exercise. While it is known that exercise is beneficial for overall physical and mental health and wellbeing, researchers from the University of Cambridge and University of Edinburgh UK, have released a study in which they say that physical activity prevents 3.9 million early deaths each year.
Publishing their work in The Lancet Global Health the researchers said that there is often too much focus on the negative health consequences of poor levels of physical activity, when we should be celebrating what we gain from physical activity.
Exercises and warm up before run
Researchers from the Medical Research Council Epidemiology Unit at the University of Cambridge looked at previously published data for 168 countries which covered the proportion of the population meeting WHO global recommendation of at least 150 minutes of moderate-intensity throughout the week or 75 minutes of vigorous-intensity activity.
By combining these data, with estimates of the relative risk of dying early for active people compared to inactive people, the researchers were able to estimate the proportion of premature deaths that were prevented because people were physically active.
They found that globally, due to physical activity, the number of premature deaths was an average 15% lower than it would have been, equating to 3.9 million lives saved each year. Despite the considerable variation in physical activity levels between countries, the positive contribution of physical activity was remarkably consistent across the globe, with a broad trend towards a greater proportion of premature deaths averted for low and middle income countries.
Hands holding red heart representing healthy heart and wellbeing
The researchers argue that the debate on physical activity has often been framed in terms of the number of early deaths due to the lack of exercise, currently estimated at 3.2 million each year. But showing how many deaths are averted it might be possible to frame the debate in a positive way which could have benefits for policy and population messaging.
Dr Tess Strain from the Medical Research Council Epidemiology Unit at the University of Cambridge said; ‘We’re used to looking at the downsides of not getting enough activity – whether that’s sports or a gym or just a brisk walk after lunch time. But by focusing on the number of lives saved, we can tell a good news story of what is already being achieved…We hope our finding will encourage governments and local authorities to protect and maintain services in these challenging times.’