How do you forge a career in process chemistry, and how do you overcome the challenges of studying in your second language? Here’s how Piera Trinchera, Associate Principal Scientist at Pharmaron, found her way.
Tell us about your career path to date.
I am an Associate Principal Scientist in the Process Chemistry department of Pharmaron UK. I am based at the Hoddesdon site in Hertfordshire, where I develop synthetic routes for the manufacture of new drugs for clinical studies.
I’m originally from Italy. I completed my MSci at the University of Salento followed by a PhD in organic chemistry at the University of Bari, focusing on new synthetic methodologies. Despite my complete lack of English at the time, I jumped at the opportunity of a six-month visiting PhD position at the University of Toronto.
This was a challenging experience initially as it was my first time living abroad, but ultimately it was very rewarding. After completing my PhD I returned to the University of Toronto to undertake a postdoctoral position focusing on organoboron chemistry. I followed this with a second postdoc at Queen Mary University of London working on aryne chemistry.
After eight years in academia, I wanted to apply the knowledge I had acquired to solving industrial problems that directly impact people’s lives. For this reason, I joined Pharmaron UK where I have been for the last three years and am currently a project lead and people manager.
What is a typical day like in your job?
I am involved in multiple projects each year and the overall aim is to provide synthetic chemistry solutions for our global clients. Depending on the type of project work, this can include either developing brand new synthetic routes to novel drug candidates or troubleshooting and improving existing chemical processes, making them suitable for large-scale manufacture.
Ultimately, the goal across all projects is the same: to support the production of large quantities of drugs that are needed for clinical studies with a line-of-sight to commercial production.
On a typical working day, I spend the majority of my time in the lab where I conduct my own experiments and lead a team of chemists who work alongside me. I am directly involved in the planning and designing of experiments, execution in the lab, and subsequent manufacture on multi-kg scale in our pilot plant.
Over the course of a project, a large part of the job is communicating to the clients the project strategy, scientific results, and timelines through regular teleconferences, emails, and written reports.
>> Read how side projects made large waves for Dr Claire McMullin
Which aspects of your job do you enjoy the most?
There are many aspects of this job that I enjoy. I have always enjoyed solving new scientific problems, with the thrill of impatiently waiting for the results of an important experiment or the curiosity in trying to understand an unexpected result.
In addition to the science, seeing your day-to-day lab work translated to the production of kg-quantities of new pharmaceutical compounds that might, after clinical studies, further global health is very rewarding.
Projects are completed on much shorter time frames than in academia (three to six months) and there is no time to stagnate as one so often does in a PhD or Postdoc. I enjoy the large breadth in the chemistry and the different challenges that come with each and every project.
Last but not least, it takes many people from different departments (e.g. in analysis, quality assurance, or manufacturing) working closely together to manufacture a drug compound on a kg-scale.
Working so closely with people from different backgrounds has tremendously enriched me during these years in Pharmaron. It has allowed me to acquire new technical knowledge and given me a deeper understanding of not just chemistry but the overall requirements for synthesising pharmaceutical compounds.
What is the most challenging part of your job?
Preparation of a synthetic process for manufacture on a kg-scale involves considerable development in the laboratory to ensure the chemistry translates from small to large scale. Part of this development is to identify potential issues and blindspots of the chemistry and processes and mitigate them by improving the process before implementation on a large scale.
Despite all these efforts, unforeseen complications do occasionally occur on the large scale and finding solutions in real time can be the most challenging aspect of the job. By keeping a clear head, the chemist can leverage both their deep knowledge of the process and the experience of their more senior colleagues to solve these problems.
How do you use the skills you obtained during your PhD and postdocs in your job?
As I’m in a synthetic chemistry job, I have benefitted enormously from the theoretical organic chemistry knowledge and practical laboratory skills that I acquired over the course of my PhD and postdoc years.
Additionally, in academia I became familiar and confident with other skills that I use on a daily basis. These include scientific communication through either written reports or oral presentations, conforming to good laboratory safety practices, and supervising and mentoring other people.In general, the overall experience of my post-graduate academic education has provided me with the competencies necessary to scientifically manage projects and lead a team in Pharmaron.
>> Get involved in the SCI Young Chemists’ Panel.
Which other skills do you need for your work?
Teamwork is a cornerstone of the job and company’s culture. The synthesis of pharmaceutical compounds according to our quality standards would not be possible without the contribution from, and close collaboration among, multiple people across several departments including analytical chemistry, process chemistry, process safety, quality assurance, formulation and manufacturing.
Is there any advice you would give to others interested in pursuing a similar career path?
Don’t be afraid to venture outside of your comfort zone and be open to opportunities, especially those that don’t come along as often. This will help you build your confidence and you will likely find that you can do more than you anticipated. If you are interested in process chemistry, I would recommend looking into internships and/or finding a mentor who can give you an insight into the job.
As with research, perseverance is an important skill you need to master. You will experience failed reactions and difficult purifications at some point in your career as a process chemist. Be open minded, ask questions and don’t be afraid to seek out support from your colleagues.
>> Read how Ofgem’s Dr Chris Unsworth creates an inclusive working environment and transfers his PhD skills.
Do you know how the Academy Awards came to be named the Oscars? What about the story behind the Nobel prize? Behind every award name there is a story, and the Julia Levy Award is no exception.
On the face of it, the Julia Levy Award is about innovation in biomedical applications, but it is the stories of the winners of this SCI Canada award, and Julia Levy herself, that really give it life.
But for a tweak of history, Julia Levy may not have ended up in Canada at all. Born Julia Coppens in Singapore in 1934, she moved to Indonesia in her early childhood. Her father uprooted the family during the Second World War and she left for Vancouver with her mother and sister – her father only joining them after release from a Japanese prisoner-of-war camp.
Julia and her family moved to Vancouver during the Second World War.
After studying bacteriology and immunology at the University of British Columbia (UBC), the young Julia received a PhD in experimental pathology from the University of London. She went on to become a professor at UBC and helped found biopharmaceutical company Quadra Logic Technologies in 1984.
More important than confining her achievements in cold prose, Julia Levy’s work made a profound difference to people’s lives. She developed a groundbreaking photodynamic therapy (PDT) that treated age-related macular degeneration – one of the leading causes of blindness in the elderly. She also created a bladder cancer drug called Photofrin in 1993 and, according to Neil and Susan Bressler, the Visudyne PDT treatment created by Julia and her colleagues was the only proven treatment for certain lesions.
Levy thrived in the business space too, serving as Chief Executive Officer and President of QLT from 1995 to 2001. She has since won a boatload of awards for her achievements, but sometimes the best testimonies come from those who have been inspired by her achievements.
For Helen Burt, winner of the 2022 Julia Levy Award and retired Angiotech Professor of Drug Delivery at the University of British Columbia (UBC), Julia has been an inspiration. Here was this UBC professor who jointly founded this big, exciting company – creating medication that improved people’s lives and showing her what was possible.
Helen, an English native, moved to Vancouver in 1976 for her PhD and loved it so much that she stayed. As a professor at UBC, Helen would become a trailblazer in drug delivery systems – a field pioneered earlier by Julia Levy.
‘I was a new assistant professor when she was building Quadra Logic and I would go to talks that she gave,’ Helen said. ‘Essentially, the early technology for QLT was a form of very sophisticated drug delivery [...] It was getting the drug they developed into the eye and irradiating it with light of a specific wavelength.
‘It was very, very targeted. And so, you didn’t get the drug going elsewhere in the body and causing unwanted side effects. So her technology was a form of very advanced drug delivery technology.’
‘For me to win an award that honours Julia Levy and her achievements – I think that's what makes it so special to me.’ – Professor Helen Burt, a former student of Julia Levy, is the Award's most recent recipient.
>> Learn more about SCI Canada.
These talks chimed with the young Helen. If a microbiologist could develop this kind of technology, what was stopping her from developing her own?
She, too, became a pioneer in her field, developing nanoparticle-based drug delivery systems (including those to treat cancer) and a novel drug-eluting coronary stent. According to Professor Laurel Schafer, who put Helen forward for the Julia Levy Award: ‘[Helen] was a trailblazer in new approaches for drug delivery and in research leadership on our campus.’
Professor Schafer is a hugely accomplished chemist in her own right; and the University of British Columbia chemistry professor’s achievements in catalysis discovery were recognised with the LeSueur Memorial Award at the 2020 Canada Awards.
Julia Levy provided an inspiration to Laurel too, in her case as an exemplar for what Canadian chemists could achieve. ‘The achievements of Julia Levy show that it really can be done right here in Canada, and even right here in British Columbia,’ she said. ‘I grew up in a Canada where I believed that better was elsewhere and our job was to attract better here – a very colonial attitude.
Julia studied at and later became a Professor at the University of British Columbia – the campus is pictured above.
‘I now believe and know that better is right here. Professor Levy’s work showed that world-leading contributions come from UBC and from the laboratories led by women.’
She noted that the Julia Levy Award acknowledges Canadian innovation in health science, whereas Canadian chemistry has historically focused on process chemistry in areas such as mining and petrochemicals.
But Julia Levy’s influence permeates beyond science. ‘Julia is one of those people who has been willing throughout her whole career – even now, well into her eighties – to give back to the community,’ Professor Burt says. ‘She mentors, she coaches, she sits on the boards of startup companies, and she advises.’
‘She’s just got this incredible amount of knowledge… She was the Chief Executive Officer [at QLT], so she learnt all of the aspects: the complex and sophisticated regulations, knowing how to find the right people to conduct clinical trials, and how to do the scale-up. She really is a legend in terms of giving back to the community. And this is not just in British Columbia – it’s Pan-Canadian.’
Pictured above: Julia Levy
For young chemists, the Julia Levy in the Julia Levy Award may just be a name for now, but for those in the Canadian chemical industry and patients all over the world, her influence and her work resonate.
As Professor Helen Burt said: ‘For me to win an award that honours Julia Levy and her achievements – I think that's what makes it so special to me.’
>> For more information on the Canada Awards, go to: https://bit.ly/3VMwNKa
Side projects and small impacts can make large waves. Dr Claire McMullin, Computational Teaching Fellow and Director of Year 1 Studies at the University of Bath, shared insights from her career journey.
What is your job?
I’m a computational chemist, with a focus on inorganic reaction systems and explaining observed experimental trends. I work at the University of Bath, but my job role is a little trickier to answer.
Four days a week, I’m employed as a Teaching Lecturer and the Year 1 Director of Studies. On the fifth day I’m a postdoctoral research assistant (PDRA), overseeing the computational aspects of an Engineering and Physical Sciences Research grant.
Tell us about your career path.
I completed my undergraduate and PhD studies at the University of Bristol – under the supervision of Guy Orpen and Natalie Fey – using crystallography and computational chemistry to investigate organometallic complexes.
I wanted to do a post-doc in the US, so I wrote to a few American computational chemists to see if they had funding or a role available. Luckily one did, and I moved to Denton (University of North Texas) to work with Tom Cundari.
I missed the UK, and so returned a year later to Edinburgh for a three-year post-doc with Stuart Macgregor at Heriot-Watt University in collaboration with Dai Davies at the University of Leicester.
Then I joined Bath, initially as a full-time Teaching Fellow for Computational Chemistry. I was lucky there were computing facilities that had a ‘free queue’ to submit calculations, and I was approached by a new colleague, who asked me if I’d be interested in modelling their reaction systems. I had gained a new side-project and hobby for my evenings.
Eventually, more people asked for me to look at their systems, mostly as the department didn’t have anyone with my specific inorganic and organometallic mechanism skills.
Now, over six years later, I’ve almost finished a three-year grant, published 36 papers, developed connections and external collaborators, and secured more funding to run calculations on our ‘premium’ queue. The only downside is that my research is rarely recognised by the university, as it’s not officially part of the role description of my employment.
Pictured above: Dr Claire McMullin
What is a typical day like in your job?
I tend to get to my office after 8am, and deal with any overnight emails first, before checking our High Throughput Cluster for how my calculations are doing. Teaching begins from 9:15am, and my day tends to be full of meetings (online nowadays), lectures and labs.
Something will always come up that I wasn’t expecting, be it teaching or research related. I always have a page-long to-do list. Normally, I manage to achieve two to three things a day, but almost always end up adding more things to it!
>> Get involved in the SCI Young Chemists’ Panel.
Which aspects of your job do you enjoy most?
I really enjoy the collaborative nature of my work – be it lecturing or teaching a lab to students, seeing a student having that ‘a-ha’ moment, or talking to my colleagues in the department about plans or issues we are trying to resolve.
Similarly, with the research I do, I am often trying to explain someone’s experimental data. I like trying to provide answers or reasons for the chemistry that has occurred. It’s almost like trying to understand a puzzle, and seeing a calculation finished always sparks joy in me!
What is the most challenging part of your job?
The emails, and the tasks and requests they bring, can sometimes derail my entire day (or week).
How do you use the skills you obtained during your degree in your job?
I feel incredibly lucky that, on any given day, I can submit a calculation and use the computational skills I developed during my degree. But I use much more than computational knowledge – doing a degree teaches you to be organised and methodical, as well as how to juggle several tasks at once.
The demonstrations I did as a PhD student are now used daily in labs. The research talks I gave have given me the confidence to stand up in front of a room full of students and lecture them on a range of topics. And the papers and thesis I wrote have given me a keen eye for detail and editing other people’s documents.
>> Read how Ofgem’s Dr Chris Unsworth creates an inclusive working environment and transfers his PhD skills.
Is there any advice you would give to others interested in pursuing a similar career path?
There are so many points where the ‘leaky pipeline’ could have meant I left chemistry and academia. In all honesty, I’m not quite sure how or why I’m still here! [A lot of it is about] luck, being in the right place at the right time, or a job vacancy coming up when you need a new position.
Timing really is key. It’s half-worked out for me. I’m now permanent in my teaching role and still get to run my calculations, which I love; but that often comes at a cost to my own time and is done more as a hobby than something I’m paid to do. It doesn’t work out for everyone, and that is no reflection on their skills or abilities.
I’ve always had back-up plans or ideas if I decided to exit the academic highway. So, if you do want to pursue a career similar to mine, make sure you have something else to fall back on. And just keep working hard, slowly building on the work you want to do. Small impacts can end up making large waves.
In the latest of our Careers for Chemistry Postdocs series, Dr Chris Unsworth, Head of Stakeholder Engagement and Hydrogen at Ofgem, talks about rising to the net zero challenge, creating a productive, inclusive working environment, and transferable PhD skills.
Tell us about your career path to date.
Currently, I’m the Head of Stakeholder Engagement and Hydrogen at Ofgem. Prior to that, I was Private Secretary to the Co-Directors of the Energy Systems Management and Security (ESMS) Directorate at the energy regulator Ofgem. I’ve also worked as Senior Manager in the GB Wholesale Markets team and as a Research & Insight Manager within Ofgem’s Consumer and Behavioural Insights team.
Pictured above: Dr Chris Unsworth
What is a typical day like for you at Ofgem?
I’d say there isn’t a typical day in my job, especially given recent events. Our work needed to shift dramatically to make sure gas and electricity kept flowing at the start of the pandemic and during the sharp increase in wholesale prices for gas.
I wore many hats in my role as Private Secretary. I often acted in a Chief of Staff role for the directorate, getting a sense of the mood within our part of the organisation and advising on how to overcome internal issues as they arise. I also often acted as advisor to the Co-Directors of ESMS as they explored which tools can be used to deliver net zero.
Which aspects of your job do you enjoy the most?
I enjoy being able to work on the net zero challenge in a really meaningful way. I also enjoy being surrounded by colleagues who feel the purpose and weight of responsibility in making progress towards a net zero future. It keeps you accountable, but it’s also really inspiring.
What is the most challenging part of your job?
The reasons I gave above for really enjoying my job can also be described as the most challenging! Delivering a net zero future represents the largest transformation that has ever needed to happen at an industrial level.
Also, because folks are so passionate about their work, it’s really important to make spaces where staff can be transparent and open on their views of the way forward. It’s more important, however, for me to act in a diplomatic manner to make sure we get aligned on a clear and singular route to solving problems.
>> Get involved in the SCI Young Chemists’ Panel.
How do you use the skills you obtained during your degree in your job?
I don’t use the skills I practised in the lab directly in my role. However, there are lots of transferable skills that I picked up from my MChem and PhD in Chemistry. Being able to interrogate evidence and critically assess it is really important in knowing which trends are valid and, therefore, which policy options are the best to investigate further.
Being able to bring data and information from lots of disparate sources and use them to create a clear view of what’s going on is another skill that I practise often. I also do a lot of thinking around systems and flows and the various interactions that go on underneath the surface. Visualising systems and interactions is definitely a helpful skill that I first practised in my degrees.
>> How do you go from a Chemistry degree to a business development specialism? Mark Dodsworth told us his story.
Which other skills are required in the work you do?
My current role is very people oriented and so I need to practise a high level of emotional intelligence. I came out as a gay man while doing my degrees at the University of York and I had specific role models there who helped me explore who I was.
I think my experiences during my degrees really helped grow my capacity for empathy and understanding in others. I’ve been afforded the opportunity to work on a huge number of Diversity & Inclusion initiatives as a result of being open and out at work. I’m also very lucky to work in a space where I feel comfortable to do so.
Pictured above: Dr Chris Unsworth
Is there any advice you would give to others interested in pursuing a similar career path?
If you feel a sense of purpose in something you’re doing, then go in that direction. You will always enjoy your work if you understand why you are doing that work.
This may involve you taking a few left turns as you move between different things, but there’s no need to worry about that so much if there’s a clear and consistent theme and purpose that ties it all together.
How do you go from a Chemistry degree to a business development specialism? We hear Mark Dodsworth’s story.
Tell us about your career path to date.
I graduated from the University of Sheffield with a degree in Chemistry, which included a one-year placement at GSK in Stevenage. Working in heterocyclic chemistry at GSK gave me valuable experience, which ultimately helped me secure my first role in industry.
I joined Vernalis Research in Cambridge as a Synthetic Chemist. After more than five years there, I moved to Manchester to work with the CRUK Drug Discovery team as a Medicinal Chemist.
I am now coming up to three years working for Teledyne ISCO – a US company that specialises in the supply of purification equipment to the scientific community. My job role is Business Development Specialist for the Midlands and Wales.
This job involves focusing on the business growth of Teledyne ISCO products throughout the region with new and existing customers. I also provide ongoing support to our growing customer base, whether that be technical or application related.
What is a typical day like in your job?
Day-to-day, my job role varies significantly, which makes it exciting and dynamic. No day or week is ever the same. It could involve anything from responding to customer enquiries by phone or email, discussions around how our equipment can help with the needs of a group or company, or travelling to a customer to run a demonstration of the equipment.
Installation and training new users is a part of the job that I particularly enjoy. We also do exhibitions, which is a great way to show new customers our equipment, and network with existing customers. Some exhibitions also give us the chance to present to an audience.
Which aspects of your job do you enjoy the most?
A job in business development is so much more than I realised. I’ve always really enjoyed helping people, and this job allows me to do that in so many ways, whether it’s providing equipment that makes the chemist’s life easier and helps them with a problem that they’ve been struggling with, or through application support. I love the networking, getting to know people, and hearing about their work too.
What is the most challenging part of your job?
Currently the biggest challenge is being at home quite a lot. We can do a lot of support through Zoom, but I’ve missed not seeing our customers and having face-to-face interactions with them.
As part of a sales role, there is a degree of cold-calling required. This is a skill that I didn’t have as a chemist and so I did find it challenging. Ultimately, you are just looking to find those who are interested in your product. A ‘no, thank you’ isn’t anything to be afraid of – you just haven’t found the right customer for you.
How do you use the skills you obtained during your degree in your job?
There are many translational skills that you develop as a chemist and times when these skills come in handy. Presentation skills come in useful when presenting at conferences or to senior management.
Communication skills are important when you are transferring information. Not everyone interprets information the same way, so being clear with the meaning of your words is also important.
Time management and organisation are key to this role too. For example, making customer appointments and allowing time for travel. You also need to make the most of your own time, too, by being organised – for example, seeing multiple customers in one location.
As a result, my calendar is usually planned a month in advance, so organisation skills really help here in the planning of your work.
Is there any advice you would give to others interested in pursuing a similar career path?
This was not a career path I’d ever considered, as I’d always been focused on synthetic chemistry throughout university. The main motivator for me was having the opportunity to work closer with CombiFlash systems, as I’d used these systems throughout my career at GSK, Vernalis and CRUK.
My advice would be to discuss [the roles you are interested in] with as many people currently working in that field as you can. I spent time discussing this kind of role with my friends and networking within the science community before deciding to make the move.
>> Get involved in the SCI Young Chemists’ Panel.
>> Read more about how Rachel Ellis began her career in drug development.
What does an academic’s day look like during term time and in the summer? And how do you get from being a student to teaching at university level? Dr David Pugh, MChem in Chemistry at the University of York, told us about his journey and the skills needed to do his job well.
Dr David Pugh
Tell us about your career path to date.
I look after the delivery of practical chemistry teaching in our undergraduate teaching laboratories in the University of York’s Department of Chemistry. This includes both planning what we are going to teach and teaching students in the lab. I actually came to York for my undergraduate degree and have never left! I completed an MChem degree here, before carrying out a Ph.D here under the supervision of Professor Richard Taylor.
What is a typical day like in your job?
In-term and out-of-term days are like two different jobs. When students are here, the days mostly revolve around delivering teaching in the lab. There are lots of organisational aspects to ensure everything runs smoothly and that everyone (students, demonstrators, technicians etc) knows what’s going on, as well as the teaching.
Out of term time, my job is much more around planning for the future, both the logistics of who’s going to come into the lab when, and the actual teaching content. We’re regularly changing parts of the course, and looking for better approaches with the practical teaching to try to ensure we deliver practicals that are effective in the skills they teach, with the right level of complexity.
>> Interested in a career in chemistry publishing? Then see how Bryden Le Bailly, Senior Editor at Nature, went about it.
So, a day out of term time might see me trying to come up with timetables and planning what goes where, or I might be spending time in the lab trying to develop new practicals or refine existing ones.
Which aspects of your job do you enjoy the most?
Teaching students! This is the most enjoyable part of the job – interacting with the students and seeing them slowly develop their practical abilities. It’s especially nice when you see students you’ve taught from when they arrived at university to studying for a PhD and demonstrating in the labs.
What is the most challenging part of your job?
I find developing new practicals for teaching particularly challenging. When you’re a researcher, the outcome of the practical is the key reason for carrying out the lab work: whether it’s to synthesise a new compound or obtain some data to analyse.
With teaching, it’s different. We’re interested in practical processes and whether they are effective at teaching the students.
Teaching labs have many constraints, and practicals need to be designed to take these into consideration. For example, we think about: reaction times, safety of materials, reaction hazards, new skills introduced, practice at existing skills, costs of materials, equipment availability, how many people could carry out the practical, complexity of any analysis, how the labs relate to theory content, and how long it will take students etc.
Developing new practicals that suit the requirements can be really challenging – and you never know exactly how it will turn out until you run it with students for real.
Dr David Pugh (in the blue coat) with Year 3 students.
How do you use the skills you obtained during your degree in your job?
I think the use of the practical skills I learnt will be self-evident in this job, so I’ll focus on some of the other skills. Communication skills are essential, whether using oral skills to explain subjects to students (individually or in groups), giving presentations (e.g. practical briefings), or using written skills (through the lab scripts).
Troubleshooting instruments is a really valuable skill, as the loss of an instrument could really affect students’ progress on a lab day – so being able to quickly fault find and fix is really useful.
And, of course, the skill of being able to learn something you didn’t know how to do is crucial. Chemistry will keep changing, with new areas coming into existence. For example,. programming and computational chemistry are core components in our undergraduate degree programme now, but I had no previous experience in those areas.
Are there any other skills required in the work you do?
Good IT Skills and administrative skills have proved essential. So much of the successful running of the labs comes down to organisation. Being able to manipulate student lists, experiments, marks, attendance data etc is a crucial part of the role – I’d really struggle without effective database and spreadsheet skills that can quickly and efficiently generate the data I need.
Is there any advice you would give to others pursuing a similar career path?
If you do pursue this career path, make sure you network with others doing the same kind of role. Meeting and discussing teaching approaches with those who can really relate is so useful, and makes you really think about how you design and deliver your teaching.
This became even more useful at the onset of the Covid-19 pandemic, when we met regularly to work together to solve the challenges of practical teaching without labs.
>> Would you like to get involved in the SCI Young Chemists’ Panel? Find out more here.
>> Excited about a career in next generation drug development? Read how Rachel Ellis got involved
Interested in a career in chemistry publishing? Then see how Bryden Le Bailly, Senior Editor at Nature, navigated the path from academia to science communication.
Tell us about your career path to date.
I am a Senior Editor at Nature magazine, overseeing what we publish at the chemistry/biology interface. I completed a MSci in Chemistry at the University of Bristol, followed by a PhD in Organic Chemistry at the University of Manchester in which I looked at signalling with synthetic systems in membranes. I was always interested in education generally, and a great teacher of mine told me Chemistry would have enough to keep me engaged. She wasn’t wrong.
Bryden Le Bailly, Senior Editor at Nature magazine
A short post-doctoral position let me carry on research for a year, but I became more certain that a career in academia wasn’t for me. I enjoyed the idea of research more than its realities, and academia didn’t really work with other life choices I wanted to make. Editorial work suits this balance far better while staying close to the science.
Coupled with my interest in science communication, it looked like a good fit. To read and discuss exciting, cutting-edge research didn’t seem too bad a way to make a living. I looked into editorial jobs and, after discussions with a former editor in the Bristol Chemistry department, I started applying for positions at Nature journals. A locum position at Nature Nanotechnology led to me applying for the permanent position at Nature, where I’ve been for a little over five years.
What is a typical day like in your job?
The core of the job is deciding which submissions to review and publish. So, I read, a lot. The areas I cover comprise how molecules are made and how they can be used to interrogate biology or as therapeutic leads, as well as biochemistry, membrane protein biology, and a few other bits and pieces.
If that sounds like a wide range of topics, it is! It’s the same for all Nature editors. This keeps the job varied and interesting. The rest of the job stems from the papers I handle: overseeing peer review, taking decisions post-review, and what reviewer requests need addressing before we can proceed.
This all involves discussions with my fellow editors. In addition, I speak to Principal Investigators (PIs) and other lab members about work coming out of their labs that might be suitable for Nature.
After we decide we’ll publish something, I look for other ways we can promote the work. I pitch papers we are publishing for associated coverage in News & Views, features, or to go on the magazine cover.
Finally, Nature editors commission reviews and perspectives on topics we think are important and timely, and we discuss with our magazine editors news or topics that we believe should be covered journalistically.
Which aspects of your job do you enjoy the most?
Travelling for the job has to be one of its best perks. I manage to take around five to six trips a year, locally and internationally, to conferences and labs. Discussing brand new science one-on-one with the foremost experts in that field is a massive privilege.
However, I also enjoy supporting early-career researchers to publish in Nature and guiding them through our selection process and expectations. A longer-term way I have looked to support early career researchers (ECRs) is by delivering writing and publishing Masterclasses.
What is the most challenging part of your job?
Saying no to about 90% of what gets sent to my desk at Nature, despite it being (mostly) great science.
>> Excited about a career in next generation drug development? Read how Rachel Ellis became involved in Rachel's Careers for Chemistry blog.
How do you use the skills you obtained during your PhD/Postdoc in your job?
A good knowledge of organic chemistry and chemical biology is very helpful, not only for assessing manuscripts but also to advise on standards for Nature and the rest of the Nature portfolio. I am glad I chose research projects that required me to learn a range of techniques and delve into lots of different areas. Some of the more tangentially related areas to my studies are core responsibilities for me in my job now.
Which other skills are required in the work you do?
An interest in a breadth of science and willingness to learn are key. You will be exposed to areas you had previously never appreciated or knew existed in this job, and it is important to understand every submission from all its angles, and quickly.
This involves effective communication with other editors. Communication and learning skills also come into play when you’re out and about, where you might discuss 15 different subjects over a poster session at the end of a long day, or during a visit to an institute. Finally, editors need a good eye for detail.
Bryden has used his background in organic chemistry to forge a career in publishing.
Is there any advice you would give to others interested in pursuing a similar career path?
Firstly, the pace of the job and its expectations are very different from research. Looking at a manuscript from a scientific and editorial standpoint are two very different things. Consider if you have a critical eye when reviewing papers for a journal or reading the literature.
If you can explain to your colleagues or friends why a piece of research is exciting or ground-breaking, this is a good starting point. However, my principal advice would be to talk to editors.
We go to conferences and are happy to discuss the job in more detail. When I first applied for editorial roles, it was helpful to discuss the position with a former editor. When I didn’t get the jobs I applied for, one of the interviewers called me to explain and encourage me in the right direction. This experience was invaluable in getting me to where I am today.
>> Suze Kundu went from academia to presenting TV shows on the Discovery Channel. Trace her storied career path in Suze's Women in Chem blog.
In the first of our new Careers for Chemistry Postdocs series, Rachel Ellis, Senior Client Proposal Coordinator at drug development company Quotient Sciences, speaks about putting her chemistry skills to the test in a new setting and integrating scientific knowledge with people skills.
Rachel Ellis, Senior Client Proposal Coordinator at Quotient Sciences
Tell us about your career path to date
In my current role as a Senior Client Proposal Coordinator, my primary responsibility is to support the Business Development team by collating technical information from the different business units at Quotient Sciences to prepare proposals that meet the prospective clients’ needs, spanning multiple disciplines of drug development.
I work with subject matter experts in Active Pharmaceutical Ingredient (API) synthesis and scale-up, carbon-14 isotope labelling, formulation development, analytical services and drug product manufacturing to generate complex written proposals for clients looking to accelerate their drug development programmes.
I started my career in chemistry with a Master’s degree from The University of York, which encompassed a year-long industrial placement with a speciality chemicals company in the Netherlands. This was a fantastic opportunity to put my chemistry skills to the test for the first time in an industrial setting and informed my decision to explore a career in chemistry outside of academia.
Following completion of my degree, I started working life as a Research Chemist within a global contract research organisation (CRO). The position was a perfect fit for my interests at the time; it was organic synthesis-focused, within the pharmaceutical sector and involved face-to-face interaction with clients.
After 18 months in the role, I identified my strengths in communication and relationship building so took the decision to pursue a career outside of the laboratory, moving into scientific recruitment where I could apply my scientific knowledge and soft skills in equal measure. I spent four years in scientific recruitment where I developed an array of new skills including networking, negotiating, influencing, account management, people management and performance evaluation.
Following a busy four years, I decided to take some personal time to focus on priorities outside of my career and embarked on a twelve-month career break. This was a fantastic opportunity to reassess my skills, interests and objectives, which ultimately brought me into my current role in proposal development. The position perfectly integrates my scientific knowledge and people skills and offers opportunities for continuous development in a dynamic sector.
What is a typical day like in your job?
A typical day as a Proposal Coordinator involves the evaluation of proposal requests from clients, technical discussions with subject matter experts to define project requirements, the preparation of comprehensive proposals including technical writing, pricing assessments and resource planning and any additional client engagement activities to support the proposal award.
Typically, I would lead the preparation of several proposals at any one given time which may include one or more drug development services.
Rachel Ellis seeks to help deliver life-changing medicines in her current role.
Which aspects of your job do you enjoy the most?
I particularly enjoy engaging with new clients to discuss how we can support them to accelerate the delivery of life-changing medicines to the market with greater speed and efficiency. I also enjoy the diversity of tasks involved in my role (scientific discussions, technical writing, pricing activities and project planning) and the balance between working independently and collaboratively as a team.
What is the most challenging part of your job?
As my role involves supporting multiple proposals at any one given time, time management and prioritisation can be challenging to ensure both internal and external deadlines are met. Organisational skills and open communication are key to ensuring projects are delivered on time and client engagement is maintained.
>> Interested in joining SCI’s Young Chemists’ Panel? Find out more on the Young Chemists Panel's webpage.
How do you use the skills you obtained during your degree in your job?
The breadth of scientific knowledge gained from my degree has provided a robust foundation for my current role and enables my participation in technical discussions across multiple scientific disciplines. Report writing, time management and attention to detail are also key skills that I now apply on a day-to-day basis.
Which other skills are required in the work you do?
My current role requires collaboration between many individuals (both internally and externally) across a multitude of disciplines, including technical experts, project managers, business development teams and financial teams.
Strong interpersonal skills are key to ensuring all parties are engaged and aligned in decision making processes. Effective communication skills are also the foundation for a career within any client-facing environment.
Is there any advice you would give to others interested in pursuing a similar career path?
In general, I would strongly advise investing time to evaluate the variety of roles available within the science sector. Don’t be afraid to explore opportunities outside of the norm. Over the course of my career to date, my eyes have been opened to the breadth of roles available within science that are not necessarily laboratory-based, such as regulatory affairs, quality assurance, medical communications and commercial positions.
I would also advise regular self-evaluation to assess your strengths and areas of interest at any given time to assist in the building of a personalised career development plan. This will help to focus your attention on opportunities to develop the skills you need and seek out exposure to relevant activities either within your current organisation (i.e. attending client calls/visits or developing interpersonal skills through participation in cross-departmental activities) or through voluntary work and networking.
>> Interested in a career in science communication? Read Suze Kundu’s inspiring story.
Innovation and close collaboration provided the platform for discussions at CIEX 2021. SCI CEO Sharon Todd gives her perspective on the two-day event.
Sharon Todd, SCI CEO
It’s always great to meet new – and old – contacts at events. For so many months, crossing borders wasn’t possible, physically at least, due to the Covid-19 pandemic. Thankfully, the Chemical Innovation Conference (CIEX) provided a welcome change.
On 6 and 7 October, we came together in Frankfurt to discuss the challenges and opportunities in our sector. It was an honour for me to give the opening address – in the same year as SCI’s 140th anniversary.
Indeed, this year’s event included a well-paced mixture of talks and panel events that addressed post-pandemic difficulties, the challenges of climate change, the need to innovate and much more.
The chemical using industries face an array of challenges besides the practical fallout from the Covid-19 pandemic. Brexit, new regulations, supply chain issues, climate change, sustainability, and geo-political unrest pose significant problems
As an innovation hub, SCI connects industry, academia, patent lawyers, consultants, entrepreneurs and government, and other organisations. And I like to think of CIEX as an innovation hub too.
We have no choice but to innovate, but we must do so in a collaborative, sustainable way. The climate change emergency, for example, means society is looking to chemistry to help find long-term innovative solutions. That’s what made CIEX such an apt time for those in the industry to come together and navigate these challenges.
Innovating beyond barriers
The theme of this year’s event was ‘Game-Changing through Collaboration’. But I also thought of it as Crossing Borders – not just physical borders, but getting through the barriers that block innovation. These barriers hold back the translation of scientific solutions from the laboratory into business and, ultimately, into society.
Our sector is in the spotlight as never before and we can shape a better future. The debates at this year’s CIEX, and the exchange of ideas that took place, will help move us all forward. And what an exchange of ideas it proved to be.
We heard from an amazing line-up of speakers, addressing some of the industry’s most salient issues. BASF’s Christian Beil spoke about how best to leverage lean experimentation and rapid prototyping to improve customer centricity in product design, while Iris AI’s Anita Schjoll Brede described how we can reimagine the R&D work environment.
Ineos Styrolution plans to recycle polystyrene using thermal decomposition or by washing and remelting waste.
Furthermore, Johnson & Johnson’s Luis Allo spoke about the rise of consumer awareness as a driver for innovation. He provided interesting insights on accessing information on real customer trends and needs. Dupont’s Fred Godbille also described several tried and tested methods to assess the voice of the customer.
Elsewhere, Croda’s Nick Challoner assessed how we can unlock innovation through collaboration and partnerships. He also provided an overview of how Croda interacts with universities. On a more technical note, Roman Honeker of Ineos Styrolution outlined the company’s plans to recycle polystyrene using thermal decomposition or by washing and remelting waste.
The discussion on ‘how SMEs interact with corporates’ provided another of the event highlights, with contributions from Clariant, BASF, Chemstars, and SCI’s David Bott. Delegates discussed how SMEs sometimes oversell the potential of their products (without necessarily having much real-world experience) and the allegedly slow-moving, risk-averse nature of some corporates.
Throughout the event, attendees examined what we can do better, how this can be achieved, and the resources needed to make this happen. After all, we must be nimble and flexible in these times of political and social uncertainty.
We can cross borders together – physically and virtually – via close collaboration. And we can cross the borders of what’s possible innovation-wise, removing barriers and journeying into new territory for us all.
To celebrate Black History Month, we take a look back at some of the great Black scientists and innovators. From laser eye surgery to the gas mask, here are some of the seminal contributions made by these ingenious inventors.
 Lewis Howard Latimer – Image credit: Unknown author Unknown author, Public domain, via Wikimedia Commons
 Leonidas Berry - Image credit: Adundi, CC BY-SA 4.0, https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons
 Betty Harris – Image credit: https://www.blackpast.org/african-american-history/harris-betty-wright-1940/ - Fair use image
 Patricia Bath - Image credit: National Library of Medicine, Public domain, via Wikimedia Commons
 Philip Emeagwali - Image credit: SakaMese, CC BY-SA 4.0, https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons
1880 – Johnson Powell
Have you ever used eye protectors to protect yourself against the glare of intense light? For those working in extreme environments such as fires and furnaces, Johnson Powell’s eye protectors will have been a sight for sore eyes.
1881 – James Wormley
James Wormley invented a life-saving apparatus for boats. His contraption included a string of floats that extended from a ship’s side via a sliding rod with projecting arms. The famous hotelier was also said to be at President Abraham Lincoln’s bedside when he died.
Image Credit: Unknown author, Public domain, via Wikimedia Commons
1882 – Lewis Howard Latimer
Lewis Howard Latimer is probably best known for inventing a durable carbon filament that was key to the success of the electric light bulb. Latimer also invented an evaporative air conditioner and even drafted the drawings to secure the patent for Alexander Graham Bell’s little known invention… the telephone.
>> Click here for more on Lewis Howard Latimer’s extraordinary contribution to science.
1912 – Garrett Morgan
Imagine using your own invention to save people’s lives? That’s exactly what Garrett Morgan did when he donned his patented smoke hood to rescue trapped men from a smoke-filled tunnel beneath Lake Erie. Morgan’s device later evolved into a gas mask, and he also invented a three-position traffic signal, hair straightening cream, and a self-extinguishing cigarette for good measure.
1916 – Madeline M. Turner
Madeline M. Turner’s ingenious invention was the fruit of her own frustration. Turner grew tired of squeezing oranges for her glass of juice, so she created the fruit press machine to solve the problem.
1932 – Richard Spikes
It’s safe to say Richard Spikes was a polymath. The American inventor created an automatic gear shift device for cars, a pressurised beer tap, and a horizontally swinging barber’s chair – all while working as a teacher and barber and being a capable pianist and violinist.
Image Credit: Adundi, CC BY-SA 4.0, via Wikimedia Commons
1966 – Leonidas Berry
This doctor and civil rights advocate invented the Eder-Berry gastroscopy endoscope in 1955, which helped doctors to biopsy the inside of the stomach without surgery. According to the US National Library of Medicine, ‘the Eder-Berry biopsy attachment made the gastroscope the first direct-vision suction instrument used for taking tissue samples during gastroscopic examination’.
Image Credit: https://www.blackpast.org/african-american-history/harris-betty-wright-1940/ - fair use image
1984 – Betty Harris
Perhaps the most explosive discovery of all belongs to Betty Harris. Harris’ spot test for detecting 1,3,5-triamino-2,4,6-trinitrobenzene in the field is used by US Homeland Security today to check for nitroaromatic explosives. In her spare time, Harris has even found the time to work with the Girl Scouts to develop a badge based on Chemistry.
>> SCI is proud to support #BlackinChem. Take a look at some of our recent work.
Image Credit: National Library of Medicine, Public domain, via Wikimedia Commons
1988 – Patricia Bath
Patricia Bath has helped return the gift of sight to thousands of people. The US ophthalmologist invented a quick and painless device that dissolves cataracts with a laser and cleans the eye, enabling the simple insertion of a new lens. Her laserphaco probe is still in use today.
Image Credit: Philip Emeagwali - SakaMese, CC BY-SA 4.0, via Wikimedia Commons
1989 – Philip Emeagwali
Nigerian computer scientist Philip Emeagwali won the prestigious1989 Gordon Bell Prize in Price Performance for a high-performance computer application that used computational fluid dynamics in oil-reservoir modelling. In the same year, Emeagwali also claimed to perform the world’s fastest computation – 3.1 billion calculations per second – using just the power of the internet.
2002 – Donald K. Jones
Donald K Jones made a notable contribution to medicine with his invention of a detachable balloon embolisation device that reduces the size of aneurysms (bulges in blood vessels). The endovascular occlusion device is implanted into the body, whereupon its clever balloon system and adhesive materials reduce the size of aneurysms.
>> Which barriers still block the way for Black chemists? Read Claudio Lourenco’s story.
SCI’s America International group has awarded the 2021 Perkin Medal to Dr Jane Frommer. The 114th Perkin Medal was presented to Jane at the Bellevue Hotel in Philadelphia, Pennsylvania, in recognition of her outstanding contribution to chemistry.
Dr Jane Frommer
Dr Frommer is renowned for her key contributions in electronically conducting polymers and scanning probe instrumentation. Her pioneering work with scanning probes paved the way for their use in chemistry, materials science and, eventually, in nanotechnology. According to SCI America, her nanoscopic analytic methods are vital to nanostructural research and are used across many industries.
Dr Frommer began her career in 1980 at Allied Corporate Laboratories (now Honeywell), where she created the solution state of electronically conducting organic polymers. In 1986, she joined IBM where, along with other instrumentalists, she demonstrated the ability to image and manipulate single molecules using scanning tunnelling microscopy. During her multi-year assignment at the University of Basel Physics Institute in the early 1990s, Dr Frommer’s team expanded the capability of scanning probes in measuring the functional properties of organic thin films with atomic force microscopy.
Since 2018, she has worked as a science advisor for Google. In this capacity, she has sought to increase the amount of open source data available in the physical and life sciences. She also helps Silicon Valley start-ups navigate the chemical and material challenges of nanotechnology and has mentored countless students and young scientists in high school, college, and in her laboratory in recent decades.
Previous recipients of the Perkin medal include Barbara Haviland Minor, of the Chemours Company, and Ann E Weber, of Kallyope Inc.
Dr Frommer has written more than 100 referred publications and is the co-inventor of more than 50 issued patents. With her extraordinary body of work spanning more than 40 years, she is a worthy recipient of the prestigious Perkin Medal.
The Perkin Medal is widely acknowledged as the highest honour in American industrial chemistry. It was established to commemorate the 50th anniversary of William Henry Perkin’s discovery of mauveine at the age of just 18. Perkin’s creation of mauveine, the world’s first synthetic aniline dye, revolutionised chemistry and opened up new frontiers in textiles, clothing, and other industries. Perkin was a founding member of SCI and this Medal was first presented to him in New York in 1906.
For more information on the Perkin Medal and the nomination process, visit: soci.org/awards/medals/perkin-medal
SCI was pleased to support #BlackInChem, working alongside our Corporate Partners and members to amplify the voices of our Black chemists.
We have heard stories from several Black chemists who highlighted the steps being taken by many companies to increase diversity. But we can also see that there are many more steps that can be taken to encourage the next generation of budding Black chemists and scientists.
#BlackInChem has had support from Scott Bader, an SCI Corporate Partner, with both Damilola Adebayo and Luyanda Mbongwa sharing their perspectives as employees of Scott Bader. Elsewhere, Cláudio Laurenço gave a compelling account of his journey to become a post-doctoral research associate at a leading consumer goods company.
Cláudio Laurenço worked for free and was overlooked before eventually securing his PhD and starting his career in chemistry.
These chemists are following in the footsteps of some pioneering Black scientists such as Percy Lavone Julian, who has been profiled on the SCI Blog.
Many organisations have expressed their support and shared thoughts on what steps they are taking to encourage and ensure diversity. Indeed, #BlackInChem is a global effort and companies such as GSK have shown their support as well as numerous Black chemists talking about their experiences and achievements over the last week.
Percy Lavon Julian’s pioneering work enabled a step-change in the treatment of glaucoma | Editorial credit: spatuletail / Shutterstock.com
Over the coming months, we will be profiling other Black chemists, past and present, and continuing the dialogue around diversity.
For Cláudio Lourenço, the path from student to multidisciplinary scientist has been far from smooth. The Postdoctoral Research Associate reflects on the institutional challenges that almost made him give up, the mentor whose support was so important, and the barriers that block the way for young Black chemists.
Please give a brief outline of your role.
I work for a leading consumer goods company. I am a multi-disciplinary scientist contributing to the development of novel formulations for household products.
Why are you supporting #BlackInChem?
I’m supporting #BlackInChem because I am a champion for diversity. I believe that what we see from our windows in the street is what we must have inside our workplaces. In an ideal world we should all have the same opportunities, but unfortunately this is somehow far from the truth. We need to motivate our young Black chemists to aim for a career in science by providing welcoming environments and real opportunities instead of just ticking boxes. We need to showcase our Black chemists to show to the younger generation that they can also be one of us.
What was it that led you to study chemistry and ultimately develop a career in this field? Was this your first choice?
I have always been passionate about research and science. My father had a pharmacy, so I was always close to chemistry and was a very curious child. Yes, it was my first choice but the lack of opportunities and trust from universities and scholarship providers made it a long run. My motivation faded and I nearly gave up.
Was there any one person or group of people who had a specific impact on your decision to pursue your career path?
Yes, but after my degree I nearly gave up. It took me nearly two years and changing cities to find something (a voluntary position). I was always keen on taking up mentors to show me how to progress in my career. There were a few people who helped me by training me and teaching me how to navigate the scientific world and pursue a career in science.
I only got my first job (which I worked for free) because of Peter Stambrook, an American scholar from the University of Cincinnati, who I met through a friend while polishing glasses in a restaurant. This man was open and keen to put a word in for me at a leading university in the UK. He taught me so much on how to be a scientist and humbly grow up and make a career in science. Eventually, all his advice kept me on the right path.
What impact would you like to see #BlackInChem have over the coming year?
More Black students in postgraduate courses and an increase in role models to motivate the younger generations to pursue careers in chemistry.
Could you outline the route that you took to get to where you are now, and how you were supported?
Personally, my career path was far from easy. I only managed to get my PhD at 38 years of age. I needed to first prove myself. Despite all my efforts and dozens of applications, I was never considered a good candidate. I needed to work for free for two years to land a proper job in my field of choice. During that time I took on many odd jobs to support myself. I worked for a top 10 university for free and they never saw my worth or gave me an opportunity. With that experience I landed a proper job at a leading pharmaceutical company. After one year with them, they funded my PhD studies and now here I am with a career in science.
Considering your own career route, what message do you have for people who would like to follow in your footsteps?
Never ever give up - it is possible. Look for the right mentors and be humble. You do not need to reinvent the wheel, but only to find someone who can lend you theirs. Learn to grow from the experiences of others and be ready to fail a couple of times - we all do. Be open to learn and never be afraid of following your dreams.
What do you think are the specific barriers that might be preventing young black people from pursuing chemistry/science?
I think one of the biggest barriers that prevent people from pursuing careers in science is the lack of role models. If we only show advertisements for chemistry degrees with White people, it’s not encouraging for Black students to pursue a career there. The same goes for when we visit universities; role models are needed. No one wants to be the only Black person in the department. Universities need to embrace diversity at all levels. I understand that tradition sometimes prevents this, but we need to change and ignore tradition for a bit.
What steps do you think can be taken by academia and businesses to increase the number of Black people studying and pursuing chemistry/science as a career?
Showcase Black chemists and inventors to motivate the younger generations and show society that Black people are not only artists and musicians. Target extracurricular activities in schools where children are from disadvantaged backgrounds. Train your staff to be open. Create cultural events that not only target Black people but also for other people to learn and see that in the end we are all equal. We all need to learn to embrace our differences and grow together.
>> As we celebrate #BlackinChem, we mark the achievements of some inspirational chemists. Read more about the amazing career of Percy Lavon Julian.
This week SCI is joining with business and academia to mark #BlackInChem, an initiative to advance and promote a new generation of Black chemists.
Over the coming weeks, we shall be profiling past and present Black chemists, many of whom are unsung heroes, and whose work established the foundations on which some of our modern science is built. We start with the outstanding contribution made by Percy Lavon Julian (1899-1975).
Born on 11 April 1899 in Montgomery, Alabama, US, Percy L Julian was the son of a clerk at the United State Post Office and a teacher. He did well at school, and even though there were no public high schools for African Americans in Montgomery, he was accepted at DePauw University, Indiana, in 1916.
Due to segregation Julian had to live off campus, even struggling initially to find somewhere that would serve him food. As well as completing his studies, he worked to pay his college expenses. Excelling in his studies, he graduated with a BA in 1920.
Julian wanted to study chemistry, but with little encouragement to continue his education, based on the fact there were few job opportunities, he found a position as a chemistry instructor at Fisk University, Nashville, Tennessee.
In 1922 Julian won an Austin Fellowship to Harvard University and received his MA in 1923. With no job offers forthcoming, he served on the staff of predominantly Black colleges, first at West Virginia State College and in 1928 as head of the department of chemistry at Howard University.
In 1929 Julian received a Rockefeller Foundation grant and the chance to earn his doctorate in chemistry. He studied natural products chemistry with Ernst Späth, an Austrian chemist, at the University of Vienna and received his PhD in 1931. He returned to Howard University, but it is said that internal politics forced him to leave.
Physostigmine was synthesised by Julian
Julian returned to DePauw University as a research fellow during 1933. Collaborating with fellow chemist and friend Josef Pikl, he completed research, in 1935, that resulted in the synthesis of physostigmine. His work was published in the Journal of the American Chemical Society.
Physostigmine, an alkaloid, was only available from its natural source, the Calabar bean, the seed of a leguminous plant native to tropical Africa. Julian’s research and synthesis process made the chemical readily available for the treatment of glaucoma. It is said that this development was the most significant chemical research publication to come from DePauw.
Once the grant funding had expired, and despite efforts of those who championed his work, the Board of Trustees at DePauw would not allow Julian to be promoted to teaching staff. He left to pursue a distinguished career in industry. It is said that he was denied one particular position as a town law forbid ‘housing of a Negro overnight.’ Other companies are also said to have rejected him because of his race.
However, in 1936 he was offered a position as director of research for soya products at Glidden in Chicago. Over the next 18 years, the results of his soybean protein research produced numerous patents and successful products for Glidden. These included a paper coating and a fire-retardant foam used widely in World War II to extinguish gasoline fires. Julian’s biomedical research made it possible to produce large quantities of synthetic progesterone and hydrocortisone at low cost.
Percy Lavon Julian | Editorial credit: spatuletail / Shutterstock.com
By 1953 Julian Laboratories had been established, an enterprise that he went on to sell for more than $2 million in 1961. He then established the Julian Research Institute, a non-profit research organisation. In 1967 he was appointed to the DePauw University Board of Trustees, and in 1973 he was elected to the National Academy of Sciences, the second African American to receive the honour.
He was also widely recognised as a steadfast advocate of human rights. Julian continued his private research studies and served as a consultant to major pharmaceutical companies until his death on 19 April 1975. Percy Lavon Julian is commemorated at DePauw University with the Percy L Julian Science and Mathematics Center named in his honour. During 1993 the United States Postal Service commemorated Julian on a stamp in recognition of his extraordinary contribution to science and society.
From genome mining and green synthesis, to tackling tuberculosis and computational methods to help cure malaria, the chemists of tomorrow have been busy showcasing their talents as part of the Society of Chemical Industry Young Chemists Panel’s National Undergraduate Online Poster Competition 2021.
A snapshot of these students’ talents is bottled below in their own words. So, which one of these 15 entries do you think contains the most potential?
Emmanuelle Acs et al., University of Glasgow
Natural products have always had a privileged place in drug development programmes, but their discovery is long and tedious. Genome mining arises as a solution allowing the finding of compounds never seen before. Using an array of bioinformatic softwares, the myxobacterial genome was explored for new Ribosomally and Post-Translationally modified Peptides (RIPPs). Myxobacteria are soil-dwelling bacteria known for the number of secondary metabolites they produce, and they have proven to hide many more within their genome. Indeed, our analyses have led to the potential discovery of nine new myxobacterial natural products. The nature and class of these products is to be confirmed by biosynthesis in the laboratory.
Olivia Baldwin et al., University of Birmingham
Lanthanides were thought to be biologically irrelevant until the discovery of bacteria containing the lanthanide-dependent methanol dehydrogenase (Ln-MDH) enzyme. There has been interest in exploiting the attractive properties of the lanthanides by the de novo design of artificial proteins, aiming to explore protein structures and functions not observed in biology. Here, a lanthanide-binding peptide, CS1-0, has been designed de novo and shown to bind to europium and pyrroloquinoline-quinone (PQQ), a key component of the Ln-MDH active site. This partial recreation of a biologically relevant lanthanide binding site is a step towards the ultimate goal of de novo design, to create functional artificial metalloproteins with simplified structures.
Janko Hergenhahn et al., University of Oxford
Template-directed synthesis provides a route to achieve porphyrin nanorings by favouring ring-closure reaction over oligomerisation. A structurally new template with 12 binding sites has been proposed for the synthesis of novel porphyrin rings; however, initial unsuccessful reactions have raised questions about the binding efficiency of this template to the linear substrate. We have employed classical and quantum modelling together with experimental techniques to explore template-substrate binding in solution and shed light on this process. Titration experiments and modelling have enabled us to study the occupancy of different binding sites and quantify the influence of strain on binding, further guiding novel designs.
Kieran Benn et al., University of Edinburgh
Hydrocyanation offers an orthogonal route to synthetically ubiquitous amines. Current hydrocyanation methodologies are dominated by the use of acutely toxic hydrogen cyanide gas and transition metal catalysts. Here the application of main-group catalysis and transborylation is reported for the formal hydrocyanation of functionalised alkenes. The catalytic protocol was optimised and applied to a broad range of substrates (20 examples), including examples where chemoselectivity was demonstrated in the presence of reducible functionalities and Lewis basic groups. Mechanistic studies support a proposed catalytic cycle in which B–N/B–H transborylation was a key to catalyst turnover.
Students at the University of Glasgow have used computational analysis to help tackle malaria.
Xiyue Leng et al., University of Birmingham
Antimicrobial peptides are increasingly employed as new-generation antibiotics, with their amphiphilic nature (contain both hydrophobic and cationic components) mimicked by polymers to enable a more cost-effective approach. However, there is a lack of a quantitative pre-experiment indicator to provide a prospect on their potency. The overall hydrophobicity represented by LogP/SA was proposed to rapidly identify candidates in future designing to reduce synthetic efforts. We show a comparison study between two computational tools used to calculate LogP/SA: ChemBio3D and Materials Studio, in terms of the predictive power and sensitivity, followed by the synthesis of copolymers with a different cationic side chain based on the calculation results.
Mirjam-Kim Rääbis et al., University of Glasgow
Traditional small molecule therapeutics in medicinal chemistry often require high doses to inhibit the target protein, leading to issues with safety and drug resistance. Proteolysis targeting chimeras (PROTACs) are a new class of molecule that combat these issues, as they can use the body’s own protein degradation systems to degrade targets even at low drug doses. Virus-targeting chimeras (VIRTACs) can use a similar mechanism to target viral proteins. This project uses molecular docking studies to explore potential VIRTAC warheads that target the papain-like protease of SARS-CoV-2, in an attempt to find a potential treatment to COVID-19 that would, among other benefits, offer a lower risk of antiviral resistance.
Miriam Turner et al., Newcastle University
Tuberculosis remains one of the top 10 causes of death worldwide, therefore there exists an unmet clinical need for new and improved therapeutics that tackle increasing bacterial resistance and affordability issues. Previous studies indicate N-substituted amino acid hydrazides exhibit good activity against several strains of Mtb. Ongoing structure-activity relationship studies utilising isoniazid, a variety of amino acids, and the active imidazo[1,2-a]pyridine-3-carboxy moiety of clinical candidate Q203 have also demonstrated excellent activities. Herein we report the results of our continued evaluation of this architecture, using a scaffold hopping approach to explore the potential of this pharmacophore as a new anti-tubercular drug.
Skye Brettell et al., University of Glasgow
Malaria continues to pose a significant challenge to humanity. Resistance to several frontline antimalarials represents a considerable threat, marking the need for new drugs with novel mechanisms of action. Kinase inhibitors represent a potential new class of antimalarials. TCMDC-135051 is a hit compound with activity against malarial kinase PfCLK3 as well as potency in liver, blood and sexual stage parasites. During this project, sequential analysis of the PfCLK3 catalytic domain identified key structural differences between the target and its human orthologs. Molecular docking studies of TCMDC-135051 analogues using GOLD then yielded potential lead compounds with predicted high affinity for the target kinase.
Matteo Albino et al., University of York
The strain-induced contortion of non-planar, chiroptically-active helicenes caused by fjord steric repulsive interactions is well known. Fjord-mediated planarisation, on the other hand, is far less common and has typically only been achieved via inherently strong covalent bond formation. Herein, I present the properties and density functional theory (DFT) analysis of electroactive azahelicenes exhibiting unexpected through-space π-electronic stabilisation in the reduced states as a result of non-covalent fjord bonding effects. Computational modelling of optical spectra and aromatic-induced current densities reveal that lone pair-repulsive nitrogens in the fjord promote favourable ring currents and reversible helicene planarisation.
Sam Andrew Young et al., Northumbria University
The synthesis of metal chelating molecules, specifically hydroxypyridones (HOPOs), have been identified as potential therapeutic agents for treating Parkinson’s Disease (PD) as bidentate ligands at the two oxygen donor atoms. These ligands are selective for ferric iron in the body, which is expected to stop the reduction of this iron accumulated in the brains of PD sufferers, hindering the Haber-Weiss mechanism from taking place in the mitochondria of the cell and preventing the associated degeneration of the cells. The lipophilicity of these HOPOs is vital to the process, allowing the molecule to transverse the blood-brain barrier, the addition of a triphenylphosphonium group on the HOPO is thought to increase therapeutic effect.
At Heriot Watt University, students have investigated the skin irritation potential of nanoclays using an IATA
Adelaide Lunga et al., Loughborough University
The aim of this project is to develop a short synthesis of N-acetylcolchinol using a greener and step-economical pathway. First, aldol condensation of 3-hydroxyacetophenone and 3,4,5-trimethoxybenzaldehye using ethanolic NaOH produced the respective chalcone. The product was reduced electrochemically in DMSO:MeOH (4:1) employing carbon electrodes and NEt4Cl to the saturated benzylic alcohol, which was converted to an acetamide via Ritter reaction using H2SO4 in MeCN. In the final step, the conditions were optimised to enable electrochemical oxidative coupling of the aromatic groups to give the desired N-acetylcolchinol. This novel four-steps reaction sequence avoids use of transition metal catalysts or toxic reagents.
Yi Xiao et al., University of Oxford
Human endosulfatases (SULFs) are enzymes on the cell surface and in the extracellular matrix that hydrolyse 6-O-sulfate on glucosamine units within heparan sulfate proteoglycans. SULFs are involved in growth and development, muscle regeneration and tumour growth via various signaling pathways, with untapped therapeutic and diagnostic potentials. However, profiling SULFs remains a challenge. Antibodies detect their presence, but do not indicate their activity state. The current activity assay is a global sulfatase assay and is not selective in a biological sample. We propose a novel small-molecule probe to profile SULF activity by exploiting the formation of 1,6-anhydrosugar, which can be potentially used in isolated proteins and in vitro.
Alexander Pine et al., University of Greenwich
Solubility parameters are important for pharmaceutical formulations, paint formulations and new material development. There is a need to improve the accuracy of solubility calculations, and to be able to make rapid predictions of the solubility of new molecular structures. In this project, a range of Python plugins, and open-source codes have been used to develop a Lasso linear regression machine learning model to predict the Hansen solubility parameters (HSP) - δd, δp and δh, which represents dispersion forces, dipole-permanent dipole forces and hydrogen bonding respectively with the intention of making faster and more accurate prediction in solubility.
Alexander David Robertson et al., The University of Glasgow
This research considers computational modelling of a SPAAC reaction involving cyclononyne. DFT calculations were performed on the strain promoted reaction between cyclononyne and mesyl azide. Three low energy conformers of cyclononyne with Cs, C2 and C1 symmetry were found with similar energy. The transition structures for the corresponding cycloaddition with mesyl azide were found and the C2 conformer was the lowest in energy. Product structures were found leading to the identification of the thermodynamic product of the reaction. Distortion/interaction analysis showed that the cycloalkyne was already significantly pre-constrained to its reacting geometry.
Holly King et al., Heriot Watt university
Clays are natural nanomaterials consisting of mineral silicate layers. They have several functional uses in everyday life. An example of nanoclays that carry out a wide range of roles is smectites which include montmorillonite (MMT), bentonite and hectorite. These nanoclays can be used in cosmetics, altering their appearance and in pharmaceuticals as drug carriers and wound dressings. Integrated approach to testing and assessment (IATA) aim to collect all relevant data into one easy to understand format that can be used to group materials. Using an IATA dedicated to skin irritation/corrosion it was found that MMT was safe for use. However, hectorite was found to be toxic at high doses indicating that it is a possible irritant to the skin.
If you’d like to see these students’ full posters, go to: https://istry.co.uk/postercompetition/5/?date_example=2021-06-28
Every tin can dropped into our recycling bins is a small act of faith. We hope each one is recycled, yet the figures take some of that fervour from our faith. According to UK government statistics from 2015-2018, only about 45% of our household waste is recycled. Similarly, the UN has noted that only 20% of the 50 million tonnes of electronics waste produced globally each year is formally recycled. So, it’s fair to say we could do better.
Thankfully, thousands of people around the globe are working on these problems and two recent developments give us grounds for optimism. The first involves upcycling metal waste into multi-purpose aerogels, and the second involves fully recyclable printed electronics that include a wood-derived ink.
Researchers at the National University of Singapore (NUS) claim to have turned one person’s trash into treasure with a low-energy way to convert aluminium and magnesium waste into high value aerogels for the construction industry.
To do this, they ground the metal waste into a powder and mixed it with chemical cross-linkers. They heated this mixture in an oven before freeze-drying it and turning it into an aerogel. The team says this simple process makes their aerogels 50% cheaper than commercially available silica aerogels.
Aerogels have many useful properties. They are absorbent, extremely light (hence the frozen smoke nickname), and have impressive thermal and sound insulation capabilities. This makes them useful as thermal insulation materials in buildings, in piping systems, or for cleaning up oil spills. However, the NUS team has loftier goals than that.
There is a great need for less energy intensive ways to recycle metals
“Our aluminium aerogel is 30 times lighter and insulates heat 21 times better than conventional concrete,” research team leader Associate Professor Duong Hai-Minh whose research has been published in the Journal of Material Cycles and Waste Management. “When optical fibres are added during the mixing stage, we can create translucent aluminium aerogels which, as building materials, can improve natural lighting, reduce energy consumption for lighting and illuminate dark or windowless areas. Translucent concrete can also be used to construct sidewalks and speed bumps that light up at night to improve safety for pedestrians and road traffic.”
The aerogels could even be used for cell cultivation. Professor Duong explains: “Microcarriers are micro-size beads for cells to anchor and grow. Our first trials were performed on stem cells, using a cell line commonly used for testing of drugs as well as cosmetics, and the results are very encouraging.”
Whatever about these speculative applications, this upcycling method will hopefully help us find new homes for all types of metal waste including metal chips and discarded electronics.
A team at Duke University has also made interesting progress in reducing electronic waste. The researchers claim to have developed fully recyclable printed electronics that could be used and reused in a wide range of sensors.
The researchers’ transistor is made from three carbon-based inks that can be printed onto paper, and their use of a wood-derived insulating dielectric ink called nanocellulose helps make them recyclable. Carbon nanotubes and graphene inks are also used for the semiconductors and conductors, respectively.
A 3D rendering of the first fully recyclable, printed transistor. CREDIT: Duke University
“Nanocellulose is biodegradable and has been used in applications like packaging for years,” said Aaron Franklin, the Addy Professor of Electrical and Computer Engineering at Duke, whose research has been published in Nature Electronics. “And while people have long known about its potential applications as an insulator in electronics, nobody has figured out how to use it in a printable ink before. That’s one of the keys to making these fully recyclable devices functional.”
The team has developed a way to suspend these nanocellulose crystals (extracted from wood fibres) with a sprinkling of table salt to create an ink that performs well in its printed transistors. At the end of their working life, these devices can be submerged in baths with gently vibrating sound waves to recover the carbon nanotubes and graphene components. These materials can be reused and the nanocellulose can be recycled just like ordinary paper.
The team conceded that these devices won’t ruffle the trillion dollar silicon-based computer component market, but they do think these devices could be useful in simple environmental sensors to monitor building energy use or in biosensing patches to track medical conditions.
Read about the Duke University research here: https://www.nature.com/articles/s41928-021-00574-0
Take a look at the NUS study here: https://link.springer.com/article/10.1007/s10163-020-01169-1
Chemists have created a new type of artificial cell that can communicate with other parts of the body. A study, published in Science Advances this month, describes a new type of artificial cell that can communicate with living cells.
“This work begins to bridge the divide between more theoretical ‘what is cellular life’ type of work and applicative, useful technologies,” said Sheref Mansy, Chemistry Professor at the University of Alberta and co-author of the study.
The artificial cells are made using an oil-water emulsion, and they can detect changes within their environments and respond by releasing protein signals to influence surrounding cells. This work is the first that can chemically communicate with and influence natural living cells. They started with bacteria, later moving to multicellular organisms.
“In the future, artificial cells like this one could be engineered to synthesizes and deliver specific therapeutic molecules tailored to distinct physiological conditions or illnesses–all while inside the body,” explained Sheref Mansy, professor in the University of Alberta’s Department of Chemistry,
Though the initial study was undertaken using a specific signalling system, the cells have applications in therapeutic use, going beyond traditional smart-drug delivery systems and allowing for an adaptable therapeutic.
Today we chat to SCI member Luca Steel about her life as a plant pathology PhD student in 2020.
Zymoseptoria tritici is a fungal pathogen of wheat which can cause yield losses of up to 50%. We’re investigating an effector protein secreted by Z. tritici which acts as a ‘mask’, hiding the pathogen from host immune receptors and avoiding immune response.
What does a day in the life of a plant pathology PhD Student look like?
My days are very varied – from sowing wheat seeds to swabbing pathogenic spores onto their leaves, imaging symptoms, discussing results with my supervisor and lab team, and of course lots of reading. It doesn’t always go to plan - I recently attempted to make some wheat leaf broth, which involved lots of messy blending and ended up turning into a swampy mess in the autoclave!
Wheat in the incubator!
How did your education prepare you for this experience?
The most valuable preparation was my placement year at GSK and my final year project at university. Being in the lab and having my own project to work on made me confident that I wanted to do a PhD – even if it was a totally different research area (I studied epigenetics/immunoinflammation at GSK!).
What are some of the highlights so far?
My highlight was probably attending the European Conference on Fungal Genetics in Rome earlier this year. It was great to hear about so much exciting work going on – and it was an added bonus that we got to explore Rome. I’ve also loved getting to know my colleagues and being able to do science every day.
What is one of the biggest challenges faced in a PhD?
My biggest challenge so far has probably been working from home during lockdown. Although I am very privileged to have a distraction-free space and good internet connection, it was difficult to adjust to working from my kitchen! It was sad abandoning unfinished experiments, and I missed being in the lab – so I’m glad to be back now.
What advice would you give to someone considering a PhD?
If you’re sure you want to do one, then absolutely go for it and don’t be afraid to sell yourself! If not, I’d recommend spending some time working in a lab before you apply and chatting to any prospective labs. If you don’t get a reply from the PI, existing students/post-docs in the group are often very happy to talk and give honest opinions.
How have things been different for you because of the global pandemic?
I was lucky that the pandemic came early on in my PhD, so I had a lot of flexibility to change what I was working on. I switched from lab work involving lots of bioimaging, towards a more bioinformatic approach. My poor laptop will be glad when I’m back to using my computer at work!
All organisms are fitted for the habitat in which they live. Some are sufficiently flexible in their requirements that they can withstand small shifts in their environment. Others are so well fitted that they cannot withstand habitat change and will eventually fail. The extent of seasonal changes varies with latitude. Plants in temperate and sub-arctic are fitted for changing weather patterns from hot and dry to cold and wet as the calendar moves from summer into winter. Deciduous plants start growing in spring with varying degrees of rapidity and move through flowering and fruiting in summer and early autumn. Finally, some produce a magnificent display of autumn colour, but all senesce and shut down with the return of winter. Evergreen plants frequently inhabit the higher latitudes and retain their foliage. This is an energy conservation measure as they can respond more quickly when winter ends and growth restarts.
Plants respond to seasonal change by sensing alterations in daylength, spectral composition and most importantly temperature. It is known as acclimatisation (acclimation in the American literature). Falling temperatures are the most potent triggers in preparation for winter dormancy. Cold and ultimately freezing weather will seriously damage plant growth where acclimatisation has not been completed. Without preparation freezing ruptures cell membranes in leaves and stems disrupting their normal functions. These effects are measurable and used as means of quantifying plant hardiness. Membrane leakiness correlates with increased ionic concentrations when damaged leaves are placed in water and the resultant pC measured. Changes in chlorophyll fluorescent indicated damaged photosynthetic apparatus and measurable. Similarly, in some species bonding in lipid molecules alters and can be traced by mass spectroscopy. Understanding these processes and their ultimate goal which is protective dormancy underpins more accurate understanding of the natural world. It also provides information useful for breeding cold tolerant crops and garden plants.
Cold Damaged Plant
The rapidity of climate change is such that the protective mechanisms of plants and other organisms cannot respond with sufficient speed. Autumn in cool temperate regions, for example, is now extending as an increasingly warm period. This means that plants are not receiving the triggers necessary for acclimatisation in preparation for severe cold. Buds are commencing growth earlier in spring and now frequently are badly damaged by short bursts of deep cold. These buds cannot be replaced and as a consequence deciduous trees and shrubs in particular are losing capacities for survival.
On the week of 10th-16th August, 2020, scientists across Twitter came together to celebrate the Black scientists working in Chemistry. The community event included a range of chemistry themes, from Organic to Physical Chemistry, showcasing a diverse range of research, and even garnered support from celebrities such as MC Hammer and Michael B. Jordan.
#BlackinChem was started by a group of early career researchers, following on from other successful weeks, who wanted to highlight the incredible range of science that Black chemists do.
The main tweets of he week were by Black chemists highlighting their research interests.
Hi everyone! #BlackinChemRollCall I’m Sonja, an Electrochemist, and a Chem lecturer at Princeton U. I worked on bimetallic/alloy electrocatalysts for fuel cells and CO2 reduction and now interested in academic support interventions. Looking forward to to #BlackInChem week! pic.twitter.com/GpTNpFnIaK
#BlackinChem Kelly here 🇿🇼. I’m a grad student @KStateChemistry in the Aakeroy lab. My work focuses on crystal engineering and inorganic chemistry to modify properties of agrochemicals, fragrances and energetics :from fundamentals to applications.Cobalt girl…#BlackinInorganic pic.twitter.com/8OQM40zVgm
The week also included online events, panels and socials throughout the week.
Issues surrounding diversity in science, particularly representation of Black scientists, was discussed.
1,656 U.S. citizens and permanent residents received a Master’s degree in chemistry in 2016.
Only 89 were Black. That’s less than 5.4%. #BlackinChem #BlackinChemRepresentation #BlackinChemGradStudent (Source: NSF NCSES) pic.twitter.com/7vd4GZBRJZ
There were even a few celebrity shout outs! Yes, this is MC Hammer tweeting about MOFs!
Mesoporous stilbene-based lanthanide metal organic frameworks: synthesis, photoluminescence and radioluminescence characteristics - Dalton Transactions (RSC Publishing) #BlackinOrganic #BlackinChemRollCall https://t.co/qhlMLv9Dod
Overall, it was an incredibly successful week. A massive congratulations to everyone involved, and especially to the organisers.
Find out more about #BlackInChem here.
Since the start of 2020 the world has been a different place. During March the UK Government instigated a lock down, with those who could required to work from home, this included scientists. Completing my PhD studying insect olfaction during a global pandemic was not something I expected, but how did I spend my days?
As a scientist I spend a portion, if not the majority of my time in a lab doing experiments. Pausing this work created several challenges, and as a final year student induced a serious amount of panic! To adapt, I focused more on computational experiments and extensive data analysis. Thankfully, I had some small computational projects already, which could be extended and explored further. This also included attending online courses and webinars to develop new skills – I really enjoyed SCI’s webinar series on computational chemistry and found it useful when completing my protein docking experiments!
Writing, Writing, Writing
As a final year PhD student, there was one task at the beginning of this year that was high on the agenda – writing my thesis. Many past PhD students will tell horror stories about how they were rushing to finish lab work and writing up in a mad dash at the end. Being forced to give up lab work, and having no social activities, meant a lot more focus was put on writing during this time. Personally, I have been privileged to be in a house with other final year PhD students, creating a distraction free zone, and managed to crack down on thesis writing!
Despite in-person events, including many large international conferences, being cancelled, many organisers were quick to move meetings online. This made so many events more accessible. Though I am sad to have missed out on a trip to San Francisco, during lockdown I have attended numerous webinars, online seminars, two international conferences and even given outreach talks to the public and school children.
Getting back to ‘normal’
It is safe to say the world, and the way science works, is never going to be the same. But scientists are slowly migrating back to the lab, adorned with a new item of PPE. On top of our lab coats, goggles and gloves we can add…a mask. Despite the stressful time, I managed to get my thesis finished handing it in with a lot more computational work included than I had initially planned!
Soil is a very precious asset whether it be in your garden or an allotment. Soil has physical and chemical properties that support its biological life. Like any asset understanding its properties is fundamental for its effective use and conservation.
Soils will contain, depending on their origin four constituents: sand, clay, silt and organic matter. Mineral soils, those derived by the weathering of rocks contain varying proportions of all four. But their organic matter content will be less than 5 percent. Above that figure and the soil is classed as organic and is derived from the deposition of decaying plants under very wet conditions forming bogs.
Essentially this anaerobic deposition produces peat which if drained yields highly fertile soils such as the Fenlands of East Anglia. Peat’s disadvantage is oxidation, steadily the organic matter breaks down, releases carbon dioxide and is lost revealing the subsoil which is probably a layer of clay.
Cracked clay soil
Mineral soils with a high sand content are free draining, warm quickly in spring and are ‘light’ land. This latter term originates from the small number of horses required for their cultivation. Consequently, sandy soils encourage early spring growth and the first crops. Their disadvantage is limited water retention and hence crops need regular watering in warm weather.
Clay soils are water retentive to the extent that they will become waterlogged during rainy periods. They are ‘heavy’ soils meaning that large teams of horses were required for their cultivation. These soils produce main season crops, especially those which are deeply rooting such as maize. But in dry weather they crack open rupturing root systems and reducing yields.
Silt soils contain very fine particles and may have originated in geological time by sedimentation in lakes and river systems. They can be highly fertile and are particularly useful for high quality field vegetable and salad crops. Because of their preponderance of fine particles silt soils ‘cap’ easily in dry weather. The sealed surface is not easily penetrated by germinating seedlings causing erratic and patchy emergence.
Soil finger test
Soil composition can be determined by two very simple tests. A finger test will identify the relative content of sand, clay and silt. Roll a small sample of moist soil between your thumb and fingers and feel the sharpness of sand particles and the relative slipperiness of clay or the very fine almost imperceptible particles of silt. For a floatation test, place a small soil sample onto the top of a jam jar filled with water. Over 24 to 48 hours the particles will sediment with the heavier sand forming the lower layer with clay and silt deposited on top. Organic matter will float on the surface of the water.
Soil floatation test
It’s quite likely that most people who end up in the vicinity of a scorpion will more than likely beat a hasty retreat, not least because they can impart a potentially life threatening dose of venom should one get stung.
But scientists are now finding that the venom from these creatures, along with snakes and spiders, could be beneficial in treating heart attacks. Scorpion venom in particular contains a peptide that has been found to have a positive impact on the cardiovascular system of rats with high blood pressure. Reporting their findings in Journal of Proteome Research, scientists from Brazil, Canada and Denmark say that they now have a better understanding of the processes involved.
Scorpion venom is a complex mixture of molecules including neurotoxins, vasodilators and antimicrobial compounds, among many others. Individual venom compounds, if isolated and administered at the proper dose, could have surprising health benefits, the researchers say.
One promising compound is the tripeptide KPP (Lys-Pro-Pro), which the researchers say is part of a larger scorpion toxin. KPP was shown to cause blood vessels to dilate and blood pressure to decline in hypertensive rats.
A blood vessel on organic tissue
To understand how KPP worked, the researchers treated cardiac muscle cells from mice, in a Petri dish, with KPP and measured the levels of proteins expressed by the cells at different times using mass spectrometry. They found that KPP regulated proteins associated with cell death, energy production, muscle contraction and protein turnover. In addition the scorpion peptide triggered the phosphorylation of a mouse protein called AKT, which activated another protein involved in production of nitric oxide, a vasodilator.
Treatment with KPP led to dephosphorylation of a protein called phospholamban, which led to reduced contraction of cardiac muscle cells. Both AKT and phospholamban are already known to protect cardiac tissue from injuries caused by lack of oxygen. The researchers said that these results indicate that KPP should be further studied as a drug lead for heart attacks and other cardiovascular problems.
Conceptual image for cardiovascular problems .
According to two studies published in The BMJ, higher consumption of fruit, vegetables and whole grain foods is linked with a lower risk of developing type 2 diabetes.
In the first study, a team of European researchers examined the link between vitamin C, carotenoids and type 2 diabetes.
The findings were based on 9754 participants with type 2 diabetes, compared with a group of 12,622 individuals who were free of diabetes. All of the participants were part of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort totalling 340 234 people.
The results revealed that individuals with the highest intake of fruits and vegetables reduced the risk of developing diabetes by up to 50%.
Fresh fruit and vegetables
The results also showed that increasing intake of fruit and vegetables by 66g per day was linked with a 25% decreased risk of developing type 2 diabetes.
In the second study, researchers in the United States examined the association between whole grain food intake and type 2 diabetes.
Their research involved 158,259 women and 36,525 men who were diabetes, heart disease and cancer free and who took part in the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-Up Study.
Those with the highest intake of whole grains had a 29% lower rate of developing type 2 diabetes compared with those who consumed the least amount. With regards to individual whole grain foods, those with an intake of one or more servings a day of whole grain cold breakfast cereal or dark bread, were associated with a 19% or 21% lower risk of type 2 diabetes, compared with the participants consuming less than one serving a month.
Although both studies took into account several well-known lifestyle risk factors and markers of dietary health, both studies are observational, therefore it should be considered that some of the results may be due to unmeasured factors.
These new research findings provide more evidence that increasing fruit, vegetable and whole grain foods can lower the risk of developing type 2 diabetes.
Single plant cells have amazing capacities for regenerating into entire plants. This property is known as ‘totipotency’ discovered in the 1920s. Linking this with increasing understanding of growth control by plant hormones resulted in the development of the sterile, in vitro, culture. Tiny groups of cells, explants, are cut from the rapidly growing tips of shoots in controlled environments and washed in sterilising agents. These are cultured sterile jars containing a layer of agar supplemented with nutrients and hormones.
Green plantlets growing on sterile agar
The process is known as ‘tissue culture’ or micropropagation. As the cells divide and multiply, they are transferred through a series of sterile conditions which encourage root formation.
Roots growing from newly developing plantlets
Ultimately numerous new whole plants are generated. At that point they are removed from sterile conditions and weaned by planting into clean compost in high humidity environments. High humidity is essential as these transplants lack the protective coating of leaf and stem waxes which prevent desiccation. Ultimately when fully weaned the plants are grown under normal nursery conditions into saleable products.
Why bother with this processes which requires expensive facilities and highly skilled staff? A prime advantage is that micropropagated plants have genotypes very closely similar to those of the original parent, essentially they are clones. As a result vast numbers of progeny can be generated from a few parents preserving their characteristics. That is particularly important as a means of bulking-up newly bred varieties of many ornamental and fruit producing plants which otherwise would be reproduced vegetatively from cuttings or by grafting and budding onto rootstocks. Micropropagation is therefore a means for safeguarding the intellectual property of plant breeding companies.
Explants cut from parent plants before culturing can be heat-treated as a means of removing virus infections. The resultant end-products of rooted plants are therefore disease-free or more accurately disease-tested. These plants are usually more vigorous and produce bigger yields of flowers and fruit. Orchids are one of the crops where the impact of micropropagation is most obvious in florists’ shops and supermarkets.
Orchids have benefitted greatly from micropropagation
Large numbers of highly attractive orchids are now readily available. Previously orchids were very expensive and available in sparse numbers.
The world is not perfect and there are disadvantages with micropropagation. Because the progeny are genetically similar they are uniformly susceptible to pests and pathogens. Crops of clonal plants can be and have been rapidly devasted by existing and new strains of insects and diseases to which they have no resistance.
Elderflowers are in full bloom this month, both in hedgerows as well as gardens across the country. Whether they are the wild Sambucus nigra or a cultivated variety with green or black leaves they are all beautiful and useful plants.
The black leaved cultivar growing in the SCIence Garden has pink blooms, whereas the wild species has white flowers. It was purchased as ‘Black Beauty’, but is also sold as ‘Gerda’.
Sambucus nigra f. porphyrophylla ‘Black Beauty’ growing in the SCIence Garden
This cultivar, along with ‘Black Lace’ (Eva) was developed by Ken Tobutt and Jacqui Prevette at the Horticulture Research International research station at East Malling in Kent and released for sale in the horticulture trade in 2000. The leaves stay a dark purple throughout the year and the flowers have a good fragrance.
The shrub will tolerate hard pruning so is useful for smaller spaces and provides a long season of interest. The plant is also a forager’s delight, both in early summer (for the flowers) and in the autumn (for the berries).
Most commonly one may think of elderflower cordial, or perhaps even elderflower champagne, but an excellent alternative to the rose flavoured traditional “Turkish Delight” can be made - https://www.rivercottage.net/recipes/elderflower-delight. I can highly recommend it!
The chemistry of the elderflower aroma is complex. Analyses such as that in the reference below* have identified many different terpene and terpenoid components including nerol oxide, hotrienol and nonanal.
* Olfactory and Quantitative Analysis of Aroma Compounds in Elder Flower (Sambucus nigra L.) Drink Processed from Five Cultivars. Ulla Jørgensen, Merete Hansen, Lars P. Christensen, Karina Jensen, and Karl Kaack. Journal of Agricultural and Food Chemistry 2000 48 (6), 2376-2383. DOI: 10.1021/jf000005f
June 27th 2020 marked the fourth Micro-, Small and Medium-sized Enterprise (MSME) day, established by the International Council for Small Businesses (ICSB).
Along with online events, the ICSB published its annual report highlighting not only the importance of MSMEs as they relate to the United Nations Sustainable Development Goals but also calling for further political and regulatory support for the sector as the global economy looks to make a recovery.
Concept of a green economy
Ahmed Osman, President of the ICSB, used the annual report to share his perspectives on the future for MSMEs in the post pandemic world and posed the question ‘What is the new normal for MSMEs?’
‘There are six key factors every MSME or start-up needs to keep in mind post Covid-19,’ Osman stated, the first of these being financial assessment and security. Encouraging MSMEs to put in place a financial action plan, obtaining information about government relief packages and getting a clear picture of investor expectations, Osman said; ‘Once this financial risk assessment and support ecosystem are in place, one can execute the plan. This may involve deciding on a potential pay cut, pull back on investments related to infrastructure or expansion, halting new recruitment etc…’
Digital Business and Technology Concept
Having secured the financial footing the next factor was to re-evaluate the business plan in light of the new conditions. Osman stressed the importance of involving all stakeholders to come up with a mutually agreed set of new targets. The third factor to consider, according to Osman, was creating a ‘strong digital ecosystem.’ ‘If there is one thing that Covid-19 has taught businesses. It is the power of digital engagement. Even as an MSME, it helps to be present and active on digital media…Additionally, a digitally enabled internal ecosystem also needs to be in place that can accommodate remote working…without compromising data security or productivity of employees.’
The fourth factor Osman highlighted was adoption of the fourth revolution for business. ‘…This is also time to leverage the new age technology innovations and adopt the fourth revolution for business. While most SMEs and MSMEs look at this as an ‘out of league’ investment, it is actually very simple and can be incorporated for a higher ROI in the long run. Be it automation, CRM, ERP, IoT, a well planned strategy to scale to technology-enabled, highly productive next generation business can be worked out with a two to three year plan,’ Osman said.
Bulb future technology
Less reliance on physical space was the fifth factor Osman highlighted, anticipating a reversal in the trend that led to increasing the number of people in an office and home working becoming more normal.
The final factor Osman highlighted was the need to have a crisis management strategy in place. ‘It is vital to chalk up an effective crisis management plan that will take into consideration both immediate and long-term impact,’ he said.
Encouraging MSMEs to take stock, Osman asked ‘How did you help in the great pandemic? Quantify what you did for your employees, customers, community and country. Leverage the opportunity to build a better business, have credible solutions to the new major challenge and think globally act locally.’
The week provides the opportunity for participants to promote overall awareness for the wide ranging aspects of wellbeing, including social, physical, emotional, financial, career and environmental.
This week, 22-26 June, 2020 is World Wellbeing Week. The observance began in Jersey, the Channel Islands in 2019 and has since been taken up across the world.
Wellbeing and healthy lifestyle concept
Since the beginning of the global lockdown, people have been encouraged to maintain some sort of physical activity or exercise. While it is known that exercise is beneficial for overall physical and mental health and wellbeing, researchers from the University of Cambridge and University of Edinburgh UK, have released a study in which they say that physical activity prevents 3.9 million early deaths each year.
Publishing their work in The Lancet Global Health the researchers said that there is often too much focus on the negative health consequences of poor levels of physical activity, when we should be celebrating what we gain from physical activity.
Exercises and warm up before run
Researchers from the Medical Research Council Epidemiology Unit at the University of Cambridge looked at previously published data for 168 countries which covered the proportion of the population meeting WHO global recommendation of at least 150 minutes of moderate-intensity throughout the week or 75 minutes of vigorous-intensity activity.
By combining these data, with estimates of the relative risk of dying early for active people compared to inactive people, the researchers were able to estimate the proportion of premature deaths that were prevented because people were physically active.
They found that globally, due to physical activity, the number of premature deaths was an average 15% lower than it would have been, equating to 3.9 million lives saved each year. Despite the considerable variation in physical activity levels between countries, the positive contribution of physical activity was remarkably consistent across the globe, with a broad trend towards a greater proportion of premature deaths averted for low and middle income countries.
Hands holding red heart representing healthy heart and wellbeing
The researchers argue that the debate on physical activity has often been framed in terms of the number of early deaths due to the lack of exercise, currently estimated at 3.2 million each year. But showing how many deaths are averted it might be possible to frame the debate in a positive way which could have benefits for policy and population messaging.
Dr Tess Strain from the Medical Research Council Epidemiology Unit at the University of Cambridge said; ‘We’re used to looking at the downsides of not getting enough activity – whether that’s sports or a gym or just a brisk walk after lunch time. But by focusing on the number of lives saved, we can tell a good news story of what is already being achieved…We hope our finding will encourage governments and local authorities to protect and maintain services in these challenging times.’
Momentum for a post-pandemic ‘green recovery’ continues, as the UK government and the European Commission set out steps to accelerate their recoveries, while supporting the paths to net zero by 2050. Here we round-up just some of the initiatives announced in recent weeks to achieve these goals.
Human hands holding earth globe and tree
Plans for preservation of biodiversity
Speaking on the 3rd June 2020, at the Organisation for Security and Cooperation in Europe (OSCE) Economic and Environmental Committee Meeting, the UK’s Second Secretary from the UK Delegation, Justin Addison, said; ‘As we recover, we have an opportunity to protect and restore nature, reducing our exposure to deadly viruses and climate impact.’
Highlighting the UK’s global outlook on addressing climate change, Addison added, ‘The UK will soon announce a £64 million package to support Colombia to tackle deforestation and build a cleaner and more resilient economy in areas affected by Covid-19 and conflict.’
As well as the UK’s efforts to preserve biodiversity, the European Commission will be looking to protect and restore biodiversity and natural ecosystems. Frans Timmermans, the European Commission’s Executive Vice President added that, ‘It can boost our resilience and prevent the emergence and spread of future virus outbreaks. We have now seen that this relationship between us and the natural environment is key to our health.’
Earth held in human hands
Enabling low-carbon solutions and boosting clean growth
In early June, a letter was sent to decision-makers across the European Union from more than 100 investors, urging the EU to ensure a green recovery from the covid-19 pandemic is delivered.
Investors are keen to ensure the government builds on The European Green deal to deliver a long term commitment that will accelerate the economy into one that is more green and carbon resilient post coronavirus.
The European Green deal, set out before the pandemic, details some of their targets including, a 50-55% emissions reduction by 2030; a climate law to reach net-zero emissions by 2050; a transition fund worth €100bn and a series of new sector policies to ensure all industries are able to decarbonise.
A shoot of a plant and planet Earth
To boost clean growth, the UK Government has recently launched a £40 million Clean Growth Fund that will ‘supercharge green start-ups’.
This fund will enable UK clean growth start-ups to scale up low-carbon solutions and drive a green economic recovery.
Potential examples of projects the fund could support include areas in power and energy, buildings, transport and waste.
Business Secretary Alok Sharma said: ‘This pioneering new fund will enable innovative low-carbon solutions to be scaled up at speed, helping to drive a green and resilient economic recovery.’
In a recent paper published in Nature Climate Change, an international group of researchers are urging countries to reconsider their strategy to remove CO2 from the atmosphere. While countries signed up to the Paris Agreement have individual quotas to meet in terms of emissions reduction, they argue this cannot be achieved without global cooperation to ensure enough CO2 is removed in a fair and equitable way.
The team of international researchers from Imperial College London, the University of Girona, ETH Zürich and the University of Cambridge, have stated that countries with greater capacity to remove CO2 should be more proactive in helping those that cannot meet their quotas.
Co-author Dr Niall Mac Dowell, from the Centre for Environmental Policy and the Centre for Process Systems Engineering at Imperial, said, ‘It is imperative that nations have these conversations now, to determine how quotas could be allocated fairly and how countries could meet those quotas via cross-border cooperation.’
The team’s modelling and research has shown that while the removal quotas vary significantly, only a handful of countries will have the capacity to meet them using their own resources.
A few ways to achieve carbon dioxide removal:
(3) CCS coupled to bioenergy – growing crops to burn for fuel. The crops remove CO2 from the atmosphere, and the CCS captures any CO2 from the power station before its release.
However, deploying these removal strategies will vary depending on the capabilities of different countries. The team have therefore suggested a system of trading quotas. For example, due to the favourable geological formations in the UK’s North Sea, the UK has space for CCS, and therefore, they could sell some of its capacity to other countries.
Co-lead author Dr Carlos Pozo from the University of Girona, concluded; ‘By 2050, the world needs to be carbon neutral - taking out of the atmosphere as much CO2 as it puts in. To this end, a CO2 removal industry needs to be rapidly scaled up, and that begins now, with countries looking at their responsibilities and their capacity to meet any quotas.’
Some plants such as lettuce require cool conditions for germination (<10 oC), a condition known as thermo-dormancy. This reflects the evolution of the wild parent species in cooler environments and growth cycles limited by higher summer temperatures. Transforming live but dormant seed into new healthy self-sufficient plants requires care and planning. The conditions in which seed is stored before use greatly affect the vigour and quality of plants post-germination. Seed which is stored too long or in unsuitable environments deteriorates resulting in unthrifty seedlings.
Seed is either sown directly into soil or into compost designed especially as an aid for germination. These composts contain carefully balanced nutrient formulae which provide larger proportions of potassium and phosphorus compounds which promote rooting and shoot growth. The amounts of nitrogen needed at and immediately post-germination are limited. Excess nitrogen immediately post-germination will cause over-rapid growth which is susceptible to pest and pathogen damage.
Minor nutrients will also be included in composts which ensures the establishment of efficient metabolic activities free from deficiency disorders. Composts require pH values at ~ 7.0 for the majority of seedlings unless they are of calicifuge (unsuited for calcareous soils) species where lime requirement is limited and the compost pH will be formulated at 6.0. Additionally, the pC will be carefully tuned ensuring correctly balanced ionic content avoiding root burning disorders. Finally, the compost should be water retentive but offering a rooting environment with at least 50 percent of the pore spaces filled with air. Active root respiration is essential while at the same time water is needed as the carrier for nutrient ions.
Seedlings encountering beneficial environments delivering suitable temperatures will germinate into healthy and productive plants.
Some plants such as lettuce require cool conditions for germination (<10 oC), a condition known as thermo-dormancy. This reflects the evolution of the wild parent species in cooler environments and growth cycles limited by higher summer temperatures.
Careful husbandry under protection such as in greenhouses provides plants which can be successfully transplanted into the garden. The soil receiving these should be carefully cultivated, providing an open crumb structure which permits swift and easy rooting into the new environment. It is essential that in the establishment phase plants are free from water stress. Measures which avoid predation from birds such as pigeons may also be required.
Netting or the placing of cotton threads above plants helps as a protection measure. Weeds must be removed otherwise competition will reduce crop growth and encourage pests and diseases, particularly slug browsing. Finally, the gardener will be rewarded for his/her work with a fruitful and enjoyable crop!
Fan of milk and cheese? Here’s some good news - researchers have associated dairy-rich diets to reduced risk of developing diabetes and high blood pressure.
According to a large international study published in BMJ Open Diabetes Research & Care, a research team has found that eating at least two daily servings of dairy is associated with lower risk of diabetes and high blood pressure.
Dairy products; milk and cheese
To see if this link exists across a range of countries, researchers drew on people taking part in the Prospective Urban Rural Epidemiology (PURE) study, in which involves participants from 21 countries aged 35–70. Information on dietary intake over a period of 12 months was collected using food frequency questionnaires. Dairy products included milk, yoghurt, yoghurt drinks, cheese, and dishes prepared with dairy products. Butter and cream were assessed separately as they are not so commonly eaten.
The results demonstrated that total and full fat dairy were associated with a lower prevalence of metabolic syndrome, which was not the case for a diet with no daily dairy intake. Two dairy servings a day was associated with a 24% lower risk of metabolic syndrome, rising to a 28% lower risk for a full fat dairy intake.
It was also noted that consuming at least two servings of full fat dairy per day was linked to an 11%–12% lower risk of high blood pressure and diabetes, whilst three servings of full fat dairy intake per day decreased the risks by 13% -14%.
Heart and stethoscope
The researchers stated that ‘If our findings are confirmed in sufficiently large and long term trials, then increasing dairy consumption may represent a feasible and low cost approach to reducing (metabolic syndrome), hypertension, diabetes, and ultimately cardiovascular disease events worldwide.’
Another month starts in the SCIence Garden with no visitors to appreciate the burgeoning growth of fresh new leaves and spring flowers, but that doesn’t mean we should forget about it!
Hopefully in our absence the Laburnum tree in the garden, Laburnum x watereri ‘Vossii’ will be flowering beautifully, its long racemes of golden yellow flowers looking stunning in the spring sunshine!
Laburnum x watereri ‘Vossii’ in the SCIence Garden
This particular cultivar originated in the late 19th century in the Netherlands, selected from the hybrid species which itself is a cross between Laburnum alpinum and L. anagyroides. This hybrid species was named for the Waterers nursery in Knaphill, Surrey and was formally named in a German publication of 1893 (Handbuch der Laubholzkunde, Berlin 3:673 (1893)
The laburnum tree is found very commonly in gardens in the UK, and is noticeable at this time of year for its long chains of golden yellow flowers. However, the beautiful flowers hide a dark side to this plant. The seeds (and indeed all parts) of the tree are poisonous to humans and many animals. They are poisonous due to the presence of a very toxic alkaloid called cytisine (not to be confused with cytosine, a component of DNA). Cytisine has a similar structure to nicotine (another plant natural product), and has similar pharmacological effects. It has been used as a smoking cessation therapy, as has varenicline, which has a structure based on that of cytisine. These molecules are partial agonists at the nicotinic receptor (compared to nicotine which is a full agonist) and reduce the cravings and “pleasurable” effects associated with nicotine.
Cytisine is found in several other plants in the legume family, including Thermopsis lanceolata, which also looks stunning in early summer and Baptisia species, also growing in the SCIence Garden and flowering later in the year.
In 2018 there were 9.6 million deaths from cancer and 33% of these were linked to exposure to tobacco smoke.* Since the link between smoking and lung cancer was established in 1950, the market for smoking cessation therapies has increased enormously. In 2018 it was worth over 18 billion dollars annually worldwide and is projected to increase to 64 billion dollars by 2026.** Staggering! Varenicline, sold under the brand names Champix and Chantix, is one of the most significant smoking cessation therapies apart from nicotine replacement products.
If you see a laburnum tree whilst out on your daily allowed exercise this month, have a thought for its use as a smoking cessation therapy!
* Data from the Cancer Research UK website https://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer#heading-Zero accessed May 2020.
Here is a roundup on some of the most recent research and scientific efforts against the coronavirus.
Novartis has reached an agreement with the US Food and Drug Administration to proceed with a phase III clinical trial of hydroxychloroquine in hospitalized Covid-19 patients. The large trial will be conducted at more than a dozen sites in the US and tested on approximately 440 patients to evaluate the use for this treatment.
Additionally, Norvatis plans to make its hydroxychloroquine intellectual property available to support broad access to hydroxychloroquine. Read more here.
Causaly, an innovative technology company that harnesses AI to interpret vast databases of biomedical knowledge, is collaborating with UCL academics to increase research on potential therapeutic agents and the identification of biomarkers.
Several researchers and research groups within UCL have been granted access to Causaly technology, allowing them the access to rapidly analyse and derive insights from biomedical literature.
Read more here.
As part of the UK’s wider efforts to support the development of a vaccine, a new government-led Vaccine Taskforce will soon be launched to drive forward the manufacturing and research efforts to fight the virus.
The government will review regulations to facilitate fast and safe vaccine trials, as well as operational plans, to ensure a vaccine can be produced at a large scale when it becomes available. Industry and academic institutions will be given the resources and support needed.
Business Secretary Alok Sharma said, ‘UK scientists are working as fast as they can to find a vaccine that fights coronavirus, saving and protecting people’s lives. We stand firmly behind them in their efforts. The Vaccine Taskforce is key to coordinating efforts to rapidly accelerate the development and manufacture of a potential new vaccine.’ Read more here.
A new biosensor for the COVID-19 virus
Research teams at Empa and ETH Zurich have developed an alternative test method in the form of an optical biosensor. The sensor made up of gold nanostructure, known as gold nonoislands on a glass substrate, combines two different effects to detect covid-19: an optical and a thermal one.
According to the release, ‘Artificially produced DNA receptors that match specific RNA sequences of the SARS-CoV-2 [virus] are grafted onto the nanoislands,’ and researchers will then use the optical phenomena, - localised surface plasmon resonance - to monitor the presence of the virus.
The biosensor is not yet ready to be used to monitor and detect COVID-19, however tests showed the sensor can distinguish between very similar RNA sequences of SARS-CoV-2 virus and its relative, SARS-Cov. Read more here.
For more information and more updates on the coronavirus, please visit our hub here.
Seed is one of Nature’s tiny miracles upon which the human race relies for its food and pleasure.
Each grain contains the genetic information for growth, development, flowering and fruiting for the preponderant plant life living on this planet. And when provided with adequate oxygen, moisture, warmth, light, physical support and nutrients germination will result in a new generation of a species. These vary from tiny short-lived alpines to the monumental redwood trees growing for centuries on the Pacific west coast of America.
Humankind has tamed and selected a few plant species for food and decorative purposes.
Seed head of beetroot, the seeds are in clusters.
Seed of these, especially food plants, is an internationally traded commodity. Strict criteria governed by legal treaties apply for the quality and health of agricultural and many horticultural seeds. This ensures that resultant crops are true to type and capable of producing high grade products as claimed by the companies who sell the seed.
Companies involved in the seed industry place considerable emphasis on ensuring that their products are capable of growing into profitable crops for farmers and growers. Parental seed crops are grown in isolation from farm crops thereby avoiding the potential for genetic cross-contamination. With some very high value seed the parent plants may be grown under protection and pollinated by hand.
Samples of seed are tested under laboratory conditions by qualified seed analysts. Quality tests identify levels of physical contamination, damage which may have resulted in harvesting and cleaning the seed and the proportion of capable of satisfactory germination. There may also be molecular tests which can identify trueness to type. Identifying the healthiness of seed is especially important. The seed coat can carry fungal and bacterial spores which could result in diseased crops. Similarly, some pathogens, including viruses, may be carried internally within seed.
Septoria apicola – seed borne pathogen causing late blight of celery
Pests, especially insects, find seed attractive food sources and may be carried with it. Careful analytical testing will identify the presence of these problems in batches of seed.
The capabilities of seed for producing vigorous plants is particularly important with very high value vegetable and salad crops. Vigour testing is a refined analytical process which tracks the uniformity and speed of germination supplemented with chemical tests determining the robustness of plant cells. Producers rely on the quality, uniformity and maturity rates of crops such as lettuce, green broccoli or cauliflower so they meet the strict delivery schedules set by supermarkets. Financial penalties are imposed for failures in the supply chain.
Biology’s seemingly inert tiny seed grains are essential ingredients of humankind’s existence!
As the COVID-19 outbreak increases pressure on the UK’s NHS services and frontline staff, leading scientists and businesses are taking on new initiatives to tackle the outbreak. As there is currently no treatment or vaccine for this virus, researchers are working at unprecedented speed to accelerate the development of a treatment. Businesses are putting in more effort to help those on the frontline of this global crisis.
INEOS has managed to built a hand sanitzer plant in the UK and will soon open the facility in Germany, aiming to produce 1m bottles per month each to address a supply shortage across the UK and Europe.
BASF will soon be producing hand sanitizers at its petrochemicals hub in Germany to address the shortage in the region.
Ramping up the supply of PPE, AstraZeneca is donating nine million face masks to support healthcare workers around the world. Alongside this, AstraZeneca is accelerating the development of its diagnostic testing capabilities to scale-up screening and is also partnering with governments on existing screening programmes.
Pharmaceutical company Novartis UK, along with several others, is making available a set of compounds from its library that it considers are suitable for in vitro antiviral testing.
GSK has announced that is donating $10 million to the COVID-19 Solidarity Response Fund. The Fund was created by the World Health Organisation (WHO) to help WHO and its partners to prevent, detect and manage the pandemic
Alongside the efforts and initiatives from industries, to continue to aid those on the frontline of this global crisis, social distancing interventions must remain to flatten the curve.
Research and data modelling has shown that policy strategies, such as social distancing and isolation interventions which aim to suppress the rate of transmission, might reduce death and peak healthcare demand by two-thirds.
Stopping non-essential contact can flatten the curve. Suppressing the curve means we may still experience the same number of people becoming infected but over a longer period of time and at a slower rate, reducing the stress on our healthcare system.
This latest SCI Energy Group blog introduces the possible avenues of carbon dioxide utilisation, which entails using carbon dioxide to produce economically valuable products through industrial processes. Broadly, utilisation can be categorised into three applications: chemical use, biological use and direct use. For which, examples of each will be highlighted throughout.
Before proceeding to introduce these, we can first consider utilisation in relation to limiting climate change. As has been discussed in previous blogs, the reduction of carbon dioxide emissions is crucial. Therefore, for carbon dioxide utilisation technologies to have a beneficial impact on climate change, several important factors must be considered and addressed.
1) Energy Source: Often these processes are energy intensive. Therefore, this energy must come from renewable resources or technologies.
2) Scale: Utilisation technologies must exhibit large scaling potential to match the limited timeframe for climate action.
3) Permanence: Technologies which provide permanent removal or displacement of CO2 emissions will be most impactful¹.
Figure 1: CO2 sign
Carbon dioxide, alongside other reactants, can be chemically converted into useful products. Examples of which include urea, methanol, and plastics and polymers. One of the primary uses of urea includes agricultural fertilisers which are pivotal to crop nutrition. Most commonly, methanol is utilised as a chemical feedstock in industrial processes.
Figure 2: Fertilizing soil
One of the key challenges faced with this application of utilisation is the low reactivity of CO2 in its standard conditions. Therefore, to successfully convert it into products of economic value, catalysts are required to significantly lower the molecules activation energy and overall energy consumption of the process. With that being said, it is anticipated that, in future, the chemical conversion of CO2 will have an important role in maintaining a secure supply of fuel and chemical feedstocks such as methanol and methane².
Carbon dioxide is fundamental to plant growth as it provides a source of required organic compounds. For this reason, it can be utilised in greenhouses to promote carbonic fertilisation. By injecting increased levels of CO2 into the air supplied to greenhouses, the yield of plant growth has been seen to increase. Furthermore, CO2 from the flue gas streams of chemical processes has been recognised, in some studies, to be of a quality suitable for direct injection³.
Figure 3: Glass greenhouse planting vegetable greenhouses
These principles are applicable to encouraging the growth of microorganisms too. One example being microalgae which boasts several advantageous properties. Microalgae has been recognised for its ability to grow in diverse environments as well as its ability to be cultured in numerous types of bioreactors. Furthermore, its production rate is considerably high meaning a greater demand for CO2 is exhibited than that from normal plants. Micro-algal biomass can be utilised across a range of industries to form a multitude of products. These include bio-oils, fuels, fertilisers, food products, plant feeds and high value chemicals. However, at present, the efficiency of CO2 fixation, in this application, can be as low as 20-50%.
Figure 4: Illustration of microalgae under the microscope
It is important to note that, at present, there are many mature processes which utilise CO2 directly. Examples of which are shown in the table below.
Many carbon dioxide utilisation technologies exist, across a broad range of industrial applications. For which, some are well-established, and others are more novel. For such technologies to have a positive impact on climate action, several factors need to be addressed such as their energy source, scaling potential and permanence of removal/ displacement of CO2.
The chemistry of carbon dioxide and its role in decarbonisation is a key topic of interest for SCI Energy Group. In the near future, we will be running a webinar concerned with this. Further details of this will be posted on the SCI website in due course.
March in the SCIence Garden
Narcissus was the classical Greek name of a beautiful youth who became so entranced with his own reflection that he killed himself and all that was left was a flower – a Narcissus. The word is possibly derived from an ancient Iranian language. But the floral narcissi are not so self-obsessed. As a member of the Amaryllidaceae, a family known for containing biologically active alkaloids, it is no surprise to learn that they contain a potent medicinal agent.
Narcissus (and in particular this cultivar) are an excellent source of galanthamine, a drug more commonly associated with snowdrops (Galanthus spp.). Galanthamine is currently recommended for the treatment of moderate Alzheimer’s disease by the National Institute of Health and Clinical Excellence (NICE) but is very effective in earlier stages of the disease too.
Today, part of the commercial supply of this molecule comes from chemical synthesis, itself an amazing chemical achievement due to the structural complexity of the molecule, and partly from the natural product isolated from different sources across the globe. In China, Lycoris radiata is grown as a crop, in Bulgaria, Leucojum aestivum is farmed and in the UK the humble daffodil, Narcissus ‘Carlton’ is the provider.
Narcissus ‘Carlton’ growing on large scale
Agroceutical Products, was established in 2012 to commercialise the research of Trevor Walker and colleagues who developed a cost effective, reliable and scalable method for producing galanthamine by extraction from Narcissus. They discovered the “Black Mountains Effect” – the increased production of galanthamine in the narcissus when they are grown under stress conditions at 1,200 feet. With support from Innovate UK and other organisations, the process is still being developed. Whilst not a full scale commercial production process just yet, the work is ongoing. As well as providing a supply of the much needed drug, this company may be showing the Welsh farming community how to secure additional income from their land. They continue to look for partners who have suitable land over 1000 ft in elevation.
The estimated global patient population for Alzheimer’s in 2010 was 30 million. It is expected to reach 120 million by 2050. The global market for Alzheimer’s disease drugs for 2019 was US$ 2870 million.
Transferring plants between countries was a profitable source for novel commercial and garden plants until quite recently.
Potato crop: Geoff Dixon
Potatoes and tomatoes are classic examples arriving in Europe from South America during the 16th century. Substantial numbers of new plants fuelled empire expansion founding new industries such as rubber and coffee. One of the earliest functions of European botanic gardens was finding potentially valuable new crops for colonial businesses. At home selecting orchids and other exotics from imported plants brought fame and fortune for head gardeners managing the large 19th century estates such as Chatsworth. Commercially seed merchants selected by eye and feel new and improved vegetables, fruit and flowers.
The rediscovery of Mendel’s laws of inheritance brought systematic science and formalised breeding new crops and garden plants. Analysing the effects of transferring physical, chemical and biological characters identified gene numbers and their functions.
Colour range in Gladioli: Geoff Dixon
As a result, varieties with improved colourfulness, fruitfulness, yield and pest and pathogen tolerance fill seedsmen’s catalogues. Breeding increased food supplies and added colour into the gardens springing up in suburban areas as affluence increased.
Greater plant reliability and uniformity arrived with the discovery of F1 hybrids.
Hybrid Sunflowers: Geoff Dixon
Selected parental lines each with very desirable characters such as fruit colour are in-breed for several generations. Then they are crossed bringing an explosion of vigour, uniformity and reliability (known as heterosis). Saving seed from the hybrid lines does not however, perpetuate these characters; new generations come only from remaking the original cross. That is a major boon for the breeder as competitors cannot pirate their intellectual property.
Knowledge at the molecular level has unravelled still further gene structure and functioning. Tagging or marking specific genes with known properties shortens the breeding cycle adding reliability and accuracy for the breeder. Simplifying the volume of genetic material used in crosses by halving the number of chromosomes involved adds further precision and control (known as haploidisation).
Opportunities for breeding new plants increases many-fold when advantageous genes are transferred between species. Recent developments of gene-editing where tailored enzymes very precisely snip out unwanted characters and insert advantageous ones is now offering huge opportunities as a non-transgenic technology. Breeding science makes possible mitigation of climate change, reducing for example the impact of soil degradation brought about by flooding.
Flood degraded land: Geoff Dixon
Batteries have an important role as energy sources with environmental advantages. They offset the negative environmental impacts of fossil fuels or nuclear-based power; they are also recyclable. These attributes have led to increasing research with the aim of improving battery design and environmental impact, particularly regarding their end of life. In addition, there is a desire to improve battery safety as well as design batteries from more sustainable and less toxic materials.
New research shows that aluminium battery could offer several advantages:
Aluminium metal anode batteries could hold promise as an environmentally friendly and sustainable replacement for the current lithium battery technology. Among aluminium’s benefits are its abundance, it is the third most plentiful element the Earth’s crust.
To date aluminium anode batteries have not moved into commercial use, mainly because using graphite as a cathode leads to a battery with an energy content which is too low to be useful.
This is promising for future research and development of aluminium as well as other metal-organic batteries.
New UK battery project is said to be vital for balancing the country’s electricity demand
Work has begun on what is said to be Europe’s biggest battery. The 100MW Minety power storage project, which is being built in southwest England, UK, will comprise two 50MW battery storage systems. The project is backed by China Huaneng Group and Chinese sovereign wealth fund CNIC.
Shell Energy Europe Limited (SEEL) has agreed a multi-year power offtake agreement which will enable the oil and gas major, along with its recently acquired subsidiary Limejump, to optimise the use of renewable power in the area.
In a statement David Wells, Vice President of SEEL said ‘Projects like this will be vital for balancing the UK’s electricity demand and supply as wind and solar power play bigger roles in powering our lives.
The major hurdles for battery design, states the EU’s document, include finding suitable materials for electrodes and electrolytes that will work well together, not compromise battery design, and meet the sustainability criteria now required. The process is trial and error, but progress is being made.
For more information, click here.
Yesterday was Shrove Tuesday, the traditional feast day before the start of Lent. Also known as Pancake Day, many people will have returned to traditional recipes or experimented with the myriad of options available for this versatile treat.
But you may not realise pancakes are helping to advance medicine. Here we revisit some interesting research
The appearance of pancakes depends on how water escapes the batter mix during the cooking process. This is impacted by the batter thickness. Understanding the physics of the process can help in producing the perfect pancake, but also provides insights into how flexible sheets, like those found in human eye, interact with flowing vapour and liquids.
Illustration of a healthy eye, glaucoma, cataract
The researchers at University College London (UCL), UK, compared recipes for 14 different types of pancake from across the world. For each pancake the team analysed and plotted the aspect ratio, i.e. the pancake diameter to the power of three in relation to the volume of batter. They also calculated the baker’s percentage, the ratio of liquid to flour in the batter.
It was found that thick, almost spherical pancakes had the lowest aspect ratio at three, whereas large thin pancakes had a ratio of 300. The baker’s percentage did not vary as dramatically, ranging from 100 for thick mixtures to 175 for thinner mixtures.
Co-author Professor Sir Peng Khaw, Director of the NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology said; ‘We work on better surgical methods for treating glaucoma, which is a build-up of pressure in eyes caused by fluid. To treat this, surgeons create an escape route for the fluid by carefully cutting the flexible sheets of the sclera.’
‘We are improving this technique by working with engineers and mathematicians. It’s a wonderful example of how the science of everyday activities can help us with medicinal treatments of the future.’
Classic american pancakes
One of the most beloved flowers in China (and elsewhere) this small tree was planted here in the SCIence garden to represent the Chinese UK group. It is in bloom from late winter and the bright pink flowers have a strong perfume. It is growing in the centre at the back of the main area of the garden.
There are 309 accepted species in the genus Prunus listed on the Plants of the World Online database (plantsoftheworldonline.org). The genus is distributed mainly across the Northern temperate zones but there are some tropical species.
The genus Prunus is generally defined based on a combination of characteristics which include: a solitary carpel (the structure enclosing the ovules – a combination of the ovary, style and stigma) with a terminal style, a fleshy drupe (fruit), five sepals and five petals and solid branch pith. The drupe contains a single, relatively large, hard coated seed (stone) – familiar to us in cherries, apricots, nectarines, peaches etc
This particular species, Prunus mume, originates from southern China in the area around the Yangtze River. The ‘Beni-chidori’ cultivar has been given an Award of Garden Merit by the Royal Horticultural Society.
Over 300 different cultivars of this species have been recorded in China, perhaps not surprisingly for a plant that has been domesticated for thousands of years due to its floral beauty. A recent study on the genetic architecture of floral traits across the cultivars of this species was published in Nature Communications.1
Prunus mume was introduced from China into Japan, Korea, Taiwan and Vietnam and it is now fully integrated into the cuisines of all these countries. In addition to its uses in many foodstuffs and drinks, extracts from the fruit are also widely used in traditional Chinese medicine and in the traditional medicines in Korea and Japan. Anti-bacterial, anti-oxidative, anti-inflammatory and anti-cancer properties have all been ascribed to the extract which has been used to treat tiredness, headaches, constipation and stomach disorders amongst other things. A recent review published in the Journal of Ethnopharmacology2 gathers together information from literature reports on the anti-cancer activity of Prunus mume fruit extract.
One standardised extract in particular (MK615) has shown antitumour activity against most common cancer types.
The anti-cancer activity has not been ascribed to a particular component. Compounds isolated from the extract include ursolic acid, amygdalin, prunasin, chlorogenic acid, mumefural and syringaresinol.
Like all the plants in the SCIence garden – there’s a lot more to this one than just its ornamental beauty.
1. Zhang, Q., Zhang, H., Sun, L. et al. The genetic architecture of floral traits in the woody plant Prunus mume. Nat Commun 9, 1702 (2018). https://doi.org/10.1038/s41467-018-04093-z
2. Bailly, C. Anti-cancer properties of Prunus mume extracts. J Ethnopharmacology 246, 2020, 112215. https://doi.org/10.1016/j.jep.2019.112215
In November 2020, the UK is set to host the major UN Climate Change summit; COP26. This will be the most important climate summit since COP21 where the Paris Agreement was agreed. At this summit, countries, for the first time, can upgrade their emission targets through to 20301. In the UK, current legislation commits government to reduce greenhouse gas emissions by at least 100% of 1990 levels by 2050, under the Climate Change Act 2008 (2050 Target Amendment)2.
Hydrogen has been recognised as a low-carbon fuel which could be utilised in large-scale decarbonisation to reach ambitious emission targets. Upon combustion with air, hydrogen releases water and zero carbon dioxide unlike alternative heavy emitting fuels. The potential applications of hydrogen span across an array of heavy emitting sectors. The focus of this blog is to highlight some of these applications, and on-going initiatives, across the following three sectors: Industry, Transport and Domestic.
Please click (here3) to access our previous SCI Energy Group blog centred around UK CO2 emissions.
Figure 1: climate change activists
Did you know that small-scale hydrogen boilers already exist?4
Through equipment modification, it is technically feasible to use clean hydrogen fuel across many industrial sectors such as: food and drink, chemical, paper and glass.
Whilst this conversion may incur significant costs and face technical challenges, it is thought that hydrogen-fuelled equipment such as furnaces, boilers, ovens and kilns may be commercially available from the mid-2020’s4.
Figure 2: gas hydrogen peroxide boiler line vector icon
Did you know that using a gas hob can emit up to or greater than 71 kg of CO2 per year?5
Hydrogen could be supplied fully or as a blend with natural gas to our homes in order to minimise greenhouse gas emissions associated with the combustion of natural gas.
As part of the HyDeploy initiative, Keele University, which has its own private gas network, have been receiving blended hydrogen as part of a trial study with no difference noticed compared to normal gas supply6.
Other initiatives such as Hydrogen 1007 and HyDeploy8 are testing the feasibility of delivering 100% hydrogen to homes and commercial properties.
Figure 3: gas burners
Did you know that, based on an average driving distance of approximately 11,500 miles per annum, an average vehicle will emit approximately 4.6 tonnes of CO2 per year?9
In the transport sector, hydrogen fuel can be utilised in fuel cells, which convert hydrogen and oxygen into water and electricity.
Hydrogen fuel cell vehicles are already commercially available in the UK. However, currently, form only a small percentage of Ultra Low Emission Vehicle (ULEV) uptake10.
Niche applications of hydrogen within the transport sector are expected to show greater potential for hydrogen such as buses and trains. Hydrogen powered buses are already operational in certain parts of the UK and hydrogen trains are predicted to run on British railways from as early as 202211.
Figure 4: h2 combustion engine for emission free ecofriendly transport
This blog gives only a brief introduction to the many applications of hydrogen and its decarbonisation potential. The purpose of which, is to highlight that hydrogen, amongst other low-carbon fuels and technologies, can play an important role in the UK’s transition to net-zero emissions.
Stay tuned for further SCI Energy Group blogs which will continue to highlight alternative low-carbon technologies and their potential to decarbonise.
Links to References:
Who is Dmitri Mendeleev?
Russian chemist, Dmitri Mendeleev was born in 1834 in a Siberian village. His early life has been described as tumultuous; his father lost his sight and died when Dmitri was thirteen, leaving his family in financial difficulties.
His mother prioritised Dmitiri’s academic potential, taking him and his sister to St Petersburg, where he studied at the Main Pedagogical Institute. When his mother died, he carried out his doctoral research in St Petersburg where he explored the interactions of alcohols with water.
Between 1859 and 1861 he went to Paris to study the densities of gases, and he travelled to Germany where he studied capillarity and surface tension that subsequently led to his theory of ‘absolute boiling point.’ In 1861 he returned to Russia to publish everything he knew on organic chemistry in a 500-page textbook, and by 1864 he became a professor at the Saint Petersburg Technological Institute and Saint Petersburg State University.
As he continued his research, he tried to classify the elements according to the chemical properties. He became aware of a repeating pattern – elements with similar properties appeared at regular intervals. He arranged the elements in order of increasing relative atomic mass and noticed the chemical properties of these elements revealed a trend, which led to the formation of the periodic table.
Beyond his work in chemistry, during the 1870s, he devoted time to help the Russian industry, particularly in strengthening the productivity in agriculture. He became very active in exploring the Russian petroleum industry and developed projects in the coal industry in the Donets Basin. Additionally, he was responsible for creating and introducing the metric system to Russia.
In this third article in our ‘How to…’ series, we reflect on what we learned from Martin Curry, STEM Healthcare, in his training session on managing the money.
What is a profit and loss table?
A table detailing all business transactions showing all incoming and outgoing cash activity. This will inform potential investors and credit sources how your business will generate its income and manage its costs. Documenting this information is important to show the progression (improvement) over a period and to forecast whether your business is set to make a future profit or loss.
So why is forecasting important?
A profit and loss table give businesses an idea of where the business is headed financially.
If your forecast suggests that profit levels will be low and therefore capital will be limited, it can help you to become more cautious with your credit and supply chain arrangements. Having this level of insight can help you to manage your risks and allow you to rethink your strategy in order to reduce loss and increase profitability.
Monitoring your manufacturing costs is critical in order to represent the efficiency of the production process. There are two types of costs: fixed and variable.
Fixed: rent, rates, employee, insurance,
Variable: raw materials, transport, utilities,
Keeping track of the manufacturing costs will allow you to review the expenses associated with all the resources spent in the process of making the finished goods. To maximise the productivity of each unit of materials you use in the manufacturing process, ensure you review your procedures, materials and ensure waste is reduced to its minimum during the process.
Awareness of the market is key to impressing potential investors; knowing what the key drivers are and understanding the risks and the market demand. Having this information enables you to provide evidence that you can effectively evaluate the commerciality of the project.
In summary, investors will be able to learn a great deal from the financial figures of a business. Thus, preparing a profit and loss account (detailing the business transactions) is critical to providing an insight of the business’s overall position within the market.
Growing in just about the most challenging of locations in the SCIence Garden are a small group of Helleborus niger. They are planted in a very dry and shady location underneath a large tree sized Escallonia and although they struggled to establish when they were first planted (in May 2017) they are now flowering and growing well.
This plant was first featured as a Horticulture Group Medicinal Plant of the Month in December 2011 and as it is now in the SCIence garden I thought a reprise was in order.
Helleborus is a genus of 15 species of evergreen perennials in the buttercup family, Ranunculaceae. In common with most members of the family, the flowers are radially symmetric, bisexual and have numerous stamen.
Helleborus is the Latin name for the lent hellebore, and niger means black – referring in this species to the roots.
This species is native to the Alps and Appenines. Helleborus niger has pure white flowers, with the showy white parts being sepals (the calyx) and the petals (corolla) reduced to nectaries. As with other hellebores, the sepals persist long after the nectaries (petals) have dropped.
All members of the Ranunculaceae contain ranunculin, an unstable glucoside, which when the plant is wounded is enzymatically broken down into glucose and protoanemonin. This unsaturated lactone is toxic to both humans and animals, causing skin irritation and nausea, vomiting, dizziness and worse if ingested.
Protoanemonin dimerises to form anemonin when it comes into contact with air and this is then hydrolysed, with a concomitant ring-opening to give a non-toxic dicarboxylic acid.
Many hellebores have been found to contain hellebrin, a cardiac glycoside. The early chemical literature suggests that this species also contains the substance but later studies did not find it suggesting that either mis-identified or adulterated material was used in the early studies.
It is reported to contain many other specialized metabolites including steroidal saponins.
This plant has long been used in traditional medicine – in European, Ayurvedic and Unani systems and recent research has been aimed at elucidating what constituents are responsible for the medicinal benefit.
Extract of black hellebore is used sometimes in Germany as an adjuvant treatment for some types of tumour.
A recent paper* reports the results of a safety and efficacy investigation. The Helleborus niger extract tested was shown to exhibit neither genotoxic nor haemolytic effects but it was shown to have anti-angiogenetic effects on human umbilical vein endothelial cells (HUVEC), anti-proliferative effects and migration-inhibiting properties on tumour cells thus supporting its use in cancer treatment.
* Felenda, J.E., Turek, C., Mörbt, N. et al. Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment. BMC Complement Altern Med 19, 105 (2019) doi:10.1186/s12906-019-2517-5
In this second article in our ‘How to…’ series, we reflect on what we learned from Mugdha Joshi, IP & Licensing expert at Kings College London, in her training session on Intellectual Property.
What is Intellectual Property?
Intellectual Property (IP) is a term that refers to the ‘creations of the mind’ such as inventions, works of art and symbols, names and images used in commerce.
Types of IP
Patents - Works to prevent another person from being able to use the same invention. They cover how inventions work, how they do it, what they are made of and how they are made. A patent lasts for 20 years and it must be renewed on its fourth anniversary. It then must be renewed every year. After 20 years the patent is given to the public. To qualify for a patent, the invention needs to meet the following criteria:
- The invention needs to be undisclosed and not in the public domain before the date of filing. However, any disclosure under a non-disclosure agreement is fine.
- Your idea needs an inventive step that is not obvious to someone with knowledge of the subject.
- It must be a solution to a problem.
- It must be something that can be made and not just speculative.
Copyrights – Protects work created by their author. It must be the author’s own intellectual creation and not have been copied from somewhere else.
Designs – This refers to the aesthetic aspects of an article. It protects 3D objects, or the designs applied to them.
Trademarks – A distinctive sign that identifies certain goods or properties provided by an individual or a company.
Commercialisation of IP
The commercialisation process involves:
- Market analysis - What does your product solve? Why is it better than your competition? Who wants it and why? What are its limitations? What is the development time? (Click here for more on marketing).
- Due Diligence - In-depth research of your company and invention and will include schedules of patents, copyrights and trademarks
- IP protection - Prior art search and patent attorney. You must ensure there is no evidence of your idea already being known.
- Proof of concept fund
- Marketing - Reaching out to companies and sending non-confidential flyers
- Licensing - What’s down the pipeline? Exclusive or non-exclusive licence? What obligations are there, e.g. development milestones?
- Spit-out creation - What do venture capitalists look for? They will want to see all your documentation that demonstrates that you meet various requirements. They will want to see your granted patents. It is a good idea to have a portfolio with multiple aspects of the product covered. They want to see that your product and company is professionally managed and that there are no issues of contested ownership or opposition.
The Bright SCIdea Challenge 2020 Final
SCI are unable to protect any intellectual property submitted as part of the competition. It is in your best interest to not disclose any information that could give away key aspects of your innovation for others to reproduce.
This latest instalment of SCI Energy Group’s blog delves deeper into the working life of another one of its own members – Peter Reineck.
Peter is currently a consultant working alongside technology developers. Throughout this article, he shares insights into his career to date.
Figure 1- Peter Reineck
Peter, can you please provide a brief introduction about yourself?
I worked with a number of chemical and environmental service companies in the UK and Canada in commercial operations roles.
I now work as a consultant with technology developers to support market and business development.
Can you please explain how your job is aligned with the energy sector?
I have a particular interest in advanced combustion systems with CO2 capture.
Most recently, I became involved in a new project to produce bio-based plastic that would replace fossil-based plastics in packaging and other applications.
Bio-based plastic has the advantage of producing biogenic CO2 if composted or sent for energy recovery at end of life.
In your current role, what are your typical day-to-day tasks?
Typically, my work involves communicating with stakeholders by phone and email and in meetings, assessing their responses and planning developments accordingly.
Figure 2 - A knowledge of science is particularly helpful
How has your education/previous experience prepared you for this role?
I would say that English language skills and a knowledge of science and chemistry in particular have been the most helpful in my career.
What is your favourite aspect of your current job role?
Consultancy works well for me as the focus is on business development activities; as well, the hours are flexible.
What is the most challenging part of your job?
A high degree of self-discipline is required in order to meet deadlines.
So far, what is your biggest accomplishment/ achievement throughout your career?
The most satisfying were moving a number of businesses forward into new markets and applications.
Figure 3 - Self-discipline is required to meet deadlines
In your opinion, what do you think is the biggest problem faced in this field of work at present?
I think the biggest problem is regulatory changes which affect the potential market for new technologies for packaging and power generation.
These changes are governmental responses to activist claims which are not based on a holistic interpretation of a complete set of data.
What advice would you give someone who is seeking / about to enter the same field of work?
A practical understanding of science and statistics is essential. Combined with, an ability to translate new technologies into solutions which are economically viable.
On 6 December 2019 SCI held its entrepreneurial training day for this year’s Bright SCIdea Challenge. The first article in our How to series will take a look at what we learned from Neil Simpson, R&D Director at Borchers, in his training session on how to market and brand your idea.
In order to successfully promote a product or service, it is essential to understand the customer and the market. It is important to be more effective than your competitors in creating, delivering and communicating your idea.
Segmentation, Targeting and Positioning (STP) is a useful tool to help you to define your product and customer base.
When segmenting your customer base, consider the demographics including age, income and gender, as well as their geographical location and behavioural traits.
Once you have segmented your customer base, you will be able to identify which groups are the most suited for your product.
After you have considered which segments to target, you need to take into consideration what your product solves for these people – what is your unique selling point?
The 4 Ps – Marketing Mix
Once you have used the STP framework to define your product and customer base, you can use the 4 Ps Marketing Mix to develop a strategy to bring your product to the market.
Product – This can be a tangible product, for example clothing, or a service. You should consider: What does your product stand for? What needs does it satisfy? How does it differ to your competitors?
Price – It is vital to think carefully about the pricing of your product. Do you compete on price or quality? Consider the perceived value of your product, along with supply costs and competitors’ prices. Pricing your product too high or too low could harm your sales and reputation.
Place – Where is the best location to provide your product to your customer base, and how do you distribute it to them? If you understand your customer base, you will be able to answer important questions such as: Where do your target customers shop? Do they buy online, or in high street shops?
Promotion – What is the most effective way to market your product and which channels should you use? Will you run a social media and email campaign? Would you benefit from attending conferences and exhibitions?
Finally, a useful tool to analyse your current position is the SWOT model. SWOT stands for Strengths, Weaknesses, Opportunities and Threats.
Strengths – How are you perceived by your customer base? What separates you from your competitors?
Weaknesses – What do others see as your weaknesses? What do your competitors do better than you?
Opportunities – What are current market trends? Are there any funding opportunities you could apply for? Are there any gaps in the market?
Threats – Are there any emerging competitors? Do you have any negative media or press coverage?
Using STP, the 4 Ps, and SWOT will be invaluable when it comes to completing your business plan. The more you understand your product, your customer base, where you sell it, and how you sell it, the more successful you will be!
>> Curious to learn how colour might affect your branding? Here's how: https://www.logodesign.net/how-colors-tint-emotions-branding
A growing population is placing greater pressure on limited resources including land, oceans, water and energy. If agricultural production continues in its present form, water degradation, biodiversity loss and climate change will continue. As a result, people are adopting an increased interest in the environmental impact of food choice, choosing alternatives like insects.
This round-up explores examples of the various insect-based alternative foods.
According to data from Grand View Research, a US-based market research company, the global healthy snacks market is expected to reach $32.88 billion by 2025. Companies across Europe are developing healthy snack products based on insects, tapping into our desire for a variety of foods and tastes.
Eat Grub, established in 2013 and based in London UK, developed an insect snack made from house crickets, which are farmed in Europe. They are a sustainable, nutritious and tasty source of food, rich in protein. Research has indicated that insects are good for gut health due to their high chitin content. Chitinous fibre has been linked to increased levels of a metabolic enzyme associated with gut health.
A start-up Belgian beer company, Belgium Beetles Beer, described their drink as a real Belgium blond beer enriched with insect vitamins and proteins.
Upon ‘accidentally’ developing this product, they realised that the dry beetle powder offered a rich, light sweet, slightly bitter flavour.
A growing number of companies are now focusing their efforts on producing a product that looks and tastes like a traditional meat-based burger.
Bugfoundation’s burgers are based on buffalo worms, which are the larvae of the Alphitobius Diaperinus beetle. The company’s founders said that they decided to use buffalo worms because of their ‘slightly nutty flavour.’
The idea stemmed from a trip to Asia, where co-founder, Max Charmer came across fried crickets. His experience inspired him to bring these flavours to the west, hoping to please western tastes and comply with evolving European regulations.
Concerns regarding the livestock system have prompted novel inventions in the food space; insects, considered a source of protein, could outperform conventional meats to reduce environmental impacts.
So, will consumers soon be able to introduce insects to their everyday diets? Only time will tell.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on Beryllium.
Beryllium copper alloys account for a huge percentage of the beryllium used in the United States. As these alloys are good conductors of electricity and heat, they are used in making connectors, switches and other electrical devices for use in many sectors including aerospace, automobile, computer, defense and medical.
Beryllium metal is very light and stiff and maintains its shape in both high and low temperatures. This makes it the ideal material for use as mirrors of the Spitzer Space Telescope and the James Webb Space Telescope (JWST), due to be launched in the next few years. The key mirror of the JWST comprises 18 hexagonal segments- each must maintain its shape even at - 400 degrees Fahrenheit.
Automobile and Aircraft
Additionally, Beryllium alloy connectors are used in the electrical systems of automobiles, as they are reliable and improve vehicle fuel efficiency.
In commercial aircraft, the strength of beryllium copper provides many advantages, as it can handle wear forces and exposure to corrosive atmospheres and temperatures. Beryllium copper also allows bearings to be made lighter and smaller, which also improves fuel efficiency.
Beryllium copper’s strength and stability makes it ideal for medical technologies and x-ray equipment.
As imaging technology progresses, beryllium copper will continue to play an important role in x-ray tube windows.
Other medical uses of beryllium:
•Springs and membranes for surgical instruments
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on Nickel.
Nickel, a silvery-white lustrous metal with a slight golden tinge may be commonly known as a US five cent coin, however, today nickel is one of the most widely used metals. According to the Nickel Institute, the metal is used in over 300,000 various products. It is also commonly used as a catalyst for hydrogeneration, cathodes for batteries and metal surface treatments.
Nickel in batteries:
Historically, nickel has been widely used in batteries; nickel cadmium (NiCd) and in nickel metal hydride (NiMH) rechargeable batteries. These batteries were used in power tools and early digital cameras. Their success as batteries in portable devices became a stepping stone that led to the significant use of NiMH batteries in car vehicles, such as the Toyota Prius.
The demand for nickel will increase even further as we move away from fossil fuel energy. More energy wll need to be stored in the cathode part of lithium-ion batteries as a result.
Socio-economic data on nickel demonstrates the importance the nickel value chain has on industries, which includes mining through end use to recycling.
The data reflects that globally, the nickel value chain supports a large number of jobs, primarily ones in manufacturing and chemical engineering. The output generated by nickel related industries is approximately €130bn, providing around 750,000 jobs.
Nickel is fully recyclable without its qualities being downgraded, making it very sustainable. It is difficult to destroy and its qualities – corrosion resistance, high-temperature stability, strength, recyclability, and catalytic and electromagnetic properties are enabling qualities required for sustainability.
Congratulations to Hallam Wheatley, voted Young Ambassador of 2019/2020!
Can you tell us about your early involvement in the chemical industry?
My career in the chemical industry began at the age of 18 as an advanced apprentice. I spent two years completing my laboratory-based apprenticeship with Lotte Chemical on Teesside, where my passion for chemistry really materialised. Applying chemical principles into the world of work gave me a great appreciation for just how big a role chemistry plays in our everyday lives. After finishing my apprenticeship, I began studying part-time, for my degree in Chemistry.
Can you tell about your work as a research chemist?
In 2017, I began working in SABIC’s research department, this really put me on the front line of the innovative technology that is being developed in the world today. As a research chemist, my main responsibilities revolve around supporting SABIC’s assets, and any chemistry related issues they may have. During my time, that’s mainly revolved around catalyst research. When I’m not helping with plant support, I work on sustainability issues, that will help answer some of the world’s toughest questions, relating to the chemical recycling of plastic waste, or helping to implement a hydrogen economy, to help reduce carbon emissions.
How do you feel to be named Young Ambassador of the year?
I was in shock when my name was called! The standard of applicants was really high, so to be named the Young Ambassador this year was a real honour.
I do feel that the award won’t mean a thing if I don’t make the most of my time as the Young Ambassador. It’s important to carry on the great work from last year and try and help the Future Forum continue to grow.
I know that task won’t be easy, but it’s really great that a lot of the short-listed finalists, have agreed to join the Leadership team this year, so I’m really excited to work with them, and I’m excited for the year ahead!
What are your plans for the year ahead as Young Ambassador and with the Future Forum?
As Young Ambassador, I’m really hoping to continue the great work that Jennifer did last year. I want to build up a resource to help Future Forum members old and new alike.
I think it’s important that as a network we communicate effectively with each other to not only get an understanding of how young people are feeling in the industry, but also to identify some of the challenges their facing, as well as offering support from within the network.
I want to make the Future Forum something that people want to join, not because it looks good on a CV, but because it will offer people real opportunities to develop and network. This won’t be easy, but through help from Jennifer and this year’s Leadership Team, I think we’ll be able to lay strong foundations, so that moving forward, to Future Forum can be more than just a young professional networking platform.
What advice would you give someone starting out their career as a research chemist?
Look around!! Whilst I knew that I had a passion for Chemistry, I wasn’t so sold on the idea of university at 18 and after college. I decided to see what my best route into the industry that was on my doorstep was, and I was fortunate enough to find an apprenticeship that suited me. The apprenticeship gave me the grounding knowledge and understanding to progress, and two years later, I felt ready to tackle the challenge of a degree.
I do know, that whilst the apprenticeship route worked for me, it won’t work for everyone, but I think it’s important that students of all ages understand that there’s multiple choices that they may not have heard. Over the coming year, I’m hoping to use the Future Forum as a tool to best showcase some of the options to get a career within the Chemical Industry.
One thing I would recommend for all students though, is email local chemical companies, ask HR departments for advice about careers, and ask about the opportunities to come in and shadow, even if it’s only for a day! You’ll learn a lot, but you never know what it might lead to!
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on tungsten.
Over three centuries ago, this metal was first used by porcelain makers in China. They used a tungsten pigment to incorporate a peach colour into their art work. In 1781, Wilhelm Scheele examined a metal containing tungsten and successfully isolated an acidic white oxide, deducing the oxide of the new metal. In 1783, Wilhelm’s brothers produced the same acidic metal oxide, and upon heating it with carbon, they successfully reduced it to tungsten.
Tungsten raises concerns regarding the health effects associated with its levels of toxicity. Initially, tungsten was perceived to be immobile in the environment and therefore used as a viable replacement for lead and uranium in military applications. However, reports showed traces of tungsten detected in soil and potable water sources, increasing the risk to human exposure. According to public health reports, it is unlikely that tungsten present in consumer products poses a hazard or causes any long-term health effects. Therefore, further assessment on the potential long-term health effects of tungsten exposure is still required.
Tungsten is a refractory metal and as it has the highest melting temperature of all metals, it is used across a range of applications. Tungsten is alloyed with other metals to strengthen them. This makes them useful to many high-temperature applications, including arc-welding electrodes.
Tungsten is a refractory metal and as it has the highest melting temperature of all metals, it is used across a range of applications. Tungsten is alloyed with other metals to strengthen them. This makes them useful to many high-temperature applications, including arc-welding electrodes.
It is used as a novel material for glass parts due to its superior thermochemical stability. As it is a good electric conductor, it is also used in solar energy devices. Tungsten compounds act as catalysts for energy converting reactions, leading many manufacturers to investigate further uses of tungsten.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry.
Discovery of this noble gas:
In 1894 argon was discovered by chemists Sir William Ramsay and Lord Rayleigh. Ramsay believed the presence of a heavy impurity in the ‘atmospheric’ nitrogen could be responsible for giving nitrogen a higher density when isolated from the air. Both scientists worked to discover this unrecognised new element hiding in the air, winning a Nobel Prize in 1904, primarily for their role in the discovery of argon.
Argon makes up 1% of the earth’s atmosphere and it is the most plentiful of the rare gases. Argon can be both used in its gaseous state and its liquid form. In its liquid state, argon can be stored and transported more easily, affording a cost-effective way to deliver product supply.
Argon as a narcotic agent
One of the most well-known biological effects of argon gas is in its narcotic capabilities. Sea divers normally develop narcotic symptoms under high pressure with normal respiratory air. These symptoms include slowed mental cognition and psychological instability. Argon exerts this narcotic effect in a physical way rather than in a chemical way, as argon, an inert gas, does not undergo chemical reactions in the body.
During the heating and cooling of printing materials, argon provides several benefits to this process. The gas reduces oxidation of the metal preventing reactions and keeping out impurities. This creates a stable printing environment as a constant pressure is maintained.
Future of argon
Argon as a clinical utility tool has received maximum attention. Although the potential benefits are still in the experimental stages, argon could be the ideal neuroprotective agent. Studies have shown that argon could improve cell survival, brain structural integrity and neurological recovery. These protective effects are also efficient when delivered up to 72 hours after brain injury.
Springtime colour is one of gardening’s greatest joys. Colourful bursts dispel the long darkness of winter with its depressing wetness and cold. Social research is clearly showing the physical and mental benefits obtained from the emergence in spring of bright garden colours linked with lengthening daylight. As with most gardening pleasures, this requires advanced financial outlay and an understanding of the rhythms of plant growth.
Planting bulbs such as daffodils, tulips and hyacinths in autumn is the necessary investment. In return, plant breeders now provide a huge array of colours, shapes, sizes and seasonal sequencing with bulbous plants.
Geoff Dixon: February Gold daffodils
Bulbs are large pieces of vegetative tissue which come pre-loaded with immature leaves and flowers, safely wrapped inside a dry coating of protective scales. Essentially, bulbs are large flower buds which are stimulated into growth by planting in warm, moist soil or compost. These conditions trigger the emergence of roots from the base of each bulb. Because bulbs are nascent plants, they require careful handling and are safest once planted.
Many bulbous species originate from higher altitude mountainous pastures and are naturally evolved for dealing with fluctuating periods of heat, cold and drought. Once safely planted at depths which should equal twice the length of each bulb, they will survive the freezing, thawing and fluctuating soil water- content delivered by winter weather.
Geoff Dixon: Bulb structure showing the flower bud embedded in the bulb
Warming soils of spring encourage growth and emergence of the leaves and flower buds contained within each bulb. Speed of emergence is governed by interaction between the genetic complement of bulbs and an interaction with their environment. Identifying and understanding the impact of this interaction formed the basis for Charles Darwin and Alfred Wallaces’ theory of natural selection. For springtime gardeners it is expressed in the multiplicity of bulbs on offer. Choosing a range of daffodil varieties for example, provides colourful gardens from February through to late May.
Geoff Dixon: Technique for planting bulbs using hand trowel and some sand for drainage under the bulb
Conserving the joys of spring pleasure over years can be achieved by naturalising bulbs. This means planting them in grass swards. This works effectively for daffodils, provided the foliage is allowed 8 to 10 weeks of uninterrupted growth and senescence after flowering. During this period, photosynthesis produces the chemical energy needed for replacement growth, which provides bulb multiplication and flower bud development for the following year. Tulips are much less easily naturalised in British gardens. This is because the leaves mature and senesce much more quickly after flowering, hence, less energy is produced, therefore, regrowth is less, and replacement flower buds are not formed.
For most gardeners the policy should be one of enjoying each springtime’s show and replacing bulbs with new ones every autumn for a relatively modest outlay.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on zinc and its contribution towards a sustainable future.
Foods high in zinc: Evan Lorne
Zinc is a naturally occurring element, considered a ‘life saving commodity’ by the United Nations. As well as playing a fundamental role in the natural development of biological processes, it is also highly recyclable which means that once it has reached the end of its life cycle, it can be recycled, and returned to the cycle as a new source of raw material. Statistically, around 45% of zinc in Europe and in the United States is recovered and recycled once it has reached the end of its life cycle.
Circular and linear economy showing product life cycle: Petovarga
Circular economy is an economic model that focuses on waste reduction and ensuring a product that has reached its end cycle is not considered for disposal, but instead becomes used as a new source of raw material. Zinc fits this model; its lifecycle begins from mining and goes through a refining process to enable its use in society. Finally, it is recycled at the end of this process.
The production of zinc-coated steel mill: gyn9037
Zinc contributes to the planet in various ways:
1. Due to its recyclable nature, it lowers the demand for new raw material
2. As zinc provides a protective coating for steel, it extends the lifecycle of steel products
3. Coating steel reduces carbon dioxide emissions
As reported by the Swedish Environmental Protection Agency, zinc uses the lowest energy on a per unit weight and per unit volume basis, (with the exception of iron). Only a small amount of zinc is needed to conserve the energy of steel, and during electrolytic zinc production, only 7% of energy is used for mining and mineral processing.
Green technology: Petrmalinak
According to a new report published by The World Bank, ‘The Growing Role of Minerals and Metals for a Low-Carbon Future,’ a low carbon future and a rise in the use of green energy technologies will lead to an increased demand in a selected range of minerals and metals. These metals include aluminium, copper, lead, lithium, manganese, nickel, silver, steel, zinc and rare earth minerals. Hence, zinc will be one of the main metals to fill this demand.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on titanium and its various uses in industries.
What is titanium?
Titanium is a silver- coloured transition metal, exhibiting low density, high strength and a strong resistance to corrosion from water and chlorine. Suitably, titanium delivers many uses to various industries with approximately 6.6 million tonnes produced annually.
Titanium Dioxide is the most popular usage of titanium, composed of approximately of 90%. It is a white powder with high opacity; its properties have been made for a broad range of applications in paints, plastic good, inks and papers. Titanium dioxide is manufactured through the chloride process or the sulphate process. The sulphate process is the more popular process making up 70% of the production within the EU.
Titanium’s characteristics - lightweight, strong and versatile, make titanium a valuable metal in the aerospace industry. In order for aircrafts to be safely airborne, the aerospace industry need parts which are both light and strong, and at the same time safe. Thus, titanium is seen as the most ideal match for these specifications.
Titanium implants have been used with success, becoming a promising material in dentistry. As a result of its features, including its physiological inertia, resistance to corrosion, and biocompatibility, titanium plays an important role in the dental market.
However, despite this, the technologies and systems used in the machining, casting and welding of titanium is slow and expensive. Despite the wide availability of these technologies and systems used in the process of creating dental prosthesis from titanium, it does depend on the technological advancements and the availability of resources, to create a more profitable and efficient manufacturing process.
Aldrin, Armstrong and Collins, Apollo 11’s brave astronauts were the first humans with the privilege of viewing Earth from another celestial body. These men uniquely wondered “what makes Earth special?” Certainly, within our Solar System, planet Earth is very special. Its environment has permitted the evolution of a panoply of life.
Green plants containing the pigment, chlorophyll either in the oceans as algae or on land as a multitude of trees, shrubs and herbs harvest energy from sunshine. Using a series of chemical reactions, known as photosynthesis, light energy is harvested and attached onto compounds containing phosphorus.
Captured energy then drives a series of reactions in which atmospheric carbon dioxide and water are combined forming simple sugars while releasing oxygen. These sugars are used further by plants in the manufacture of larger carbohydrates, amino acids and proteins, oils and fats.
The release of oxygen during photosynthesis forms the basis of life’s second vital process, respiration. Almost all plants and animals utilise oxygen in this energy releasing process during which sugars are broken down.
Released energy then drives all subsequent growth, development and reproduction. These body-building processes in plants are reliant on the transfer of the products of photosynthesis from a point of manufacture, the source, to the place of use, a sink.
Leaves and shoots are the principle sources of energy harvesting while flowers and fruits are major sinks with high levels of respiration.
Figure 1: Photosynthesis vs respiration, drawn by James Hadley
Transfer between sources and sinks occurs in a central system of pipes, the vascular system, using water as the carrier. Water is obtained by land plants from the soils in which they grow. Without water there would be no transfer and subsequent growth. Earth’s environment is built around a ‘water-cycle’ supplying the land and oceans with rain or snow and recycles water back into the atmosphere in a sustainable manner.
Early in Earth’s evolution, very primitive marine organisms initiated photosynthetic processes, capturing sunlight’s energy. As a result, in our atmosphere oxygen became a major component. That encouraged the development of the vast array of land plants which utilise rain water as the key element in their transport systems.
Subsequently, plants formed the diets of all animals either by direct consumption as herbivores or at second-hand as carnivores. As a result, evolution produced balanced ecosystems and humanity has inherited what those astronauts saw, “the Green Planet”.
Earth will only retain this status if humanity individually and collectively defeats our biggest challenge – climate change. Burning rain forests in South America, Africa and Arctic tundra will disbalance these ecosystems and quicken climate change.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on sodium and its role in the next series of innovative nuclear energy systems.
Sodium; the sixth most abundant element on the planet is being considered as a crucial part of nuclear reactors. Implementing new safety levels in reactors is crucial as governments are looking for environmentally friendly, risk-free and financially viable reactors. Therefore, ensuring new safety levels is a main challenge that is being tackled by many industries and projects.
In the wake of Fukushima, several European nations and a number of U.S plants have shut down and switched off their ageing reactors in order to eliminate risk and safety hazards.
The sodium- cooled fast reactor (SFR), a concept pioneered in the 1950s in the U.S, is one of the nuclear reactors developed to operate at higher temperatures than today’s reactors and seems to be the viable nuclear reactor model. The SFR’s main advantage is that it can burn unwanted byproducts including uranium, reducing the need for storage. In the long run, this is deemed cost-competitive as it can produce power without having to use new natural uranium.
Nuclear reactor. Source: Hallowhalls
However, using sodium also presents challenges. When sodium comes into contact with air, it burns and when it is mixed with water, it is explosive. To prevent sodium from mixing with water, nitrogen - driven turbines are in the process of being designed as a solution to this problem.
A European Horizon 2020 Project, ESFR-SMART project (European Sodium Fast Reactor Safety Measures Assessment and Research Tools), launched in September 2017, aims to improve the safety of Generation-IV Sodium Fast Reactors (SFR). This project hopes to prove the safety of new reactors and secure its future role in Europe. The new reactor is designed to be able to reprocess its own waste, act more reliably in operation, more environmentally friendly and more affordable. It is hoped that this reactor will be considered as one of the SFR options by Generation IV International Forum (GIF), who are focused on finding new reactors with safety, reliability and sustainability as just some of their main priorities.
European Horizon. Source: artjazz
Globally, the SFR is deemed an attractive energy source, and developments are ongoing, endeavouring to meet the future energy demands in a cost-competitive way.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on lead and its place in the battery industry.
2019 is a critical year for the European Battery Industry. As policymakers set priorities to decarbonise the energy systems, whilst boosting Europe’s economic and technical performance, lead-acid batteries have become a viable player in the battery industry.
Increased government action and ongoing transformations to address the environmental situation has furthered global interest in the lead battery market, as they remain crucial in the battle to fight against the adverse effects of climate change. Subsequently, reliance on fuel technologies is lessening as we see a rise in the lead battery industry which had a market share of 31% in year 2018 with an annual growth rate of 5.4%.
According to reports by Reports and Data, the Global Lead- Acid Battery market is predicted to reach USD 95.32 Billion by 2026. Rising demand for electric vehicles and significant increases of this battery use in sectors including automotive, healthcare, and power industries, are a large push behind the growth in this market.
Thus, expansion of these sectors and particularly the automobile sector, means further development in this market will be underway, especially as it is the only battery technology to meet the technical requirements for energy storage on a large market scale.
Lead-acid battery is a rechargeable cell, comprising plates of lead and lead oxide, mixed in a sulfuric acid solution, which converts chemical energy into electrical power. The oxide component in the sulfuric acid oxidizes the lead which in turn generates electric current.
In the past, lead has fallen behind competing technologies, such as lithium-ion batteries which captured approximately 90% of the battery market. Although lithium-ion batteries are a strong opponent, lead still has advantages. Lead batteries do not have same fire risks as lithium-ion batteries and they are the most efficiently recycled commodity metal, with over 99% of lead batteries being collected and recycled in Europe and U.S.
Researchers are trying to better understand how to improve lead battery performance. A build-up of sulfation can limit lead battery performance by half its potential, and by fixing this issue, unused potential would offer even lower cost recyclable batteries. Once the chemical interactions inside the batteries are better understood, one can start to consider how to extend battery life.
Scottish chemist and past SCI President, Sir William Ramsay (1852–1916) came from a long line of scientists on both sides of his family and was described as ‘the greatest chemical discoverer of his time’.
Born in Glasgow, he showed a strong interest in science from a young age and, in his teenage years, he experimented with making fireworks, using materials acquired by his father.
He completed his doctorate in organic chemistry and later, in 1887, was appointed as the Chair of Chemistry at University College London, where he made his most renowned discoveries.
Working with British physicist John William Strutt (better known as Lord Rayleigh), the two men discovered an unknown gas. Owing to its apparent lack of chemical activity, they named the gas argon, meaning “the lazy one”.
After the co-identification of argon, Sir William Ramsay suggested that it be placed into the periodic table between chlorine and potassium in a group with helium. Due to the zero valency of the elements this was named the “zero” group.
From 1895 Ramsay spent three years trying to prove the theory of this new group of gasses, leading to the isolation of helium, neon, krypton and xenon. Eventually, a new column was added to the periodic table.
Ramsay was an outstanding experimentalist. He rolled his own cigarettes, claiming that machine-made ones were unworthy of an experimentalist such as himself.
In 1904, he was awarded the Nobel Prize in Chemistry “for his discovery of the inert gaseous elements in air, and his determination of their place in the Periodic system”. As a result, Ramsay became a considerable celebrity in London and was cartooned both by Spy for Vanity Fair and by Henry Tonks, Head of UCL’s Slade School of Art.
Ramsay ascribed his success in isolating the rare gases to his large flat thumb which could close the end of eudiometer tubes (graduated glass tube used to mix gases) full of mercury.
The group of elements that he discovered is now known commonly as the noble gases and is comprised of helium, neon, argon, krypton, xenon, and radon. Generally, they are chemically inert (they do not react with other elements) this is because they have the desired amount of total s and p electrons in their outermost energy orbital. However, only helium and neon are truly inert. Under very specific conditions, the other noble gases will react on a limited scale.
Today, the noble gasses are in wide use in the real world.
Argon is particularly important for the metal industry, due to the fact that it does not react with the metal at high temperatures. It is used in arc welding (a welding process that is used to join metal to metal by using electricity to create enough heat to melt metal) and is also used in light bulbs to prevent oxygen from corroding the hot filament.
Helium, one of the most common and lightest elements in the universe, is used for diluting the pure oxygen in deep-sea diving tanks. It’s also used to inflate the tires of large aircraft, weather balloons, blimps and party balloons.
Neon, which means ‘New one’ in Greek, is commonly used in colourful glass tube neon signs, it glows bright red when an electric current is sent through the gas, as it enters a plasma state. Other uses of Neon include in vacuum tubes, television tubes, and helium-neon lasers.
Krypton and xenon, valued for their total inertness, are used in photographic flash units, in lightbulbs and in lighthouses, as these elements generate a bright light when an electric current is run through them.
The original glass tubes that Ramsay used to isolate and collect his samples at UCL still exist today, they continue to glow red, yellow, purple and green, more than a century later.
Not only did Ramsay’s successes complete gaps in the periodic table, but he also paved the way for a deeper understanding of how the elements are connected, shaping our understanding today, a huge achievement that can be attributed in no small part to his experimental nature and his large flat thumb!
Controlling when and how vigorously plants flower is a major discovery in horticultural science. Its use has spawned vast industries worldwide supplying flowers and potted plants out-of-season. The control mechanism was uncovered by two American physiologists in the 1920s. Temperate plants inhabit zones where seasonal daylength varies between extending light periods in spring and decreasing ones in autumn.
Those environmental changes result in plants which flower in long-days and those which flower in short-days. ‘Photoperiodism’ was coined as the term describing these events. Extensive subsequent research demonstrated that it is the period of darkness which is crucially important. Short-day plants flower when darkness exceeds a crucial minimum, usually about 12 hours which is typical of autumn. Long-day plants flower when the dark period is shorter than the crucial minimum.
Irises are long day flowers. Image: Geoffery R Dixon
A third group of plants usually coming from tropical zones are day-neutral; flowering is unaffected by day-length. Long-day plants include clover, hollyhock, iris, lettuce, spinach and radish. Gardeners will be familiar with the way lettuce and radish “bolt” in early summer. Short-day plants include: chrysanthemum, goldenrod, poinsettia, soybean and many annual weed species. Day-neutral types include peas, runner and green beans, sweet corn (maize) and sunflower.
Immense research efforts identified a plant pigment, phytochrome as the trigger molecule. This exists in two states, active and inactive and they are converted by receiving red or far-red wavelengths of light.
Sunflowers are day neutral flowers. Image: Geoffery R Dixon
In short-day plants, for example, the active form suppresses flowering but decays into the inactive form with increasing periods of darkness. But a brief flash of light restores the active form and stops flowering. That knowledge underpins businesses supplying cut-flowered chrysanthemums and potted-plants and supplies of poinsettias for Christmas markets. Identifying precise demands of individual cultivars of these crops means that growers can schedule production volumes gearing very precisely for peak markets.
Providing the appropriate photoperiods requires very substantial capital investment. Consequently, there has been a century-long quest for the ‘Holy Grail of Flowering’, a molecule which when sprayed onto crops initiates the flowering process.
Chrysanthemums are short day flowers. Image: Geoffery R Dixon
In 2006 the hormone, florigen, was finally identified and characterised. Biochemists and molecular biologists are now working furiously looking for pathways by which it can be used effectively and provide more efficient flower production in a wider range of species.
The banana colour scheme distinguishes seven stages from ‘All green’ to ‘All yellow with brown flecks’. The green, unripe banana peel contains leucocyanidin, a flavonoid that induces cell proliferation, accelerating the healing of skin wounds. But once it is yellowish and ready to eat, the chlorophyll breaks down, leaving the recognisable yellow colour of carotenoids.
Unripe (green) and ready-to-eat (yellow) bananas.
The fruits are cut from the plant whilst green and on average, 10-30 % of the bananas do not meet quality standards at harvest. Then they are packaged and kept in cold temperatures to reduce enzymatic processes, such as respiration and ethylene production.
However, below 14°C bananas experience ‘chilling injury’ which changes fruit ripening physiology and can lead to the brown speckles on the skin. Above 24°C, bananas also stop developing fully yellow colour as they retain high levels of chlorophyll.
Once the green bananas arrive at the ripening facility, the fruits are kept in ripening rooms where the temperature and humidity are kept constant while the amount of oxygen, carbon dioxide and ethene are controlled.
The gas itself triggers the ripening process, leads to cell walls breakdown and the conversion of starches to sugars. Certain fruits around bananas can ripen quicker because of their ethene production.
By day five, bananas should be in stage 2½ (’Green with trace of yellow’ to ‘More green than yellow’) according to the colour scale and are shipped to the shops. From stage 5 (’All yellow with green tip’), the fruits are ready to be eaten and have a three-day shelf-life.
A fruit market. Image: Gidon Pico
The very short shelf-life of the fruit makes it a very wasteful system. By day five, the sugar content and pH value are ideal for yeasts and moulds. Bananas not only start turning brown and mouldy, but they also go through a 1.5-4 mm ‘weight loss’ as the water is lost from the peel.
While scientists have been trying out different chemical and natural lipid ‘dips’ for bananas to extend their shelf-life, such methods remain one of the greatest challenges to the industry.
In fruit salads, to stop the banana slices go brown, the cut fruits are sprayed with a mixture of citric acid and amino acid to keep them yellow and firm without affecting the taste.
Bananas are a good source of potassium and vitamins.
The high starch concentration – over 70% of dry weight – banana processing into flour and starch is now also getting the attention of the industry. There are a great many pharmaceutical properties of bananas as well, such as high dopamine levels in the peel and high amounts of beta-carotene, a precursor of vitamin A.
Whilst the ‘seven shades of yellow’ underpin the marketability of bananas, these plants are also now threatened by the fungal Panama disease. This vascular wilt disease led to the collapse of the banana industry in the 1950’s which was overcome by a new variety of bananas.
However, the uncontrollable disease has evolved to infect Cavendish bananas and has been rapidly spreading from Australia, China to India, the Middle East and Africa.
The future of the banana industry relies on strict quarantine procedures to limit further spread of the disease to Latin America, integrated crop management and continuous development of banana ‘dips’ for extending shelf-life.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog focuses on silicon’s positive effects on the body.
Silicon was not originally regarded as an important element for human health, as it was seen to have a larger presence in (other) animal and plant tissue. It was not until a 2002 ‘The American Journal of Clinical Nutrition’ paper that surmised that accumulating research found that silicon plays an important role in bone formation in humans.
Silicon was first known to ‘wash’ through biology with no toxological or biological properties. However, in the 1970s, animal studies provided evidence to suggest that silicon deficiency in diets produced defects in connective and skeletal tissues. Ongoing research has added to these findings, demonstrating the link between dietary silicon and bone health.
Silicon plays an important role in protecting humans against many diseases. Silicon is an important trace mineral essential for strengthening joints. Additionally, silicon is thought to help heal and repair fractures.
The most important source of exposure to silicon is your diet. According to two epidemiological studies (Int J Endocrinol. 2013: 316783 ; J Nutr Health Aging. 2007 Mar-Apr; 11(2): 99–110) conducted, dietary silicon intake has been linked to higher bone mineral density.
Silicon is needed to repair tissue, as it is important for collagen synthesis – the most abundant protein in connective tissue in the body – which is needed for the strengthening of bones.
However, silicon is very common in the body and therefore it is difficult to prove how essential it is to this process when symptoms of deficiency vary among patients.
There has also been a plausible link between Alzheimer’s disease and human exposure to aluminium. Research has been underway to test whether silicon-rich mineral waters can be used to reduce the body burden of aluminium in individuals with Alzheimer’s disease.
However, longer term study is needed to prove the aluminium hypothesis of Alzheimer’s disease.
Globally, beers with flavours of fruits and touches of acidity notes have become very popular among consumers. Nowadays, experience has become the biggest trend in drinks; consumers desire an immersive experience and seek drinks with enhanced characteristics which include texture, mouthfeel, taste, flavour and colour.
Over the course of history, brewing became an essential element in rural communities. A study at Simon Fraser University in Canada investigated beer-brewing tools in archaeological remains belonging to the Natufian culture in the Eastern Mediterranean. The examination showed that the brewing of beer was an important cultural component of their society. Studies in Mexico suggested that generations of Mexican farmers domesticated grass into maize, which became a staple of the local diet before it became great for making beer.
As suggested, brewing became an essential element in rural communities and has now transformed from a small-scale local activity to a worldwide industry.
Belgium is known for its traditional and spontaneous mixed fermented beers, such as lambic beers which harbour complex micro-biotics.
Lambic beers are among the most ancient brewing styles and its unique flavour profile has garnered global popularity.
Wooden barrels play an essential role during its fermentation processes. Lambic brewers prefer using wooden barrels, which often come from red wine productions, as the wooden surfaces harbour a resident microbiota, providing an additional microbial inoculation source for lambic production.
These barrels are preferred because most of the oak flavours will not come through in the final production of lambic, as the oak character has been stripped from the barrel.
Consumers regard the combination of taste and odour as essential factors to their choice. Flavour quality degradation can be triggered by various factors.
Prolonged periods of transportation and storage causes the fresh flavour of beer to deteriorate. Different temperatures in combination with vibrations during transport can negatively influence the quality of beer.
High temperatures can reduce the freshness of beer, increasing the amount of oxidative and non-oxidative chemical reactions which take place. These oxidative reactions degrade the flavour and quality of beer.
It seems vibrations can cause an impact on beer quality subject to an elevated temperature, therefore, temperature reductions during transport and storage should be a primary focus for brewers. However, further research is required with regard to closely examining the influence of transport vibrations on the flavour of beer.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today, we investigate the uses of platinum.
Around 1200BC, archaeologists discovered traces of platinum in gold in ancient Egyptian burials.
However, the extent of Egyptians’ knowledge of the metal remains unknown, which suggests that Egyptians might have been unaware that platinum existed in the gold.
The Ancient Egyptians made elaborate masks for royals to wear once they were mummified.
Platinum was also used by South Americans with dates going back 2000 years. Burial goods show that in the pacific coast of South America, people were able to work platinum, producing artifacts of a white gold-platinum alloy.
Archaeologists link the South American tradition of platinum-working with the La Tolita Culture. Archaeological sites show the highly artistic nature of this culture, with the artifacts characterised by gold and platinum jewellery, and anthropomorphic masks symbolising the hierarchical and ritualistic society.
What are its properties?
Platinum is a silvery white metal, also known as ‘white gold’. It is extremely resistant to tarnishing and corrosion and it is one of the least reactive metals, unaffected by water and air, which means it will not oxidise with air.
It is also very soft and malleable, and therefore can be shaped easily and due to its ductility, it can be easily stretched into wire.
Platinum is a member of group 10 of the periodic table. The group 10 metals have several uses including decorative purposes, electrical components, catalysts in a variety of chemical reactions and play an important role in biochemistry, particularly platinum compounds which have widely been used as anticancer drugs.
Additionally, platinum’s tarnish resistance characteristics makes it one the most well-suited elements for making jewelry.
Platinum bonds are often used as a form of medicine in treatments for cancer. However, the health effects of platinum are dependent on the kinds of bonds that are formed, levels of exposure, and the immunity of the individual.
In 1844, Michele Peyrone, an Italian chemist, discovered the anti-neo plastic properties (apparently prohibiting the development of tumours) and later in 1971, the first human cancer patient was treated with drugs containing platinum.
Today, approximately 50% of patient are treated using medicine which includes the rare metal. Scientists will look further into all the ways platinum drugs affect biology, and how to design better platinum drugs in the future.
In an era of glass and steel construction, wood may seem old-school. But researchers are currently saying its time to give timber a makeover and bring to use a material that is able to store and release heat.
Transparent wood could be the construction material of choice for eco-friendly houses of the future, after researchers have now created an even more energy efficient version that not only transmits light but also absorbs and releases heat, potentially saving on energy bills.
Researchers from KTH Royal Institute of Technology in Stockholm reported in 2019 that they would add polymer polyethylene glycol (PEG) to the formulation to stabilise the wood.
PEG can go really deep into the wood cells and store and release heat. Known as a phase change material, PEG is a solid that melts at 80°F – storing energy in the process. This process reverses at night when the PEG re-solidifies, turning the window glass opaque and releasing heat to maintain a constant temperature in the house.
Transparent wood for windows and green architecture. Video: Wise Wanderer
In principle, a whole house could be made from the wooden window glass, which is due to the property of PEG. The windows could be adapted for different climates by simply tailoring the molecular weight of the PEG, to raise or lower its melting temperature depending on the location.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today we look at copper and some of its popular uses.
A brief history
Copper was one of the first metals ever extracted and used by humans. According to the US Geological Survey, copper ranks as the third most consumed industrial metal in the world, dating back to around 5000BC.
Around 5500BC, early ancestors discovered the malleable properties of copper, and discovered they could be fashioned into tools and weapons – a discovery that allowed humans to emerge out of the stone age and drift into the age of metals.
Volcanic rocks in Tenerife, Spain.
Approximately two-thirds of the Earth’s copper is found in volcanic rocks, while approximately one-quarter occurs in sedimentary rocks.
Th metal is malleable, meaning it can conduct heat and electricity, making copper an extremely useful industrial metal and is used to make electronics, cables and wiring.
What is it used for?
Since 4500BC humans have made and manufactured items from copper. Copper is used mostly as a pure metal, but its strength and hardness can be adjusted by adding tin to create a copper alloy known as bronze.
In the 1700s, pennies were made from pure copper; in the 1800s they were made from bronze; and today, pennies consist of approximately 97.5% zinc and 2.5% copper.
Copper is utilised for a variety of industrial purposes. In addition to copper’s good thermal and electric conductivity, copper now plays an important role in renewable energy systems.
As copper is an excellent conductor of heat and electricity, power systems use copper to generate and transmit energy with high efficiency and minimal environmental impacts.
E. Coli cultures on a Petri dish.
Copper plays an important role as an anti-bacterial material. Copper alloy surfaces have properties which are set out to destroy a wide range of microorganisms.
Recent studies have shown that copper alloy surfaces kill over 99.9% of E.coli microbes within two hours. In the interest of public health, especially in healthcare environments, studies led by the Environmental Protection Agency (EPA) have listed 274 different copper alloys as certified antimicrobial materials, making copper the first solid surfaced material to have been registered by the EPA.
Copper has always maintained an important role in modern society with a vast list of extensive uses. With further development of renewable energy systems and electric vehicles, we will likely see an ongoing increase in demand for copper.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today we look at arsenic and some of its effects.
What is arsenic?
Arsenic is a chemical element found in nature – low levels of arsenic are found in water, air and soil – in man-made products. As arsenic is distributed throughout the environment, people have high exposure to elevated levels of inorganic arsenic through contaminated drinking water, as well as exposure to arsenic through oceans, food and insecticides.
Is arsenic harmful?
Arsenic can occur in an organic and inorganic form. Organic arsenic compounds are less harmful to our health, whereas, inorganic arsenic compounds (e.g those found in water) are carcinogens, which are highly toxic and dangerous. Arsenic contamination of groundwater has led to arsenic poisoning which affects the skin, liver, lungs and kidneys.
Prominently, arsenic has attracted much attention in Bangladesh, as 21.4% of all the deaths in a highly affected area were caused by levels of arsenic surpassing WHO’s provisional guideline value of 10 μg/L.
Long-term exposure to low doses of arsenic can cause a negative interference in the way cells communicate, which may minimise their ability to function, subsequently playing a role in the development of disease and causing an increase in health risks.
For example, cells use phosphate to communicate with other cells, but arsenate, which is one form of arsenic, can replace and imitate phosphate in the cell. This damages cells so they can not generate energy and impairs the ability of cells to communicate.
The health risks of arsenic in drinking water. Video: EnviroHealthBerkeley
Symptoms of arsenic poisoning can be acute, severe or chronic depending on the period of exposure and method of exposure. Symptoms may include vomiting, abdominal pain and diarrhoea, and long-term exposure can lead to cancers of the bladder and lungs.
Certain industries may face exposure to arsenic’s toxicity, but the maximum exposure to arsenic allowed is limited to 10 micrograms per cubic metre of air for every 8-hour shift. These industries include glass production, smelting, wood treatment, and the use of pesticides. Traces of arsenic can also be found in tobacco, posing a risk to people who smoke cigarettes and other tobacco products.
A global threat
Arsenic is naturally found in the Earth’s crust and can easily contaminate water and food.
WHO has ranked arsenic as one of the top 10 chemicals posing a huge threat to public health. WHO is working to reduce arsenic exposure, however, assessing the dangers on health from arsenic is not straightforward.
As symptoms and signs caused by long-term exposure to inorganic arsenic varies across population groups, geographical regions, as well as between individuals, there is no universal definition of the disease caused by this element. However, continuous efforts and measures are being made to keep concentrations as low as possible.
The aerogel could be used to coat spacecrafts due to its resilience to certain conditions.
The aerogel comprises a network of tiny air pockets, with each pocket separated by two atomically thin layers of hexagonal boron nitride. It’s at least 99% space. To build the aerogel, Duan’s team used a graphene template coated with borazine, which forms crystalline boron nitride when heated. When the graphene template oxidises, this leaves a ‘double-pane’ boron nitride structure.
The basis of the newly developed aerogel is the 2D structure of graphene.
‘The key to the durability of our new ceramic aerogel is its unique architecture,’ says study co-author Xiangfeng Duan of the University of California, US.
‘The “double-pane” ceramic barrier makes it difficult for heat to transfer from one air bubble to another, or to spread through the material by traveling along the hexagonal boron nitride layers themselves, because that would require following long, circuitous routes.’
How does Aerogel technology work? Video: Outdoor Research
Unlike other ceramic aerogels, the material doesn’t become brittle under extreme conditions. The new aerogel withstood 500 cycles of rapid heating and cooling from -198°C to 900°C, as well as 1400°C for one week. A piece of the insulator shielded a flower held over a 500°C flame.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today we look at mercury and some of its reactions.
Mercury is a silver, heavy, liquid metal. Though mercury is a liquid at room temperature, as a solid it is very soft. Mercury has a variety of uses, mainly in thermometers or as an alloy for tooth fillings.
Mercury & Aluminium
Mercury is added directly to aluminium after the oxide layer is removed. Source: NileRed
The reaction between mercury and aluminium forms an amalgam (alloy of mercury). The aluminium’s oxide layer is disturbed When the amalgam forms, in the following reaction:
Al+ Hg → Al.Hg
Some of the Al.Mg get’s dissolved in the mercury. The aluminium from the amalgam then reacts with the air to form white aluminium oxide fibres, which grow out of the solid metal.
Mercury & Bromine
Mercury and bromine are the only two elements that are liquid at room temperature on the periodic table. Source: Gooferking Science
When mercury and bromine are added together they form mercury(I) bromide in the following reaction:
Hg2 + Br2 → Hg2Br2
This reaction is unique as mercury can form a metal-metal covalent bond, giving mercury(I) bromide a structure of Br-Hg-Hg-Br
Making the Pharaoh's Serpent by igniting mercury (II) thiocyanate. Source: NileRed
The first step of this reaction is to generate water-soluble mercury (II) nitrate by combining mercury and concentrate nitric acid. The reaction goes as follows:
Hg + 4NO3 → Hg(NO3)2 + 2H2O + 2NO2
Next, the reaction is boiled to remove excess NO2 and convert mercury(I) nitrate by-product to mercury (II) nitrate. The mixture is them washed with water and potassium thiocyanate added to the mercury (II) nitrate:
Hg(NO3)2 + 2KSCN→ Hg(SCN)2 + 2KNO3
The mercury (II) thiocyanate appears as a white solid. After this is dried, it can be ignited to produce the Pharaoh’s serpent, as it is converted to mercury sulfide in the following reaction:
Hg(SCN)2 → 2HgS + CS2 + + C3N4
The result is the formation of a snake-like structure. Many of the final products of this process are highly toxic, so although this used to be used as a form of firework, it is no longer commercially available.
Though many reactions of mercury look like a lot of fun, mercury and many of it’s products is highly toxic - so don’t try these at home!
Cassie Sims is a PhD student and SCI early career member, sitting on the committees of SCI’s Agrisciences Group and Agrifood Early Career Committee. Read more of Cassie’s work at soci.org/news and sciblog.com.
As part of my PhD programme – the BBSRC Doctoral Training Partnership (DTP) with the University of Nottingham – I have had the opportunity to do a 12-week internship in something different to research. Today, I am going to tell you why I think every PhD student should step outside their comfort zone and do an internship.
1. Expand your community
Doing a PhD internship allows you to temporarily leave the academic bubble, and meet some new and different people. During my internship, I had the opportunity to engage with members of SCI’s community, including a range of industrial partners, academics and other early career scientists.
Attending events at SCI HQ has given me the chance to network with people I may never have met otherwise, gaining valuable connections and career advice. I was also able to see the range of work that goes on in chemistry and the chemical industry, including the variety of different career paths that are available.
Taking a step back from the practical side of science can also allow you to gain an appreciation for other areas of science. Learning about science in journalism and digital media will inform my decisions when trying to communicate my research to the general public in the future.
2. Gain transferable skills
Undertaking an internship in an area that you are unfamiliar with will diversify your skills. Digital media has taught me many new skills, such as social media and Photoshop, but also refined skills that are valuable and transferable.
The main skills I have worked on are my writing and editing capabilities. I have found my flow for writing, learnt about proofreading, and refreshed my memory in grammar and spelling. These skills will be incredibly useful when trying to write a PhD thesis, and my experience will shine on my CV when applying for future jobs.
3. A break from the lab
A PhD can be an overwhelming experience; sometimes it can feel like you are drowning in lab work and data analysis. Doing an internship means you can take a few months to escape, allowing you the chance to free your mind from data and reactions.
During my internship, I have had time to think about my research in more depth, considering options and planning, instead of rushing into things. The opportunity to take a step back means I will be re-entering the lab with clear, coherent plans and a new-found energy.
Although I have missed the rush of scientific research, my internship has taught me useful skills and allowed me to meet so many interesting people. I have really enjoyed my time in the SCI Digital Media team, and I would urge anyone considering an internship to take the leap.
I hope to continue working with SCI through the Agri-Food Early Careers Committee and other SCI activities that I am involved with.
All Images: Andrew Lunn/SCI
On 19 March 2019, SCI hosted the second annual final of the Bright SCIdea Challenge, bringing together some of the brightest business minds of the future to pitch their science-based innovation to a panel of expert judges and a captivated audience.
As an opportunity to support UK/ROI students interested in commercialising their ideas and developing their business skills, the final included talks and training from our judges and networking with industry professionals.
The day started with a poster session and networking, including posters from teams Glubiotech, Online Analytics, HappiAppi and NovaCAT.
Training sessions came next, with Neil Wakemen from Alderley Park Accelerator speaking first on launching a successful science start-up.
Lucinda Bruce-Gardyne from Genius Foods spoke next on her personal business story, going from the kitchen to lab to supermarket shelves.
Participants could catch a glimpse of the trophies before giving their pitches.
The first team to pitch were Team Seta from UCL, with their idea for a high-throughput synthetic biology approach for biomaterials.
Team Plastech Innovation from Durham University presented their sustainable plastic-based concrete.
Closing the first session, Team DayDreamers. pitched their AI-driven mental wellness app.
The break was filled with networking between delegates and industry professionals.
Opening the second session, Team BRISL Antimicrobials, from UCL, showcased their innovative light-activated antimicrobial bristles that could be used in toothbrushes.
The final pitch of the day was from Team OxiGen, from the University of St Andrews, presenting their designer cell line for optimised protein expression.
After asking lots of questions during each pitch, the judges were left with the difficult task of deciding a winner.
Team HappiAppi, from Durham University, were voted the best poster by the audience!
The second runner-up was Team Seta!
The first runner-up was Team BRISL Antimicrobials!
Congratulations to the winners Team Plastech Innovation!! They win £5000 towards their idea.
We would like to thank our participating teams, sponsors (INEOS and Synthomer), guest speakers and judges (Lucinda Bruce-Gardyne, Robin Harrison, Inna Baigozina-Goreli, Ian Howell & Dave Freeman).
All images: Andrew Lunn/SCI
The event, organised by SCI’s Young Chemists Panel and Fine Chemicals Group, alongside RSC’s Heterocycle and Synthesis Group and Organic Division Council, saw 11 teams from across academia and industry to showcase their synthetic prowess.
At the event, the teams presented their synthetic routes for the novel sulfonated alkaloid Aconicarmisulfonine A. After their presentations, teams were questioned by the judges and audience on their synthetic route selections.
Scroll down to experience the day…
Chair of the Retrosynthesis Competition Organising Committee, Jason Camp, opens proceedings.
Live and Let Diene from Concept Life Sciences kick off the day’s pitches.
The Tryptophantastic Four from the University of Bristol followed.
Total Synthesisers from the University of Manchester deliver their synthesis model to a packed audience.
The Bloomsbury Group from the University of Manchester close the first session of the day.
During breaks, the competitors networked with senior scientists and our company exhibitors.
SygTeamTwo from Sygnature Discovery take to the podium.
The judges seem impressed with this year’s teams as Shawshank Reduction from the University of Oxford pitch next.
Next up is In Tsuji We Trost from Evotec.
Totally Disconnected from the University of Strathclyde close the second session.
The competition gets more competitive and popular each year! SCI and RSC members discuss the teams so far.
Hold Me Closer Vinyl Dancer from the University of Cambridge are up.
Flower Power from Syngenta give an intriguing talk.
The second University of Oxford Team, Reflux and Chill?, finish the day’s impressive set of pitches.
Audience members then casted their votes for the Audience Vote winner…
…which went to In Tsuji We Trost!
Our 3rd place finalists were SygTeamTwo…
Oxford team Shawshank Reduction took 2nd place…
Congratulations to 2019 winners, Flower Power!
Scientists from the Department of Energy’s Lawrence Berkeley National Laboratory, California, US, have designed a method in which semiconducting materials have been turned into quantum machines.
This work could revolutionise the field, and lead to new efficient electronic systems and exciting physics.
Quantum machines are generally made from two-dimensional (2D) materials – often graphene. These materials are one atom thick and can be stacked. When the materials form a repeating pattern, this can generate unique properties.
Studies with graphene have resulted in large advancements in the field of 2D materials. A new study has found a way to use two semiconducting materials – tungsten disulphide and tungsten diselenide – to develop a material with highly interacting electrons.
The researchers determined that the ‘twist angle’ – the angle between the two layers – provides the key to turning a 2D system into a quantum material.
Dr Gary Harris talks about radio technology to quantum materials. Source: TEDx Talks
‘This is an amazing discovery because we didn’t think of these semiconducting materials as strongly interacting,’ said Feng Wang, Professor of Physics at UC Berkeley. ‘Now this work has brought these seemingly ordinary semiconductors into the quantum materials space.’
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog is an element which gives us life, oxygen.
Oxygen is a group 5 gas that is found abundantly in nature. Of the air we breathe, 20.8% is oxygen in its elemental, diatomic form of O2. Oxygen is also one of the most abundant elements in nature, and along with carbon, hydrogen and nitrogen, makes up the structures of most of the natural world. Oxygen can be found in DNA, sugar, hormones, proteins and so many more natural structures.
Although oxygen mainly exists as a colourless gas, at -183°C it can be condensed as a pale blue liquid. Oxygen may seem unsuspecting, but it is highly reactive and highly oxidising. A common example of this reactivity is how oxygen reacts with iron to produce iron oxide, which appears as rust.
Oxygen molecules are paramagnetic – they exhibit magnetic characteristics when in the presence of a magnetic field. Liquid oxygen is so magnetic that the effect can be seen by suspending it between the poles of a powerful magnet.
Oxygen gas has applications for medicine and space travel in breathing apparatus.
Oxygen can be found as ozone or O3. Ozone is a pale blue gas and has a distinctive smell. It is not as stable as diatomic oxygen (dioxygen) and is formed when ultraviolet light (UV) and electrical charges interact with O2.
The highest concentration of ozone can be found in the Earth’s stratosphere, which absorbs the Sun’s UV radiation, providing natural protection for planet Earth.
Ozone (O3) is most concentrated in the stratosphere. Image: Pixabay
Ozone can be used industrially as a powerful oxidising agent. Unfortunately, it can be a dangerous respiratory hazard and pollutant so much be used with care.
Water consists of an oxygen atom and two hydrogen atoms. Though this may seem remarkably unassuming, this combination gives water unique properties that are crucial to it’s functions in the natural world.
Water can form hydrogen bonds between the slightly positive hydrogen and the slightly negative oxygen. These hydrogen bonds, along with waters other practical properties, make water useful in nature.
Without the hydrogen bonding found in water, plants could not transpire – transport water through their phloem’s against gravity. The surface tension of water provides stability for many natural structures.
Oxygen plays a key role in nature, including in water molecules. Image: Pixabay
Oxygen plays a key role in nature, from the ozone layer that encapsulates our planet, to our DNA. It’s combination with hydrogen in water makes a molecule which is integral to the natural world, and both water and oxygen itself are pivotal to our existence the planet.
To celebrate World Poetry Day, today we look at how poetry and science interlink, and how poetry can be a unique medium for science communication.
Poetry and science have an interesting history – John Keats once said that Isaac Newton, one of the most prominent scientists of the time, had ‘destroyed the poetry of the rainbow by reducing it to a prism’. However, poetry can be a powerful tool to disseminate scientific research to a wider audience.
In 1984, J. W. V. Storey published his works on ‘The Detection of Shocked CO Emission’ in The Proceedings of the Astronomical Society of Australia as a lengthy poem. He even noted on the paper that his colleagues may wish to dissociate themselves from the presentation style.
A note from J. M. V. Storey’s paper dissociating his colleagues from the poetry style. Source: The Detection of Shocked CO Emission
Modern Science Poetry
Notable British poet Ruth Gabel, also the great-great-granddaughter of Charles Darwin, has written a plethora of poetry about science, including works on Darwin’s writings. She has written a multitude of poems, mainly on zoology and genetics.
In 2015, Professor Stephen Hawking, world-renowned physicist, collaborated with poet Sarah Howe to write a poem about relativity for National Poetry Day in the UK.
Stephen Hawking reads “Relativity” By Sarah Howe Film Bridget Smith. Source: National Poetry Day
Poetry can also be utilised for outreach, especially for younger audiences. The SAW Trust is a charity that uses art and poetry to engage school children in science. SAW Trust was founded by Professor Anne Osbourne, Associate Research Director and Institute Strategic Programme Leader, Plant and Microbial Metabolism at the John Innes Centre, Norwich, UK. The charity inspires children to find a love for science through the arts.
Science and poetry, or more generally art have always been interlinked, and by using poetry we can spread science to a wider audience.
For British Science Week 2019, we are looking back at how Great Britain has shaped different scientific fields through its research and innovation. First, we are delving into genetics and molecular biology – from Darwin’s legacy, to the structure of DNA and now modern molecular techniques.
The theory of evolution by natural selection is one of the most famous scientific theories in biology to come from Britain. Before Charles Darwin famously published this theory, several classical philosophers considered how some traits may have occurred and survived, including works where Aristotle pondered the shape of teeth.
These ideas were forgotten until the 18th century, when they were re-introduced by philosophers and scientists including Darwin’s own grandfather, Erasmus Darwin.
Darwin used birds, particularly pigeons and finches to demonstrate his theories. Image: Pixabay
In 1859, Darwin first set out his theory of evolution by natural selection to explain adaptation and speciation. He was inspired by observations made on his second voyage of HM Beagle, along with the work of political economist Thomas Robert Malthus on population.
Darwin coined the term ‘natural selection’, thinking of it as like the artificial selection imposed by farmers and breeders. After publishing a series of papers with Alfred Russel Wallace, followed by On the Origin of Species, the concept of evolution was widely accepted.
Although many initially contested the idea of natural selection, Darwin was ahead of his time, and further evidence was yet to come in the form of genetics.
Gregor Mendel first discovered genetics whilst working on peas and inheritance in the late 19th century. The unraveling of the molecular processes that were involved in this inheritance, however, allowed scientists to study inheritance and genetics in a high level of detail, ultimately advancing the field dramatically.
A major discovery in the history of genetics was the determination of the structure of deoxyribose nucleic acid (DNA).
DNA was first isolated by Swiss scientists, and it’s general structure – four bases, a sugar and a phosphate chain – was elucidated by researchers from the United States. It was a British team that managed to make the leap to the three-dimensional (3D)structure of DNA.
Using x-ray diffraction techniques, Rosalind Franklin, a British chemist, discovered that the bases of DNA were paired. This lead to the first accurate model of DNA’s molecular structure by James Watson and Francis Crick. The work was initially published in Nature in 1953, and would later win them a Nobel Prize.
The age of genetic wonder. Source: TED
By understanding the structure of DNA, further advances in the field were made. This has lead to a wide range of innovations, from Crispr/CAS9 gene editing to targeted gene therapies. The British-born science has been utilised by British pharmaceutical companies – pharma-giants GlaxoSmithKline (GSK) and AstraZeneca use this science today in driving new innovations.
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today, on International Women’s Day, we look at the two elements radium and polonium and the part Marie Curie that played in their discovery.
Who is Marie Curie?
Marie Sklodowska and her future husband Pierre Curie.
Marie Sklodowska-Curie was born in 1867 in Poland. As a young woman she had a strong preference for science and mathematics, so in 1891 she moved to Paris, France, and began her studies in physics, chemistry and mathematics at the University of Paris.
After gaining a degree in physics, Curie began working on her second degree whilst working in an industrial laboratory. As her scientific career progressed, she met her future husband, Pierre Curie, whilst looking for larger laboratory space. The two bonded over their love of science, and went on to marry, have two children and discover two elements together.
After finishing her thesis on ‘Studies in radioactivity’, Curie became the first woman to win a Nobel Prize, the first and only woman to win twice, and the only person to win in two different sciences.
Curie, along with husband Pierre and collaborator Henri Becquerel, won the 1903 Nobel prize in Physics for their radioactivity studies, and the 1911 Nobel prize in Chemistry for the isolation and study of elements radium and polonium.
Curie won the Nobel prize twice in two different subjects. Image: Pixabay
As of 2018, Curie is one of only three women to have won the Nobel Prize in Physics and one of the five women to be awarded the Nobel Prize in Chemistry.
Polonium, like radium, is a rare and highly reactive metal with 33 isotopes, all of which are unstable. Polonium was named after Marie Curie’s home country of Poland and was discovered by Marie and Pierre Curie from uranium ore in 1898.
Polonium is not only radioactive but is highly toxic. It was the first element discovered by the Curies when they were investigating radioactivity. There are very few applications of polonium due to its toxicity, other than for educational or experimental purposes.
Radium is an alkaline earth metal which was discovered in the form of radium chloride by Marie and her husband Pierre in December 1898. They also extracted it from uranite (uranium ore), as they did with polonium. Later, in 1911, Marie Curie and André-Louis Debierne isolated the metal radium by electrolysing radium chloride.
The discovery of radium led to the development of modern cancer treatments, like radiotherapy.
Pure radium is a silvery-white metal, which has 33 known isotopes. All isotopes of radium are radioactive – some more than others. The common historical unit for radioactivity, the curie, is based on the radioactivity of Radium-226.
Famously, radium was historically used as self-luminescent paint on clock hands. Unfortunately, many of the workers that were responsible for handling the radium became ill – radium is treated by the body as calcium, where it is deposited in bones and causes damage because of its radioactivity. Safety laws were later introduced, followed by discontinuation of the use of radium paint in the 1960s.
Marie Curie: A life of sacrifice and achievement. Source: Biographics
Curie’s work was exceptional not only in its contributions to science, but in how women in science were perceived. She was an incredibly intelligent and hard-working woman who should be celebrated to this day.
Spaceflight is a high-risk business. Spacecraft break down all the time and when that happens funding and careers evaporate. Back in the late 1960s, NASA decided to double the odds of success and send two spacecraft on one mission. Voyagers 1 and 2, for example, were the spacecraft that returned the first detailed pictures of the outer planets of our solar system and introduced us to the neighbourhood. Launched in 1977, both are still flying.
Any spacecraft must have three components: a payload, an engine and a fuel supply – by far the heaviest component. But what if we could do away with the onboard fuel supply and replace it with an external fuel supply? Say light itself?
Can you push a spacecraft with light? Video: Physics Girl
The idea of solar sail technology has been floating around for decades. Indeed, the notion of a solar pressure can be traced back to 1610 in a letter that Johannes Kepler wrote to Galileo.
But it was only in the 20th century that solar sails began to be considered as an achievable engineering reality. Broadly, solar sails fall into two categories: those using light from natural sources – the sun and ambient starlight in space; and those using coherent light from lasers.
At the SCI HQ in Belgrave Square, London, we have curated a beautiful garden filled with plants that represent our technical and regional interest groups. Each of these plants has a scientific significance. On World Wildlife Day, we take a look at how some of our plants are doing in March.
Cyclamen hederifolium - the ivy-leaved cyclamen. Image: SCI
Cyclamen hederifolium is included in the SCIence garden to represent the horticulture group. This beautiful pink flower has a mutualistic relationship with ants, in which the ants carry the seeds far away, ensuring no competition between young plants and the original.
Dichroa febrifuga - a hydrangea with anti-malarial properties. Image: SCI
Not yet flowering, D. febrifuga is a traditional Chinese herbal medicine that is used for treatment of malaria. It contains the alkaloids febrifugine and isofebrifugine which are thought to be responsible for it’s anti-malaria properties.
Fatsia japonica - the paper plant. Image: SCI
F. japonica is also known as the glossy-leaved paper plant and is native to Japan, southern Korea and Taiwan. This plant represents our materials group.
Rosmarinus officinalis aka rosemary - a herb with many uses from culinary to chemical. Image: SCI
Rosemary is a common herb that originates in the Mediterranean. It has many uses, including as a herb for cooking and fragrance. One of it’s more scientific uses is as a supply of lucrative useful phytochemicals such as camphor and rosemarinic acid.
Prunus mume ‘Beni-chidori’ - a Chinese ornamental flower. Image: SCI
The Prunus mume tree is a beautiful ornamental tree that has significance in East Asian culture. It has a wide variety of applications, from medicinal to beverages, and can been seen in many pieces of art. This plant is in the SCIence garden to represent our Chinese Group UK.
Pieris japonica - the Dwarf-Lilly-of-the-Valley-Shrub. Image: SCI
The Pieris japonica ree has Asian origins, and represents our Agrisciences group. The leaves contain diterpenoids which inhibit the activity of feeding pests, such as insects.
Pulmonaria ‘Blue Ensign’ - lungwort. Image: SCI
The lungwort has been used since the Middle Ages as a medicinal herb to treat chest or lung diseases. It is an example of the use of the doctrine of signatures - where doctors believed that if a plant resembled a body, it could be used to treat illness in that body part.
Euphorbia amygdaloides - the wood spruce. Image:SCI
Euphorbia amygdaloides is planted to represent our Materials Chemistry group. It has a waxy feel, and has potential to be used as an alternative to latex.
Erysimum ‘Bowles Mauve’ - a flowering plant in the cabbage family. Image: SCI
The Erysimum ‘Bowles Mauve’ is a member of the cabbage family (Brassicaceae). This plant was used to make the first synthetic dye, Mauvine, when SCI founding member William Perkin discovered in in 1858.
A big congratulations to our Agri-Food Early Careers Committee #agrifoodbecause Twitter competition winner, Hannah Blyth. Hannah is a PhD student at Rothamsted Research. Her winning entry, a fungal plate, really wowed us!
#agrifoodbecause understanding crop diseases (eg. my fungal wheat pathogen of choice, causing Septoria Tritici Blotch) will reduce yield losses, important for future food security… Photo of some mutants on a spotting plate. Spot a difference? #phdchat @SCI_AgriFood @SCIupdate pic.twitter.com/0cqK3711Uu— Hannah Blyth (@StellaRemnant)February 21, 2019
Hannah will receive a a years free membership to SCI and a £50 Amazon voucher!
2019 has been declared by UNESCO as the Year of the Periodic Table. To celebrate, we are releasing a series of blogs about our favourite elements and their importance to the chemical industry. Today’s blog is about iodine and some of the exciting reactions it can do!
Iodine & Aluminium
Reaction between iodine and aluminum. These two components were mixed together, followed by a few drops of hot water. Source: FaceOfChemistry
Reactions between iodine and group 2 metals generally produce a metal iodide. The reaction that occurs is:
2Al(s) + 3I2(s) → Al2I6(s)
Freshly prepared aluminium iodide reacts vigorously with water, particularly if its hot, releasing fumes of hydrogen iodide. The purple colour is given by residual iodine vapours.
Iodine & Zinc
Zinc and iodine react similarly to aluminium and iodine. Source: koen2all
Zinc is another metal, and when it reacts with iodine it too forms a salt – zinc iodide. The reaction is as follows:
Zn + I2→ ZnI2
The reaction is highly exothermic, so we see sublimation of some of the iodide and purple vapours, as with the aluminium reaction. Zinc iodide has uses in industrial radiography and electron microscopy.
Iodine & Sodium
Iodine reacting with molten sodium gives an explosive reaction that resembles fireworks. Source: Bunsen Burns
As with the other two metals, sodium reacts violently with iodine, producing clouds of purple sublimated iodine vapour and sodium iodide. The reaction proceeds as follows:
Na + I2→ 2NaI
Sodium iodide is used as a food supplement and reactant in organic chemistry.
Iodine Clock reaction
The iodine clock reaction – a classic chemical clock used to